JP6336563B2 - 基板への活性作用剤の固定 - Google Patents

基板への活性作用剤の固定 Download PDF

Info

Publication number
JP6336563B2
JP6336563B2 JP2016502451A JP2016502451A JP6336563B2 JP 6336563 B2 JP6336563 B2 JP 6336563B2 JP 2016502451 A JP2016502451 A JP 2016502451A JP 2016502451 A JP2016502451 A JP 2016502451A JP 6336563 B2 JP6336563 B2 JP 6336563B2
Authority
JP
Japan
Prior art keywords
substrate
active agent
trihydroxyphenyl
primer
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016502451A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016515029A5 (enExample
JP2016515029A (ja
Inventor
トン ザット ハイ，
トン ザット ハイ，
ジョン−ブルース デボルト グリーン，
ジョン−ブルース デボルト グリーン，
ティモシー マイケル フルガム，
ティモシー マイケル フルガム，
フィリップ バイロン メッサースミス，
フィリップ バイロン メッサースミス，
タダス スタニスロヴァス シレイカ，
タダス スタニスロヴァス シレイカ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of JP2016515029A publication Critical patent/JP2016515029A/ja
Publication of JP2016515029A5 publication Critical patent/JP2016515029A5/ja
Application granted granted Critical
Publication of JP6336563B2 publication Critical patent/JP6336563B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0094—Physical treatment, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/04—Use of organic materials, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016502451A 2013-03-15 2014-03-14 基板への活性作用剤の固定 Active JP6336563B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798765P 2013-03-15 2013-03-15
US61/798,765 2013-03-15
PCT/US2014/027466 WO2014152551A1 (en) 2013-03-15 2014-03-14 Immobilization of active agent on a substrate

Publications (3)

Publication Number Publication Date
JP2016515029A JP2016515029A (ja) 2016-05-26
JP2016515029A5 JP2016515029A5 (enExample) 2017-04-13
JP6336563B2 true JP6336563B2 (ja) 2018-06-06

Family

ID=50896500

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016502451A Active JP6336563B2 (ja) 2013-03-15 2014-03-14 基板への活性作用剤の固定

Country Status (11)

