JP6253702B2 - コンナルス ルーバー抽出物を配合した皮膚外用化粧料 - Google Patents
コンナルス ルーバー抽出物を配合した皮膚外用化粧料 Download PDFInfo
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- JP6253702B2 JP6253702B2 JP2016087641A JP2016087641A JP6253702B2 JP 6253702 B2 JP6253702 B2 JP 6253702B2 JP 2016087641 A JP2016087641 A JP 2016087641A JP 2016087641 A JP2016087641 A JP 2016087641A JP 6253702 B2 JP6253702 B2 JP 6253702B2
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Landscapes
- Cosmetics (AREA)
Description
一般に、皮膚は外部に曝されており、酸素などの外気成分や紫外線などを原因として、皮膚の老化に伴うシワ、クスミ、キメの消失、弾力性の低下が生じることが知られている。 また、皮膚細胞に発生するROS(活性酸素種)について、特にフリーラジカル型活性酸素は脂質などの酸化を受け易い基質と連鎖的な酸化反応を誘発する結果、皮膚組織にダメージを与えることも知られている。
生体内におけるタンパク質の糖化反応(ブドウ糖などの還元糖の間のメイラード反応)において、糖尿病などで高血糖状態が続いたり、加齢により分解反応が進行し難くなると、糖化産物の生成に傾き、タンパク質の機能が損なわれたり、糖化産物が蓄積したりする。
紫外線に起因して、その刺激により皮膚色素細胞内におけるメラニン生成が亢進し、メラニンが表皮に過剰に沈着することによって生じるシミ、ソバカスなどの色素沈着が生じることが知られているが、メラニンは、表皮色素細胞内で生合成された酵素であるチロシナーゼの働きによって、チロシン、ドーパ、ドーパキノン、5,6−ヒドロキシインドフェノールと数段階の中間体を経て生成されるものと考えられており、この生成過程の抑制や生成したメラニンの淡色化という手段によって、シミ、ソバカス、皮膚色素沈着症を予防、治療または改善するする方法が一般的に知られている。例えば、チロシナーゼ活性抑制効果を有する生薬である籐茶抽出物、ヤナギタケ抽出物等の使用、L−アスコルビン酸の大量投与、グルタチオン等の皮下注射、コウジ酸、システイン、ハイドロキシキノン等の皮膚への塗布などが挙げられる。
ここで、コンナルス ルーバーの抽出物には、抽出液、この抽出液の希釈液もしくは濃縮液、抽出液を乾燥して得られる乾燥物、若しくは粗抽出物または精製物並びに超臨界抽出物若しくは亜臨界抽出物のいずれかが含まれてもよい。
90質量部を混合することが好ましい。
上記コンナルス ルーバーからの抽出物は、皮膚に適用した場合の使用感と安全性に優れているため、皮膚化粧料に配合するのに好適である。この場合、コンナルス ルーバーの抽出物をそのまま配合してもよいし、当該抽出物から製剤化した抗酸化剤、美白剤、抗老化剤又は抗炎症剤を配合してもよい。
<製造例1>
乾燥コンナルス ルーバー樹皮1kgを50%1,3−ブチレングリコールに常温で24時間浸漬した後、ろ過し、抽出物を得た。
紫外線やストレスなどにより生体内に発生した活性酸素種(ROS)は、DNAの酸化傷害やタンパク質の変性等を誘発し、シワやしみの要因の一つと考えられている。そのため、酸化の抑制は抗老化素材として有用である。
DPPHラジカル消去率(%)={1−(A−B)/(C−D)}×100
(式中、A、B、C、Dは以下の測定値を示す。A:各濃度の試料溶液における反応溶液の吸光度、B:各濃度の試料溶液における調整溶液の吸光度、C:試料無添加における反応溶液の吸光度、D:試料無添加における調整溶液の吸光度)
糖化は糖とタンパク質などによる非酵素的な反応であり、最終的に終末糖化産物(AGEs)を形成することが知られている。特に糖化に伴うコラーゲンの架橋化は皮膚弾力性の低下を生じさせるなど、近年、皮膚における糖化ストレスの亢進が老化に大きく影響することが示唆されている。そのため、糖化の抑制は抗老化素材として期待できる。
紫外線などにより過剰に産生されるメラニンは肌のくすみの原因となる。そのため、メラニン生成の産生作用は美白剤として期待できる。
セチルアルコール 5
