JP6297546B2 - 結合磁性粒子及び未結合磁性粒子の処理 - Google Patents
結合磁性粒子及び未結合磁性粒子の処理 Download PDFInfo
- Publication number
- JP6297546B2 JP6297546B2 JP2015519424A JP2015519424A JP6297546B2 JP 6297546 B2 JP6297546 B2 JP 6297546B2 JP 2015519424 A JP2015519424 A JP 2015519424A JP 2015519424 A JP2015519424 A JP 2015519424A JP 6297546 B2 JP6297546 B2 JP 6297546B2
- Authority
- JP
- Japan
- Prior art keywords
- magnetic particles
- magnetic
- region
- magnetic field
- coupling region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000006249 magnetic particle Substances 0.000 title claims description 117
- 238000010168 coupling process Methods 0.000 claims description 76
- 230000008878 coupling Effects 0.000 claims description 74
- 238000005859 coupling reaction Methods 0.000 claims description 74
- 230000027455 binding Effects 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 35
- 239000002245 particle Substances 0.000 claims description 21
- 239000000523 sample Substances 0.000 claims description 14
- 238000000926 separation method Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000004186 food analysis Methods 0.000 claims description 2
- 238000004374 forensic analysis Methods 0.000 claims description 2
- 239000011324 bead Substances 0.000 description 74
- 238000005286 illumination Methods 0.000 description 16
- 238000001514 detection method Methods 0.000 description 14
- 230000005484 gravity Effects 0.000 description 13
- 239000012530 fluid Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 230000005653 Brownian motion process Effects 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 101100537532 Rattus norvegicus Tnni3 gene Proteins 0.000 description 1
- 102000013394 Troponin I Human genes 0.000 description 1
- 108010065729 Troponin I Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
- H01F7/0273—Magnetic circuits with PM for magnetic field generation
- H01F7/0294—Detection, inspection, magnetic treatment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
- H01F7/20—Electromagnets; Actuators including electromagnets without armatures
- H01F7/206—Electromagnets for lifting, handling or transporting of magnetic pieces or material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
- H01F7/20—Electromagnets; Actuators including electromagnets without armatures
- H01F7/206—Electromagnets for lifting, handling or transporting of magnetic pieces or material
- H01F2007/208—Electromagnets for lifting, handling or transporting of magnetic pieces or material combined with permanent magnets
Landscapes
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Powder Metallurgy (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665922P | 2012-06-29 | 2012-06-29 | |
| US61/665,922 | 2012-06-29 | ||
| PCT/IB2013/055072 WO2014001982A1 (en) | 2012-06-29 | 2013-06-20 | Processing of bound and unbound magnetic particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522155A JP2015522155A (ja) | 2015-08-03 |
| JP2015522155A5 JP2015522155A5 (enExample) | 2016-08-04 |
| JP6297546B2 true JP6297546B2 (ja) | 2018-03-20 |
Family
ID=49162179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015519424A Active JP6297546B2 (ja) | 2012-06-29 | 2013-06-20 | 結合磁性粒子及び未結合磁性粒子の処理 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10079086B2 (enExample) |
| EP (1) | EP2867663B1 (enExample) |
| JP (1) | JP6297546B2 (enExample) |
| CN (1) | CN104395736B (enExample) |
| BR (1) | BR112014031983A2 (enExample) |
| RU (1) | RU2015102829A (enExample) |
| WO (1) | WO2014001982A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012032476A1 (en) * | 2010-09-09 | 2012-03-15 | Koninklijke Philips Electronics N.V. | A method and a device for attracting magnetic particles to a surface |
| EP2527814A1 (en) * | 2011-04-27 | 2012-11-28 | Koninklijke Philips Electronics N.V. | Sensor system with an exchangeable cartridge and a reader |
