JP6159391B2 - 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ - Google Patents
核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ Download PDFInfo
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- JP6159391B2 JP6159391B2 JP2015504550A JP2015504550A JP6159391B2 JP 6159391 B2 JP6159391 B2 JP 6159391B2 JP 2015504550 A JP2015504550 A JP 2015504550A JP 2015504550 A JP2015504550 A JP 2015504550A JP 6159391 B2 JP6159391 B2 JP 6159391B2
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
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- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Clinical Laboratory Science (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Measuring Cells (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
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- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619784P | 2012-04-03 | 2012-04-03 | |
| US61/619,784 | 2012-04-03 | ||
| PCT/US2013/025963 WO2013151622A1 (en) | 2012-04-03 | 2013-02-13 | Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514218A JP2015514218A (ja) | 2015-05-18 |
| JP6159391B2 true JP6159391B2 (ja) | 2017-07-05 |
Family
ID=47891920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504550A Active JP6159391B2 (ja) | 2012-04-03 | 2013-02-13 | 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9193996B2 (enExample) |
| EP (2) | EP4219012A1 (enExample) |
| JP (1) | JP6159391B2 (enExample) |
| KR (3) | KR20210080618A (enExample) |
| CN (1) | CN204832037U (enExample) |
| AU (4) | AU2013243998B2 (enExample) |
| BR (2) | BR122021002358B8 (enExample) |
| CA (2) | CA2867665C (enExample) |
| ES (1) | ES2949570T3 (enExample) |
| IL (3) | IL234864B (enExample) |
| IN (1) | IN2014DN07992A (enExample) |
| MX (1) | MX337140B (enExample) |
| WO (1) | WO2013151622A1 (enExample) |
Families Citing this family (357)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| KR101866401B1 (ko) | 2010-04-05 | 2018-06-11 | 프로그노시스 바이오사이언스, 인코포레이티드 | 공간적으로 엔코딩된 생물학적 검정 |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| JP6159391B2 (ja) * | 2012-04-03 | 2017-07-05 | イラミーナ インコーポレーテッド | 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ |
| US8932815B2 (en) | 2012-04-16 | 2015-01-13 | Biological Dynamics, Inc. | Nucleic acid sample preparation |
| BR112014025695B1 (pt) | 2012-04-16 | 2021-08-03 | Biological Dynamics, Inc | Preparação de amostra de ácido nucleico |
| EP3901280B1 (en) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
| US9193998B2 (en) | 2013-03-15 | 2015-11-24 | Illumina, Inc. | Super resolution imaging |
| US20140274747A1 (en) | 2013-03-15 | 2014-09-18 | Illumina, Inc. | Super resolution imaging |
| US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
| CN111500680B (zh) | 2013-06-25 | 2024-04-16 | 普罗格诺西斯生物科学公司 | 检测样品中生物靶标的空间分布的方法和系统 |
| CN113789372B (zh) * | 2013-08-08 | 2025-02-25 | 伊鲁米那股份有限公司 | 用于向流动池的试剂输送的流体系统 |
| CA2930802C (en) | 2013-08-28 | 2017-01-17 | Illumina, Inc. | Optical alignment tool |
| US10540783B2 (en) | 2013-11-01 | 2020-01-21 | Illumina, Inc. | Image analysis useful for patterned objects |
| PT3077943T (pt) | 2013-12-03 | 2020-08-21 | Illumina Inc | Métodos e sistemas para analisar dados de imagem |
| SI3108009T1 (sl) | 2014-02-18 | 2021-09-30 | Illumina, Inc. | Postopki in sestavki za profiliranje DNK |
| EP3116651B1 (en) * | 2014-03-11 | 2020-04-22 | Illumina, Inc. | Disposable, integrated microfluidic cartridge and methods of making it |
| AU2015259024B2 (en) | 2014-05-16 | 2021-07-01 | Illumina, Inc. | Nucleic acid synthesis techniques |
| JP6960223B2 (ja) * | 2014-05-27 | 2021-11-05 | イラミーナ インコーポレーテッド | 基礎器具と取外可能カートリッジとを含む生化学的解析のためのシステム及び方法 |
| RU2688746C2 (ru) | 2014-06-05 | 2019-05-22 | Иллумина, Инк. | Системы и способы с использованием поворотного клапана для по меньшей мере одного из приготовления образца или анализа образца |
| US20150353989A1 (en) | 2014-06-09 | 2015-12-10 | Illumina Cambridge Limited | Sample preparation for nucleic acid amplification |
| WO2016040602A1 (en) | 2014-09-11 | 2016-03-17 | Epicentre Technologies Corporation | Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv |
| GB201416422D0 (en) * | 2014-09-17 | 2014-10-29 | Illumina Cambridge Ltd | Flexible tape-based chemistry apparatus |
| MX391361B (es) | 2014-10-09 | 2025-03-21 | Illumina Inc | Metodo y dispositivo para la separacion de liquidos inmiscibles para aislar de modo efectivo al menos uno de los liquidos. |
| US9897791B2 (en) | 2014-10-16 | 2018-02-20 | Illumina, Inc. | Optical scanning systems for in situ genetic analysis |
| GB201419731D0 (en) | 2014-11-05 | 2014-12-17 | Illumina Cambridge Ltd | Sequencing from multiple primers to increase data rate and density |
| DK3215616T3 (da) | 2014-11-05 | 2020-03-02 | Illumina Cambridge Ltd | Reducering af DNA-skade under prøvepræparering og sekventering ved anvendelse af siderophor-chelatorer |
| PL3218511T3 (pl) | 2014-11-11 | 2020-10-19 | Illumina Cambridge Limited | Sposoby i macierze do wytwarzania i sekwencjonowania monoklonalnych klastrów kwasu nukleinowego |
| WO2016130962A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
| USD766761S1 (en) * | 2015-03-20 | 2016-09-20 | Life Technologies Corporation | Analytical equipment |
| US10576471B2 (en) | 2015-03-20 | 2020-03-03 | Illumina, Inc. | Fluidics cartridge for use in the vertical or substantially vertical position |
| CA2979850C (en) | 2015-03-24 | 2020-07-21 | Illumina, Inc. | Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis |
| ES2984193T3 (es) | 2015-03-31 | 2024-10-29 | Illumina Cambridge Ltd | Concatemerización de moldes en la superficie |
| US11971354B2 (en) | 2015-04-08 | 2024-04-30 | Molecular Devices, Llc | Methods and systems for fluorescence detection using infrared dyes |
| US10379046B2 (en) * | 2015-04-08 | 2019-08-13 | Molecular Devices, Llc | Method and system for multiplexed time-resolved fluorescence detection |
| EP4321627A3 (en) | 2015-04-10 | 2024-04-17 | 10x Genomics Sweden AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US9222935B1 (en) * | 2015-05-28 | 2015-12-29 | Pixcell Medical Technologies Ltd | Fluid sample analysis system |
| EP3303614B1 (en) | 2015-05-29 | 2020-03-11 | Illumina Cambridge Limited | Enhanced utilization of surface primers in clusters |
| WO2016196358A1 (en) | 2015-05-29 | 2016-12-08 | Epicentre Technologies Corporation | Methods of analyzing nucleic acids |
| CN115261468A (zh) | 2015-07-06 | 2022-11-01 | 伊卢米纳剑桥有限公司 | 用于核酸扩增的样品制备 |
| US10913975B2 (en) | 2015-07-27 | 2021-02-09 | Illumina, Inc. | Spatial mapping of nucleic acid sequence information |
| CN108138229B (zh) | 2015-08-14 | 2022-07-26 | 亿明达股份有限公司 | 使用磁响应式传感器确定遗传特征的系统和方法 |