Country Link
US (2) US9642949B2 (enExample)
EP (1) EP2968676B1 (enExample)
JP (1) JP6336563B2 (enExample)
KR (1) KR102253319B1 (enExample)
CN (1) CN105263536B (enExample)
AU (1) AU2014239600B2 (enExample)
BR (1) BR112015022379B1 (enExample)
CA (1) CA2906621A1 (enExample)
MX (1) MX363474B (enExample)
RU (1) RU2667966C2 (enExample)
WO (1) WO2014152551A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6513643B2 (ja) * 2013-06-07 2019-05-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ トリヒドロキシフェニル基を含む化合物を使用する基体上の活性剤の固定化
CN108926490B (zh) * 2017-05-25 2021-01-26 南方医科大学南方医院 一种抗凝胃管的制作方法
WO2019232177A1 (en) * 2018-05-30 2019-12-05 Wisconsin Alumni Research Foundation PROMOTING ENDOTHELIAL CELL AFFINITY AND ANTITHROMBOGENICITY OF POLYTETRAFLUOROETHYLENE (ptfe) BY MUSSEL-INSPIRED MODIFICATION AND RGD/HEPARIN GRAFTING
US11484626B2 (en) 2018-05-30 2022-11-01 Wisconsin Alumni Research Foundation Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (PTFE) by mussel-inspired modification and RGD/heparin grafting
US12251496B2 (en) 2018-05-30 2025-03-18 Wisconsin Alumni Research Foundation Wavy multi-component vascular grafts with biomimetic mechanical properties, antithrombogenicity, and endothelial cell affinity
CN108498878B (zh) * 2018-07-05 2019-06-11 四川大学 一种具有“三明治”夹心结构的生物医用水凝胶涂层及其制备方法
CN108686267B (zh) * 2018-07-05 2020-07-28 四川大学 一种兼具抗凝血、抗炎、抗增生功能的涂层及其制备方法
CN108969805B (zh) * 2018-07-05 2019-06-11 四川大学 一种可催化一氧化氮释放的抗凝血水凝胶涂层及其制备方法
CN108796491B (zh) * 2018-07-05 2019-07-09 四川大学 一种具有高耐腐蚀性和表面功能化的镁基金属转化涂层及其制备方法
CN108815587B (zh) * 2018-07-05 2020-07-21 四川大学 一种具有长期抗菌功能的水凝胶涂层及其制备方法
CN113164647B (zh) * 2018-11-29 2023-04-18 爱惜康股份有限公司 低温固化的有机硅润滑涂料
US12528913B2 (en) 2020-05-28 2026-01-20 Ethicon, Inc. Antimicrobial anhydrous topical skin closure compositions and systems
US11479669B2 (en) 2020-05-28 2022-10-25 Ethicon, Inc. Topical skin closure compositions and systems
US11718753B2 (en) 2020-05-28 2023-08-08 Ethicon, Inc. Topical skin closure compositions and systems
US11712229B2 (en) 2020-05-28 2023-08-01 Ethicon, Inc. Systems, devices and methods for dispensing and curing silicone based topical skin adhesives
US11589867B2 (en) 2020-05-28 2023-02-28 Ethicon, Inc. Anisotropic wound closure systems
US11518604B2 (en) 2020-05-28 2022-12-06 Ethicon, Inc. Systems, methods and devices for aerosol spraying of silicone based topical skin adhesives for sealing wounds
US12465577B2 (en) 2020-05-28 2025-11-11 Ethicon, Inc. Antimicrobial topical skin closure compositions and systems
CN112618791A (zh) * 2020-12-25 2021-04-09 福建医科大学附属协和医院 聚醚醚酮三维多孔化并修饰聚多巴胺/庆大霉素用于植入物抗菌、抗炎及促进骨整合
US20220211478A1 (en) * 2021-01-06 2022-07-07 Medtronic Inc. Surgical system and methods of use
CN113244897B (zh) * 2021-05-26 2021-10-01 高频美特利环境科技（北京）有限公司 一种水体除氟开孔聚合物泡沫材料及其制备方法和应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH472219A (de) 1963-06-15 1969-05-15 Spofa Vereinigte Pharma Werke Hochporöse Kollagen-Gewebe-Blutgefässprothese und Verfahren zur Herstellung derselben
JPS51101077A (enExample) 1975-03-04 1976-09-07 Konishiroku Photo Ind
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
US5242432A (en) 1991-09-26 1993-09-07 Ivac Needleless adapter
US5360413A (en) 1991-12-06 1994-11-01 Filtertek, Inc. Needleless access device
ES2215359T3 (es) 1991-12-18 2004-10-01 Icu Medical, Inc. Procedimiento de transferencia de fluido.
US5782816A (en) 1995-09-07 1998-07-21 David R. Kipp Bi-directional valve and method of using same
US5730418A (en) 1996-09-30 1998-03-24 The Kipp Group Minimum fluid displacement medical connector
DE69728422T2 (de) 1996-11-18 2005-03-03 Nypro Inc., Clinton Abwischbares luer-ventil
CA2260781A1 (en) 1997-05-20 1998-11-26 Baxter International Inc. Needleless connector
EP1043720A1 (en) 1999-04-07 2000-10-11 Agfa-Gevaert N.V. Heat mode recording element based on a thin metal layer
US7618937B2 (en) 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
US7858679B2 (en) 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
US7682669B1 (en) * 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
US6651956B2 (en) 2002-01-31 2003-11-25 Halkey-Roberts Corporation Slit-type swabable valve
US20030208165A1 (en) 2002-05-01 2003-11-06 Christensen Kelly David Needless luer access connector
EP1501565B1 (de) 2002-05-09 2006-11-02 Hemoteq GmbH Verbindungen und verfahren zur hemokompatiblen beschichtung von oberflächen
JP2004217540A (ja) * 2003-01-10 2004-08-05 Mitsubishi Chemicals Corp 没食子酸配糖体の製造方法
JP5133048B2 (ja) * 2004-02-27 2013-01-30 ノースウエスタン ユニバーシティ 重合化合物及び関連した使用方法
JP5028605B2 (ja) * 2004-11-22 2012-09-19 国立大学法人九州大学 バイオフィルム形成阻害剤及び治療用器具
WO2007133479A2 (en) 2006-05-10 2007-11-22 Cook Incorporated Delivery of elastin-stabilizing compound within a body lumen
US20080021392A1 (en) 2006-07-20 2008-01-24 Lurvey Kent L Medical fluid access site with antiseptic indicator
US20080107564A1 (en) 2006-07-20 2008-05-08 Shmuel Sternberg Medical fluid access site with antiseptic indicator
JP5597836B2 (ja) * 2006-08-04 2014-10-01 ケンジー ナッシュ コーポレイション バイオミメティック化合物およびその合成方法
US8563117B2 (en) 2006-08-04 2013-10-22 Phillip B. Messersmith Biomimetic modular adhesive complex: materials, methods and applications therefore
WO2008080162A2 (en) 2006-12-22 2008-07-03 The Johns Hopkins University Anti-cholesterolemic compounds and methods of use
US8383092B2 (en) 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
DK2114477T3 (da) * 2007-02-28 2012-08-20 Dsm Ip Assets Bv Hydrofil coating
JP2008253707A (ja) 2007-04-05 2008-10-23 Bio Verde:Kk 薬剤溶出ステント
US9125973B2 (en) 2007-07-20 2015-09-08 Baxter International Inc. Antimicrobial housing and cover for a medical device
US20090024096A1 (en) 2007-07-20 2009-01-22 Baxter International Inc. Immobilization of dyes and antimicrobial agents on a medical device
WO2009062146A2 (en) 2007-11-09 2009-05-14 Northwestern University Substrate-independent layer-by-layer assembly using catechol-functionalized polymers
US10676509B2 (en) 2008-07-31 2020-06-09 Northwestern University Surface-immobilized antimicrobial peptoids
CA2738490A1 (en) 2008-09-26 2010-04-01 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
EP2348835A4 (en) 2008-09-28 2014-01-22 Knc Ner Acquisition Sub Inc MIXES FROM MULTICOLOR CATECHOL COMPOUNDS
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
US20100297745A1 (en) 2009-05-19 2010-11-25 Nanyang Technological University Flow-through method of functionalizing inner surfaces of a microfluidic device
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
EP2380605A1 (en) * 2010-04-19 2011-10-26 InnoRa Gmbh Improved formulations for drug-coated medical devices
KR101257996B1 (ko) 2010-11-01 2013-04-30 아주대학교산학협력단 폴리페놀산화효소를 이용한 생리활성 물질의 표면 고정화 방법
EP2637707A4 (en) 2010-11-09 2014-10-01 Kensey Nash Corp ADHESIVES AND METHOD OF USE FOR HERNIEREPARATUR
US8949411B2 (en) * 2010-12-16 2015-02-03 Microsoft Corporation Determining whether a device is inside a network
US9273238B2 (en) 2011-02-23 2016-03-01 Yaolin ZHANG Process for fungal modification of lignin and preparing wood adhesives with the modified lignin and wood composites made from such adhesives
US9937255B2 (en) * 2011-05-18 2018-04-10 Nectero Medical, Inc. Coated balloons for blood vessel stabilization
WO2013033168A1 (en) * 2011-08-30 2013-03-07 Mast Biosurgery Ag Polyactic acid/alginate containing surgical barrier
US9415140B2 (en) * 2011-10-14 2016-08-16 Innora Gmbh Formulations for drug-coated medical devices
US10179114B2 (en) * 2013-01-24 2019-01-15 Northwestern University Phenolic coatings and methods of making and using same
JP6513643B2 (ja) 2013-06-07 2019-05-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ トリヒドロキシフェニル基を含む化合物を使用する基体上の活性剤の固定化

