JP6150518B2 - ポリフェノール組成物の製造方法 - Google Patents

ポリフェノール組成物の製造方法 Download PDF

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Publication number
JP6150518B2
JP6150518B2 JP2012284338A JP2012284338A JP6150518B2 JP 6150518 B2 JP6150518 B2 JP 6150518B2 JP 2012284338 A JP2012284338 A JP 2012284338A JP 2012284338 A JP2012284338 A JP 2012284338A JP 6150518 B2 JP6150518 B2 JP 6150518B2
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Prior art keywords
water
soluble
polyphenol
polyphenols
soluble polyphenols
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JP2012284338A
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English (en)
Japanese (ja)
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JP2014125461A (ja
JP2014125461A5 (cg-RX-API-DMAC7.html
Inventor
山田　泰司
泰司 山田
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Kao Corp
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Kao Corp
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Priority to JP2012284338A priority Critical patent/JP6150518B2/ja
Priority to PCT/JP2013/084797 priority patent/WO2014104157A1/ja
Priority to CN201380068025.9A priority patent/CN104884054B/zh
Priority to US14/758,111 priority patent/US9669047B2/en
Publication of JP2014125461A publication Critical patent/JP2014125461A/ja
Publication of JP2014125461A5 publication Critical patent/JP2014125461A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
JP2012284338A 2012-12-27 2012-12-27 ポリフェノール組成物の製造方法 Active JP6150518B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2012284338A JP6150518B2 (ja) 2012-12-27 2012-12-27 ポリフェノール組成物の製造方法
PCT/JP2013/084797 WO2014104157A1 (ja) 2012-12-27 2013-12-26 ポリフェノール組成物の製造方法
CN201380068025.9A CN104884054B (zh) 2012-12-27 2013-12-26 多酚组合物的制造方法
US14/758,111 US9669047B2 (en) 2012-12-27 2013-12-26 Method for producing polyphenol composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012284338A JP6150518B2 (ja) 2012-12-27 2012-12-27 ポリフェノール組成物の製造方法

Publications (3)

Publication Number Publication Date
JP2014125461A JP2014125461A (ja) 2014-07-07
JP2014125461A5 JP2014125461A5 (cg-RX-API-DMAC7.html) 2015-11-19
JP6150518B2 true JP6150518B2 (ja) 2017-06-21

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Family Applications (1)

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JP2012284338A Active JP6150518B2 (ja) 2012-12-27 2012-12-27 ポリフェノール組成物の製造方法

Country Status (4)

Country Link
US (1) US9669047B2 (cg-RX-API-DMAC7.html)
JP (1) JP6150518B2 (cg-RX-API-DMAC7.html)
CN (1) CN104884054B (cg-RX-API-DMAC7.html)
WO (1) WO2014104157A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9822091B2 (en) 2013-07-11 2017-11-21 Kao Corporation Method for producing ellagic acid composition
JP6691752B2 (ja) * 2014-08-29 2020-05-13 花王株式会社 難溶解性ポリフェノール類を含有する固体分散体の製造方法
EP3233188A4 (en) * 2014-12-19 2018-11-07 Halo Life Science, LLC Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels
US20160296490A1 (en) * 2015-04-13 2016-10-13 Kodimule Prasad Composition and method for the treatment of obesity
WO2018025871A1 (ja) * 2016-08-04 2018-02-08 花王株式会社 ノビレチン含有固体分散体の製造方法
CN106883278A (zh) * 2017-03-21 2017-06-23 广东药科大学 一种3,5,7‑三羟基‑2‑(4‑羟基苯基)‑苯并吡喃‑4‑酮衍生物
US10952985B2 (en) 2017-10-12 2021-03-23 Vidya Herbs, Inc. Chlorogenic acid composition for the treatment of metabolic disorders
EP3769760B1 (en) * 2018-03-22 2023-01-04 Kao Corporation Method for producing solid dispersion containing nobiletin
CN111138282A (zh) * 2018-11-05 2020-05-12 北京科莱博医药开发有限责任公司 绿原酸l-精氨酸盐及其用途
JP7321743B2 (ja) * 2019-04-09 2023-08-07 花王株式会社 固形状組成物
US11896600B2 (en) 2019-09-21 2024-02-13 Vidya Herbs, Inc. Composition and method of using eicosanoyl-5-hydroxytryptamide for treating neurodegenerative disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2108575C (en) 1991-04-16 2002-10-22 Kouichi Nakamichi Method of manufacturing solid dispersion
WO2002024168A1 (fr) 2000-09-25 2002-03-28 Nippon Shinyaku Co., Ltd. Procede de production d'une dispersion solide medicinale
JP4826740B2 (ja) 2003-07-02 2011-11-30 不二製油株式会社 フラボノイドの可溶化剤及び可溶化方法
JP4429262B2 (ja) 2005-12-09 2010-03-10 壽製薬株式会社 フェノフィブラートの固体分散体
JP2007208414A (ja) * 2006-01-31 2007-08-16 Victor Co Of Japan Ltd 捜索システム
JP5160049B2 (ja) * 2006-05-18 2013-03-13 花王株式会社 ヘスペリジン組成物
JP5000373B2 (ja) 2007-04-27 2012-08-15 東洋精糖株式会社 水溶性フラボノイド組成物およびその製造方法、ならびに水溶性フラボノイド組成物を含む食品等
JP5653602B2 (ja) 2009-09-02 2015-01-14 東洋精糖株式会社 高吸収性薬剤組成物およびその製造方法
KR101774075B1 (ko) 2010-06-09 2017-09-01 카오카부시키가이샤 폴리페놀 조성물의 제조 방법
JP5228083B2 (ja) 2010-06-09 2013-07-03 花王株式会社 ヘスペリジン組成物の製造方法
JP2014503470A (ja) * 2010-10-14 2014-02-13 アボット ゲーエムベーハー ウント カンパニー カーゲー クルクミノイド固体分散製剤

Also Published As

Publication number Publication date
JP2014125461A (ja) 2014-07-07
US20150335673A1 (en) 2015-11-26
CN104884054A (zh) 2015-09-02
WO2014104157A1 (ja) 2014-07-03
US9669047B2 (en) 2017-06-06
CN104884054B (zh) 2017-08-01

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