| CN116338219A (zh) | 2015-08-24 | 2023-06-27 | 亿明达股份有限公司 | 用于生物和化学测定的线路内蓄压器和流量控制系统 |
| JP6720526B2 (ja) * | 2015-12-25 | 2020-07-08 | 東洋紡株式会社 | 検査装置 |
| JP2019508669A (ja) | 2016-01-11 | 2019-03-28 | イラミーナ インコーポレーテッド | マイクロフルオロメータ、流体システム、およびフローセルラッチクランプモジュールを有する検出装置 |
| USD819829S1 (en) * | 2016-02-12 | 2018-06-05 | Illumina, Inc. | Sequencing cartridge |
| US10508305B2 (en) * | 2016-02-28 | 2019-12-17 | Damoun Nashtaali | DNA sequencing and processing |
| CN115487880A (zh) | 2016-03-24 | 2022-12-20 | 生物动力学公司 | 一次性射流卡盘及组件 |
| SG11201805665UA (en) | 2016-03-28 | 2018-10-30 | Illumina Inc | Multi-plane microarrays |
| ITUA20162851A1 (it) * | 2016-04-04 | 2017-10-04 | Euritmi S A S Di Dalla Sega Daniela E C | Sistema per microscopia |
| WO2018018008A1 (en) | 2016-07-22 | 2018-01-25 | Oregon Health & Science University | Single cell whole genome libraries and combinatorial indexing methods of making thereof |
| EP3493908B1 (en) | 2016-08-05 | 2023-11-29 | Vital Signs Solutions Limited | Device and method for liquid analysis to detect biomarkers |
| US20210370299A1 (en) * | 2016-09-23 | 2021-12-02 | Archerdx, Llc | Thermal assemblies for nucleic acid preparation |
| WO2018064116A1 (en) | 2016-09-28 | 2018-04-05 | Illumina, Inc. | Methods and systems for data compression |
| CN111781139B (zh) * | 2016-10-14 | 2023-09-12 | 亿明达股份有限公司 | 夹盒组件 |
| USD825078S1 (en) * | 2016-10-14 | 2018-08-07 | Illumina, Inc. | Sequencing cartridge |
| CN108265112B (zh) | 2016-12-30 | 2023-04-25 | 深圳市真迈生物科技有限公司 | 对序列测定反应进行控制的方法、序列测定系统和控制装置 |
| GB201704761D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Common line selector valve for a system |
| GB201704766D0 (en) * | 2017-01-05 | 2017-05-10 | Illumia Inc | System and methods for selective effluent collection |
| GB201704768D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Flow cell liquid degassing systema and method |
| GB201704763D0 (enExample) * | 2017-01-05 | 2017-05-10 | Illumina Inc | |
| GB201704747D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Reagent mixing system and methods |
| GB201704760D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Reagent nozzle sipper mixing system and method |
| GB201704772D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Automated volumetric reagent delivery testing |
| CN116612818A (zh) | 2017-01-06 | 2023-08-18 | 伊鲁米那股份有限公司 | 移相校正 |
| TWI689720B (zh) * | 2017-01-07 | 2020-04-01 | 美商伊路米納有限公司 | 固態檢驗設備及使用方法 |
| AU2018210316A1 (en) | 2017-01-17 | 2019-06-27 | Illumina, Inc. | Oncogenic splice variant determination |
| GB201701689D0 (en) | 2017-02-01 | 2017-03-15 | Illumia Inc | System and method with fiducials of non-closed shapes |
| GB201701686D0 (en) | 2017-02-01 | 2017-03-15 | Illunina Inc | System & method with fiducials having offset layouts |
| GB201701691D0 (en) | 2017-02-01 | 2017-03-15 | Illumina Inc | System and method with reflective fiducials |
| GB201701688D0 (en) * | 2017-02-01 | 2017-03-15 | Illumia Inc | System and method with fiducials in non-recliner layouts |
| CN109414673B (zh) | 2017-02-01 | 2021-09-07 | 伊鲁米那股份有限公司 | 具有响应于多个激发频率的基准的系统和方法 |
| BR112019014683A2 (pt) * | 2017-03-07 | 2020-02-18 | Illumina, Inc. | Sequenciamento com dois canais óticos, com fonte de luz única |
| EP3601597A4 (en) * | 2017-03-22 | 2020-12-23 | The Board of Trustees of the University of Illinois | SYSTEM FOR RAPID, PORTABLE AND MULTIPLEXED DETECTION AND IDENTIFICATION OF SPECIFIC NUCLEIC ACID SEQUENCES OF PATHOGENIC AGENTS |
| EP4462437A3 (en) | 2017-03-30 | 2025-03-26 | Illumina, Inc. | Genomic data analysis system and method |
| WO2018187013A1 (en) | 2017-04-04 | 2018-10-11 | Omniome, Inc. | Fluidic apparatus and methods useful for chemical and biological reactions |
| WO2018197945A1 (en) | 2017-04-23 | 2018-11-01 | Illumina Cambridge Limited | Compositions and methods for improving sample identification in indexed nucleic acid libraries |
| EP3622084A4 (en) | 2017-05-08 | 2021-02-17 | Biological Dynamics, Inc. | METHODS AND SYSTEMS FOR PROCESSING ANALYTICAL INFORMATION |
| ES3014783T3 (en) | 2017-06-07 | 2025-04-24 | Univ Oregon Health & Science | Single cell whole genome libraries for methylation sequencing |
| WO2018236631A1 (en) | 2017-06-20 | 2018-12-27 | Illumina, Inc. | METHODS AND COMPOSITIONS FOR RESOLVING INEFFICIENCY IN AMPLIFICATION REACTIONS |
| WO2019027767A1 (en) | 2017-07-31 | 2019-02-07 | Illumina Inc. | SEQUENCING SYSTEM COMPRISING AGGREGATION OF MULTIPLEXED BIOLOGICAL SAMPLES |
| CN119842876A (zh) | 2017-08-01 | 2025-04-18 | 伊鲁米纳公司 | 使用的水凝胶珠和流动池的遗传物质的空间索引和文库制备 |
| JP2021500531A (ja) | 2017-08-15 | 2021-01-07 | オムニオム インコーポレイテッドOmniome, Inc. | 化学的および生物学的検体の検出に有用なスキャン装置および方法 |
| WO2019036055A2 (en) | 2017-08-18 | 2019-02-21 | Ignite Biosciences, Inc. | METHODS OF SELECTING BINDING REAGENTS |
| WO2019118989A1 (en) * | 2017-12-15 | 2019-06-20 | Evanostics Llc | Optical reader for analyte testing |
| WO2019116296A1 (en) | 2017-12-15 | 2019-06-20 | Creoptix Ltd. | Methods and assemblies for high throughput screening |
| US11731132B2 (en) | 2017-12-19 | 2023-08-22 | Biological Dynamics, Inc. | Methods and devices for detection of multiple analytes from a biological sample |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| CN110832086A (zh) | 2018-04-02 | 2020-02-21 | 伊鲁米那股份有限公司 | 用于制造用于基于序列的遗传检验的对照的组合物和方法 |
| WO2019195196A1 (en) | 2018-04-02 | 2019-10-10 | Biological Dynamics, Inc. | Dielectric materials |
| US11441978B1 (en) * | 2018-04-12 | 2022-09-13 | Elemental Scientific, Inc. | Automatic evaporative sample preparation |
| CA3097583A1 (en) | 2018-04-19 | 2019-10-24 | Omniome, Inc. | Improving accuracy of base calls in nucleic acid sequencing methods |
| NL2021147B1 (en) * | 2018-05-15 | 2019-11-21 | Illumina Inc | Flow cell with flexible connection |
| WO2019221913A1 (en) | 2018-05-15 | 2019-11-21 | Illumina, Inc. | Flow cell with flexible connection |
| RU2744175C1 (ru) | 2018-05-17 | 2021-03-03 | Иллумина, Инк. | Высокопроизводительное секвенирование одиночной клетки со сниженной ошибкой амплификации |
| CA3253118A1 (en) | 2018-06-04 | 2026-03-02 | Illumina, Inc. | High-throughput single-cell transcriptome libraries and methods of making and of using |
| JP6688342B2 (ja) | 2018-07-06 | 2020-04-28 | 日本板硝子株式会社 | 反応処理装置 |
| DE102018212489A1 (de) | 2018-07-26 | 2020-01-30 | Implen GmbH | Vorrichtung für eine lichtspektroskopische Analyse |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| CN113767175B (zh) | 2018-08-28 | 2025-07-25 | 10X基因组学股份有限公司 | 增加空间阵列分辨率 |
| WO2020047005A1 (en) | 2018-08-28 | 2020-03-05 | 10X Genomics, Inc. | Resolving spatial arrays |
