JP6216798B2 - β−グルカン製造方法 - Google Patents
β−グルカン製造方法 Download PDFInfo
- Publication number
- JP6216798B2 JP6216798B2 JP2015540586A JP2015540586A JP6216798B2 JP 6216798 B2 JP6216798 B2 JP 6216798B2 JP 2015540586 A JP2015540586 A JP 2015540586A JP 2015540586 A JP2015540586 A JP 2015540586A JP 6216798 B2 JP6216798 B2 JP 6216798B2
- Authority
- JP
- Japan
- Prior art keywords
- glucan
- mill
- pulverized powder
- extraction
- mushroom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002498 Beta-glucan Polymers 0.000 title claims description 69
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 title claims description 67
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 53
- 239000000843 powder Substances 0.000 claims description 46
- 238000000605 extraction Methods 0.000 claims description 44
- 238000010298 pulverizing process Methods 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 12
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 11
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 11
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 11
- 239000011425 bamboo Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000006228 supernatant Substances 0.000 claims description 9
- 239000002244 precipitate Substances 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 241000222336 Ganoderma Species 0.000 claims description 2
- 240000001080 Grifola frondosa Species 0.000 claims description 2
- 235000007710 Grifola frondosa Nutrition 0.000 claims description 2
- 240000000599 Lentinula edodes Species 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 235000001715 Lentinula edodes Nutrition 0.000 claims 1
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 23
- 239000003513 alkali Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- 239000000047 product Substances 0.000 description 12
- 241001330002 Bambuseae Species 0.000 description 10
- 229920001503 Glucan Polymers 0.000 description 10
- 238000009210 therapy by ultrasound Methods 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000002137 ultrasound extraction Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000000527 sonication Methods 0.000 description 6
- 230000001093 anti-cancer Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229920000310 Alpha glucan Polymers 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000272503 Sparassis radicata Species 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000003912 environmental pollution Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007602 hot air drying Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001543 one-way ANOVA Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 244000191482 Cantharellus cibarius Species 0.000 description 1
- 235000015722 Cantharellus cibarius Nutrition 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010022769 Glucan 1,3-beta-Glucosidase Proteins 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000123241 Sparassis Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003579 anti-obesity Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Sustainable Development (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120128239A KR101477140B1 (ko) | 2012-11-13 | 2012-11-13 | β-글루칸 제조방법 |
| KR10-2012-0128239 | 2012-11-13 | ||
| PCT/KR2013/003683 WO2014077476A1 (ko) | 2012-11-13 | 2013-04-29 | β-글루칸 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015535310A JP2015535310A (ja) | 2015-12-10 |
| JP6216798B2 true JP6216798B2 (ja) | 2017-10-18 |
Family
ID=50731365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540586A Active JP6216798B2 (ja) | 2012-11-13 | 2013-04-29 | β−グルカン製造方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6216798B2 (ko) |
| KR (1) | KR101477140B1 (ko) |
| WO (1) | WO2014077476A1 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL224430B1 (pl) * | 2014-10-27 | 2016-12-30 | Beta Bio Tech Spółka Z Ograniczoną Odpowiedzialnością | Sposób wyodrębniania beta-glukanu ze zbóż |
| KR101955895B1 (ko) * | 2018-04-30 | 2019-03-08 | 푸른솔푸드 주식회사 | 잎새버섯을 이용한 건강기능성식품 및 그 제조방법 |
