EA027688B1 - Меглуминовая соль 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и ее кристаллическая форма и их применение в качестве ингибиторов dgat1 - Google Patents
Меглуминовая соль 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и ее кристаллическая форма и их применение в качестве ингибиторов dgat1 Download PDFInfo
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- EA027688B1 EA027688B1 EA201591300A EA201591300A EA027688B1 EA 027688 B1 EA027688 B1 EA 027688B1 EA 201591300 A EA201591300 A EA 201591300A EA 201591300 A EA201591300 A EA 201591300A EA 027688 B1 EA027688 B1 EA 027688B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- crystalline form
- cyclohexyl
- pyridin
- phenyl
- diffraction pattern
- Prior art date
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Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751443P | 2013-01-11 | 2013-01-11 | |
| PCT/US2014/011005 WO2014110344A1 (en) | 2013-01-11 | 2014-01-10 | Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201591300A1 EA201591300A1 (ru) | 2015-11-30 |
| EA027688B1 true EA027688B1 (ru) | 2017-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201591300A EA027688B1 (ru) | 2013-01-11 | 2014-01-10 | Меглуминовая соль 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и ее кристаллическая форма и их применение в качестве ингибиторов dgat1 |
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| EP (1) | EP2943488B1 (enExample) |
| JP (1) | JP6302937B2 (enExample) |
| KR (1) | KR20150103747A (enExample) |
| CN (1) | CN104995188B (enExample) |
| AR (1) | AR101523A1 (enExample) |
| AU (1) | AU2014205276B2 (enExample) |
| BR (1) | BR112015016370A2 (enExample) |
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| EA (1) | EA027688B1 (enExample) |
| ES (1) | ES2675398T3 (enExample) |
| MX (1) | MX2015008978A (enExample) |
| PL (1) | PL2943488T3 (enExample) |
| PT (1) | PT2943488T (enExample) |
| TR (1) | TR201808198T4 (enExample) |
| WO (1) | WO2014110344A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2943488T3 (pl) * | 2013-01-11 | 2018-09-28 | Novartis Ag | Postacie soli megluminowej kwasu 2-((1r,4r)-4-(4-(5-(benzoksazol-2-iloamino)pirydyn-2-ylo)fenylo)cykloheksylo)octowego i ich zastosowania jako inhibitory dgat1 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| AU2019255233A1 (en) * | 2018-04-17 | 2020-11-26 | Cardurion Pharmaceuticals, Llc | Meglumine salts of thienopyrimidines |
| WO2022099431A1 (en) * | 2020-11-10 | 2022-05-19 | Unity Biotechnology, Inc. | Crystalline solid meglumine salt inhibitor of bcl and methods of making and using same |
Citations (2)
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|---|---|---|---|---|
| WO2007126957A2 (en) * | 2006-03-31 | 2007-11-08 | Novartis Ag | New compounds |
| WO2013169648A1 (en) * | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| PL2943488T3 (pl) * | 2013-01-11 | 2018-09-28 | Novartis Ag | Postacie soli megluminowej kwasu 2-((1r,4r)-4-(4-(5-(benzoksazol-2-iloamino)pirydyn-2-ylo)fenylo)cykloheksylo)octowego i ich zastosowania jako inhibitory dgat1 |
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2014
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- 2014-01-10 BR BR112015016370A patent/BR112015016370A2/pt not_active IP Right Cessation
- 2014-01-10 EP EP14701273.6A patent/EP2943488B1/en not_active Not-in-force
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- 2014-01-10 TR TR2018/08198T patent/TR201808198T4/tr unknown
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- 2014-01-10 WO PCT/US2014/011005 patent/WO2014110344A1/en not_active Ceased
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007126957A2 (en) * | 2006-03-31 | 2007-11-08 | Novartis Ag | New compounds |
| WO2013169648A1 (en) * | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
Non-Patent Citations (1)
| Title |
|---|
| STEFFEN DENZINGER: "A counter ion that fulfils all needs", WORLD PHARMACEUTICAL FRONTIERS, VOL. 2, 2011, GLOBAL TRADE MEDIA, LONDON, UK, London, UK, pages 90, XP055102822, Retrieved from the Internet <URL:http://pages.cdn.pagesuite.com/c/1/c1487298-3c31-4c6e-a19f-b426a152fe0b/page.pdf> [retrieved on 20140218] * |
Also Published As
| Publication number | Publication date |
|---|---|
| US9242971B2 (en) | 2016-01-26 |
| BR112015016370A2 (pt) | 2017-07-11 |
| CN104995188B (zh) | 2018-09-14 |
| US20140200246A1 (en) | 2014-07-17 |
| CA2896861A1 (en) | 2014-07-17 |
| KR20150103747A (ko) | 2015-09-11 |
| AU2014205276B2 (en) | 2016-10-20 |
| TR201808198T4 (tr) | 2018-07-23 |
| WO2014110344A1 (en) | 2014-07-17 |
| CN104995188A (zh) | 2015-10-21 |
| PT2943488T (pt) | 2018-06-12 |
| PL2943488T3 (pl) | 2018-09-28 |
| MX2015008978A (es) | 2015-09-29 |
| AR101523A1 (es) | 2016-12-28 |
| EP2943488B1 (en) | 2018-03-28 |
| US20150166522A1 (en) | 2015-06-18 |
| JP6302937B2 (ja) | 2018-03-28 |
| EP2943488A1 (en) | 2015-11-18 |
| EA201591300A1 (ru) | 2015-11-30 |
| AU2014205276A1 (en) | 2015-07-16 |
| ES2675398T3 (es) | 2018-07-11 |
| US8987459B2 (en) | 2015-03-24 |
| JP2016505017A (ja) | 2016-02-18 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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