| US11426723B2 (en) * | 2018-10-05 | 2022-08-30 | Illumina, Inc. | System and method for sequestered wash buffered reuse |
| NL2021970B1 (en) * | 2018-10-05 | 2020-05-12 | Illumina Inc | System and method for sequestered wash buffered reuse |
| EP3867637B1 (en) * | 2018-10-18 | 2024-12-04 | The Regents Of The University Of California | Device and method for motility-based label-free detection of motile objects in a fluid sample |
| US10768173B1 (en) * | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US10704094B1 (en) | 2018-11-14 | 2020-07-07 | Element Biosciences, Inc. | Multipart reagents having increased avidity for polymerase binding |
| JP2022513092A (ja) | 2018-11-20 | 2022-02-07 | ノーティラス・バイオテクノロジー・インコーポレイテッド | 親和性試薬の設計および選択 |
| CN111277744B (zh) * | 2018-12-04 | 2022-04-15 | 武汉华大智造科技有限公司 | 对焦方法及系统、基因测序仪、计算机可读存储介质 |
| CN211311438U (zh) | 2018-12-04 | 2020-08-21 | 欧姆尼欧美公司 | 流动池 |
| DE202019005610U1 (de) * | 2018-12-07 | 2021-06-10 | Element Biosciences, Inc. | Durchflusszellenvorrichtung und ihre Verwendung |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| EP3894585A2 (en) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| ES3074987T3 (es) * | 2018-12-11 | 2026-07-24 | Carrier Corp | Calibración de un detector óptico usando una cámara de microflujo |
| EP3894598B1 (en) * | 2018-12-14 | 2024-01-03 | Illumina Cambridge Limited | Decreasing phasing with unlabeled nucleotides during sequencing |
| WO2020132146A1 (en) | 2018-12-18 | 2020-06-25 | Evanostics Llc | Optical analyte detection |
| EP3899032A2 (en) | 2018-12-20 | 2021-10-27 | Omniome, Inc. | Temperature control for analysis of nucleic acids and other analytes |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11493441B2 (en) | 2019-01-15 | 2022-11-08 | Wyatt Technology Corporation | Flow cell, read head, and skid attachment |
| US11499189B2 (en) | 2019-02-14 | 2022-11-15 | Pacific Biosciences Of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
| US11680950B2 (en) | 2019-02-20 | 2023-06-20 | Pacific Biosciences Of California, Inc. | Scanning apparatus and methods for detecting chemical and biological analytes |
| EP3931354A1 (en) | 2019-02-28 | 2022-01-05 | 10X Genomics, Inc. | Profiling of biological analytes with spatially barcoded oligonucleotide arrays |
| WO2020180778A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | High-throughput single-nuclei and single-cell libraries and methods of making and of using |
| EP3938538A1 (en) | 2019-03-15 | 2022-01-19 | 10X Genomics, Inc. | Methods for using spatial arrays for single cell sequencing |
| NL2023316B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based sequencing |
| NL2023314B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based quality scoring |
| NL2023310B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Training data generation for artificial intelligence-based sequencing |
| NL2023312B1 (en) | 2019-03-21 | 2020-09-28 | Illumina Inc | Artificial intelligence-based base calling |
| US11210554B2 (en) | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| NL2023311B9 (en) | 2019-03-21 | 2021-03-12 | Illumina Inc | Artificial intelligence-based generation of sequencing metadata |
| WO2020205296A1 (en) | 2019-03-21 | 2020-10-08 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| EP3887542A1 (en) | 2019-03-22 | 2021-10-06 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| AU2020266136B2 (en) | 2019-04-29 | 2026-04-02 | Nautilus Subsidiary, Inc. | Methods and systems for integrated on-chip single-molecule detection |
| EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| US11644406B2 (en) | 2019-06-11 | 2023-05-09 | Pacific Biosciences Of California, Inc. | Calibrated focus sensing |
| US10656368B1 (en) | 2019-07-24 | 2020-05-19 | Omniome, Inc. | Method and system for biological imaging using a wide field objective lens |
| EP4028407B1 (en) | 2019-09-10 | 2023-08-16 | Pacific Biosciences of California, Inc. | Reversible modification of nucleotides |
| JP7672338B2 (ja) | 2019-09-18 | 2025-05-07 | イルミナ インコーポレイテッド | システム及び関連するサンプル装填マニホールドアセンブリ |
| WO2021055353A1 (en) * | 2019-09-18 | 2021-03-25 | Illumina, Inc. | Systems and related pump manifold assemblies |
| JP7457798B2 (ja) * | 2019-09-24 | 2024-03-28 | 深▲セン▼華大智造科技股▲ふん▼有限公司 | 生化学物質分析システム、方法及び装置 |
| US11514575B2 (en) | 2019-10-01 | 2022-11-29 | 10X Genomics, Inc. | Systems and methods for identifying morphological patterns in tissue samples |
| CN114901946A (zh) * | 2019-10-29 | 2022-08-12 | 宽腾矽公司 | 用于生物分析应用的流体的蠕动泵送以及相关的方法、系统和装置 |
| EP4051903A1 (en) | 2019-10-29 | 2022-09-07 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
| US12157124B2 (en) | 2019-11-06 | 2024-12-03 | 10X Genomics, Inc. | Imaging system hardware |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| US12154266B2 (en) | 2019-11-18 | 2024-11-26 | 10X Genomics, Inc. | Systems and methods for binary tissue classification |
| EP4062373B1 (en) | 2019-11-21 | 2025-01-22 | 10X Genomics, Inc. | Spatial analysis of analytes |
| DE202019106694U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
| DE202019106695U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
| WO2021127436A2 (en) | 2019-12-19 | 2021-06-24 | Illumina, Inc. | High-throughput single-cell libraries and methods of making and of using |
| CN114981011B (zh) * | 2019-12-30 | 2024-03-29 | 伊鲁米那有限公司 | 流通池组件和相关试剂选择器阀 |
| US11815458B2 (en) * | 2019-12-31 | 2023-11-14 | Illumina, Inc. | Autofocus functionality in optical sample analysis |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11408032B2 (en) | 2020-01-17 | 2022-08-09 | Element Biosciences, Inc. | Tube lens design for improved depth-of-field |
| JP7233385B2 (ja) * | 2020-01-20 | 2023-03-06 | 日本板硝子株式会社 | 反応処理装置 |
| WO2021158511A1 (en) | 2020-02-04 | 2021-08-12 | Omniome, Inc. | Flow cells and methods for their manufacture and use |
| US12112833B2 (en) | 2020-02-04 | 2024-10-08 | 10X Genomics, Inc. | Systems and methods for index hopping filtering |
| EP4104179B1 (en) | 2020-02-13 | 2026-01-28 | 10X Genomics, Inc. | Systems and methods for joint interactive visualization of gene expression and dna chromatin accessibility |
| WO2021167986A1 (en) | 2020-02-17 | 2021-08-26 | 10X Genomics, Inc. | In situ analysis of chromatin interaction |
| US12354008B2 (en) | 2020-02-20 | 2025-07-08 | Illumina, Inc. | Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller |
| EP4107285B1 (en) | 2020-02-21 | 2024-10-09 | 10X Genomics, Inc. | Methods and compositions for integrated in situ spatial assay |
| US12188085B2 (en) | 2020-03-05 | 2025-01-07 | 10X Genomics, Inc. | Three-dimensional spatial transcriptomics with sequencing readout |
