JP6347743B2 - コクリエート組成物およびその製造および使用方法 - Google Patents
コクリエート組成物およびその製造および使用方法 Download PDFInfo
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- JP6347743B2 JP6347743B2 JP2014509488A JP2014509488A JP6347743B2 JP 6347743 B2 JP6347743 B2 JP 6347743B2 JP 2014509488 A JP2014509488 A JP 2014509488A JP 2014509488 A JP2014509488 A JP 2014509488A JP 6347743 B2 JP6347743 B2 JP 6347743B2
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- cocreatate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Diabetes (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482996P | 2011-05-05 | 2011-05-05 | |
| US61/482,996 | 2011-05-05 | ||
| US201161534075P | 2011-09-13 | 2011-09-13 | |
| US61/534,075 | 2011-09-13 | ||
| US201161547325P | 2011-10-14 | 2011-10-14 | |
| US61/547,325 | 2011-10-14 | ||
| US201161570067P | 2011-12-13 | 2011-12-13 | |
| US61/570,067 | 2011-12-13 | ||
| US201261590531P | 2012-01-25 | 2012-01-25 | |
| US61/590,531 | 2012-01-25 | ||
| US201261608272P | 2012-03-08 | 2012-03-08 | |
| US61/608,272 | 2012-03-08 | ||
| US201261620656P | 2012-04-05 | 2012-04-05 | |
| US61/620,656 | 2012-04-05 | ||
| US201261636793P | 2012-04-23 | 2012-04-23 | |
| US61/636,793 | 2012-04-23 | ||
| PCT/US2012/036576 WO2012151517A1 (en) | 2011-05-05 | 2012-05-04 | Cochleate compositions and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061681A Division JP2018138552A (ja) | 2011-05-05 | 2018-03-28 | コクリエート組成物およびその製造および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513135A JP2014513135A (ja) | 2014-05-29 |
| JP2014513135A5 JP2014513135A5 (enExample) | 2015-06-25 |
| JP6347743B2 true JP6347743B2 (ja) | 2018-06-27 |
Family
ID=47108070
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509488A Active JP6347743B2 (ja) | 2011-05-05 | 2012-05-04 | コクリエート組成物およびその製造および使用方法 |
| JP2018061681A Pending JP2018138552A (ja) | 2011-05-05 | 2018-03-28 | コクリエート組成物およびその製造および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061681A Pending JP2018138552A (ja) | 2011-05-05 | 2018-03-28 | コクリエート組成物およびその製造および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140220108A1 (enExample) |
| EP (1) | EP2704688B1 (enExample) |
| JP (2) | JP6347743B2 (enExample) |
| AU (1) | AU2012250568B2 (enExample) |
| CA (1) | CA2834788C (enExample) |
| ES (1) | ES2741282T3 (enExample) |
| WO (1) | WO2012151517A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6347743B2 (ja) * | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
| MX361155B (es) * | 2012-07-30 | 2018-11-28 | Matinas Biopharma Nanotechnologies Inc | Cocleatos hechos con fosfatidilserina de soja. |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| CN104398745A (zh) * | 2014-12-07 | 2015-03-11 | 王月水 | 一种治疗颈肩腰腿痛、腰椎间盘突出症的中药药浴及其制备方法 |
| KR20180004104A (ko) * | 2015-03-03 | 2018-01-10 | 마티나스 바이오파마 나노테크놀로지스, 인코포레이티드 | 코클레이트 및 약리학적 활성제의 조직 침투를 향상시키기 위해 이를 사용하는 방법 |
| CN108136212A (zh) * | 2015-04-22 | 2018-06-08 | 马丁尼斯生物制药纳米技术公司 | 用于治疗分枝杆菌感染和肺病的组合物和方法 |
| CN107920991A (zh) * | 2015-06-18 | 2018-04-17 | 马丁尼斯生物制药纳米技术公司 | 治疗炎性疾病或病状的组合物和方法 |
| WO2017205550A1 (en) * | 2016-05-24 | 2017-11-30 | Matinas Biopharma Nanotechnologies, Inc. | Immunogenic cochleates and methods of use |
| CA3027668A1 (en) * | 2016-07-12 | 2018-01-18 | Matinas Biopharma Nanotechnologies, Inc. | Encochleated antifungal compounds for central nervous system delivery and treatment of cryptococcus infections |
| AU2018337955B2 (en) * | 2017-09-20 | 2024-01-18 | Atopic Medical, Inc. | Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa |
| KR101989789B1 (ko) * | 2017-11-30 | 2019-06-18 | (주) 에이치엔에이파마켐 | 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트 |
| KR102019589B1 (ko) * | 2018-01-23 | 2019-11-04 | 가톨릭대학교 산학협력단 | 내이에서의 약물전달용 나노입자 |
| JP2022544077A (ja) * | 2019-08-13 | 2022-10-17 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | クリプトコッカス感染症を治療する方法 |
| EP4572770A1 (en) | 2022-08-16 | 2025-06-25 | Matinas BioPharma Nanotechnologies, Inc. | Antifungal agent encapsulated in a lipid nanocrystal for treating mucormycosis |
| WO2024039733A1 (en) * | 2022-08-16 | 2024-02-22 | Matinas Biopharma Nanotechnologies, Inc. | Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4078052A (en) | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
