JP6149043B2 - ２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 - Google Patents
２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 Download PDFInfo
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- JP6149043B2 JP6149043B2 JP2014543762A JP2014543762A JP6149043B2 JP 6149043 B2 JP6149043 B2 JP 6149043B2 JP 2014543762 A JP2014543762 A JP 2014543762A JP 2014543762 A JP2014543762 A JP 2014543762A JP 6149043 B2 JP6149043 B2 JP 6149043B2
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- Prior art keywords
- tanshinone
- cancer
- methyl
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- compound
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2011/083261 | 2011-11-30 | ||
| CN2011083261 | 2011-11-30 | ||
| PCT/CN2012/085660 WO2013079022A1 (zh) | 2011-11-30 | 2012-11-30 | 2-位胺化亚甲基或2-位酯化亚甲基丹参酮衍生物、及其制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500801A JP2015500801A (ja) | 2015-01-08 |
| JP2015500801A5 JP2015500801A5 (enExample) | 2016-01-14 |
| JP6149043B2 true JP6149043B2 (ja) | 2017-06-14 |
Family
ID=48534682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543762A Expired - Fee Related JP6149043B2 (ja) | 2011-11-30 | 2012-11-30 | ２−アミノ化メチレン又は２−エステル化メチレンタンシノン誘導体、並びにその調製方法及び使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9328083B2 (enExample) |
| EP (1) | EP2786990B1 (enExample) |
| JP (1) | JP6149043B2 (enExample) |
| DK (1) | DK2786990T3 (enExample) |
| WO (1) | WO2013079022A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6059734B2 (ja) * | 2011-11-30 | 2017-01-11 | ハンジョウ ベンシェン ファーマシューティカル シーオー．， エルティーディー．Ｈａｎｇｚｈｏｕ Ｂｅｎｓｈｅｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 |
| CN105884723B (zh) * | 2014-12-25 | 2019-08-02 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
| CN105884857B (zh) * | 2015-01-23 | 2018-10-12 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
| CN106831934B (zh) * | 2016-12-26 | 2018-09-21 | 郑州大学 | 一种丹参酮类化合物15位酰胺类衍生物及其制备工艺和应用 |
| CN106810593B (zh) * | 2016-12-26 | 2018-12-04 | 郑州大学 | 一种丹参酮类化合物17位酯化衍生物及其制备工艺和应用 |
| CN111000851B (zh) * | 2019-12-31 | 2021-09-07 | 扬州大学 | 丹参酮i在制备肿瘤细胞自噬诱导剂药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1837200A (zh) | 2006-04-26 | 2006-09-27 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| CN100387585C (zh) | 2006-04-26 | 2008-05-14 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| KR20080047956A (ko) * | 2006-11-27 | 2008-05-30 | 주식회사 엠디바이오알파 | 발기부전의 치료 및 예방을 위한 약제 조성물 |
| CN101012270A (zh) | 2007-01-26 | 2007-08-08 | 广东工业大学 | 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用 |
| CN101274925A (zh) * | 2007-03-29 | 2008-10-01 | 中国科学院上海药物研究所 | 一类萘并呋喃邻醌化合物及其制备方法和用途 |
| JP2011500557A (ja) * | 2007-10-11 | 2011-01-06 | マゼンス インコーポレイテッド | ナフトキノン系化合物の微粒化粒子を含有する医薬組成物 |
| KR20090073381A (ko) * | 2007-12-31 | 2009-07-03 | 주식회사 머젠스 | 심장질환의 치료 및 예방을 위한 약제 조성물 |
-
2012
- 2012-11-30 DK DK12854507.6T patent/DK2786990T3/en active
- 2012-11-30 US US14/361,548 patent/US9328083B2/en not_active Expired - Fee Related
- 2012-11-30 JP JP2014543762A patent/JP6149043B2/ja not_active Expired - Fee Related
- 2012-11-30 WO PCT/CN2012/085660 patent/WO2013079022A1/zh not_active Ceased
- 2012-11-30 EP EP12854507.6A patent/EP2786990B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2786990B1 (en) | 2018-08-08 |
| WO2013079022A1 (zh) | 2013-06-06 |
| DK2786990T3 (en) | 2018-11-19 |
| EP2786990A4 (en) | 2015-07-15 |
| EP2786990A1 (en) | 2014-10-08 |
| JP2015500801A (ja) | 2015-01-08 |
| US20150126552A1 (en) | 2015-05-07 |
| US9328083B2 (en) | 2016-05-03 |
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