| US11188778B1 (en) | 2020-05-05 | 2021-11-30 | Illumina, Inc. | Equalization-based image processing and spatial crosstalk attenuator |
| US12209266B2 (en) | 2020-05-12 | 2025-01-28 | Illumina, Inc. | Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase |
| US12416603B2 (en) | 2020-05-19 | 2025-09-16 | 10X Genomics, Inc. | Electrophoresis cassettes and instrumentation |
| EP4153775B1 (en) | 2020-05-22 | 2024-07-24 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| KR20230020977A (ko) | 2020-06-09 | 2023-02-13 | 일루미나, 인코포레이티드 | 시퀀싱 라이브러리의 생성을 증가시키는 방법 |
| EP4164796A4 (en) | 2020-06-10 | 2024-03-06 | 10x Genomics, Inc. | Fluid delivery methods |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| JP2023532231A (ja) | 2020-06-30 | 2023-07-27 | イルミナ インコーポレイテッド | 傷なしdnaを生成するための触媒的に制御された合成による配列決定 |
| US12168801B1 (en) | 2020-07-02 | 2024-12-17 | 10X Genomics, Inc. | Hybrid/capture probe designs for full-length cDNA |
| MX2023000345A (es) | 2020-07-08 | 2023-02-13 | Illumina Inc | Globulos como portadores de transposomas. |
| US12580044B1 (en) | 2020-09-02 | 2026-03-17 | 10X Genomics, Inc. | Systems and methods for identifying cells that are antigen-specific for an immunogenic feature |
| CN116194590A (zh) | 2020-09-18 | 2023-05-30 | 10X基因组学有限公司 | 样品处理设备和图像配准方法 |
| CN114688301A (zh) * | 2020-12-31 | 2022-07-01 | 深圳市真迈生物科技有限公司 | 流动路径选择阀、流动池组件、液路系统及测序系统 |
| CN114321036A (zh) * | 2020-09-29 | 2022-04-12 | 深圳市真迈生物科技有限公司 | 液路系统、检测系统和应用 |
| EP4224020A4 (en) * | 2020-09-29 | 2024-11-13 | GeneMind Biosciences Company Limited | FLOW PATH SELECTION VALUE, SYSTEM AND METHOD, STORAGE MEDIUM AND APPLICATION |
| CN114682310B (zh) * | 2020-12-31 | 2023-12-05 | 深圳市真迈生物科技有限公司 | 液路系统、测序系统和方法 |
| US12071667B2 (en) | 2020-11-04 | 2024-08-27 | 10X Genomics, Inc. | Sequence analysis using meta-stable nucleic acid molecules |
| EP4244382A1 (en) | 2020-11-11 | 2023-09-20 | Nautilus Subsidiary, Inc. | Affinity reagents having enhanced binding and detection characteristics |
| GB2603451B (en) * | 2020-11-25 | 2024-10-02 | Oxford Nanoimaging Ltd | Reagent cartridge and measurement devices incorporating such cartridges |
| EP4012046A1 (en) | 2020-12-11 | 2022-06-15 | 10X Genomics, Inc. | Methods and compositions for multimodal in situ analysis |
| CA3206828A1 (en) | 2020-12-31 | 2022-07-07 | Q-State Biosciences, Inc. | Calibrating and normalizing an imager for optogenetics |
| US12478971B2 (en) | 2020-12-31 | 2025-11-25 | Quiver Holdings Inc. | Optical plate controller and reader |
| JP7900889B2 (ja) | 2020-12-31 | 2026-08-05 | キュー-ステート バイオサイエンシーズ, インコーポレイテッド | 空間撮像およびビームホモジナイザを伴う顕微鏡 |
| US12060603B2 (en) | 2021-01-19 | 2024-08-13 | 10X Genomics, Inc. | Methods for internally controlled in situ assays using padlock probes |
| US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| EP4284945B1 (en) | 2021-01-26 | 2024-10-23 | 10X Genomics, Inc. | Nucleic acid analog probes for in situ analysis |
| ES2989523T3 (es) | 2021-02-19 | 2024-11-26 | 10X Genomics Inc | Método de uso de un dispositivo modular de soporte para ensayos |
| WO2022187366A1 (en) | 2021-03-03 | 2022-09-09 | 10X Genomics, Inc. | Analyte detection in situ using nucleic acid origami |
| WO2022187310A1 (en) * | 2021-03-03 | 2022-09-09 | Illumina, Inc. | Reagent cartridges and related systems and methods for controlling reagent temperature |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| IL307378A (en) | 2021-04-02 | 2023-11-01 | Illumina Inc | A machine learning model for bubble detection within a nucleotide sample slide for sequencing |
| CA3212595A1 (en) | 2021-04-13 | 2022-10-20 | Sebastien RICOULT | Compositions, systems, and methods of making and using encapsulated lyophilised microspheres |
| CN117396613A (zh) | 2021-06-01 | 2024-01-12 | 10X基因组学有限公司 | 用于分析物检测和探针解析的方法和组合物 |
| US20230084407A1 (en) | 2021-06-02 | 2023-03-16 | 10X Genomics, Inc. | Sample analysis using asymmetric circularizable probes |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| WO2022272260A1 (en) | 2021-06-23 | 2022-12-29 | Illumina, Inc. | Compositions, methods, kits, cartridges, and systems for sequencing reagents |
| EP4359129A1 (en) | 2021-06-25 | 2024-05-01 | Illumina, Inc. | Linear fourier fiducial |
| EP4359122A1 (en) | 2021-06-25 | 2024-05-01 | Illumina, Inc. | Fiducials for use in registration of a patterned surface |
| MX2023015504A (es) | 2021-06-29 | 2024-01-22 | Illumina Inc | Metrica de la relacion se?al a ruido para determinar llamadas de bases de nucleotidos y la calidad de las llamadas de base. |
| CA3224393A1 (en) | 2021-06-29 | 2023-01-05 | Mitchell A BEKRITSKY | Machine-learning model for generating confidence classifications for genomic coordinates |
| EP4363832A4 (en) | 2021-06-30 | 2025-05-07 | Q-State Biosciences, Inc. | MULTIPLEX OPTICAL STIMULUS AND READOUT PROCESS |
| EP4779305A2 (en) | 2021-07-13 | 2026-07-22 | 10X Genomics, Inc. | Methods for preparing polymerized matrix with controllable thickness |
| EP4679300A3 (en) | 2021-07-19 | 2026-04-22 | Illumina, Inc. | Intensity extraction with interpolation and adaptation for base calling |
| US11455487B1 (en) | 2021-10-26 | 2022-09-27 | Illumina Software, Inc. | Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling |
| CN119061125A (zh) | 2021-07-21 | 2024-12-03 | 元素生物科学公司 | 用于核酸测序的方法 |
| US12651646B2 (en) | 2021-07-23 | 2026-06-09 | Illumina, Inc. | Machine-learning model for recalibrating nucleotide-base calls |
| EP4326900B1 (en) | 2021-07-30 | 2024-09-04 | 10X Genomics, Inc. | Methods and compositions for synchronizing reactions in situ |
| US12139751B2 (en) | 2021-07-30 | 2024-11-12 | 10X Genomics, Inc. | Circularizable probes for in situ analysis |
| US12553805B2 (en) | 2021-08-02 | 2026-02-17 | 10X Genomics, Inc. | Methods of preserving a biological sample |
| US12391984B2 (en) | 2021-08-03 | 2025-08-19 | 10X Genomics, Inc. | Compositions and methods for rolling circle amplification |
| US12460251B2 (en) | 2021-08-03 | 2025-11-04 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid molecules |
| EP4381095A1 (en) | 2021-08-03 | 2024-06-12 | 10X Genomics, Inc. | Nucleic acid concatemers and methods for stabilizing and/or compacting the same |
| US12529096B2 (en) | 2021-08-03 | 2026-01-20 | 10X Genomics, Inc. | Stabilization and/or compaction of nucleic acid structures |
| US20230051226A1 (en) * | 2021-08-10 | 2023-02-16 | Mgi Tech Co., Ltd. | Flow cell imaging systems and methods, and flow cells and other substrates for use in the same |
| US12435364B2 (en) | 2021-08-16 | 2025-10-07 | 10X Genomics, Inc. | Probes comprising a split barcode region and methods of use |
| EP4344443A1 (en) | 2021-08-31 | 2024-04-03 | Illumina, Inc. | Flow cell with enhanced well imaging resolution |
