JP6334396B2 - 安定化スブチリシン組成物 - Google Patents
安定化スブチリシン組成物 Download PDFInfo
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- JP6334396B2 JP6334396B2 JP2014517745A JP2014517745A JP6334396B2 JP 6334396 B2 JP6334396 B2 JP 6334396B2 JP 2014517745 A JP2014517745 A JP 2014517745A JP 2014517745 A JP2014517745 A JP 2014517745A JP 6334396 B2 JP6334396 B2 JP 6334396B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38663—Stabilised liquid enzyme compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
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Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105189724A (zh) * | 2013-03-14 | 2015-12-23 | 诺维信公司 | 含有酶和抑制剂的水溶性膜 |
| WO2014173980A2 (en) * | 2013-04-23 | 2014-10-30 | Novozymes A/S | Liquid automatic dish washing detergent compositions |
| EP2799533A1 (en) * | 2013-04-30 | 2014-11-05 | Novozymes A/S | Protease and inhibitor containing water-soluble films |
| WO2016001319A1 (en) | 2014-07-03 | 2016-01-07 | Novozymes A/S | Improved stabilization of non-protease enzyme |
| WO2016097352A1 (en) * | 2014-12-19 | 2016-06-23 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| DE102015210828A1 (de) | 2015-06-12 | 2016-12-15 | Henkel Ag & Co. Kgaa | Phosphatfreies flüssiges Geschirrspülmittel |
| EP3310911B1 (en) | 2015-06-17 | 2023-03-15 | Danisco US Inc. | Bacillus gibsonii-clade serine proteases |
| CA3175255A1 (en) | 2015-07-01 | 2017-01-05 | Novozymes A/S | Methods of reducing odor |
| EP3317389B1 (en) * | 2015-07-03 | 2019-04-10 | Novozymes A/S | Detergent compositions with improved stability in the presence of sulfites |
| CN114292829A (zh) | 2015-07-06 | 2022-04-08 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| BR112018007474A2 (pt) | 2015-10-14 | 2018-10-30 | Novozymes A/S | ?limpeza de membranas de filtração de água? |
| ES2906780T3 (es) * | 2016-01-28 | 2022-04-20 | Novozymes As | Método de limpieza de un instrumento médico o dental |
| DE102016209406A1 (de) | 2016-05-31 | 2017-11-30 | Henkel Ag & Co. Kgaa | Stabilisierte Enzym-haltige Wasch- und Reinigungsmittel |
| US11661567B2 (en) | 2016-05-31 | 2023-05-30 | Danisco Us Inc. | Protease variants and uses thereof |
| WO2017210188A1 (en) | 2016-05-31 | 2017-12-07 | Novozymes A/S | Stabilized liquid peroxide compositions |
| CA3027745A1 (en) | 2016-06-17 | 2017-12-21 | Danisco Us Inc. | Protease variants and uses thereof |
| EP3309244A1 (en) | 2016-10-11 | 2018-04-18 | Basf Se | Low temperature protease |
| WO2018069158A1 (en) | 2016-10-11 | 2018-04-19 | Basf Se | Protease resistant to natural inhibitors |
| US20190264138A1 (en) | 2016-11-07 | 2019-08-29 | Danisco Us Inc. | Laundry detergent composition |
| WO2018118917A1 (en) | 2016-12-21 | 2018-06-28 | Danisco Us Inc. | Protease variants and uses thereof |
| CN110312794B (zh) | 2016-12-21 | 2024-04-12 | 丹尼斯科美国公司 | 吉氏芽孢杆菌进化枝丝氨酸蛋白酶 |
| WO2018169750A1 (en) | 2017-03-15 | 2018-09-20 | Danisco Us Inc | Trypsin-like serine proteases and uses thereof |
| US11078445B2 (en) | 2017-05-05 | 2021-08-03 | Novozymes A/S | Compositions comprising lipase and sulfite |
| CN111108183A (zh) | 2017-06-30 | 2020-05-05 | 诺维信公司 | 酶浆液组合物 |
| WO2019086528A1 (en) | 2017-11-01 | 2019-05-09 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| EP4379029A1 (en) | 2017-11-01 | 2024-06-05 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| DE102017219993A1 (de) | 2017-11-09 | 2019-05-09 | Henkel Ag & Co. Kgaa | Enzymhaltiges Wasch- oder Reinigungsmittel |