グリセリン 2
1,3−ブチレングリコール 5
トリメチルグリシン 1
ポリアスパラギン酸ナトリウム 0.1
ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル 0.25
α−トコフェロール 2−L−アスコルビン酸リン酸ジエステルカリウム 0.1
HEDTA3ナトリウム 0.1
コンナルス ルーバー抽出物 0.1
ヘキサメタリン酸ナトリウム 0.003
カルボキシビニルポリマー 0.05
水酸化カリウム 0.025
フェノキシエタノール 適量
精製水 残余
香料 適量
グリセリン 2.5
1,3−ブチレングリコール 4
エリスリトール 1.5
ポリオキシエチレンメチルグルコシド 1
ポリオキシエチレン硬化ヒマシ油 0.5
コンナルス ルーバー抽出物 0.1
クエン酸 0.02
クエン酸ナトリウム 0.08
フェノキシエタノール 適量
精製水 残余
香料 適量
ジメチルポリシロキサン 2.5
デカメチルシクロペンタシロキサン 23
ドデカメチルシクロヘキサシロキサン 15
ポリオキシエチレン・メチルポリシロキサン共重合体 1.5
トリメチルシロキシケイ酸 1
1,3−ブチレングリコール 5
スクワラン 1.5
タルク 6
グリチルリチン酸ジカリウム 0.1
コンナルス ルーバー抽出物 0.1
酢酸トコフェロール 0.1
エデト酸三ナトリウム 0.05
パラメトキシ桂皮酸2−エチルヘキシル 5
シリコーン被覆微粒子酸化チタン 4
ジメチルジステアリルアンモニウムヘクトライト 0.5
球状ポリエチレン末 3
フェノキシエタノール 適量
精製水 残余
香料 適量
流動パラフィン 9
ワセリン 2
ジメチルポリシロキサン 2
ステアリルアルコール 4
ベヘニルアルコール 2
グリセリン 5
ジプロピレングリコール 4
キシリトール 1
テトラ2−エチルヘキサン酸ペンタエリスリット 4
親油型モノステアリン酸グリセリン 2
モノイソステアリン酸ポリオキシエチレングリセリル 2
モノステアリン酸ポリオキシエチレングリセリン 1
クエン酸 0.05
クエン酸ナトリウム 0.05
水酸化ナトリウム 0.015
油溶性甘草エキス 0.1
酢酸トコフェロール 0.1
コンナルス ルーバー抽出物 0.1
パラオキシ安息香酸エステル 適量
フェノキシエタノール 適量
エデト酸三ナトリウム 0.05
ポリビニルアルコール 0.5
ヒドロキシエチルセルロース 0.5
カルボキシビニルポリマー 0.05
精製水 残余
香料 適量
グリセリン 2
1,3−ブチレングリコール 4
水酸化ナトリウム 0.2
エデト酸三ナトリウム 0.05
コンナルス ルーバー抽出物 0.1
カルボキシビニルポリマー 0.25
パラオキシ安息香酸エステル 適量
精製水 残余
ベヘニルアルコール 0.5
ジプロピレングリコール 6
ステアリン酸 1.5
モノステアリン酸グリセリン 1
水酸化ナトリウム 0.15
トリエタノールアミン 0.6
酢酸トコフェロール 0.1
パラオキシ安息香酸エステル 適量
黄酸化鉄 1
ジメチルポリシロキサン(6cs) 2
ジメチルポリシロキサン(100cs) 5
ステアリルアルコール 1.5
イソステアリン酸 1.5
ベヘニン酸 0.5
2−エチルヘキサン酸セチル 10
モノステアリン酸ポリオキシエチレングリセリン 1
酸化チタン 3
表面処理酸化チタン 10
ポリアクリル酸アルキル被覆雲母チタン 0.5
黒酸化鉄 適量
無水ケイ酸 6
パラメトキシ桂皮酸2−エチルヘキシル 2
ベンガラ 適量
群青 適量
法定色素 適量
キサンタンガム 0.1
ベントナイト 1
カルボキシメチルセルロース 0.1
コンナルス ルーバー抽出物 0.1
精製水 残余
香料 適量
タルク 43
カオリン 15
セリサイト 10
亜鉛 7
酸化チタン 4
黄酸化鉄 3
黒酸化鉄 適量
ベンガラ 適量
スクワラン 8
イソステアリン酸 4
モノオレイン酸POEソルビタン 3
オクタン酸イソセチル 2
コンナルス ルーバー抽出物 0.5
パラオキシ安息香酸エステル 適量
香料 適量
Claims (2)
- コンナルス ルーバー(Connarus Ruber)樹皮の極性溶媒(多価アルコールを必ず含む)抽出物からなることを特徴とする抗酸化剤
- 請求項1に記載の抗酸化剤を有効成分として0.001重量%以上1重量%以下含有することを特徴とする皮膚外用剤
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