| CN117580961A (zh) | 2021-09-01 | 2024-02-20 | Illumina公司 | 用于加速碱基判读的幅度调制 |
| EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| WO2023044229A1 (en) | 2021-09-17 | 2023-03-23 | Illumina, Inc. | Automatically identifying failure sources in nucleotide sequencing from base-call-error patterns |
| USD1064308S1 (en) | 2021-09-17 | 2025-02-25 | 10X Genomics, Inc. | Sample handling device |
| WO2023049558A1 (en) | 2021-09-21 | 2023-03-30 | Illumina, Inc. | A graph reference genome and base-calling approach using imputed haplotypes |
| WO2023049212A2 (en) | 2021-09-22 | 2023-03-30 | Illumina, Inc. | State-based base calling |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| US20230114905A1 (en) | 2021-10-11 | 2023-04-13 | Nautilus Biotechnology, Inc. | Highly multiplexable analysis of proteins and proteomes |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| CN117581303A (zh) | 2021-12-02 | 2024-02-20 | 因美纳有限公司 | 产生用于确定核苷酸碱基检出的簇特异性信号校正 |
| EP4441711A1 (en) | 2021-12-20 | 2024-10-09 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
| WO2023122589A2 (en) * | 2021-12-22 | 2023-06-29 | Nautilus Subsidiary, Inc. | Systems and methods for carrying out highly multiplexed bioanalyses |
| WO2023122363A1 (en) | 2021-12-23 | 2023-06-29 | Illumina Software, Inc. | Dynamic graphical status summaries for nucelotide sequencing |
| US20230215515A1 (en) | 2021-12-23 | 2023-07-06 | Illumina Software, Inc. | Facilitating secure execution of external workflows for genomic sequencing diagnostics |
| US20230242974A1 (en) | 2021-12-27 | 2023-08-03 | 10X Genomics, Inc. | Methods and compositions for rolling circle amplification |
| US20230207050A1 (en) | 2021-12-28 | 2023-06-29 | Illumina Software, Inc. | Machine learning model for recalibrating nucleotide base calls corresponding to target variants |
| AU2022425440A1 (en) | 2021-12-29 | 2024-07-11 | Illumina, Inc. | Automatically switching variant analysis model versions for genomic analysis applications |
| CN118475822A (zh) | 2021-12-30 | 2024-08-09 | 伊鲁米那有限公司 | 成像系统以及相关系统和方法 |
| US12674196B2 (en) | 2022-01-18 | 2026-07-07 | 10X Genomics, Inc. | Methods and compositions for improved probe specificity |
| EP4733410A3 (en) | 2022-01-21 | 2026-05-27 | 10X Genomics, Inc. | Multiple readout signals for analyzing a sample |
| US20230296516A1 (en) | 2022-02-17 | 2023-09-21 | Illumina, Inc. | Ai-driven signal enhancement of sequencing images |
| EP4479928B1 (en) | 2022-02-17 | 2026-04-01 | Illumina, Inc. | Ai-driven enhancement of motion blurred sequencing images |
| US20240254537A1 (en) | 2022-02-23 | 2024-08-01 | Insitro, Inc. | Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations |
| EP4483372B1 (en) | 2022-02-25 | 2026-04-01 | Illumina, Inc. | Calibration sequences for nucelotide sequencing |
| AU2023225949A1 (en) | 2022-02-25 | 2024-01-18 | Illumina, Inc. | Machine-learning models for detecting and adjusting values for nucleotide methylation levels |
| CA3245990A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES |
| US12703879B2 (en) | 2022-03-29 | 2026-08-11 | 10X Genomics, Inc. | RNase H assisted in situ rolling circle amplification |
| CN119032271A (zh) | 2022-04-01 | 2024-11-26 | 10X基因组学有限公司 | 用于靶向掩蔽自发荧光的组合物和方法 |
| WO2023196526A1 (en) | 2022-04-06 | 2023-10-12 | 10X Genomics, Inc. | Methods for multiplex cell analysis |
| AU2023248405A1 (en) | 2022-04-07 | 2024-01-04 | Illumina, Inc. | Altered cytidine deaminases and methods of use |
| EP4515026A1 (en) | 2022-04-25 | 2025-03-05 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| EP4515547A1 (en) | 2022-04-26 | 2025-03-05 | Illumina, Inc. | Machine-learning models for selecting oligonucleotide probes for array technologies |
| WO2023209606A1 (en) | 2022-04-29 | 2023-11-02 | Illumina Cambridge Limited | Methods and systems for encapsulating lyophilised microspheres |
| US20240002902A1 (en) | 2022-05-06 | 2024-01-04 | 10X Genomics, Inc. | Analysis of antigen and antigen receptor interactions |
| EP4523215A1 (en) | 2022-05-10 | 2025-03-19 | Illumina Inc. | Adaptive neural network for nucelotide sequencing |
| CN119317964A (zh) | 2022-06-09 | 2025-01-14 | 因美纳有限公司 | 碱基检出对流通池倾斜的依赖 |
| US20240035071A1 (en) | 2022-06-17 | 2024-02-01 | 10X Genomics, Inc. | Catalytic de-crosslinking of samples for in situ analysis |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| EP4544558A1 (en) | 2022-06-24 | 2025-04-30 | Illumina, Inc. | Improving split-read alignment by intelligently identifying and scoring candidate split groups |
| US20260011405A1 (en) | 2022-06-27 | 2026-01-08 | Illumina, Inc. | Human leukocyte antigen (hla) genotyping |
| WO2024006769A1 (en) | 2022-06-27 | 2024-01-04 | Illumina Software, Inc. | Generating and implementing a structural variation graph genome |
| EP4544552A1 (en) | 2022-06-27 | 2025-04-30 | Illumina Inc. | Accelerators for a genotype imputation model |
| WO2024026356A1 (en) | 2022-07-26 | 2024-02-01 | Illumina, Inc. | Rapid single-cell multiomics processing using an executable file |
| US12692484B2 (en) | 2022-08-12 | 2026-07-28 | 10X Genomics, Inc. | PUMA1 polymerases and uses thereof |
| US12116626B2 (en) | 2022-08-16 | 2024-10-15 | 10X Genomics, Inc. | AP50 polymerases and uses thereof |
| EP4328569A1 (en) * | 2022-08-23 | 2024-02-28 | NanoTemper Technologies GmbH | Measuring high protein concentrations |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| US20240100518A1 (en) | 2022-09-26 | 2024-03-28 | Illumina, Inc. | Flow cell based motion system calibration and control methods |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240112753A1 (en) | 2022-09-29 | 2024-04-04 | Illumina, Inc. | Target-variant-reference panel for imputing target variants |
| WO2024073047A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Cytidine deaminases and methods of use in mapping modified cytosine nucleotides |
| WO2024073519A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Machine-learning model for refining structural variant calls |
| US20250388894A1 (en) | 2022-09-30 | 2025-12-25 | Illumina, Inc. | Methods of using cpg binding proteins in mapping modified cytosine nucleotides |
| EP4594481A1 (en) | 2022-09-30 | 2025-08-06 | Illumina, Inc. | Helicase-cytidine deaminase complexes and methods of use |
| EP4599449A1 (en) | 2022-10-05 | 2025-08-13 | Illumina, Inc. | Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture |
| US20240127906A1 (en) | 2022-10-11 | 2024-04-18 | Illumina, Inc. | Detecting and correcting methylation values from methylation sequencing assays |
| US20240191297A1 (en) | 2022-10-14 | 2024-06-13 | 10X Genomics, Inc. | Methods, compositions, and systems for assessing biological sample quality |