| US10613038B2 (en) | 2015-03-13 | 2020-04-07 | 3M Innovative Properties Company | Light detection system and method of using same |
| ES2912190T3 (es) | 2015-03-13 | 2022-05-24 | 3M Innovative Properties Co | Sistema de detección de luz |
| KR102567775B1 (ko) | 2015-03-13 | 2023-08-16 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 광 검출 시스템 및 그의 사용 방법 |
| CN106596473A (zh) * | 2016-10-27 | 2017-04-26 | 中国科学院电子学研究所 | 基于电控磁富集‑分离和全内反射磁成像的光学检测仪 |
| EP3470141B1 (en) | 2017-10-11 | 2024-04-24 | F. Hoffmann-La Roche AG | Apparatus and method for processing a biological sample with magnetic particles |
| CN114649130B (zh) * | 2022-03-24 | 2024-08-16 | 威海厚源工业设计有限公司 | 一种具备磁珠有序直线形移动的磁力线圈结构及其控制系统 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3967892A (en) * | 1974-07-26 | 1976-07-06 | Xerox Corporation | Development system |
| US3945343A (en) * | 1975-03-24 | 1976-03-23 | General Electric Company | Magnetic brush for use in magnetic printing |
| JPS5635162A (en) * | 1979-08-31 | 1981-04-07 | Konishiroku Photo Ind Co Ltd | Electrostatic recorder |
| JPS58163961A (ja) * | 1982-03-25 | 1983-09-28 | Fujitsu Ltd | 多色印字方式 |
| JPS5923358A (ja) * | 1982-07-30 | 1984-02-06 | Toshiba Corp | 現像装置 |
| GB2145942B (en) * | 1983-08-05 | 1987-03-18 | Konishiroku Photo Ind | Developing latent eletrostatic images |
| CN1034617A (zh) * | 1987-10-09 | 1989-08-09 | 奈吉尼股份有限公司 | 鉴定生化物种之方法及装置 |
| US5047807A (en) * | 1990-10-15 | 1991-09-10 | Eastman Kodak Company | Development apparatus having a plate scavenging device |
| US5184194A (en) * | 1991-10-28 | 1993-02-02 | Eastman Kodak Company | Carrier particle scavenging device |
| US5445971A (en) * | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| DE69329135T2 (de) * | 1992-09-24 | 2001-01-11 | Amersham Pharmacia Biotech Uk Ltd., Little Chalfont | Verfahren und Vorrichtung zur magnetischen Abscheidung |
| JP4284431B2 (ja) * | 1997-12-15 | 2009-06-24 | 株式会社シノテスト | 粒子を使用する被検物質の測定器具及び測定方法 |
| FR2826882B1 (fr) * | 2001-07-09 | 2003-09-12 | Bio Merieux | Procede de traitement de particules magnetiques et configurations d'aimants permettant la mise en oeuvre de ce procede |
| DE10136060A1 (de) * | 2001-07-25 | 2003-02-13 | Roche Diagnostics Gmbh | System zur Separation von magnetisch anziehbaren Partikeln |
| EP1469311B1 (en) * | 2002-01-29 | 2007-08-08 | Asahi Kasei Kabushiki Kaisha | Biosensor, magnetic molecule measurement method, and measurement object measuring method |
| FI120863B (fi) * | 2002-10-18 | 2010-04-15 | Biocontrol Systems Inc | Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite |
| US8118044B2 (en) | 2004-03-12 | 2012-02-21 | Applied Materials, Inc. | Single workpiece processing chamber with tilting load/unload upper rim |
| US8211386B2 (en) * | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| EP1844162B1 (en) | 2005-02-01 | 2014-10-15 | Applied Biosystems, LLC | Method for identifying a sequence in a polynucleotide |
| AU2007237909A1 (en) | 2006-04-19 | 2007-10-25 | Applied Biosystems, Llc. | Reagents, methods, and libraries for gel-free bead-based sequencing |
| WO2007129275A2 (en) * | 2006-05-10 | 2007-11-15 | Koninklijke Philips Electronics N.V. | Rapid magnetic biosensor |
| WO2008010110A1 (en) * | 2006-07-17 | 2008-01-24 | Koninklijke Philips Electronics N. V. | Attraction and repulsion of magnetic of magnetizable objects to and from a sensor surface |
| CN104764724A (zh) | 2006-12-12 | 2015-07-08 | 皇家飞利浦电子股份有限公司 | 用于检测标记颗粒的微电子传感器装置 |
| WO2008115723A1 (en) | 2007-03-19 | 2008-09-25 | Atm Metabolics Lllp | Composition for treating diabetes and metabolic disorders with quercetin, myrcetin and chlorogenic acid |
| EP2181322A1 (en) | 2007-06-21 | 2010-05-05 | Koninklijke Philips Electronics N.V. | Microelectronic sensor device for detecting label particles |