| GB8505882D0 (en) * | 1985-03-07 | 1985-04-11 | Central Blood Lab Authority | Purification of blood coagulation factor viii |
| US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| US4643987A (en) | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| US4639433A (en) | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| IL96603A (en) | 1989-12-13 | 1998-02-08 | Lilly Co Eli | Antibacterial glycopeptide derivatives, process for their preparation and pharmaceutical compositions containing them |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| AU670793B2 (en) * | 1992-04-30 | 1996-08-01 | Alpha Therapeutic Corporation | Improved solubilization and stabilization of factor VIII complex |
| US5840707A (en) | 1993-10-04 | 1998-11-24 | Albany Medical College | Stabilizing and delivery means of biological molecules |
| US5994318A (en) | 1993-10-04 | 1999-11-30 | Albany Medical College | Cochleate delivery vehicles |
| US5643574A (en) | 1993-10-04 | 1997-07-01 | Albany Medical College | Protein- or peptide-cochleate vaccines and methods of immunizing using the same |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| TW457248B (en) | 1994-01-28 | 2001-10-01 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
| JP2927225B2 (ja) | 1995-11-30 | 1999-07-28 | 日本電気株式会社 | 画像入力装置 |
| US6320029B1 (en) * | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| EP0914094A4 (en) * | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| US6153217A (en) * | 1999-01-22 | 2000-11-28 | Biodelivery Sciences, Inc. | Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents |
| WO2001052817A2 (en) * | 2000-01-24 | 2001-07-26 | Biodelivery Sciences, Inc. | Cochleate formulations and their use for delivering biologically relevant molecules |
| CA2454183C (en) | 2001-07-23 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| US20030167490A1 (en) | 2001-11-26 | 2003-09-04 | Hunter Craig P. | Gene silencing by systemic RNA interference |
| US20030219473A1 (en) * | 2002-03-26 | 2003-11-27 | Leila Zarif | Cochleates made with purified soy phosphatidylserine |
| US8980310B2 (en) * | 2002-12-31 | 2015-03-17 | Bharat Serums and Vaccines, Ltd. | Non-pegylated long-circulating liposomes |
| US7351688B2 (en) * | 2003-02-05 | 2008-04-01 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein formulations |
| US20050013854A1 (en) * | 2003-04-09 | 2005-01-20 | Mannino Raphael J. | Novel encochleation methods, cochleates and methods of use |
| WO2005110361A2 (en) * | 2004-04-09 | 2005-11-24 | Biodelivery Sciences International, Inc. | Nucleotide-cochleate compositions and methods of use |
| JP4789208B2 (ja) | 2003-04-09 | 2011-10-12 | バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド | タンパク質発現に向けられた渦巻型組成物 |
| US20060110441A1 (en) * | 2004-10-28 | 2006-05-25 | Harry Wong | Lyophilized liposome formulations and method |
| JP2008544990A (ja) * | 2005-06-29 | 2008-12-11 | ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク | 低免疫原性蛋白質−脂質複合体に関する組成物および方法 |
| WO2007055789A2 (en) * | 2005-10-31 | 2007-05-18 | Neose Technologies, Inc. | Expression of soluble therapeutic proteins |
| AU2006322076C1 (en) * | 2005-12-08 | 2013-11-14 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| WO2008024389A2 (en) * | 2006-08-23 | 2008-02-28 | Biodelivery Sciences International, Inc. | Amphiphilic nucleotide cochleate compositions and methods of using the same |
| US20100310541A1 (en) * | 2007-05-25 | 2010-12-09 | Ironwood Pharmaceuticals, Inc. | Compositions and Methods for Reducing the Toxicity of Certain Toxins |
| JP6347743B2 (ja) * | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
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| JP2018138552A (ja) | 2018-09-06 |
| CA2834788C (en) | 2020-11-17 |
| JP2014513135A (ja) | 2014-05-29 |
| EP2704688A1 (en) | 2014-03-12 |
| AU2012250568A1 (en) | 2013-11-07 |
| EP2704688B1 (en) | 2019-07-10 |
| AU2012250568B2 (en) | 2017-06-29 |
| EP2704688A4 (en) | 2014-11-05 |
| CA2834788A1 (en) | 2012-11-08 |
| US20140220108A1 (en) | 2014-08-07 |
| WO2012151517A1 (en) | 2012-11-08 |
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