| WO2024102736A1 (en) | 2022-11-08 | 2024-05-16 | 10X Genomics, Inc. | Immobilization methods and compositions for in situ detection |
| US20240158852A1 (en) | 2022-11-16 | 2024-05-16 | 10X Genomics, Inc. | Methods and compositions for assessing performance of in situ assays |
| WO2024107727A1 (en) | 2022-11-18 | 2024-05-23 | 10X Genomics, Inc. | Systems and methods for actively mitigating vibrations |
| US12644837B2 (en) | 2022-11-22 | 2026-06-02 | 10X Genomics, Inc. | Systems and methods for imaging samples |
| EP4622746A1 (en) | 2022-11-22 | 2025-10-01 | 10X Genomics, Inc. | Systems and methods for interfacing with a bottle |
| US12581050B2 (en) | 2022-11-23 | 2026-03-17 | 10X Genomics, Inc. | Optical assemblies for machine vision calibration |
| EP4627115A1 (en) | 2022-11-29 | 2025-10-08 | Element Biosciences, Inc. | Flow cell devices and optical systems for nucleic acid sequencing |
| WO2024118791A1 (en) | 2022-11-30 | 2024-06-06 | Illumina, Inc. | Accurately predicting variants from methylation sequencing data |
| AU2022279500B1 (en) * | 2022-12-01 | 2023-11-23 | Provectus IP Pty Ltd | Automated cell analyser and method |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240218437A1 (en) | 2022-12-16 | 2024-07-04 | 10X Genomics, Inc. | Methods and compositions for assessing performance |
| EP4638789A1 (en) | 2022-12-21 | 2025-10-29 | 10X Genomics, Inc. | Methods for tethering ribonucleic acids in biological samples |
| WO2024148300A1 (en) | 2023-01-06 | 2024-07-11 | 10X Genomics, Inc. | Methods and compositions for in situ analysis of variant sequences |
| US20240241110A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| CA3259427A1 (en) | 2023-01-27 | 2024-08-02 | Illumina, Inc. | JIG CORRECTION IMAGE ANALYSIS |
| EP4662663A1 (en) | 2023-02-06 | 2025-12-17 | Illumina, Inc. | Determining and removing inter-cluster light interference |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20250384952A1 (en) | 2023-03-30 | 2025-12-18 | Illumina, Inc. | Tandem repeat genotyping |
| JP2026517529A (ja) | 2023-05-03 | 2026-06-02 | イルミナ インコーポレイテッド | 既存の配列決定データファイルから遺伝子型コールを再較正するための機械学習モデル |
| WO2024229260A1 (en) | 2023-05-03 | 2024-11-07 | 10X Genomics, Inc. | Methods and compositions for spatial assay |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| WO2024249200A1 (en) | 2023-05-26 | 2024-12-05 | Illumina, Inc. | Methods for preserving methylation status during clustering |
| US20240404624A1 (en) | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Structural variant alignment and variant calling by utilizing a structural-variant reference genome |
| WO2024249973A2 (en) | 2023-06-02 | 2024-12-05 | Illumina, Inc. | Linking human genes to clinical phenotypes using graph neural networks |
| EP4736169A1 (en) | 2023-06-27 | 2026-05-06 | Illumina, Inc. | Variant calling with methylation-level estimation |
| EP4735634A1 (en) | 2023-06-30 | 2026-05-06 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with modified bases |
| WO2025006466A1 (en) | 2023-06-30 | 2025-01-02 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with four labeled nucleotides |
| EP4736170A1 (en) | 2023-06-30 | 2026-05-06 | Illumina, Inc. | Machine-learning model for recalibrating genotype calls corresponding to germline variants and somatic mosaic variants |
| EP4735635A1 (en) | 2023-06-30 | 2026-05-06 | Illumina, Inc. | Systems and methods of sequencing polynucleotides with alternative scatterplots |
| WO2025007300A1 (zh) * | 2023-07-05 | 2025-01-09 | 武汉华大智造科技有限公司 | 用于基因测序的流路系统及其控制方法和基因测序仪 |
| WO2025029831A1 (en) | 2023-07-31 | 2025-02-06 | 10X Genomics, Inc. | Methods and systems for targeted rna cleavage and target rna-primed rolling circle amplification |
| EP4758217A1 (en) | 2023-08-11 | 2026-06-17 | Illumina, Inc. | Optical alignment targets |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| WO2025054389A1 (en) | 2023-09-07 | 2025-03-13 | Illumina, Inc. | Identification of methylated cytosine using landmarks |
| AU2023464289A1 (en) | 2023-09-08 | 2026-03-12 | The Regents Of The University Of Michigan | MICRORNA-DERIVED RNAs AND POLYPEPTIDES AND USES THEREOF |
| EP4784740A1 (en) | 2023-09-28 | 2026-08-05 | Illumina, Inc. | Altered cytidine deaminases and methods of use |
| US20250111898A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Tracking and modifying cluster location on nucleotide-sample slides in real time |
| US20250111899A1 (en) | 2023-09-29 | 2025-04-03 | Illumina, Inc. | Predicting insert lengths using primary analysis metrics |
| WO2025081064A2 (en) | 2023-10-11 | 2025-04-17 | Illumina, Inc. | Thermophilic deaminase and methods for identifying modified cytosine |
| WO2025090883A1 (en) | 2023-10-27 | 2025-05-01 | Illumina, Inc. | Detecting variants in nucleotide sequences based on haplotype diversity |
| US20250163502A1 (en) | 2023-11-22 | 2025-05-22 | 10X Genomics, Inc. | Methods for processing ribonucleic acids in biological samples |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| WO2025129133A1 (en) | 2023-12-15 | 2025-06-19 | Illumina, Inc. | Minimal residual disease (mrd) models for determining likelihoods or probabilities of a subject comprising cancer |
| US20250201346A1 (en) | 2023-12-18 | 2025-06-19 | Illumina, Inc. | Using machine learning models for detecting minimum residual disease (mrd) in a subject |
| WO2025137222A1 (en) | 2023-12-19 | 2025-06-26 | Illumina, Inc. | Methylation detection assay |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| EP4578960A1 (en) | 2023-12-20 | 2025-07-02 | 10x Genomics, Inc. | In situ detection of copy number variations in biological samples |
| WO2025137341A1 (en) | 2023-12-20 | 2025-06-26 | Illumina, Inc. | Directly determining signal-to-noise-ratio metrics for accelerated convergence in determining nucleotide-base calls and base-call quality |
| US20250210141A1 (en) | 2023-12-21 | 2025-06-26 | Illumina, Inc. | Enhanced mapping and alignment of nucleotide reads utilizing an improved haplotype data structure with allele-variant differences |
| WO2025160089A1 (en) | 2024-01-26 | 2025-07-31 | Illumina, Inc. | Custom multigenome reference construction for improved sequencing analysis of genomic samples |
| WO2025174774A1 (en) | 2024-02-12 | 2025-08-21 | Illumina, Inc. | Determining offline corrections for sequence specific errors caused by low complexity nucleotide sequences |
| WO2025174708A1 (en) | 2024-02-13 | 2025-08-21 | Illumina, Inc. | Design and method for cross-sequencing platform compatibility of flow cells |
| WO2025184234A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | A personalized haplotype database for improved mapping and alignment of nucleotide reads and improved genotype calling |
