PT2888269T - Haptenos de olanzapina - Google Patents
Haptenos de olanzapinaInfo
- Publication number
- PT2888269T PT2888269T PT13753774T PT13753774T PT2888269T PT 2888269 T PT2888269 T PT 2888269T PT 13753774 T PT13753774 T PT 13753774T PT 13753774 T PT13753774 T PT 13753774T PT 2888269 T PT2888269 T PT 2888269T
- Authority
- PT
- Portugal
- Prior art keywords
- olanzapine
- haptens
- Prior art date
Links
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 title 1
- 229960005017 olanzapine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/77—Ovalbumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691454P | 2012-08-21 | 2012-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2888269T true PT2888269T (pt) | 2019-01-17 |
Family
ID=49081007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT13753774T PT2888269T (pt) | 2012-08-21 | 2013-08-20 | Haptenos de olanzapina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9303041B2 (enExample) |
| EP (2) | EP3492473B1 (enExample) |
| JP (3) | JP6171014B2 (enExample) |
| CN (1) | CN104854110B (enExample) |
| AU (1) | AU2013306018B2 (enExample) |
| CA (1) | CA2882454C (enExample) |
| ES (2) | ES2701062T3 (enExample) |
| PL (1) | PL2888269T3 (enExample) |
| PT (1) | PT2888269T (enExample) |
| TR (1) | TR201816378T4 (enExample) |
| WO (1) | WO2014031587A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2888287A4 (en) | 2012-08-21 | 2016-04-20 | Ortho Clinical Diagnostics Inc | ANTIBODIES AGAINST PALIPERIDONE HAPTENES AND THEIR USE |
| JP6131414B2 (ja) | 2012-08-21 | 2017-05-24 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールのハプテン及びイムノアッセイにおけるそれらの使用 |
| EP3581195B1 (en) | 2012-08-21 | 2025-10-01 | Janssen Pharmaceutica NV | Antibodies to olanzapine haptens and use thereof |
| CN104736567B (zh) | 2012-08-21 | 2019-09-03 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| AU2013305901B2 (en) * | 2012-08-21 | 2017-10-26 | Saladax Biomedical Inc. | Antibodies to olanzapine and use thereof |
| US9465041B2 (en) | 2012-08-21 | 2016-10-11 | Janssen Pharmaceutica Nv | Antibodies to paliperidone and use thereof |
| AU2013305887B2 (en) | 2012-08-21 | 2018-02-22 | Saladax Biomedical Inc. | Antibodies to risperidone and use thereof |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| PL2888373T3 (pl) | 2012-08-21 | 2018-08-31 | Janssen Pharmaceutica Nv | Przeciwciała dla arypiprazolu i ich zastosowanie |
| JP6450314B2 (ja) | 2012-08-21 | 2019-01-09 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンハプテンに対する抗体及びその使用 |
| US9751953B2 (en) | 2012-08-21 | 2017-09-05 | Janssen Pharmaceutica Nv | Antibodies to risperidone haptens and use thereof |
| EP3492473B1 (en) * | 2012-08-21 | 2025-07-30 | Janssen Pharmaceutica NV | Haptens of olanzapine |
| CA3008809A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| MA44067A (fr) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica Nv | Anticorps dirigés contre la quétiapine et utilisation associée |
| CN110938082A (zh) * | 2019-10-30 | 2020-03-31 | 杭州博拓生物科技股份有限公司 | 一种奥氮平人工抗原及其制备方法 |
| CN110950808A (zh) * | 2019-10-30 | 2020-04-03 | 杭州博拓生物科技股份有限公司 | 一种氯氮平人工抗原及其制备方法 |
| EP4267187A1 (en) * | 2020-12-22 | 2023-11-01 | Intervet International B.V. | Conjugated zearalenone to protect against mycotoxicosis |
| CN114685527B (zh) * | 2020-12-25 | 2024-03-05 | 长沙博源医疗科技有限公司 | 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用 |
| CN114685477B (zh) * | 2020-12-25 | 2023-11-17 | 长沙博源医疗科技有限公司 | 一种利奈唑胺衍生物、免疫原、抗利奈唑胺特异性抗体及其制备方法与应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022780A (en) | 1973-03-06 | 1977-05-10 | Imperial Chemical Industries Limited | Process for the manufacture of indole derivatives |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US6034078A (en) | 1992-05-29 | 2000-03-07 | Eli Lilly And Company Limited | Thienobenzodiazepine compounds |
| TW268005B (enExample) | 1992-05-29 | 1996-01-11 | Lilly Industries Ltd | |
| DE69323244T2 (de) * | 1992-06-26 | 1999-07-08 | Johnson & Johnson Clinical Diagnostics, Inc., Rochester, N.Y. | Immunotests unter Verwendung von markierten Thyronin-Analogen |