| KR102517662B1 (ko) * | 2022-07-12 | 2023-04-06 | (주)파이토메디 | 차가버섯을 유효성분으로 함유하는 근육 질환 개선, 치료 또는 예방용, 또는 근 기능 개선용 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100295623B1 (ko) * | 1998-03-24 | 2001-09-06 | 서경배 | 치마버섯유래의베타-1,6-분지-베타-1,3-글루칸의제조방법및이방법에의해제조된베타-1,6-분지-베타-1,3-글루칸을함유하는화장료조성물 |
| CA2345606A1 (en) * | 2000-09-27 | 2002-03-27 | The Governors Of The University Of Alberta | Grain fractionation |
| KR20040096000A (ko) * | 2003-05-07 | 2004-11-16 | 김관호 | 초음파에 의한 세포벽 파쇄 및 효소발효법을 이용한상황버섯 베타글루칸 추출방법 |
| JP2006037016A (ja) * | 2004-07-29 | 2006-02-09 | Shiriusu:Kk | 鹿角霊芝からのβ−グルカン抽出法 |
| JP2007217661A (ja) * | 2006-01-17 | 2007-08-30 | Asahi Kasei Chemicals Corp | 水溶性キシラン含有多糖類の製造方法、及びその用途 |
| JP2008125360A (ja) * | 2006-11-16 | 2008-06-05 | Omushii:Kk | βグルカン抽出方法 |
| KR20090121824A (ko) * | 2008-05-23 | 2009-11-26 | 농업회사법인 하나바이오텍(주) | 수용성 베타글루칸의 제조방법 |
| KR20100119922A (ko) * | 2009-05-04 | 2010-11-12 | 한림대학교 산학협력단 | 차신고버섯 추출 베타글루칸을 함유하는 항염증성 조성물 |
-
2012
- 2012-11-13 KR KR1020120128239A patent/KR101477140B1/ko active IP Right Grant
-
2013
- 2013-04-29 JP JP2015540586A patent/JP6216798B2/ja active Active
- 2013-04-29 WO PCT/KR2013/003683 patent/WO2014077476A1/ko active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140061078A (ko) | 2014-05-21 |
| JP2015535310A (ja) | 2015-12-10 |
| KR101477140B1 (ko) | 2014-12-29 |
| WO2014077476A1 (ko) | 2014-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Effect of extraction method on structure and antioxidant activity of Hohenbuehelia serotina polysaccharides | |
| JP4375266B2 (ja) | β−１，３−１，６−Ｄ−グルカンおよびその用途 | |
| KR101467903B1 (ko) | 흑미의 담자균류균사 발효 및 생물전환공정을 통해 생산된 면역증강제 | |
| JP2002262820A (ja) | きのこ類の有効成分の抽出方法 | |
| US20050271613A1 (en) | Beta-1, 3-1, 6-D-glucan and its use | |
| CN101282732A (zh) | 含有岩藻多糖或岩藻多糖水解产物和免疫赋活材料的组合物 | |
| JP6438111B2 (ja) | 乳化剤を含まずに紅参有効成分摂取率が極大化された発酵紅参粉末分散液の製造方法 | |
| JP2007217466A (ja) | コーヒー豆または／およびコーヒー抽出残渣より多糖類を製造する方法 | |
| JP6216798B2 (ja) | β−グルカン製造方法 | |
| Choi et al. | Enhancement of anti-complementary and radical scavenging activities in the submerged culture of Cordyceps sinensis by addition of citrus peel | |
| US20140220078A1 (en) | Method for Preparing Glucans Based on Aspergillus niger | |
| Han et al. | Effect of extraction method on the chemical profiles and bioactivities of soybean hull polysaccharides | |
| JP6353225B2 (ja) | 担子菌を原料としたβ−グルカン含有組成物の製造方法 | |
| Yue et al. | Extraction, purification, structural features and biological activities of longan fruit pulp (Longyan) polysaccharides: A review | |
| CN104387495A (zh) | 一种灵芝多糖的制备方法 | |
| CN105770557A (zh) | 一种具有缓解心脑血管疾病的碱性植物盐及其制备方法 | |
| CN103892256B (zh) | 一种灵芝固体饮料的制备方法 | |
| KR20170082288A (ko) | 물리적 초미세분쇄로 홍삼 전체의 섭취가 가능하며, 유효성분의 소화 흡수 극대화를 위한 통홍삼 분말 및 통홍삼 분말 농축액의 제조 방법 | |
| JP4451100B2 (ja) | タモギタケ子実体組成物を有効成分として含有する免疫賦活剤、及び抗癌剤 | |
| JP2006037016A (ja) | 鹿角霊芝からのβ−グルカン抽出法 | |
| Han et al. | Structural features, antitumor and antioxidant activities of rice bran polysaccharides using different extraction methods | |
| KR101825067B1 (ko) | 물리적 초미세분쇄로 홍삼 전체의 섭취를 가능하게한 제조장치와 생화학적 발효, 효소분해를 통한 홍삼 유효성분의 소화 흡수 극대화를 위한 통홍삼액 제조 방법 | |
| CN114259515A (zh) | 一种具有抗糖化作用的组合物及应用 | |
| Lomovsky et al. | The concentration of melanin in powder materials obtained from white-rot fungi by the mechanochemical method | |
| CN111034837A (zh) | 一种β-(1-3),(1-4)-葡聚糖降血脂咖啡及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160524 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160819 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160923 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161122 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20170321 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170721 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20170724 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20170814 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170829 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170925 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6216798 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |