JP6270717B2 - 磁性粒子のクラスタの検出 - Google Patents
磁性粒子のクラスタの検出 Download PDFInfo
- Publication number
- JP6270717B2 JP6270717B2 JP2014517993A JP2014517993A JP6270717B2 JP 6270717 B2 JP6270717 B2 JP 6270717B2 JP 2014517993 A JP2014517993 A JP 2014517993A JP 2014517993 A JP2014517993 A JP 2014517993A JP 6270717 B2 JP6270717 B2 JP 6270717B2
- Authority
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- Prior art keywords
- magnetic particles
- sample
- clusters
- magnetic field
- sensor device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000006249 magnetic particle Substances 0.000 title claims description 57
- 238000001514 detection method Methods 0.000 title claims description 15
- 239000000523 sample Substances 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 20
- 230000003993 interaction Effects 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 4
- 230000027455 binding Effects 0.000 claims description 4
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- 230000003252 repetitive effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000004186 food analysis Methods 0.000 claims description 2
- 238000004374 forensic analysis Methods 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 10
- 238000003556 assay Methods 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 5
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000005054 agglomeration Methods 0.000 description 2
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- 230000001419 dependent effect Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000002122 magnetic nanoparticle Substances 0.000 description 2
- 230000005389 magnetism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
- G01N2021/1727—Magnetomodulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11172070.2 | 2011-06-30 | ||
| EP11172070A EP2541230A1 (en) | 2011-06-30 | 2011-06-30 | Detection of clusters of magnetic particles |
| PCT/IB2012/053051 WO2013001400A1 (en) | 2011-06-30 | 2012-06-18 | Detection of clusters of magnetic particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518389A JP2014518389A (ja) | 2014-07-28 |
| JP2014518389A5 JP2014518389A5 (cg-RX-API-DMAC7.html) | 2015-07-09 |
| JP6270717B2 true JP6270717B2 (ja) | 2018-01-31 |
Family
ID=44910028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517993A Active JP6270717B2 (ja) | 2011-06-30 | 2012-06-18 | 磁性粒子のクラスタの検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10036729B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2541230A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6270717B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103635788B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013001400A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130051647A (ko) * | 2011-11-10 | 2013-05-21 | 한국전자통신연구원 | 자성 입자를 이용한 바이오 물질의 분석 방법 |
| US9863863B2 (en) | 2011-11-14 | 2018-01-09 | Koninklijke Philips N.V. | Apparatus for cluster detection |
| JP7225656B2 (ja) * | 2018-10-10 | 2023-02-21 | 凸版印刷株式会社 | 目的物質検出装置及び目的物質検出方法 |
| TWI776251B (zh) * | 2020-10-08 | 2022-09-01 | 中原大學 | 基於目標分子吸附之磁控量測系統 |
| CN113515868B (zh) * | 2021-08-04 | 2024-07-19 | 常熟理工学院 | 一种磁流变弹性体的链簇模型构建方法及性能估测方法 |
| CN118818588B (zh) * | 2024-07-12 | 2025-02-28 | 中国科学院近代物理研究所 | 高计数率twin-TPC的在线簇团重建方法、装置及设备 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62118255A (ja) * | 1985-11-19 | 1987-05-29 | Toshimitsu Musha | 磁界を用いた免疫反応の検出法 |
| CN1032399A (zh) * | 1986-05-22 | 1989-04-12 | 尤尼利弗公司 | 免疫测定方法 |
| EP0287665B1 (en) * | 1986-09-22 | 1996-07-31 | Nippon Telegraph And Telephone Corporation | Laser magnetic immunoassay method and apparatus therefor |
| JP3244509B2 (ja) * | 1991-01-16 | 2002-01-07 | 株式会社シノテスト | 磁性粒子担体を用いた間接凝集反応法 |
| WO2003067258A1 (fr) | 2002-01-29 | 2003-08-14 | Asahi Kasei Kabushiki Kaisha | Biocapteur, procede de mesure de molecules magnetiques et procede de mesure de l'objet mesure |
| GB0410976D0 (en) | 2004-05-17 | 2004-06-16 | Randox Lab Ltd | Magnetic particle detector system |
| RU2415433C2 (ru) * | 2005-01-31 | 2011-03-27 | Конинклейке Филипс Электроникс Н.В. | Быстрое и чувствительное измерение биоинформации |
| JP2006247535A (ja) * | 2005-03-10 | 2006-09-21 | Toyo Univ | 回転磁場を利用した反応促進方法 |
| SE529474C2 (sv) | 2006-04-19 | 2007-08-21 | Imego Ab | Detekteringsanordning och förfarande |
| WO2008001263A2 (en) | 2006-06-28 | 2008-01-03 | Koninklijke Philips Electronics N. V. | Magnetic sensor device with field generators and sensor elements |
| RU2460058C2 (ru) * | 2006-12-19 | 2012-08-27 | Конинклейке Филипс Электроникс Н.В. | Измерение параметров агглютинации |
| WO2008102218A1 (en) | 2007-02-23 | 2008-08-28 | Koninklijke Philips Electronics N.V. | A sensor device for and a method of sensing magnetic particles |
| US9068977B2 (en) * | 2007-03-09 | 2015-06-30 | The Regents Of The University Of Michigan | Non-linear rotation rates of remotely driven particles and uses thereof |
| US20100188076A1 (en) | 2007-07-09 | 2010-07-29 | Koninklijke Philips Electronics N.V. | Microelectronic sensor device with magnetic field generator and carrier |
| WO2009081309A2 (en) | 2007-12-18 | 2009-07-02 | Koninklijke Philips Electronics N. V. | A magnetic sensor device |
| JP2011508199A (ja) * | 2007-12-20 | 2011-03-10 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 標的粒子を検出するためのマイクロエレクトロニクスセンサデバイス |
| WO2009115951A1 (en) * | 2008-03-17 | 2009-09-24 | Koninklijke Philips Electronics N.V. | Cartridge for assays with magnetic particles |
| BRPI0913469A2 (pt) * | 2008-09-05 | 2015-12-22 | Koninkl Philips Electronics Nv | método para a realização de um ensaio de aglomerado, aparelho para a realização de um ensaio de aglomerado, uso de um método e uso de um aparelho |
| US8933694B2 (en) * | 2009-01-22 | 2015-01-13 | Koninklijkle Philips N.V. | Mixed actuation protocol for a magnetic biosensor device |
| US20120251392A1 (en) | 2009-10-19 | 2012-10-04 | Tokyo Institute Of Technology | Biosensor Using Magnetic Microparticles |
-
2011
- 2011-06-30 EP EP11172070A patent/EP2541230A1/en not_active Ceased
-
2012
- 2012-06-18 EP EP12735037.9A patent/EP2726848B1/en active Active
- 2012-06-18 US US14/125,618 patent/US10036729B2/en active Active
- 2012-06-18 CN CN201280032198.0A patent/CN103635788B/zh active Active
- 2012-06-18 WO PCT/IB2012/053051 patent/WO2013001400A1/en not_active Ceased
- 2012-06-18 JP JP2014517993A patent/JP6270717B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10036729B2 (en) | 2018-07-31 |
| EP2541230A1 (en) | 2013-01-02 |
| US20140120632A1 (en) | 2014-05-01 |
| EP2726848B1 (en) | 2016-04-13 |
| CN103635788A (zh) | 2014-03-12 |
| JP2014518389A (ja) | 2014-07-28 |
| EP2726848A1 (en) | 2014-05-07 |
| CN103635788B (zh) | 2016-12-14 |
| WO2013001400A1 (en) | 2013-01-03 |
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