| US5395933A (en) * | 1992-08-07 | 1995-03-07 | Eastman Kodak Company | Carbamazepine hapten analogues |
| UA76708C2 (uk) * | 1999-12-08 | 2006-09-15 | Сінгента Патисипейшонс Аг | Антитіло, яке застосовується в імунологічному аналізі зразка для визначення неонікотиноїдного інсектициду, білковий кон'югат для одержання антитіла, спосіб визначення концентрації неонікотиноїдного інсектициду в зразку та набір для визначення кількості неонікотиноїдного інсектициду |
| US6958156B2 (en) | 2000-12-15 | 2005-10-25 | Vyrex Corporation | Isoflavone derivatives |
| JP2005533009A (ja) * | 2002-03-28 | 2005-11-04 | イーライ・リリー・アンド・カンパニー | ピペラジン置換されたアリールベンゾジアゼピン類およびそのドーパミン受容体アンタゴニストとしての精神病性障害の処置のための使用 |
| ATE361289T1 (de) * | 2002-08-05 | 2007-05-15 | Lilly Co Eli | Piperazinsubstituierte arylbenzodiazepine |
| WO2005028458A1 (en) | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
| TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| JP5198063B2 (ja) * | 2004-08-26 | 2013-05-15 | アッパラオ・サティアム | 新規バイオ開裂性リンカー |
| WO2009040409A1 (en) | 2007-09-27 | 2009-04-02 | Novartis Ag | Drug monitoring assay |
| WO2010033270A1 (en) | 2008-09-17 | 2010-03-25 | Auspex Pharmaceuticals, Inc. | Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors |
| EA201100613A1 (ru) | 2008-10-14 | 2011-12-30 | Астразенека Аб | Конденсированные, спироциклические гетероароматические соединения для лечения бактериальных инфекций |
| EP2194048A1 (en) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
| EP2987789A1 (en) | 2009-12-31 | 2016-02-24 | Kempharm, Inc. | Amino acid conjugates of quetiapine, process for making and using the same |
| PT2544536T (pt) | 2010-03-11 | 2019-01-23 | Kempharm Inc | Conjugados de ácido gordo e quetiapina, processo de preparação e utilização do destes |
| US8088594B2 (en) * | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| JP5757497B2 (ja) * | 2010-10-06 | 2015-07-29 | 公立大学法人大阪府立大学 | シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット |
| EP2790734B1 (en) * | 2011-12-15 | 2019-02-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| EP3492473B1 (en) * | 2012-08-21 | 2025-07-30 | Janssen Pharmaceutica NV | Haptens of olanzapine |
-
2013
- 2013-08-20 EP EP18202081.8A patent/EP3492473B1/en active Active
- 2013-08-20 ES ES13753774T patent/ES2701062T3/es active Active
- 2013-08-20 PT PT13753774T patent/PT2888269T/pt unknown
- 2013-08-20 WO PCT/US2013/055700 patent/WO2014031587A1/en not_active Ceased
- 2013-08-20 JP JP2015528568A patent/JP6171014B2/ja active Active
- 2013-08-20 TR TR2018/16378T patent/TR201816378T4/tr unknown
- 2013-08-20 ES ES18202081T patent/ES3043017T3/es active Active
- 2013-08-20 PL PL13753774T patent/PL2888269T3/pl unknown
- 2013-08-20 CN CN201380054963.3A patent/CN104854110B/zh active Active
- 2013-08-20 AU AU2013306018A patent/AU2013306018B2/en active Active
- 2013-08-20 CA CA2882454A patent/CA2882454C/en active Active
- 2013-08-20 EP EP13753774.2A patent/EP2888269B1/en active Active
- 2013-08-20 US US13/970,653 patent/US9303041B2/en active Active
-
2017
- 2017-07-03 JP JP2017130471A patent/JP6423490B2/ja active Active
-
2018
- 2018-10-18 JP JP2018196525A patent/JP6763000B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TR201816378T4 (tr) | 2018-11-21 |
| EP3492473B1 (en) | 2025-07-30 |
| AU2013306018A1 (en) | 2015-03-12 |
| CN104854110B (zh) | 2016-12-28 |
| JP6763000B2 (ja) | 2020-09-30 |
| JP6423490B2 (ja) | 2018-11-14 |
| US20140213766A1 (en) | 2014-07-31 |
| CA2882454A1 (en) | 2014-02-27 |
| JP6171014B2 (ja) | 2017-07-26 |
| CA2882454C (en) | 2020-08-11 |
| PL2888269T3 (pl) | 2019-06-28 |
| ES2701062T3 (es) | 2019-02-20 |
| US9303041B2 (en) | 2016-04-05 |
| HK1211933A1 (en) | 2016-06-03 |
| JP2015532645A (ja) | 2015-11-12 |
| ES3043017T3 (en) | 2025-11-24 |
| EP3492473A1 (en) | 2019-06-05 |
| JP2017222671A (ja) | 2017-12-21 |
| EP2888269A1 (en) | 2015-07-01 |
| AU2013306018B2 (en) | 2017-08-10 |
| CN104854110A (zh) | 2015-08-19 |
| EP2888269B1 (en) | 2018-10-24 |
| WO2014031587A1 (en) | 2014-02-27 |
| JP2019034955A (ja) | 2019-03-07 |
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