Also Published As

Publication number Publication date
EP2968676B1 (en) 2017-05-03
RU2015144297A3 (enExample) 2018-03-21
MX2015012627A (es) 2016-07-07
US20170173226A1 (en) 2017-06-22
EP2968676A1 (en) 2016-01-20
KR102253319B1 (ko) 2021-05-21
US20140287016A1 (en) 2014-09-25
AU2014239600B2 (en) 2017-11-02
US9642949B2 (en) 2017-05-09
AU2014239600A1 (en) 2015-09-24
MX363474B (es) 2019-03-25
BR112015022379B1 (pt) 2022-04-26
CN105263536B (zh) 2017-10-31
WO2014152551A1 (en) 2014-09-25
JP2016515029A (ja) 2016-05-26
HK1213823A1 (zh) 2016-07-15
RU2015144297A (ru) 2017-04-19
KR20150126944A (ko) 2015-11-13
RU2667966C2 (ru) 2018-09-25
CA2906621A1 (en) 2014-09-25
US9895468B2 (en) 2018-02-20
CN105263536A (zh) 2016-01-20
BR112015022379A2 (pt) 2017-07-18

Similar Documents

Publication Publication Date Title
US9895468B2 (en) Immobilization of an active agent on a substrate
KR102271653B1 (ko) 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화
CA2503490C (en) Medical device surface coating comprising bioactive compound
AU2009290833B2 (en) Immobilised biological entities
Yu et al. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions
HK1213823B (en) Immobilization of active agent on a substrate
HK1216237B (en) Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups
NZ714379B2 (en) Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups
CN112516410A (zh) 一种具有可调节止血—抗凝功能的智能留置针及其制备方法和应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170313

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170313

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171121

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180409

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180502

R150 Certificate of patent or registration of utility model

Ref document number: 6336563

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250