JP6169687B2 - 新規化合物 - Google Patents

新規化合物 Download PDF

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Publication number
JP6169687B2
JP6169687B2 JP2015513266A JP2015513266A JP6169687B2 JP 6169687 B2 JP6169687 B2 JP 6169687B2 JP 2015513266 A JP2015513266 A JP 2015513266A JP 2015513266 A JP2015513266 A JP 2015513266A JP 6169687 B2 JP6169687 B2 JP 6169687B2
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methyl
acid
compound
disorder
formula
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JP2015513266A
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Japanese (ja)
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JP2015517561A (ja
Inventor
エム ピー ギブリン ジェラルド
エム ピー ギブリン ジェラルド
ティー マクファーソン デビッド
ティー マクファーソン デビッド
アール ウィッティ デビッド
アール ウィッティ デビッド
ジェイ スタンウェイ スティーブン
ジェイ スタンウェイ スティーブン
Original Assignee
クオンベルゲンセ プハルマセウトイカルス リミテッド
クオンベルゲンセ プハルマセウトイカルス リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015513266A 2012-05-22 2013-05-22 新規化合物 Expired - Fee Related JP6169687B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US61/650,325 2012-05-22
GB1209015.5 2012-05-22
US201361773710P 2013-03-06 2013-03-06
US61/773,710 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (en) 2012-05-22 2013-05-22 Novel Compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017125716A Division JP6378404B2 (ja) 2012-05-22 2017-06-28 新規化合物

Publications (2)

Publication Number Publication Date
JP2015517561A JP2015517561A (ja) 2015-06-22
JP6169687B2 true JP6169687B2 (ja) 2017-07-26

Family

ID=46546493

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015513266A Expired - Fee Related JP6169687B2 (ja) 2012-05-22 2013-05-22 新規化合物
JP2015513267A Withdrawn JP2015517562A (ja) 2012-05-22 2013-05-22 新規化合物
JP2017125716A Expired - Fee Related JP6378404B2 (ja) 2012-05-22 2017-06-28 新規化合物

Family Applications After (2)

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JP2015513267A Withdrawn JP2015517562A (ja) 2012-05-22 2013-05-22 新規化合物
JP2017125716A Expired - Fee Related JP6378404B2 (ja) 2012-05-22 2017-06-28 新規化合物

Country Status (27)

Country Link
US (7) US9376445B2 (enExample)
EP (3) EP2861594B1 (enExample)
JP (3) JP6169687B2 (enExample)
KR (2) KR20200113027A (enExample)
CN (2) CN107344942B (enExample)
AU (3) AU2013265001B2 (enExample)
BR (1) BR112014029280B1 (enExample)
CA (1) CA2873956C (enExample)
CY (2) CY1118274T1 (enExample)
DK (2) DK3106464T3 (enExample)
EA (1) EA025579B1 (enExample)
ES (3) ES2782088T3 (enExample)
GB (1) GB201209015D0 (enExample)
HR (2) HRP20161349T1 (enExample)
HU (2) HUE049445T2 (enExample)
IL (4) IL235805A (enExample)
IN (1) IN2014MN02393A (enExample)
LT (2) LT2861602T (enExample)
MX (1) MX355303B (enExample)
PL (2) PL3106464T3 (enExample)
PT (2) PT3106464T (enExample)
RS (2) RS60368B1 (enExample)
SG (2) SG11201407755UA (enExample)
SI (2) SI2861602T1 (enExample)
SM (2) SMT202000210T1 (enExample)
WO (2) WO2013175206A1 (enExample)
ZA (1) ZA201408253B (enExample)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
JP2020536070A (ja) * 2017-09-28 2020-12-10 バイオジェン インコーポレイテッド 新規な塩
MX2020003821A (es) 2017-10-10 2023-01-12 Biogen Inc Proceso de elaboración de espiroderivados.
WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
US7683083B2 (en) * 2005-10-12 2010-03-23 Vertex Pharmaceuticals Incorporated Biphenyl derivatives as modulators of voltage gated ion channels
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BRPI0719166A2 (pt) 2006-10-12 2014-06-03 Xenon Pharmaceuticals Inc Derivados de espiro-oxindol tricíclicos e seus usos como agentes terapêuticos
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
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JP6437911B2 (ja) * 2012-03-21 2018-12-12 インターデイジタル パテント ホールディングス インコーポレイテッド ワイヤレスネットワークにおいて移動局セッションを別の移動局によって資金援助すること
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