| WO2019108599A1 (en) | 2017-11-29 | 2019-06-06 | Danisco Us Inc | Subtilisin variants having improved stability |
| EP3799601A1 (en) | 2018-06-19 | 2021-04-07 | Danisco US Inc. | Subtilisin variants |
| EP3810767A1 (en) | 2018-06-19 | 2021-04-28 | Danisco US Inc. | Subtilisin variants |
| EP3856882A1 (en) | 2018-09-27 | 2021-08-04 | Danisco US Inc. | Compositions for medical instrument cleaning |
| ES2981999T3 (es) | 2018-10-31 | 2024-10-14 | Henkel Ag & Co Kgaa | Composiciones limpiadoras que contienen dispersinas V |
| EP3647397A1 (en) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Cleaning compositions containing dispersins iv |
| DE102018129277A1 (de) | 2018-11-21 | 2020-05-28 | Henkel Ag & Co. Kgaa | Mehrkomponenten Wasch- oder Reinigungsmittel enthaltend eine Chinon-Oxidoreduktase |
| US20230028935A1 (en) | 2018-11-28 | 2023-01-26 | Danisco Us Inc | Subtilisin variants having improved stability |
| WO2020242858A1 (en) | 2019-05-24 | 2020-12-03 | Danisco Us Inc | Subtilisin variants and methods of use |
| US20220306968A1 (en) | 2019-06-06 | 2022-09-29 | Danisco Us Inc | Methods and compositions for cleaning |
| WO2021001244A1 (en) | 2019-07-01 | 2021-01-07 | Basf Se | Peptide acetals for stabilising enzymes |
| EP3997202A1 (en) | 2019-07-12 | 2022-05-18 | Novozymes A/S | Enzymatic emulsions for detergents |
| WO2021123307A2 (en) | 2019-12-20 | 2021-06-24 | Novozymes A/S | Polypeptides having proteolytic activity and use thereof |
| WO2021121394A1 (en) | 2019-12-20 | 2021-06-24 | Novozymes A/S | Stabilized liquid boron-free enzyme compositions |
| US20240034960A1 (en) | 2020-08-27 | 2024-02-01 | Danisco Us Inc | Enzymes and enzyme compositions for cleaning |
| WO2022063699A1 (en) | 2020-09-22 | 2022-03-31 | Basf Se | Improved combination of protease and protease inhibitor with secondary enzyme |
| WO2023288294A1 (en) | 2021-07-16 | 2023-01-19 | Novozymes A/S | Compositions and methods for improving the rainfastness of proteins on plant surfaces |
| EP4032966A1 (en) | 2021-01-22 | 2022-07-27 | Novozymes A/S | Liquid enzyme composition with sulfite scavenger |
| WO2022165107A1 (en) | 2021-01-29 | 2022-08-04 | Danisco Us Inc | Compositions for cleaning and methods related thereto |
| US20240301328A1 (en) | 2021-03-12 | 2024-09-12 | Novozymes A/S | Polypeptide variants |
| JP7411607B2 (ja) * | 2021-06-17 | 2024-01-11 | 花王株式会社 | 洗剤用酵素安定化剤 |
| KR20240027619A (ko) | 2021-06-30 | 2024-03-04 | 헨켈 아게 운트 코. 카게아아 | 개선된 수분 관리 성능을 갖는 조성물 |
| US20240287418A1 (en) | 2021-06-30 | 2024-08-29 | Henkel Ag & Co. Kgaa | Cleaning composition with improved anti-gray performance and/or anti-pilling performance |
| US20240294888A1 (en) | 2021-06-30 | 2024-09-05 | Danisco Us Inc. | Variant enzymes and uses thereof |
| CN117580940A (zh) | 2021-06-30 | 2024-02-20 | 汉高股份有限及两合公司 | 包含具有聚酯酶活性的脂肪分解酶的清洁组合物 |
| WO2023034486A2 (en) | 2021-09-03 | 2023-03-09 | Danisco Us Inc. | Laundry compositions for cleaning |
| WO2023114932A2 (en) | 2021-12-16 | 2023-06-22 | Danisco Us Inc. | Subtilisin variants and methods of use |
| EP4448751A2 (en) | 2021-12-16 | 2024-10-23 | Danisco US Inc. | Subtilisin variants and methods of use |
| WO2023114939A2 (en) | 2021-12-16 | 2023-06-22 | Danisco Us Inc. | Subtilisin variants and methods of use |
| CN118974227A (zh) | 2022-03-01 | 2024-11-15 | 丹尼斯科美国公司 | 用于清洁的酶和酶组合物 |
