JP6171014B2 - オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン - Google Patents

オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン Download PDF

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JP6171014B2
JP6171014B2 JP2015528568A JP2015528568A JP6171014B2 JP 6171014 B2 JP6171014 B2 JP 6171014B2 JP 2015528568 A JP2015528568 A JP 2015528568A JP 2015528568 A JP2015528568 A JP 2015528568A JP 6171014 B2 JP6171014 B2 JP 6171014B2
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group
compound
methyl
hapten
nhc
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Japanese (ja)
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JP2015532645A5 (enExample
JP2015532645A (ja
Inventor
ドナエ，マシュー，ギャレット
ゴング，ヨン
サルター，ライズ
リョホレンコ，エリック
デコリー，トーマス，アール．
レメリー，バート，エム．
サンカラン，バヌマティ
Original Assignee
ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/77—Ovalbumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015528568A 2012-08-21 2013-08-20 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン Active JP6171014B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261691454P 2012-08-21 2012-08-21
US61/691,454 2012-08-21
PCT/US2013/055700 WO2014031587A1 (en) 2012-08-21 2013-08-20 Haptens of olanzipine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017130471A Division JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Publications (3)

Publication Number Publication Date
JP2015532645A JP2015532645A (ja) 2015-11-12
JP2015532645A5 JP2015532645A5 (enExample) 2016-05-26
JP6171014B2 true JP6171014B2 (ja) 2017-07-26

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JP2015528568A Active JP6171014B2 (ja) 2012-08-21 2013-08-20 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2017130471A Active JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2018196525A Active JP6763000B2 (ja) 2012-08-21 2018-10-18 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

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JP2017130471A Active JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2018196525A Active JP6763000B2 (ja) 2012-08-21 2018-10-18 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Country Status (11)

Country Link
US (1) US9303041B2 (enExample)
EP (2) EP2888269B1 (enExample)
JP (3) JP6171014B2 (enExample)
CN (1) CN104854110B (enExample)
AU (1) AU2013306018B2 (enExample)
CA (1) CA2882454C (enExample)
ES (2) ES2701062T3 (enExample)
PL (1) PL2888269T3 (enExample)
PT (1) PT2888269T (enExample)
TR (1) TR201816378T4 (enExample)
WO (1) WO2014031587A1 (enExample)

Cited By (1)

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JP2017222671A (ja) * 2012-08-21 2017-12-21 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

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JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
EP2888277A4 (en) 2012-08-21 2016-05-18 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF
AU2013305970B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to aripiprazole haptens and use thereof
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ES3057437T3 (en) 2012-08-21 2026-03-02 Janssen Pharmaceutica Nv Antibodies to olanzapine haptens and use thereof
PL2888286T3 (pl) 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie
ES2870004T3 (es) 2012-08-21 2021-10-26 Janssen Pharmaceutica Nv Anticuerpos contra la risperidona y uso de los mismos
PL2888373T3 (pl) 2012-08-21 2018-08-31 Janssen Pharmaceutica Nv Przeciwciała dla arypiprazolu i ich zastosowanie
CN108368180B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 喹硫平的抗体及其用途
JP6949025B2 (ja) 2015-12-17 2021-10-13 ヤンセン ファーマシューティカ エヌ．ベー． リスペリドンに対する抗体及びその使用
CN110938082A (zh) * 2019-10-30 2020-03-31 杭州博拓生物科技股份有限公司 一种奥氮平人工抗原及其制备方法
CN110950808A (zh) * 2019-10-30 2020-04-03 杭州博拓生物科技股份有限公司 一种氯氮平人工抗原及其制备方法
EP4267187A1 (en) * 2020-12-22 2023-11-01 Intervet International B.V. Conjugated zearalenone to protect against mycotoxicosis
CN114685477B (zh) * 2020-12-25 2023-11-17 长沙博源医疗科技有限公司 一种利奈唑胺衍生物、免疫原、抗利奈唑胺特异性抗体及其制备方法与应用
CN114685527B (zh) * 2020-12-25 2024-03-05 长沙博源医疗科技有限公司 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用

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JP2017222671A (ja) * 2012-08-21 2017-12-21 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2019034955A (ja) * 2012-08-21 2019-03-07 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Also Published As

Publication number Publication date
JP6423490B2 (ja) 2018-11-14
JP2017222671A (ja) 2017-12-21
ES2701062T3 (es) 2019-02-20
CA2882454A1 (en) 2014-02-27
JP2015532645A (ja) 2015-11-12
PT2888269T (pt) 2019-01-17
JP2019034955A (ja) 2019-03-07
CA2882454C (en) 2020-08-11
EP3492473A1 (en) 2019-06-05
US9303041B2 (en) 2016-04-05
EP2888269A1 (en) 2015-07-01
CN104854110B (zh) 2016-12-28
CN104854110A (zh) 2015-08-19
US20140213766A1 (en) 2014-07-31
WO2014031587A1 (en) 2014-02-27
HK1211933A1 (en) 2016-06-03
AU2013306018A1 (en) 2015-03-12
EP3492473B1 (en) 2025-07-30
TR201816378T4 (tr) 2018-11-21
ES3043017T3 (en) 2025-11-24
PL2888269T3 (pl) 2019-06-28
EP2888269B1 (en) 2018-10-24
AU2013306018B2 (en) 2017-08-10
JP6763000B2 (ja) 2020-09-30

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