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PL3106464T3 (pl) 2020-11-16
ES2782088T3 (es) 2020-09-10
BR112014029280A2 (pt) 2017-06-27
SG10201703527WA (en) 2017-06-29
PL2861602T3 (pl) 2017-05-31
IL252033A0 (en) 2017-06-29
LT3106464T (lt) 2020-04-10
WO2013175206A1 (en) 2013-11-28
US10010551B2 (en) 2018-07-03
SI3106464T1 (sl) 2020-12-31
CA2873956A1 (en) 2013-11-28
KR20200113027A (ko) 2020-10-05
EP2861594B1 (en) 2016-08-24
EP3106464B1 (en) 2020-01-08
US20200289508A1 (en) 2020-09-17
HRP20161349T1 (hr) 2017-01-27
JP2015517561A (ja) 2015-06-22
SG11201407755UA (en) 2014-12-30
PT2861602T (pt) 2016-11-14
JP6378404B2 (ja) 2018-08-22
EA201492169A1 (ru) 2015-04-30
CY1123044T1 (el) 2021-10-29
KR20150023401A (ko) 2015-03-05
CN107344942B (zh) 2020-09-25
WO2013175205A1 (en) 2013-11-28
EP3106464A1 (en) 2016-12-21
RS60368B1 (sr) 2020-07-31
HRP20200580T1 (hr) 2020-10-02
SMT202000210T1 (it) 2020-05-08
AU2013265001B2 (en) 2016-12-01
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AU2017201421A1 (en) 2017-03-23
US10485801B2 (en) 2019-11-26
US20180360833A1 (en) 2018-12-20
ES2602193T3 (es) 2017-02-20
HK1209423A1 (en) 2016-04-01
IL271330A (en) 2020-01-30
EP2861602A1 (en) 2015-04-22
IL280595A (en) 2021-03-25
AU2013265001A1 (en) 2014-12-18
SI2861602T1 (sl) 2017-03-31
SMT201600421B (it) 2017-01-10
AU2018201653B2 (en) 2019-05-02
EA025579B1 (ru) 2017-01-30
CN104640867B (zh) 2017-07-21
US20160184306A1 (en) 2016-06-30
JP2015517562A (ja) 2015-06-22
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CA2873956C (en) 2021-03-23
EP2861594A1 (en) 2015-04-22
KR102161101B1 (ko) 2020-10-20
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US20160263115A1 (en) 2016-09-15
CN104640867A (zh) 2015-05-20
DK3106464T3 (da) 2020-03-23
CN107344942A (zh) 2017-11-14
IL271330B (en) 2021-02-28
AU2017201421B2 (en) 2017-12-07
GB201209015D0 (en) 2012-07-04
DK2861602T3 (en) 2016-11-28
ES2602308T3 (es) 2017-02-20
US9309254B2 (en) 2016-04-12
US20150166551A1 (en) 2015-06-18
MX355303B (es) 2018-04-12
IL235805A0 (en) 2015-02-01
PT3106464T (pt) 2020-04-03
JP2017206534A (ja) 2017-11-24
US20170304303A1 (en) 2017-10-26
HUE049445T2 (hu) 2020-09-28
BR112014029280B1 (pt) 2022-10-04
US9737536B2 (en) 2017-08-22
IN2014MN02393A (enExample) 2015-08-21
LT2861602T (lt) 2016-11-10

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