| AU2023272468A1 (en) | 2022-05-14 | 2024-11-14 | Novonesis Plant Biosolutions A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4544016A1 (en) | 2022-06-21 | 2025-04-30 | Danisco US Inc. | Methods and compositions for cleaning comprising a polypeptide having thermolysin activity |
| CA3265718A1 (en) | 2022-09-02 | 2024-03-07 | Danisco Us Inc | VARIANTS OF SUBTILISINE AND ASSOCIATED PROCESSES |
| CN119855892A (zh) | 2022-09-02 | 2025-04-18 | 丹尼斯科美国公司 | 洗涤剂组合物及其相关方法 |
| EP4615968A1 (en) | 2022-11-09 | 2025-09-17 | Danisco US Inc. | Subtilisin variants and methods of use |
| EP4634219A1 (en) | 2022-12-14 | 2025-10-22 | Novozymes A/S | High strength liquid protease formulations |
| WO2024131880A2 (en) | 2022-12-23 | 2024-06-27 | Novozymes A/S | Detergent composition comprising catalase and amylase |
| CN120677237A (zh) | 2023-02-01 | 2025-09-19 | 丹尼斯科美国公司 | 枯草杆菌蛋白酶变体和使用方法 |
| EP4414443A1 (en) | 2023-02-09 | 2024-08-14 | Henkel AG & Co. KGaA | Cleaning composition comprising polyesterase |
| CN120712348A (zh) | 2023-03-06 | 2025-09-26 | 丹尼斯科美国公司 | 枯草杆菌蛋白酶变体和使用方法 |
| CN120813242A (zh) | 2023-03-16 | 2025-10-17 | 营养与生物科学美国第四公司 | 用于清洁和臭味控制的短芽孢杆菌发酵物提取物及其用途 |
| WO2025071996A1 (en) | 2023-09-28 | 2025-04-03 | Danisco Us Inc. | Variant cutinase enzymes with improved solubility and uses thereof |
| WO2025085351A1 (en) | 2023-10-20 | 2025-04-24 | Danisco Us Inc. | Subtilisin variants and methods of use |
| WO2025093368A1 (en) | 2023-11-02 | 2025-05-08 | Basf Se | Enzyme stabilization in compositions containing a protease inhibitor |
| WO2025217017A1 (en) | 2024-04-08 | 2025-10-16 | Novozymes A/S | Compositions and methods for increasing phosphorous availability |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1296839A (enExample) | 1969-05-29 | 1972-11-22 | ||
| GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| HU184368B (en) | 1981-01-13 | 1984-08-28 | Gyogyszerkutato Intezet | Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate |
| EP0124317B1 (en) * | 1983-04-27 | 1990-04-11 | Ici Americas Inc. | Proline derivatives |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| US4933287A (en) | 1985-08-09 | 1990-06-12 | Gist-Brocades N.V. | Novel lipolytic enzymes and their use in detergent compositions |
| US4810414A (en) | 1986-08-29 | 1989-03-07 | Novo Industri A/S | Enzymatic detergent additive |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| US4765916A (en) | 1987-03-24 | 1988-08-23 | The Clorox Company | Polymer film composition for rinse release of wash additives |
| US4972017A (en) | 1987-03-24 | 1990-11-20 | The Clorox Company | Rinse soluble polymer film composition for wash additives |
| EP0305216B1 (en) | 1987-08-28 | 1995-08-02 | Novo Nordisk A/S | Recombinant Humicola lipase and process for the production of recombinant humicola lipases |
| JPS6474992A (en) | 1987-09-16 | 1989-03-20 | Fuji Oil Co Ltd | Dna sequence, plasmid and production of lipase |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| JP3079276B2 (ja) | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
| WO1989009259A1 (en) | 1988-03-24 | 1989-10-05 | Novo-Nordisk A/S | A cellulase preparation |
| US5648263A (en) | 1988-03-24 | 1997-07-15 | Novo Nordisk A/S | Methods for reducing the harshness of a cotton-containing fabric |
| GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
| WO1991016422A1 (de) | 1990-04-14 | 1991-10-31 | Kali-Chemie Aktiengesellschaft | Alkalische bacillus-lipasen, hierfür codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren |
| WO1991017243A1 (en) | 1990-05-09 | 1991-11-14 | Novo Nordisk A/S | A cellulase preparation comprising an endoglucanase enzyme |
| DK115890D0 (da) | 1990-05-09 | 1990-05-09 | Novo Nordisk As | Enzym |
| BR9106839A (pt) | 1990-09-13 | 1993-07-20 | Novo Nordisk As | Variante de lipase,construcao de dna,vetor de expressao de recombinante,celula,planta,processo para produzir uma variante de lipase,aditivo e composicao de detergente |
| DE69133035T2 (de) | 1991-01-16 | 2003-02-13 | The Procter & Gamble Company, Cincinnati | Kompakte Waschmittelzusammensetzungen mit hochaktiven Cellulasen |
| EP0583339B1 (en) | 1991-05-01 | 1998-07-08 | Novo Nordisk A/S | Stabilized enzymes and detergent compositions |
| RU2108320C1 (ru) | 1991-12-13 | 1998-04-10 | Дзе Проктер Энд Гэмбл Компани | Активатор пероксида водорода и композиция для отбеливания или дезинфекции на его основе |
| DK28792D0 (da) | 1992-03-04 | 1992-03-04 | Novo Nordisk As | Nyt enzym |
| DK88892D0 (da) | 1992-07-06 | 1992-07-06 | Novo Nordisk As | Forbindelse |
| KR100294361B1 (ko) | 1992-07-23 | 2001-09-17 | 피아 스타르 | 돌연변이체알파-아밀라제,세정제,접시세척제,및액화제 |
| DE69217934T2 (de) | 1992-08-14 | 1997-09-04 | The Procter & Gamble Co., Cincinnati, Ohio | Peptidaldehydhaltige flüssige Waschmittel |
| KR100303619B1 (ko) | 1992-10-06 | 2001-11-22 | 피아 스타르 | 셀룰라제변이체 |
| KR100322793B1 (ko) | 1993-02-11 | 2002-06-20 | 마가렛 에이.혼 | 산화안정성알파-아밀라아제 |
| DK0652946T3 (da) | 1993-04-27 | 2005-05-30 | Genencor Int | Nye lipase-varianter til anvendelse i detergenter |
| DE69413036D1 (de) | 1993-06-14 | 1998-10-08 | Procter & Gamble | Konzentriertes phosphatfreies flüssiges enzymhaltiges maschinengeschirrspülmittel |
| GB9314350D0 (en) | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| JP2859520B2 (ja) | 1993-08-30 | 1999-02-17 | ノボ ノルディスク アクティーゼルスカブ | リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物 |
| JPH07143883A (ja) | 1993-11-24 | 1995-06-06 | Showa Denko Kk | リパーゼ遺伝子及び変異体リパーゼ |
| WO1995022615A1 (en) | 1994-02-22 | 1995-08-24 | Novo Nordisk A/S | A method of preparing a variant of a lipolytic enzyme |
| US5436229A (en) * | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
| CA2143533A1 (en) | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
| ES2251717T3 (es) | 1994-03-08 | 2006-05-01 | Novozymes A/S | Nuevas celulasas alcalinas. |
| EP0751991A1 (en) | 1994-03-22 | 1997-01-08 | The Procter & Gamble Company | Protease enzyme manufacture using non-protein protease inhibitors |
| US5453216A (en) | 1994-04-28 | 1995-09-26 | Creative Products Resource, Inc. | Delayed-release encapsulated warewashing composition and process of use |
| AU2524695A (en) | 1994-05-04 | 1995-11-29 | Genencor International, Inc. | Lipases with improved surfactant resistance |
| WO1995035381A1 (en) | 1994-06-20 | 1995-12-28 | Unilever N.V. | Modified pseudomonas lipases and their use |
| WO1996000292A1 (en) | 1994-06-23 | 1996-01-04 | Unilever N.V. | Modified pseudomonas lipases and their use |
| US5919691A (en) | 1994-10-06 | 1999-07-06 | Novo Nordisk A/S | Enzyme and enzyme preparation with endoglucanase activity |
| BE1008998A3 (fr) | 1994-10-14 | 1996-10-01 | Solvay | Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci. |
| CA2203398A1 (en) | 1994-10-26 | 1996-05-09 | Thomas Sandal | An enzyme with lipolytic activity |
| AR000862A1 (es) | 1995-02-03 | 1997-08-06 | Novozymes As | Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del |
