JP6302937B2 - ２−（（１ｒ，４ｒ）−４−（４−（５−（ベンゾオキサゾール−２−イルアミノ）ピリジン−２−イル）フェニル）シクロヘキシル）酢酸のメグルミン塩形態、およびｄｇａｔ１阻害剤としてのそれらの使用 - Google Patents
２−（（１ｒ，４ｒ）−４−（４−（５−（ベンゾオキサゾール−２−イルアミノ）ピリジン−２−イル）フェニル）シクロヘキシル）酢酸のメグルミン塩形態、およびｄｇａｔ１阻害剤としてのそれらの使用 Download PDFInfo
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- JP6302937B2 JP6302937B2 JP2015552797A JP2015552797A JP6302937B2 JP 6302937 B2 JP6302937 B2 JP 6302937B2 JP 2015552797 A JP2015552797 A JP 2015552797A JP 2015552797 A JP2015552797 A JP 2015552797A JP 6302937 B2 JP6302937 B2 JP 6302937B2
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- ylamino
- cyclohexyl
- phenyl
- pyridin
- powder diffraction
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- 231100000331 toxic Toxicity 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751443P | 2013-01-11 | 2013-01-11 | |
| US61/751,443 | 2013-01-11 | ||
| PCT/US2014/011005 WO2014110344A1 (en) | 2013-01-11 | 2014-01-10 | Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505017A JP2016505017A (ja) | 2016-02-18 |
| JP2016505017A5 JP2016505017A5 (enExample) | 2016-12-15 |
| JP6302937B2 true JP6302937B2 (ja) | 2018-03-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2015552797A Expired - Fee Related JP6302937B2 (ja) | 2013-01-11 | 2014-01-10 | ２−（（１ｒ，４ｒ）−４−（４−（５−（ベンゾオキサゾール−２−イルアミノ）ピリジン−２−イル）フェニル）シクロヘキシル）酢酸のメグルミン塩形態、およびｄｇａｔ１阻害剤としてのそれらの使用 |
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| EP (1) | EP2943488B1 (enExample) |
| JP (1) | JP6302937B2 (enExample) |
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| AR (1) | AR101523A1 (enExample) |
| AU (1) | AU2014205276B2 (enExample) |
| BR (1) | BR112015016370A2 (enExample) |
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| TR (1) | TR201808198T4 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104995188B (zh) * | 2013-01-11 | 2018-09-14 | 诺华股份有限公司 | 2-((1r,4r)-4-(4-(5-(苯并噁唑-2-基氨基)吡啶-2-基)苯基)环己基)乙酸的葡甲胺盐形式和它们作为dgat1抑制剂的用途 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| US10822346B2 (en) * | 2018-04-17 | 2020-11-03 | Cardurion Pharmaceuticals, Llc | Meglumine salts of thienopyrimidines |
| MX2023005447A (es) * | 2020-11-10 | 2023-09-25 | Unity Biotechnology Inc | Inhibidor de sales sólidas cristalinas de meglumina de bcl y métodos de elaboración y uso de estos. |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| PT2402319T (pt) * | 2006-03-31 | 2017-12-11 | Novartis Ag | Inibidores de dgat |
| WO2013169648A1 (en) * | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
| CN104995188B (zh) * | 2013-01-11 | 2018-09-14 | 诺华股份有限公司 | 2-((1r,4r)-4-(4-(5-(苯并噁唑-2-基氨基)吡啶-2-基)苯基)环己基)乙酸的葡甲胺盐形式和它们作为dgat1抑制剂的用途 |
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2014
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- 2014-01-10 PT PT147012736T patent/PT2943488T/pt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20150103747A (ko) | 2015-09-11 |
| CA2896861A1 (en) | 2014-07-17 |
| EA201591300A1 (ru) | 2015-11-30 |
| CN104995188B (zh) | 2018-09-14 |
| AU2014205276A1 (en) | 2015-07-16 |
| EP2943488A1 (en) | 2015-11-18 |
| MX2015008978A (es) | 2015-09-29 |
| WO2014110344A1 (en) | 2014-07-17 |
| AU2014205276B2 (en) | 2016-10-20 |
| CN104995188A (zh) | 2015-10-21 |
| ES2675398T3 (es) | 2018-07-11 |
| PL2943488T3 (pl) | 2018-09-28 |
| US8987459B2 (en) | 2015-03-24 |
| EA027688B1 (ru) | 2017-08-31 |
| PT2943488T (pt) | 2018-06-12 |
| EP2943488B1 (en) | 2018-03-28 |
| BR112015016370A2 (pt) | 2017-07-11 |
| JP2016505017A (ja) | 2016-02-18 |
| US20150166522A1 (en) | 2015-06-18 |
| US9242971B2 (en) | 2016-01-26 |
| AR101523A1 (es) | 2016-12-28 |
| TR201808198T4 (tr) | 2018-07-23 |
| US20140200246A1 (en) | 2014-07-17 |
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