DE07797600T1 - Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren - Google Patents

Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren Download PDF

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DE07797600T1
DE07797600T1 DE07797600T DE07797600T DE07797600T1 DE 07797600 T1 DE07797600 T1 DE 07797600T1 DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T1 DE07797600 T1 DE 07797600T1
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foam
composition
foamable
blowing agent
hfo
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Paul J. Champaign Hergenrother
Vitaliy Rantoul Nesterenko
Karson S. Champaign Putt
Rahul Champaign Palchaudhuri
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University of Illinois
University of Illinois at Urbana Champaign
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
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    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/54—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
    • C07C13/573—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/54—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
    • C07C13/573—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
    • C07C13/58—Completely or partially hydrogenated anthracenes
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/42—Halides thereof
    • C07F9/425—Acid or estermonohalides thereof, e.g. RP(=X)(YR)(Hal) (X, Y = O, S; R = H, or hydrocarbon group)
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Abstract

Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.

Claims (13)

  1. Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.
  2. Verwendung nach Anspruch 1, wobei die Zusammensetzung mindestens etwa 5 Gew.-% und vorzugsweise mindestens etwa 15 Gew.-% HFO 1234ze umfaßt.
  3. Verschäumbare Zusammensetzung, umfassend ein Polyol und ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel.
  4. Verschäumbare Zusammensetzung nach Anspruch 3, die zu einem unter Polyurethan- und Polyisocyanurat-Schaumstoffen ausgewählten Schaumstoff verschäumbar ist.
  5. Verschäumbare Zusammensetzung, die zu einem thermoplastischen Schaumstoff verschäumbar ist und als Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
  6. Verschäumbare Zusammensetzung nach Anspruch 5, bei der der thermoplastische Schaumstoff unter Polystyrol- und Polyethylen-Schaumstoffen ausgewählt ist.
  7. Schaumstoff, umfassend eine Polymerschaumstoffzusammensetzung, die ein Blähmittel enthält, wobei das Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
  8. Schaumstoff nach Anspruch 7, bei dem es sich um einen geschlossenzelligen Schaumstoff handelt.
  9. Schaumstoff nach Anspruch 7, bei der die Polymerschaumstoffzusammensetzung unter Polyurethan-Schaumstoffen, Polyisocyanurat-Schaumstoffen und thermoplastischen Schaumstoffen ausgewählt ist.
  10. Vorgemischte Zusammensetzung, umfassend: (A) eine erste Komponente, die ein Isocyanat umfaßt; und (B) eine zweite Komponente, die ein Polyol oder eine Polyolmischung, ein Tensid, Katalysatoren, Blähmittel und ein Flammschutzmittel umfaßt.
  11. Verfahren zur Bildung eines Schaumstoffs, bei dem man: 1) ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel bereitstellt; 2) das Blähmittel zu einer verschäumbaren Zusammensetzung gibt und 3) die verschäumbare Zusammensetzung unter zur Bildung eines Schaumstoffs oder einer zelligen Struktur effektiven Bedingungen zur Reaktion bringt.
  12. Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs durch Zusammenmischen der ersten und zweiten Komponente gemäß Anspruch 10.
  13. Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs, bei dem man ein Isocyanat; ein Polyol oder eine Polyolmischung; ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel und andere, mindestens unter Katalysatoren und Tensiden ausgewählte Substanzen vereinigt.
DE07797600T 2006-05-19 2007-05-18 Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren Pending DE07797600T1 (de)

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US74774706P 2006-05-19 2006-05-19
US747747P 2006-05-19
PCT/US2007/069307 WO2007137200A2 (en) 2006-05-19 2007-05-18 Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers

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DE07797600T1 true DE07797600T1 (de) 2009-08-13

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US (1) US7709465B2 (de)
EP (1) EP2034828A4 (de)
JP (1) JP2009537636A (de)
KR (1) KR20090020585A (de)
CN (1) CN101489380A (de)
AU (1) AU2007253753A1 (de)
BR (1) BRPI0711769A2 (de)
CA (1) CA2651395A1 (de)
DE (1) DE07797600T1 (de)
IL (1) IL194906A0 (de)
MX (1) MX2008014712A (de)
NO (1) NO20084635L (de)
RU (1) RU2008149461A (de)
WO (1) WO2007137200A2 (de)

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RU2636234C2 (ru) 2012-03-06 2017-11-21 Зэ Борд оф Трастиз оф зэ Юниверсити оф Иллинойс Прокаспазная комбинированная терапия при глиобластоме
BR112014022103B1 (pt) * 2012-03-06 2022-04-19 The Board Of Trustees Of The University Of Illinois Composições e seus usos
US10113131B2 (en) * 2017-01-11 2018-10-30 The Boeing Company Phosphono paraffins
MX2020004991A (es) 2017-11-17 2022-02-10 Univ Illinois Terapia oncológica mediante la degradación de la señalización dual de mek.

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IL194906A0 (en) 2009-08-03
RU2008149461A (ru) 2010-06-27
KR20090020585A (ko) 2009-02-26
US20090004293A1 (en) 2009-01-01
CA2651395A1 (en) 2007-11-29
WO2007137200A2 (en) 2007-11-29
EP2034828A2 (de) 2009-03-18
AU2007253753A1 (en) 2007-11-29
NO20084635L (no) 2008-12-12
EP2034828A4 (de) 2011-04-06
CN101489380A (zh) 2009-07-22
US7709465B2 (en) 2010-05-04
JP2009537636A (ja) 2009-10-29
WO2007137200A3 (en) 2008-03-13
MX2008014712A (es) 2009-03-20
BRPI0711769A2 (pt) 2011-12-13

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