| JPH08228778A (ja) | 1995-02-27 | 1996-09-10 | Showa Denko Kk | 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法 |
| BRPI9607646B1 (pt) | 1995-03-17 | 2016-07-05 | Novo Nordisk As | vetor de expressão recombinante, célula fúngica, método para produzir uma enzima apresentando atividade de endoglucanase e para prover clarificação da cor nas roupas de lavagem, composição de lavanderia , uso da enzima, e, composição de enzima |
| DE69633825T2 (de) | 1995-07-14 | 2005-11-10 | Novozymes A/S | Modifiziertes enzym mit lipolytischer aktivität |
| EP0851913B1 (en) | 1995-08-11 | 2004-05-19 | Novozymes A/S | Novel lipolytic enzymes |
| US5763385A (en) | 1996-05-14 | 1998-06-09 | Genencor International, Inc. | Modified α-amylases having altered calcium binding properties |
| AU3938997A (en) | 1996-08-26 | 1998-03-19 | Novo Nordisk A/S | A novel endoglucanase |
| EP0937138B1 (en) | 1996-09-17 | 2006-04-26 | Novozymes A/S | Cellulase variants |
| CN1113088C (zh) | 1996-09-24 | 2003-07-02 | 普罗格特-甘布尔公司 | 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂 |
| CA2266527A1 (en) * | 1996-09-24 | 1998-04-02 | John Mcmillan Mciver | Liquid detergents containing proteolytic enzyme, peptide aldehyde and calcium ions |
| BR9712114A (pt) | 1996-09-24 | 1999-08-31 | Procter & Gamble | Composições detergente líquidas para lavanderia contendo enzima proteolítica e inibidores de protease. |
| WO1998013458A1 (en) * | 1996-09-24 | 1998-04-02 | The Procter & Gamble Company | Liquid detergents containing proteolytic enzyme and protease inhibitors |
| DE69717652T2 (de) | 1996-09-24 | 2003-09-18 | The Procter & Gamble Company, Cincinnati | Flüssige reinigungsmittel, die proteolytisches enzym, peptidaldehyd und eine borsäurequelle enthalten |
| HUP0000117A2 (hu) | 1996-10-18 | 2000-06-28 | The Procter And Gamble Company | Mosószerkészítmények |
| ATE510910T1 (de) | 1996-11-04 | 2011-06-15 | Novozymes As | Subtilase-varianten und verbindungen |
| JP2001503269A (ja) | 1996-11-04 | 2001-03-13 | ノボ ノルディスク アクティーゼルスカブ | ズブチラーゼ変異体及び、組成物 |
| WO1998034946A1 (en) | 1997-02-12 | 1998-08-13 | Massachusetts Institute Of Technology | Daxx, a novel fas-binding protein that activates jnk and apoptosis |
| NZ500045A (en) | 1997-04-18 | 2001-02-23 | Cephalon Inc | Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors |
| AU7908898A (en) | 1997-07-04 | 1999-01-25 | Novo Nordisk A/S | Family 6 endo-1,4-beta-glucanase variants and cleaning composit ions containing them |
| PL343254A1 (en) | 1997-11-24 | 2001-07-30 | Novozymes As | Novel pectate lyases |
| US6124127A (en) | 1997-11-24 | 2000-09-26 | Novo Nordisk A/S | Pectate lyase |
| WO1999027083A1 (en) | 1997-11-24 | 1999-06-03 | Novo Nordisk A/S | PECTIN DEGRADING ENZYMES FROM $i(BACILLUS LICHENIFORMIS) |
| ATE528394T1 (de) | 1998-06-10 | 2011-10-15 | Novozymes As | Neuartige mannasen |
| AU3420100A (en) | 1999-03-31 | 2000-10-23 | Novozymes A/S | Lipase variant |
| EP1244779B1 (en) | 1999-12-15 | 2014-05-07 | Novozymes A/S | Subtilase variants having an improved wash performance on egg stains |
| AU777210C (en) | 2000-02-08 | 2005-08-04 | Dsm Ip Assets B.V. | Use of acid-stable subtilisin proteases in animal feed |
| DE60137510D1 (de) | 2000-07-19 | 2009-03-12 | Novozymes As | Zellwandabbauende enzymvarianten |
| GB2365018A (en) | 2000-07-24 | 2002-02-13 | Procter & Gamble | Water soluble pouches |
| US7611882B2 (en) | 2001-05-14 | 2009-11-03 | Novozymes A/S | Detergent compositions comprising Bacillus subtilis pectate lyases |
