JP6267239B2 - 極めて低粘度の新規エステル化セルロースエーテル - Google Patents

極めて低粘度の新規エステル化セルロースエーテル Download PDF

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Publication number
JP6267239B2
JP6267239B2 JP2015560340A JP2015560340A JP6267239B2 JP 6267239 B2 JP6267239 B2 JP 6267239B2 JP 2015560340 A JP2015560340 A JP 2015560340A JP 2015560340 A JP2015560340 A JP 2015560340A JP 6267239 B2 JP6267239 B2 JP 6267239B2
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Japan
Prior art keywords
cellulose ether
esterified cellulose
viscosity
esterified
solution
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Expired - Fee Related
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JP2015560340A
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English (en)
Japanese (ja)
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JP2016516835A5 (cg-RX-API-DMAC10.html
JP2016516835A (ja
Inventor
オリヴァー・ピーターマン
ロバート・ビー・アッペル
マインオルフ・ブラックハーゲン
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015560340A 2013-03-07 2014-02-28 極めて低粘度の新規エステル化セルロースエーテル Expired - Fee Related JP6267239B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774161P 2013-03-07 2013-03-07
US61/774,161 2013-03-07
PCT/US2014/019266 WO2014137778A1 (en) 2013-03-07 2014-02-28 Novel esterified cellulose ethers of very low viscosity

Publications (3)

Publication Number Publication Date
JP2016516835A JP2016516835A (ja) 2016-06-09
JP2016516835A5 JP2016516835A5 (cg-RX-API-DMAC10.html) 2016-11-04
JP6267239B2 true JP6267239B2 (ja) 2018-01-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015560340A Expired - Fee Related JP6267239B2 (ja) 2013-03-07 2014-02-28 極めて低粘度の新規エステル化セルロースエーテル

Country Status (7)

Country Link
US (1) US9617351B2 (cg-RX-API-DMAC10.html)
EP (1) EP2964204B1 (cg-RX-API-DMAC10.html)
JP (1) JP6267239B2 (cg-RX-API-DMAC10.html)
KR (1) KR101661952B1 (cg-RX-API-DMAC10.html)
CN (1) CN105025887B (cg-RX-API-DMAC10.html)
BR (1) BR112015015846A2 (cg-RX-API-DMAC10.html)
WO (1) WO2014137778A1 (cg-RX-API-DMAC10.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017018146A2 (pt) * 2015-03-16 2018-04-10 Dow Global Technologies Llc processo para a preparação de um éter de celulose esterificado na presença de um ácido carboxílico alifático
MX2017011128A (es) * 2015-03-16 2017-11-28 Dow Global Technologies Llc Eteres de celulosa esterificada de gelificacion.
JP6356923B2 (ja) * 2015-03-16 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー 水溶性エステル化セルロースエーテル
WO2016148970A1 (en) * 2015-03-16 2016-09-22 Dow Global Technologies Llc Aqueous solution of an esterified cellulose ether
MX2017011092A (es) * 2015-03-16 2017-11-10 Dow Global Technologies Llc Proceso para fraccionar un eter esterificado de celulosa.
MX2017011095A (es) 2015-03-16 2017-11-10 Dow Global Technologies Llc Eteres de celulosa esterificados solubles en agua que tienen grado bajo de neutralizacion.
EP3463314B1 (en) 2016-05-25 2020-07-22 Dow Global Technologies LLC Aqueous solution of cellulose ether acetate
KR102490265B1 (ko) * 2016-11-02 2023-01-20 신에쓰 가가꾸 고교 가부시끼가이샤 히프로멜로오스아세트산에스테르숙신산에스테르 및 제조 방법
WO2018170083A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
EP3596132B1 (en) 2017-03-17 2021-05-05 Nutrition & Biosciences USA 1, LLC Process for recovering an esterified cellulose ether from a reaction product mixture
WO2018170060A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4819231B1 (cg-RX-API-DMAC10.html) * 1970-03-06 1973-06-12
US4226981A (en) * 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
US4365060A (en) 1979-04-28 1982-12-21 Shin-Etsu Chemical Co. Ltd. Enterosoluble capsules
JPS59167521A (ja) * 1983-03-14 1984-09-21 Shin Etsu Chem Co Ltd 腸溶性コ−テイング剤組成物
JPS6281402A (ja) * 1985-10-07 1987-04-14 Shin Etsu Chem Co Ltd セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法
JP3149122B2 (ja) 1994-11-07 2001-03-26 信越化学工業株式会社 固形腸溶製剤のコーティング用基剤
JPH10167959A (ja) * 1996-12-04 1998-06-23 Zensei Yakuhin Kogyo Kk ジクロフェナクナトリウムの徐放性カプセル製剤
EP0872233A1 (en) 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
PT901786E (pt) 1997-08-11 2007-08-07 Pfizer Prod Inc Disperções farmacêuticas sólidas com biodisponibilidade melhorada
KR100387126B1 (ko) * 2001-04-19 2003-06-12 삼성정밀화학 주식회사 히드록시프로필메틸 셀룰로오스 프탈레이트의 분리정제방법
DE10141680B4 (de) 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
CA2485903C (en) * 2002-05-17 2011-08-16 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
CN1681479A (zh) 2002-08-12 2005-10-12 辉瑞产品公司 半有序药物和聚合物的药物组合物
EP1753402B1 (en) * 2004-05-28 2008-10-01 Pfizer Products Incorporated Pharmaceutical compositions with enhanced performance comprising a hpmca polymer
WO2009061815A1 (en) 2007-11-09 2009-05-14 Union Carbide Chemicals & Plastics Technology Llc Method for preparing very low viscosity cellulose ether and product
JP2011504524A (ja) 2007-11-09 2011-02-10 ダウ グローバル テクノロジーズ インコーポレイティド セルロースエーテルコーティング組成物および方法
JP5745855B2 (ja) * 2007-11-28 2015-07-08 セコイア、ファーマシューティカルズ、インコーポレイテッドＳｅｑｕｏｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． シトクロムｐ４５０ ２ｄ６を阻害するための組成物および方法
JP5322740B2 (ja) 2009-04-01 2013-10-23 国立大学法人東京農工大学 有害生物防除方法
WO2011159626A1 (en) 2010-06-14 2011-12-22 Bend Research, Inc. Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
US20120251588A1 (en) * 2011-03-30 2012-10-04 Miyuki Fukasawa Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation
US9453081B2 (en) 2012-03-27 2016-09-27 Dow Global Technologies Llc Process of preparing an ester of a cellulose ether
US9320799B2 (en) * 2012-04-11 2016-04-26 Dow Global Technologies Llc Esterified cellulose ethers having a specific substituent distribution
EP2888289B1 (en) 2012-08-24 2019-08-07 Dow Global Technologies LLC Partially cross-linked esterified cellulose ethers
CN107602710A (zh) 2012-08-24 2018-01-19 陶氏环球技术有限责任公司 新的具有高分子量和均匀性的酯化纤维素醚
BR112015002055A2 (pt) * 2012-08-24 2017-07-04 Dow Global Technologies Llc acetato succinato de hidroxialquil metil celulose, composição, dispersão sólida, processo para produzir uma dispersão sólida, forma de dosagem e cápsula de envoltório

Also Published As

Publication number Publication date
EP2964204A1 (en) 2016-01-13
KR20150119472A (ko) 2015-10-23
WO2014137778A1 (en) 2014-09-12
CN105025887B (zh) 2017-07-28
KR101661952B1 (ko) 2016-10-04
BR112015015846A2 (pt) 2017-07-11
CN105025887A (zh) 2015-11-04
US9617351B2 (en) 2017-04-11
US20150376299A1 (en) 2015-12-31
EP2964204B1 (en) 2017-01-04
JP2016516835A (ja) 2016-06-09

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