| WO2025193747A1 (en) | 2024-03-12 | 2025-09-18 | Illumina, Inc. | Machine-learning models for ordering and expediting sequencing tasks or corresponding nucleotide-sample slides |
| US20250288988A1 (en) | 2024-03-15 | 2025-09-18 | 10X Genomics, Inc. | Systems and methods for covering and sealing an open well |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| CN121359208A (zh) | 2024-05-13 | 2026-01-16 | 因美纳有限公司 | 在测序运行期间修改测序循环以满足针对目标基因组区域的定制化覆盖度估计 |
| WO2025240924A1 (en) | 2024-05-17 | 2025-11-20 | Illumina, Inc. | Blind equalization systems for base calling applications |
| WO2025240918A1 (en) | 2024-05-17 | 2025-11-20 | 10X Genomics, Inc. | Systems and methods for generating codebooks |
| WO2025250996A2 (en) | 2024-05-31 | 2025-12-04 | Illumina, Inc. | Call generation and recalibration models for implementing personalized diploid reference haplotypes in genotype calling |
| WO2025255457A1 (en) | 2024-06-07 | 2025-12-11 | 10X Genomics, Inc. | Compositions and methods for improved on-target spatial profiling |
| WO2025264702A1 (en) | 2024-06-18 | 2025-12-26 | 10X Genomics, Inc. | 3d hydrogels for nucleic acid sequencing |
| WO2026006771A1 (en) | 2024-06-28 | 2026-01-02 | Illumina, Inc. | Cluster-filtering scores |
| WO2026006774A1 (en) | 2024-06-28 | 2026-01-02 | Illumina, Inc. | Altered cytidine deaminases and methods of use |
| WO2026030370A1 (en) | 2024-07-30 | 2026-02-05 | Illumina, Inc. | Generating adaptive intensity value decision boundaries for nucleotide sequencing |
| WO2026030369A1 (en) | 2024-07-31 | 2026-02-05 | 10X Genomics, Inc. | Methods and compositions for in situ analyte detection |
| WO2026039468A1 (en) | 2024-08-16 | 2026-02-19 | Illumina, Inc. | Sequencing illumination adjustment system |
| WO2026043885A1 (en) | 2024-08-20 | 2026-02-26 | 10X Genomics, Inc. | Methods and systems for preparing a nucleic acid library |
| WO2026072725A1 (en) | 2024-09-25 | 2026-04-02 | Illumina, Inc. | Adjusting oligonucleotide-cluster location in images in real time using band-edge spectral regions |
| WO2026072436A1 (en) | 2024-09-27 | 2026-04-02 | Illumina, Inc. | Systems and methods for quantifying sequence read connectivity |
| WO2026072464A1 (en) | 2024-09-27 | 2026-04-02 | Illumina, Inc. | Read mapping enhanced by spatial information |
| WO2026072986A1 (en) | 2024-09-27 | 2026-04-02 | Illumina, Inc. | Determining offline corrections for sequence specific errors caused by low complexity sequences using a machine learning model |
| WO2026117717A1 (en) | 2024-11-27 | 2026-06-04 | Illumina, Inc. | Genotype calling from sequencing data representing spontaneous deamination and/or methylation |
| WO2026122702A1 (en) | 2024-12-04 | 2026-06-11 | Illumina, Inc. | Linking variants to phenotypes using a machine-learning model |
| WO2026136945A1 (en) | 2024-12-20 | 2026-06-25 | 10X Genomics, Inc. | Methods and compositions for selective control of signal generation efficiency |
| WO2026151579A1 (en) | 2025-01-08 | 2026-07-16 | Illumina, Inc. | Methods and systems for mapping sequence reads from duplicated regions using flow cell proximity information |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160263A (en) | 1978-05-15 | 1979-07-03 | George R. Cogar | Dual or multiple objective video microscope for superimposing spaced images |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US6953676B1 (en) * | 1992-05-01 | 2005-10-11 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5641658A (en) | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
| DE19536903C2 (de) * | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Vorrichtung zum Haltern eines fluidischen Bauteils |
| US5803117A (en) | 1996-06-10 | 1998-09-08 | Rheodyne, L.P. | Multi-route full sweep selection valve |
| US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
| JP2001517948A (ja) | 1997-04-01 | 2001-10-09 | グラクソ、グループ、リミテッド | 核酸配列決定法 |
| US6399936B1 (en) | 1997-12-01 | 2002-06-04 | New Dimension Research Instrument, Inc. | Optical confocal device having a common light directing means |
| US20030036855A1 (en) * | 1998-03-16 | 2003-02-20 | Praelux Incorporated, A Corporation Of New Jersey | Method and apparatus for screening chemical compounds |
| US6185030B1 (en) * | 1998-03-20 | 2001-02-06 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6012488A (en) | 1998-09-17 | 2000-01-11 | Rheodyne, L.P. | Segmenting valve |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6326612B1 (en) * | 1998-10-13 | 2001-12-04 | Texas Instruments Incorporated | System and method for optical sensing utilizing a portable, detachable sensor cartridge |
| US6424404B1 (en) | 1999-01-11 | 2002-07-23 | Kenneth C. Johnson | Multi-stage microlens array |
| DE60040741D1 (de) | 1999-04-20 | 2008-12-18 | Illumina Inc | Detektion von nukleinsäurereaktionen auf kügelchen-arrays |
| US20030215821A1 (en) | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
| US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
| US6320174B1 (en) | 1999-11-16 | 2001-11-20 | Ikonisys Inc. | Composing microscope |
| US20030091477A1 (en) * | 1999-12-22 | 2003-05-15 | Paul Eric A. | Flow-thru chip cartridge, chip holder, system & method thereof |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US6770441B2 (en) | 2000-02-10 | 2004-08-03 | Illumina, Inc. | Array compositions and methods of making same |
| US6526658B1 (en) * | 2000-05-23 | 2003-03-04 | Silverbrook Research Pty Ltd | Method of manufacture of an ink jet printhead having a moving nozzle with an externally arranged actuator |
| EP2100971A3 (en) | 2000-07-07 | 2009-11-25 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
| US6603546B1 (en) | 2000-07-21 | 2003-08-05 | I.S.S. (Usa) Inc. | Rapid high throughput spectrometer and method |
| US6875973B2 (en) * | 2000-08-25 | 2005-04-05 | Amnis Corporation | Auto focus for a flow imaging system |
| US6374684B1 (en) | 2000-08-25 | 2002-04-23 | Cepheid | Fluid control and processing system |
| US7514046B2 (en) * | 2000-10-31 | 2009-04-07 | Caliper Life Sciences, Inc. | Methods and systems for processing microscale devices for reuse |
| AU2002230524A1 (en) * | 2000-11-16 | 2002-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
| JP2002219849A (ja) | 2000-11-27 | 2002-08-06 | Riso Kagaku Corp | 孔版印刷装置 |
| US7211414B2 (en) | 2000-12-01 | 2007-05-01 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| US7864369B2 (en) | 2001-03-19 | 2011-01-04 | Dmetrix, Inc. | Large-area imaging by concatenation with array microscope |
| AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| WO2003025838A1 (en) | 2001-09-14 | 2003-03-27 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inter-objective baffle system |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US20040002090A1 (en) | 2002-03-05 | 2004-01-01 | Pascal Mayer | Methods for detecting genome-wide sequence variations associated with a phenotype |
| US6982166B2 (en) | 2002-05-16 | 2006-01-03 | Applera Corporation | Lens assembly for biological testing |
| US6987259B2 (en) | 2002-05-30 | 2006-01-17 | Dmetrix, Inc. | Imaging system with an integrated source and detector array |
| US7193775B2 (en) | 2002-05-30 | 2007-03-20 | Dmetrix, Inc. | EPI-illumination system for an array microscope |
| US7312432B2 (en) | 2002-07-08 | 2007-12-25 | Dmetrix, Inc. | Single axis illumination for multi-axis imaging system |
| US7582470B2 (en) * | 2002-07-31 | 2009-09-01 | Gen-Probe Incorporated | Device for amplifying and detecting a target nucleic acid |
| AU2003259350A1 (en) | 2002-08-23 | 2004-03-11 | Solexa Limited | Modified nucleotides for polynucleotide sequencing |
| US7388714B2 (en) | 2002-09-18 | 2008-06-17 | Dmetrix, Inc. | Independent focus compensation for a multi-axis imaging system |
| US6950241B1 (en) | 2002-09-18 | 2005-09-27 | Dmetrix, Inc. | Miniature microscope objective for an array microscope |
| AU2003294224A1 (en) | 2002-09-23 | 2004-05-04 | Dmetrix, Inc. | Multi-mode scanning imaging system |
| US7034317B2 (en) | 2002-12-17 | 2006-04-25 | Dmetrix, Inc. | Method and apparatus for limiting scanning imaging array data to characteristics of interest |
| US20050221281A1 (en) * | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| DE602004026033D1 (de) | 2003-01-29 | 2010-04-29 | 454 Corp | Zweiendige sequenzierung |
| US7148043B2 (en) * | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| US7330574B2 (en) | 2003-05-08 | 2008-02-12 | Ometrix, Inc. | Best-focus estimation by lateral scanning |
| US20050181394A1 (en) | 2003-06-20 | 2005-08-18 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| US8048627B2 (en) | 2003-07-05 | 2011-11-01 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| EP1520837B1 (en) | 2004-05-22 | 2007-02-07 | Agilent Technologies, Inc. | Component part of a microfluidic valve |
| US20080125330A1 (en) | 2004-07-01 | 2008-05-29 | Cornell Research Foundation, Inc. | Real-Time Pcr Detection of Microorganisms Using an Integrated Microfluidics Platform |
| WO2006018044A1 (en) | 2004-08-18 | 2006-02-23 | Agilent Technologies, Inc. | Microfluidic assembly with coupled microfluidic devices |
| US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
| US8133703B2 (en) * | 2004-10-27 | 2012-03-13 | Ceoheid | Closed-system multi-stage nucleic acid amplification reactions |
| FI20055043A0 (fi) * | 2005-01-31 | 2005-01-31 | Wallac Oy | Sovitelma mikrotiterkaivojen kuvausjärjestelmässä |
| US7507575B2 (en) * | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| DK1907571T3 (en) | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
| WO2007021820A2 (en) | 2005-08-11 | 2007-02-22 | Eksigent Technologies, Llc | Methods for measuring biochemical reactions |
| JP5058483B2 (ja) * | 2005-09-14 | 2012-10-24 | オリンパス株式会社 | 生体試料の長期間ないし連続的検出方法 |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| JP4742242B2 (ja) * | 2005-09-30 | 2011-08-10 | カシオ計算機株式会社 | 撮像装置及びそのプログラム |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
| JP5063616B2 (ja) | 2006-02-03 | 2012-10-31 | インテジェニックス インコーポレイテッド | マイクロ流体デバイス |
| WO2007107710A1 (en) | 2006-03-17 | 2007-09-27 | Solexa Limited | Isothermal methods for creating clonal single molecule arrays |
| SG170802A1 (en) | 2006-03-31 | 2011-05-30 | Solexa Inc | Systems and devices for sequence by synthesis analysis |
| US8900828B2 (en) * | 2006-05-01 | 2014-12-02 | Cepheid | Methods and apparatus for sequential amplification reactions |
| US8137626B2 (en) * | 2006-05-19 | 2012-03-20 | California Institute Of Technology | Fluorescence detector, filter device and related methods |
| US7641860B2 (en) | 2006-06-01 | 2010-01-05 | Nanotek, Llc | Modular and reconfigurable multi-stage microreactor cartridge apparatus |
| US7586674B2 (en) * | 2006-10-17 | 2009-09-08 | Hnu-Photonics | Compuscope |
| EP2089517A4 (en) | 2006-10-23 | 2010-10-20 | Pacific Biosciences California | POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING |
| BRPI0717385A2 (pt) * | 2006-10-24 | 2013-10-15 | Koninkl Philips Electronics Nv | Dispositivo, aparelho e método para formar imagem de um objeto |
| US7813013B2 (en) * | 2006-11-21 | 2010-10-12 | Illumina, Inc. | Hexagonal site line scanning method and system |
| US7835871B2 (en) | 2007-01-26 | 2010-11-16 | Illumina, Inc. | Nucleic acid sequencing system and method |
| US9322063B2 (en) | 2007-01-26 | 2016-04-26 | Illumina, Inc. | Efficient biomolecule recycling method and system |
| US8298763B2 (en) | 2007-03-02 | 2012-10-30 | Lawrence Livermore National Security, Llc | Automated high-throughput flow-through real-time diagnostic system |
| US8039817B2 (en) | 2008-05-05 | 2011-10-18 | Illumina, Inc. | Compensator for multiple surface imaging |
| DE102008002509A1 (de) * | 2008-06-18 | 2009-12-31 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Stopped-Flow-Chip |
| US20110224574A1 (en) * | 2008-11-13 | 2011-09-15 | Sadler John W | Methods and systems for tissue processing and imaging |
| EP2359289A4 (en) | 2008-11-26 | 2015-11-11 | Illumina Inc | METHODS AND SYSTEMS FOR ANALYZING SEQUENCING DATA |
| US20100157086A1 (en) * | 2008-12-15 | 2010-06-24 | Illumina, Inc | Dynamic autofocus method and system for assay imager |
| US8673627B2 (en) * | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| US8304704B2 (en) * | 2009-07-27 | 2012-11-06 | Sensovation Ag | Method and apparatus for autofocus using a light source pattern and means for masking the light source pattern |
| US8934098B2 (en) * | 2009-08-31 | 2015-01-13 | Life Technologies Corporation | Fast-indexing filter wheel and method of use |
| EP2507387B1 (en) | 2009-12-01 | 2017-01-25 | Oxford Nanopore Technologies Limited | Biochemical analysis instrument and method |
| FI4060325T3 (fi) * | 2009-12-07 | 2024-09-25 | Meso Scale Technologies Llc | Määrityskasetin lukija |
| EP2609742A4 (en) * | 2010-08-27 | 2015-07-08 | Univ Leland Stanford Junior | MICROSCOPIC IMAGING DEVICE WITH ADVANCED IMAGING FEATURES |
| WO2012042226A2 (en) | 2010-10-01 | 2012-04-05 | Oxford Nanopore Technologies Limited | Biochemical analysis apparatus and rotary valve |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| JP6159391B2 (ja) * | 2012-04-03 | 2017-07-05 | イラミーナ インコーポレーテッド | 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ |
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