| GB0114847D0 (en) | 2001-06-18 | 2001-08-08 | Unilever Plc | Water soluble package and liquid contents thereof |
| DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
| GB0207430D0 (en) | 2002-03-28 | 2002-05-08 | Unilever Plc | Liquid cleaning compositionsand their use |
| ATE494369T1 (de) | 2002-05-14 | 2011-01-15 | Novozymes As | Pektatlyasevarianten |
| US7507569B2 (en) | 2003-05-07 | 2009-03-24 | Novozymes A/S | Variant subtilisin enzymes (subtilases) |
| EP2371948B1 (en) | 2006-01-23 | 2017-04-19 | Novozymes A/S | Lipase variants |
| BRPI0712113A2 (pt) | 2006-06-05 | 2012-01-31 | Procter & Gamble | estabilização de enzimas |
| BRPI0712344A2 (pt) | 2006-06-05 | 2012-01-31 | Procter & Gamble | estabilização de enzimas |
| EP2014756B1 (en) | 2007-07-02 | 2011-03-30 | The Procter & Gamble Company | Laundry multi-compartment pouch composition |
| ES2603979T3 (es) | 2008-02-29 | 2017-03-02 | Novozymes A/S | Polipéptidos con actividad lipásica y polinucleótidos que codifican los mismos |
| PL2271660T3 (pl) | 2008-03-26 | 2020-11-02 | Novozymes A/S | Stabilizowane ciekłe kompozycje enzymów |
| WO2010003934A1 (en) | 2008-07-07 | 2010-01-14 | Basf Se | Enzyme composition comprising enzyme containing polymer particles |
| US10577568B2 (en) | 2008-11-13 | 2020-03-03 | Novozymes A/S | Detergent composition |
| US20120149625A1 (en) | 2009-09-25 | 2012-06-14 | Novozymes A/S | Detergent Composition |
| EP2480650B1 (en) | 2009-09-25 | 2017-03-22 | Novozymes A/S | Subtilase variants |
-
2012
- 2012-06-29 DK DK12733657.6T patent/DK2726592T3/en active
- 2012-06-29 CN CN201280033107.5A patent/CN103649292B/zh active Active
- 2012-06-29 JP JP2014517745A patent/JP6334396B2/ja active Active
- 2012-06-29 AU AU2012280414A patent/AU2012280414B2/en active Active
- 2012-06-29 KR KR1020147001037A patent/KR101956895B1/ko active Active
- 2012-06-29 US US14/129,748 patent/US9085750B2/en active Active
- 2012-06-29 CN CN201711032216.6A patent/CN107858217B/zh active Active
- 2012-06-29 IN IN700CHN2014 patent/IN2014CN00700A/en unknown
- 2012-06-29 BR BR112013033811A patent/BR112013033811A2/pt not_active Application Discontinuation
- 2012-06-29 EP EP12733657.6A patent/EP2726592B1/en active Active
- 2012-06-29 RU RU2014103501A patent/RU2635355C2/ru active
- 2012-06-29 ES ES12733657.6T patent/ES2539504T3/es active Active
- 2012-06-29 WO PCT/EP2012/062760 patent/WO2013004636A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2013004636A1 (en) | 2013-01-10 |
| CN103649292A (zh) | 2014-03-19 |
| MX2014000060A (es) | 2014-05-01 |
| US20140336098A1 (en) | 2014-11-13 |
| KR20140053102A (ko) | 2014-05-07 |
| MX346246B (es) | 2017-03-13 |
| IN2014CN00700A (enExample) | 2015-04-03 |
| CN103649292B (zh) | 2017-11-28 |
| EP2726592B1 (en) | 2015-04-01 |
| JP2018139598A (ja) | 2018-09-13 |
| EP2726592A1 (en) | 2014-05-07 |
| BR112013033811A2 (pt) | 2017-02-14 |
| RU2635355C2 (ru) | 2017-11-13 |
| KR101956895B1 (ko) | 2019-03-12 |
| ES2539504T3 (es) | 2015-07-01 |
| JP2014525739A (ja) | 2014-10-02 |
| AU2012280414B2 (en) | 2015-06-25 |
| JP6927920B2 (ja) | 2021-09-01 |
| AU2012280414A1 (en) | 2014-01-16 |
| DK2726592T3 (en) | 2015-07-06 |
| RU2014103501A (ru) | 2015-08-10 |
| CN107858217A (zh) | 2018-03-30 |
| ZA201400692B (en) | 2015-05-27 |
| US9085750B2 (en) | 2015-07-21 |
| CN107858217B (zh) | 2021-03-23 |
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