JP6113828B2 - プロテインキナーゼｃ阻害剤およびその使用 - Google Patents

プロテインキナーゼｃ阻害剤およびその使用 Download PDF

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JP6113828B2
JP6113828B2 JP2015504725A JP2015504725A JP6113828B2 JP 6113828 B2 JP6113828 B2 JP 6113828B2 JP 2015504725 A JP2015504725 A JP 2015504725A JP 2015504725 A JP2015504725 A JP 2015504725A JP 6113828 B2 JP6113828 B2 JP 6113828B2
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Japan
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compound
amino
ylamino
fluoro
tetrazol
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Expired - Fee Related
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JP2015504725A
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JP2015519307A5 (enExample
JP2015519307A (ja
Inventor
シング，ラジンダー
ダンクトン，マシュー
チャン，ジン
アルバレス，サルバドール
ツォ，キン
ホランド，サッシャ
イェン，ローズ
コルリ，ラオ
ヘックロード，ティロ
チェン，ヤン
マスダ，エステバン
リ，ホイ
ジー． パヤン，ドナルド
ジー． パヤン，ドナルド
ケリー，ライアン
Original Assignee
ライジェル ファーマシューティカルズ， インコーポレイテッド
ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2015504725A 2012-04-04 2013-04-04 プロテインキナーゼｃ阻害剤およびその使用 Expired - Fee Related JP6113828B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261620232P 2012-04-04 2012-04-04
US61/620,232 2012-04-04
US201361783647P 2013-03-14 2013-03-14
US61/783,647 2013-03-14
PCT/US2013/035285 WO2013152198A1 (en) 2012-04-04 2013-04-04 Protein kinase c inhibitors and uses thereof

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JP2015519307A JP2015519307A (ja) 2015-07-09
JP2015519307A5 JP2015519307A5 (enExample) 2016-06-02
JP6113828B2 true JP6113828B2 (ja) 2017-04-12

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US (3) US9321763B2 (enExample)
EP (1) EP2833889B1 (enExample)
JP (1) JP6113828B2 (enExample)
CA (1) CA2867760C (enExample)
ES (1) ES2658395T3 (enExample)
WO (1) WO2013152198A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519657A (ja) * 2013-03-14 2016-07-07 ライジェル ファーマシューティカルズ， インコーポレイテッド プロテインキナーゼｃ阻害剤およびその使用

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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HUE046727T2 (hu) * 2013-12-06 2020-03-30 Vertex Pharma Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
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