JP6172865B2 - 併用療法によるプロカスパーゼ3活性化 - Google Patents
併用療法によるプロカスパーゼ3活性化 Download PDFInfo
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- JP6172865B2 JP6172865B2 JP2014561084A JP2014561084A JP6172865B2 JP 6172865 B2 JP6172865 B2 JP 6172865B2 JP 2014561084 A JP2014561084 A JP 2014561084A JP 2014561084 A JP2014561084 A JP 2014561084A JP 6172865 B2 JP6172865 B2 JP 6172865B2
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607098P | 2012-03-06 | 2012-03-06 | |
| US61/607,098 | 2012-03-06 | ||
| PCT/US2013/029405 WO2013134407A2 (en) | 2012-03-06 | 2013-03-06 | Procaspase 3 activation by combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509965A JP2015509965A (ja) | 2015-04-02 |
| JP6172865B2 true JP6172865B2 (ja) | 2017-08-02 |
Family
ID=49117502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561084A Active JP6172865B2 (ja) | 2012-03-06 | 2013-03-06 | 併用療法によるプロカスパーゼ3活性化 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9399035B2 (enEXAMPLES) |
| EP (2) | EP2822558B1 (enEXAMPLES) |
| JP (1) | JP6172865B2 (enEXAMPLES) |
| KR (1) | KR102074530B1 (enEXAMPLES) |
| CN (1) | CN104507479B (enEXAMPLES) |
| AU (1) | AU2016213862B2 (enEXAMPLES) |
| BR (1) | BR112014022103B1 (enEXAMPLES) |
| CA (1) | CA2866021C (enEXAMPLES) |
| DK (1) | DK2822558T3 (enEXAMPLES) |
| ES (1) | ES2774930T3 (enEXAMPLES) |
| IN (1) | IN2014MN01945A (enEXAMPLES) |
| MX (2) | MX365392B (enEXAMPLES) |
| RU (1) | RU2659936C2 (enEXAMPLES) |
| WO (2) | WO2013134407A2 (enEXAMPLES) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008134474A2 (en) | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| IN2014MN01945A (enEXAMPLES) | 2012-03-06 | 2015-07-10 | Univ Illinois | |
| AU2014344789B2 (en) * | 2013-11-01 | 2019-10-03 | Pitney Pharmaceuticals Pty Limited | Pharmaceutical combinations for the treatment of cancer |
| CA2977298A1 (en) * | 2014-11-07 | 2016-05-12 | Lipoxen Technologies Limited | Method for treatment of primary hormone resistant endometrial and breast cancers |
| EP3227437A4 (en) | 2014-12-05 | 2018-08-22 | An2H Discovery Limited | Parkin ligase activation methods and compositions |
| DK3302478T3 (da) | 2015-06-05 | 2022-02-14 | The Board Of Trustees Of The Univ Of Illionis | Pac-1 kombinations behandling |
| KR101712638B1 (ko) * | 2015-08-19 | 2017-03-07 | 한국과학기술연구원 | Pac-1을 이용한 단백질 발현 조절 시스템과 방법 및 pac-1을 유효성분 포함하는 독시사이클린 길항제 |
| US10308617B2 (en) | 2016-06-03 | 2019-06-04 | An2H Discovery Limited | Triazole benzamide derivatives and the compositions and methods of treatment regarding the same |
| MX2020004991A (es) | 2017-11-17 | 2022-02-10 | Univ Illinois | Terapia oncológica mediante la degradación de la señalización dual de mek. |
| US10889553B2 (en) | 2017-12-01 | 2021-01-12 | Nysnobio Ireland Dac | Asymmetric triazole benzamide derivatives and the compositions and methods of treatment regarding the same |
| JP7591283B2 (ja) * | 2018-10-05 | 2024-11-28 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ | ブドウ膜黒色腫の治療のための併用療法 |
| SG11202113213RA (en) * | 2019-05-30 | 2021-12-30 | Univ Illinois | Procaspase-3 activation and immunotherapy for treatment of cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US597287A (en) | 1898-01-11 | Bicycle attachment | ||
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5723459A (en) * | 1991-05-09 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
| US5844001A (en) * | 1993-02-26 | 1998-12-01 | Research Development Foundation | Combination platinum chemotherapeutic/antiestrogen therapy for human cancers |
| US6403765B1 (en) | 1998-06-16 | 2002-06-11 | Thomas Jefferson University | Truncated Apaf-1 and methods of use thereof |
| JP2002522032A (ja) | 1998-07-27 | 2002-07-23 | ファルマシア・アンド・アップジョン・カンパニー | プロカスパーゼ8の自己活性化方法 |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6110691A (en) | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
| US6608026B1 (en) | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
| US20030008015A1 (en) | 2000-10-11 | 2003-01-09 | Levisage Catherine S. | Polymer controlled delivery of a therapeutic agent |
| WO2002048329A2 (en) | 2000-11-20 | 2002-06-20 | Idun Pharmaceuticals, Inc. | Membrane derived caspase-3, compositions comprising the same and methods of use therefor |
| DE10128840A1 (de) * | 2001-06-15 | 2003-01-09 | Otis Elevator Co | Verfahren und Vorrichtung zur Steuerung des Antriebs einer Fördereinrichtung |
| US6878743B2 (en) | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| US6702122B2 (en) * | 2002-07-11 | 2004-03-09 | Frank G. Hopkins | Rack for fork lift extensions |
| US20040180828A1 (en) | 2003-01-30 | 2004-09-16 | Yigong Shi | Caspase-9 : BIR domain of XIAP complexes and methods of use |
| US7632972B2 (en) | 2003-10-30 | 2009-12-15 | The Board Of Trustees Of The University Of Illionis | Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells |
| TR200604485T1 (tr) * | 2003-12-09 | 2007-01-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi |
| RU2007141654A (ru) * | 2005-05-12 | 2009-05-20 | Пфайзер Инк. (US) | Противоопухолевая комбинированная терапия, в которой используется сунитиниб-малат |
| CN101184491A (zh) * | 2005-05-26 | 2008-05-21 | 伊利诺伊大学评议会 | 包括活化半胱天冬酶-3酶原的癌细胞内选择性细胞凋亡诱导 |
| WO2008134474A2 (en) | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| US20070049602A1 (en) * | 2005-05-26 | 2007-03-01 | The Board Of Trustees Of The University Of Illinois | Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3 |
| RU2408584C2 (ru) | 2005-06-23 | 2011-01-10 | Мерк Шарп Энд Домэ Корп. | Ингибиторы тирозинкиназы |
| TWI373473B (en) | 2005-09-02 | 2012-10-01 | Otsuka Pharma Co Ltd | Anticancer agent |
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