JP6266659B2 - 癌の治療のための安息香酸誘導体ｍｄｍ２阻害剤 - Google Patents
癌の治療のための安息香酸誘導体ｍｄｍ２阻害剤 Download PDFInfo
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- JP6266659B2 JP6266659B2 JP2015560283A JP2015560283A JP6266659B2 JP 6266659 B2 JP6266659 B2 JP 6266659B2 JP 2015560283 A JP2015560283 A JP 2015560283A JP 2015560283 A JP2015560283 A JP 2015560283A JP 6266659 B2 JP6266659 B2 JP 6266659B2
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- MANSWCXFKVIKPE-HIJQLYNKSA-N CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(N)=O)c2cc(Cl)ccc2)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(N)=O)c2cc(Cl)ccc2)c(cc2)ccc2Cl)C1=O)(=O)=O MANSWCXFKVIKPE-HIJQLYNKSA-N 0.000 description 1
- BEBAQWUEVUWBRD-RTIGCHDFSA-N CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)cc(OC)c2C(O)=O)=O)c2cccc(Cl)c2)C(/C=C(\C(\Cl)=C/C)/F)=C)C1=O)(=O)=O Chemical compound CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)cc(OC)c2C(O)=O)=O)c2cccc(Cl)c2)C(/C=C(\C(\Cl)=C/C)/F)=C)C1=O)(=O)=O BEBAQWUEVUWBRD-RTIGCHDFSA-N 0.000 description 1
- QGOICCMBEDDFCI-NXQGQTBASA-N CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)cc(OC)c2C(O)=O)=O)c2cccc(Cl)c2)c(cc2F)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)cc(OC)c2C(O)=O)=O)c2cccc(Cl)c2)c(cc2F)ccc2Cl)C1=O)(=O)=O QGOICCMBEDDFCI-NXQGQTBASA-N 0.000 description 1
- IHUMWHKQAVMWCV-HXZUPTHJSA-N CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cc(Cl)ccc2)c(cc2F)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cc(Cl)ccc2)c(cc2F)ccc2Cl)C1=O)(=O)=O IHUMWHKQAVMWCV-HXZUPTHJSA-N 0.000 description 1
- JEGRBRICAOMWLN-LCQQBMRFSA-N CC(C)(C)SC[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cc(Cl)ccc2)c(cc2)ccc2Cl)C1=O Chemical compound CC(C)(C)SC[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cc(Cl)ccc2)c(cc2)ccc2Cl)C1=O JEGRBRICAOMWLN-LCQQBMRFSA-N 0.000 description 1
- UPKBNWFSKZKMBB-UHFFFAOYSA-N CC(CC(C(c(cc1F)ccc1Cl)=O)c1cc(Cl)ccc1)C(OC)=O Chemical compound CC(CC(C(c(cc1F)ccc1Cl)=O)c1cc(Cl)ccc1)C(OC)=O UPKBNWFSKZKMBB-UHFFFAOYSA-N 0.000 description 1
- ZVXWVVRTWLVZKV-UHFFFAOYSA-N COC(c(cc1F)ccc1Cl)=O Chemical compound COC(c(cc1F)ccc1Cl)=O ZVXWVVRTWLVZKV-UHFFFAOYSA-N 0.000 description 1
- QNQSZYRUBCVBEK-JECHBYEQSA-N C[C@@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O Chemical compound C[C@@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O QNQSZYRUBCVBEK-JECHBYEQSA-N 0.000 description 1
- QBWGADZCVCWHEF-LQYCBEJQSA-N C[C@@](C[C@H](c1cccc(Cl)c1)O)(CC=C)C(N[C@H](CO)C(C1)[C@@H]1c(c(C)c1)cc(Cl)c1F)=O Chemical compound C[C@@](C[C@H](c1cccc(Cl)c1)O)(CC=C)C(N[C@H](CO)C(C1)[C@@H]1c(c(C)c1)cc(Cl)c1F)=O QBWGADZCVCWHEF-LQYCBEJQSA-N 0.000 description 1
- QNQSZYRUBCVBEK-LQAWEQHXSA-N C[C@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cccc(Cl)c2)C1=O Chemical compound C[C@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cccc(Cl)c2)C1=O QNQSZYRUBCVBEK-LQAWEQHXSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770901P | 2013-02-28 | 2013-02-28 | |
| US61/770,901 | 2013-02-28 | ||
| PCT/US2014/018759 WO2014134201A1 (en) | 2013-02-28 | 2014-02-26 | A benzoic acid derivative mdm2 inhibitor for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510028A JP2016510028A (ja) | 2016-04-04 |
| JP2016510028A5 JP2016510028A5 (enExample) | 2017-02-23 |
| JP6266659B2 true JP6266659B2 (ja) | 2018-01-24 |
Family
ID=50272765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560283A Active JP6266659B2 (ja) | 2013-02-28 | 2014-02-26 | 癌の治療のための安息香酸誘導体ｍｄｍ２阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8952036B2 (enExample) |
| EP (1) | EP2961735B1 (enExample) |
| JP (1) | JP6266659B2 (enExample) |
| CN (1) | CN105121407B (enExample) |
| AR (1) | AR094970A1 (enExample) |
| AU (1) | AU2014223547B2 (enExample) |
| CA (1) | CA2902856C (enExample) |
| MX (1) | MX368703B (enExample) |
| TW (1) | TW201505630A (enExample) |
| UY (1) | UY35353A (enExample) |
| WO (1) | WO2014134201A1 (enExample) |
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| ES2430067T3 (es) | 2007-03-28 | 2013-11-18 | President And Fellows Of Harvard College | Polipéptidos cosidos |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
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| MX362492B (es) | 2012-02-15 | 2019-01-21 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos. |
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| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
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| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| PT3068393T (pt) | 2013-11-11 | 2022-06-14 | Amgen Inc | Terapia de combinação, incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos adicionais para o tratamento de cancros |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| HK1247204A1 (zh) | 2015-01-20 | 2018-09-21 | Arvinas Operations, Inc. | 用於雄激素受体的靶向降解的化合物和方法 |
| AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP3302482A4 (en) | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| US9962380B2 (en) * | 2015-09-23 | 2018-05-08 | Wisconsin Alumni Research Foundation | Methods for treating cognitive deficits associated with fragile X syndrome |
| JP7037500B2 (ja) * | 2016-04-06 | 2022-03-16 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Ｍｄｍ２タンパク質分解剤 |
| AU2017250076B2 (en) * | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
| JP7286539B2 (ja) | 2016-11-01 | 2023-06-05 | アルビナス・オペレーションズ・インコーポレイテッド | タウタンパク質標的化ｐｒｏｔａｃ、および関連使用方法 |
| DK3689868T3 (da) | 2016-12-01 | 2024-01-02 | Arvinas Operations Inc | Tetrahydronaphthalen- og tetrahydroisoquinolinderivater som østrogenreceptordegraderende midler |
| CN110753693A (zh) | 2016-12-23 | 2020-02-04 | 阿尔维纳斯运营股份有限公司 | Egfr蛋白水解靶向嵌合分子和相关使用方法 |
| US10806737B2 (en) | 2016-12-23 | 2020-10-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| AU2017382436C1 (en) | 2016-12-23 | 2021-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| EP3573977A4 (en) | 2017-01-26 | 2020-12-23 | Arvinas Operations, Inc. | Modulators of estrogen receptor proteolysis and associated methods of use |
| WO2019099926A1 (en) | 2017-11-17 | 2019-05-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides |
| CN119569702A (zh) | 2018-04-04 | 2025-03-07 | 阿尔维纳斯运营股份有限公司 | 蛋白水解调节剂及相关使用方法 |
| IL308399B2 (en) * | 2018-04-30 | 2025-08-01 | Kartos Therapeutics Inc | Methods of treating cancer |
| WO2019224803A2 (en) * | 2018-05-25 | 2019-11-28 | Kartos Therapeutics, Inc. | Methods of treating myeloproliferative neoplasms |
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| CN110963958B (zh) * | 2018-09-30 | 2025-10-10 | 上海长森药业有限公司 | 一种mdm2抑制剂，及其制备方法、药物组合物和应用 |
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| EA201200321A1 (ru) | 2009-08-26 | 2012-09-28 | Новартис Аг | Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4 |
| US8088815B2 (en) * | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| JO2998B1 (ar) * | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| US20120010235A1 (en) * | 2010-07-12 | 2012-01-12 | Xin-Jie Chu | N-substituted pyrrolidines |
| US20120046306A1 (en) * | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
| CN102153557B (zh) | 2011-01-21 | 2013-03-20 | 中国科学院上海有机化学研究所 | 具有乙二胺骨架的多手性中心氮杂环卡宾前体盐、合成方法及用途 |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
-
2014
- 2014-02-26 CN CN201480011184.XA patent/CN105121407B/zh active Active
- 2014-02-26 JP JP2015560283A patent/JP6266659B2/ja active Active
- 2014-02-26 MX MX2015011245A patent/MX368703B/es active IP Right Grant
- 2014-02-26 EP EP14709849.5A patent/EP2961735B1/en active Active
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| AU2014223547A1 (en) | 2015-09-03 |
| EP2961735B1 (en) | 2017-09-27 |
| AU2014223547B2 (en) | 2017-11-16 |
| CA2902856A1 (en) | 2014-09-04 |
| JP2016510028A (ja) | 2016-04-04 |
| CN105121407B (zh) | 2017-07-18 |
| US20140243372A1 (en) | 2014-08-28 |
| MX368703B (es) | 2019-10-11 |
| US8952036B2 (en) | 2015-02-10 |
| UY35353A (es) | 2014-09-30 |
| MX2015011245A (es) | 2016-05-31 |
| WO2014134201A1 (en) | 2014-09-04 |
| TW201505630A (zh) | 2015-02-16 |
| CA2902856C (en) | 2021-02-16 |
| CN105121407A (zh) | 2015-12-02 |
| AR094970A1 (es) | 2015-09-09 |
| EP2961735A1 (en) | 2016-01-06 |
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