JP6149043B2 - ２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 - Google Patents

２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 Download PDF

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Publication number
JP6149043B2
JP6149043B2 JP2014543762A JP2014543762A JP6149043B2 JP 6149043 B2 JP6149043 B2 JP 6149043B2 JP 2014543762 A JP2014543762 A JP 2014543762A JP 2014543762 A JP2014543762 A JP 2014543762A JP 6149043 B2 JP6149043 B2 JP 6149043B2
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Japan
Prior art keywords
tanshinone
cancer
methyl
formula
compound
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Expired - Fee Related
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JP2014543762A
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Japanese (ja)
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JP2015500801A (ja
JP2015500801A5 (enExample
Inventor
ロンツェン シュー
ロンツェン シュー
フランク ロン
フランク ロン
フーウェン シェ
フーウェン シェ
ホンシ ライ
ホンシ ライ
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Hangzhou Bensheng Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
JP2014543762A 2011-11-30 2012-11-30 ２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 Expired - Fee Related JP6149043B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2011/083261 2011-11-30
CN2011083261 2011-11-30
PCT/CN2012/085660 WO2013079022A1 (zh) 2011-11-30 2012-11-30 2-位胺化亚甲基或2-位酯化亚甲基丹参酮衍生物、及其制备方法和应用

Publications (3)

Publication Number Publication Date
JP2015500801A JP2015500801A (ja) 2015-01-08
JP2015500801A5 JP2015500801A5 (enExample) 2016-01-14
JP6149043B2 true JP6149043B2 (ja) 2017-06-14

Family

ID=48534682

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014543762A Expired - Fee Related JP6149043B2 (ja) 2011-11-30 2012-11-30 ２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用

Country Status (6)

Country Link
US (1) US9328083B2 (enExample)
EP (1) EP2786990B1 (enExample)
JP (1) JP6149043B2 (enExample)
CN (1) CN103946217B (enExample)
DK (1) DK2786990T3 (enExample)
WO (1) WO2013079022A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013079017A1 (zh) * 2011-11-30 2013-06-06 杭州本生药业有限公司 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用
CN105884723B (zh) * 2014-12-25 2019-08-02 上海三帆生物医药科技有限公司 丹参酮衍生物、其制备方法及其应用
CN105884857B (zh) * 2015-01-23 2018-10-12 上海三帆生物医药科技有限公司 丹参酮衍生物、其制备方法及其应用
CN106810593B (zh) * 2016-12-26 2018-12-04 郑州大学 一种丹参酮类化合物17位酯化衍生物及其制备工艺和应用
CN106831934B (zh) * 2016-12-26 2018-09-21 郑州大学 一种丹参酮类化合物15位酰胺类衍生物及其制备工艺和应用
CN111000851B (zh) * 2019-12-31 2021-09-07 扬州大学 丹参酮i在制备肿瘤细胞自噬诱导剂药物中的应用
CN113773289B (zh) * 2021-09-15 2023-05-12 沈阳药科大学 一种萘[1,2-b]杂环-4,5-二酮类化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100387585C (zh) 2006-04-26 2008-05-14 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN1837200A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
KR20080047957A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 고혈압의 치료 및 예방을 위한 약제 조성물
CN101012270A (zh) * 2007-01-26 2007-08-08 广东工业大学 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用
CN101274925A (zh) * 2007-03-29 2008-10-01 中国科学院上海药物研究所 一类萘并呋喃邻醌化合物及其制备方法和用途
US20100209513A1 (en) * 2007-10-11 2010-08-19 In Geun Jo Pharmaceutical composition containing micronized particles of naphthoquinone-based compound
KR20090073381A (ko) * 2007-12-31 2009-07-03 주식회사 머젠스 심장질환의 치료 및 예방을 위한 약제 조성물

Also Published As

Publication number Publication date
JP2015500801A (ja) 2015-01-08
US9328083B2 (en) 2016-05-03
US20150126552A1 (en) 2015-05-07
EP2786990B1 (en) 2018-08-08
CN103946217B (zh) 2017-04-19
EP2786990A1 (en) 2014-10-08
WO2013079022A1 (zh) 2013-06-06
EP2786990A4 (en) 2015-07-15
DK2786990T3 (en) 2018-11-19
CN103946217A (zh) 2014-07-23

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