JP6255550B2 - Ｃｃｒ３阻害薬の製造方法 - Google Patents
Ｃｃｒ３阻害薬の製造方法 Download PDFInfo
- Publication number
- JP6255550B2 JP6255550B2 JP2015503828A JP2015503828A JP6255550B2 JP 6255550 B2 JP6255550 B2 JP 6255550B2 JP 2015503828 A JP2015503828 A JP 2015503828A JP 2015503828 A JP2015503828 A JP 2015503828A JP 6255550 B2 JP6255550 B2 JP 6255550B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- formula
- ethanol
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 Cc(cc(CN(CC1)CCC1N([C@](CC1)C(Nc2cc(C(N(*)*)=O)cc(C)n2)=O)C1=O)cc1)c1Cl Chemical compound Cc(cc(CN(CC1)CCC1N([C@](CC1)C(Nc2cc(C(N(*)*)=O)cc(C)n2)=O)C1=O)cc1)c1Cl 0.000 description 3
- YEJSPQZHMWGIGP-RXMQYKEDSA-N COC(CC[C@H](C(OC)=O)N)=O Chemical compound COC(CC[C@H](C(OC)=O)N)=O YEJSPQZHMWGIGP-RXMQYKEDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12162852.3 | 2012-04-02 | ||
| EP12162852 | 2012-04-02 | ||
| PCT/EP2013/056638 WO2013149926A1 (en) | 2012-04-02 | 2013-03-28 | Process for the manufacturing of ccr3 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516959A JP2015516959A (ja) | 2015-06-18 |
| JP2015516959A5 JP2015516959A5 (OSRAM) | 2016-05-26 |
| JP6255550B2 true JP6255550B2 (ja) | 2018-01-10 |
Family
ID=47998462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503828A Active JP6255550B2 (ja) | 2012-04-02 | 2013-03-28 | Ｃｃｒ３阻害薬の製造方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8680280B2 (OSRAM) |
| EP (1) | EP2834229B1 (OSRAM) |
| JP (1) | JP6255550B2 (OSRAM) |
| AR (1) | AR090566A1 (OSRAM) |
| DK (1) | DK2834229T3 (OSRAM) |
| ES (1) | ES2641862T3 (OSRAM) |
| TW (1) | TW201400474A (OSRAM) |
| UY (1) | UY34719A (OSRAM) |
| WO (1) | WO2013149926A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| US8680280B2 (en) | 2012-04-02 | 2014-03-25 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of CRR inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| BR112019020798A2 (pt) | 2017-04-05 | 2020-04-28 | Alkahest Inc | métodos e composições para tratamento de danos associados ao envelhecimento usando inibidores de ccr3 |
| JP7179755B2 (ja) | 2017-04-05 | 2022-11-29 | アルカヘスト インコーポレイテッド | Ｃｃｒ３阻害剤を使用した網膜関連疾患を治療するための方法および組成物 |
| US11426399B2 (en) | 2018-05-15 | 2022-08-30 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
| US11957671B2 (en) | 2021-11-01 | 2024-04-16 | Alkahest, Inc. | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7907121L (sv) | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
| JP2807577B2 (ja) | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| JPH08134041A (ja) * | 1994-11-10 | 1996-05-28 | Fuji Photo Film Co Ltd | ピラゾールアミド類の製造方法 |
| US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| CA2319781A1 (en) | 1998-02-02 | 1999-08-05 | Liping Wang | Cyclic amine modulators of chemokine receptor activity |
| US6140349A (en) | 1998-02-02 | 2000-10-31 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| ATE428422T1 (de) | 2004-02-05 | 2009-05-15 | Schering Corp | Piperidin-derivate als ccr3-antagonisten |
| JP2006137718A (ja) | 2004-11-12 | 2006-06-01 | Astellas Pharma Inc | インドール若しくはインダゾール誘導体 |
| US8030003B2 (en) | 2004-12-07 | 2011-10-04 | Children's Hospital Medical Center | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 |
| DOP2006000051A (es) | 2005-02-24 | 2006-08-31 | Lilly Co Eli | Inhibidores de vegf-r2 y métodos |
| JP2009533416A (ja) | 2006-04-12 | 2009-09-17 | ファイザー・リミテッド | ケモカインｃｃｒ５受容体の調節剤としてのピロリジン誘導体 |
| GB0701992D0 (en) | 2007-02-02 | 2007-03-14 | 7Tm Pharma As | Grehlin Receptor Modulators |
| US8008092B2 (en) | 2007-10-09 | 2011-08-30 | University Of Kentucky Research Foundation | CCR3 inhibition for ocular angiogenesis and macular degeneration |
| TW201000446A (en) | 2008-05-30 | 2010-01-01 | Astrazeneca Ab | New compounds useful in pain therapy |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| US8680280B2 (en) | 2012-04-02 | 2014-03-25 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of CRR inhibitors |
| US20130261153A1 (en) | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
-
2013
- 2013-03-27 US US13/851,547 patent/US8680280B2/en active Active
- 2013-03-27 AR ARP130101059A patent/AR090566A1/es unknown
- 2013-03-28 WO PCT/EP2013/056638 patent/WO2013149926A1/en not_active Ceased
- 2013-03-28 JP JP2015503828A patent/JP6255550B2/ja active Active
- 2013-03-28 DK DK13712567.0T patent/DK2834229T3/da active
- 2013-03-28 EP EP13712567.0A patent/EP2834229B1/en active Active
- 2013-03-28 ES ES13712567.0T patent/ES2641862T3/es active Active
- 2013-04-01 TW TW102111742A patent/TW201400474A/zh unknown
- 2013-04-02 UY UY0001034719A patent/UY34719A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY34719A (es) | 2013-10-31 |
| TW201400474A (zh) | 2014-01-01 |
| WO2013149926A1 (en) | 2013-10-10 |
| JP2015516959A (ja) | 2015-06-18 |
| DK2834229T3 (da) | 2017-11-20 |
| US20130261307A1 (en) | 2013-10-03 |
| AR090566A1 (es) | 2014-11-19 |
| ES2641862T3 (es) | 2017-11-14 |
| EP2834229A1 (en) | 2015-02-11 |
| EP2834229B1 (en) | 2017-08-09 |
| US8680280B2 (en) | 2014-03-25 |
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