| CN101779117B (zh) * | 2007-07-31 | 2013-12-04 | 皇家飞利浦电子股份有限公司 | 具有经调制的光源的微电子传感器设备 |
| WO2009046149A1 (en) | 2007-10-01 | 2009-04-09 | Applied Biosystems Inc. | Chase ligation sequencing |
| WO2010111265A1 (en) | 2009-03-24 | 2010-09-30 | University Of Chicago | Slip chip device and methods |
| EP2599548B1 (de) * | 2009-05-13 | 2018-07-04 | ibidi GmbH | Probenträger zum Positionieren einer organischen, biologischen und/oder medizinischen Probe |
| EP2433129A1 (en) | 2009-05-19 | 2012-03-28 | Koninklijke Philips Electronics N.V. | Sensor device for magnetic particles with a high dynamic range |
| EP2720060A1 (en) | 2009-09-28 | 2014-04-16 | Koninklijke Philips N.V. | A biosensor system for single particle detection |
| EP2516991A2 (en) * | 2009-09-28 | 2012-10-31 | Koninklijke Philips Electronics N.V. | Sensor device with imaging optics |
| WO2011073867A1 (en) * | 2009-12-18 | 2011-06-23 | Koninklijke Philips Electronics N.V. | Substance determining apparatus |
| JP5573335B2 (ja) * | 2010-04-28 | 2014-08-20 | 株式会社島津製作所 | 磁性体粒子操作デバイス及び磁性体粒子操作方法 |
| US9612236B2 (en) | 2010-06-17 | 2017-04-04 | Koninklijke Philips N.V. | Multi epitope assay |
-
2013
- 2013-06-20 JP JP2015519424A patent/JP6297546B2/ja active Active
- 2013-06-20 CN CN201380034882.7A patent/CN104395736B/zh active Active
- 2013-06-20 US US14/409,922 patent/US10079086B2/en active Active
- 2013-06-20 BR BR112014031983A patent/BR112014031983A2/pt not_active IP Right Cessation
- 2013-06-20 EP EP13760113.4A patent/EP2867663B1/en active Active
- 2013-06-20 WO PCT/IB2013/055072 patent/WO2014001982A1/en not_active Ceased
- 2013-06-20 RU RU2015102829A patent/RU2015102829A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104395736B (zh) | 2018-12-11 |
| US10079086B2 (en) | 2018-09-18 |
| EP2867663A1 (en) | 2015-05-06 |
| BR112014031983A2 (pt) | 2017-06-27 |
| CN104395736A (zh) | 2015-03-04 |
| US20150187479A1 (en) | 2015-07-02 |
| EP2867663B1 (en) | 2022-12-07 |
| RU2015102829A (ru) | 2016-08-20 |
| JP2015522155A (ja) | 2015-08-03 |
| WO2014001982A1 (en) | 2014-01-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6297546B2 (ja) | 結合磁性粒子及び未結合磁性粒子の処理 | |
| EP2225547B1 (en) | Microelectronic sensor device for the detection of target particles | |
| JP6291491B2 (ja) | 干渉粒子を含有する流体の処理 | |
| JP5488695B2 (ja) | 試料分析装置及び試料分析方法 | |
| EP3450961A1 (en) | Optical detection method and optical detection device | |
| JP2011516878A (ja) | 小サンプル体積における光検出のための担体 | |
| CN102947900A (zh) | 磁性颗粒及其聚类的检测 | |
| JP6225114B2 (ja) | クラスタ検出に関する装置 | |
| JP7635994B2 (ja) | 被検出物質の検出方法および被検出物質の検出システム | |
| JP6154393B2 (ja) | 磁性粒子を検出する方法及びセンサデバイス | |
| CN103635788B (zh) | 对磁性粒子的团簇的检测 | |
| JP5654487B2 (ja) | 磁気バイオセンサ装置用の混合アクチュエーションプロトコル | |
| EP3534148B1 (en) | Target substance detection device and target substance detection method | |
| CN102165318A (zh) | 磁性标签传感器和筒体 | |
| JP2013253977A (ja) | 関心ある標的の検出のためのセンサー | |
| JPWO2018100780A1 (ja) | 標的物質検出装置及び標的物質検出方法 | |
| JP2017067759A (ja) | 検出方法および検出装置 | |
| Wiklund et al. | Ultrasound-enhanced immunoassays and particle sensors | |
| JP2021156679A (ja) | 磁場と重力を用いる標的物質検出装置及び標的物質検出方法 | |
| JP6414209B2 (ja) | 表面プラズモン増強蛍光測定方法および表面プラズモン増強蛍光測定装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160616 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160616 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170220 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170307 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170529 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171010 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171226 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180123 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180221 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6297546 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |