CA2867760C - Indolizinyl derivatives as protein kinase c inhibitors and uses thereof - Google Patents

Indolizinyl derivatives as protein kinase c inhibitors and uses thereof Download PDF

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Publication number
CA2867760C
CA2867760C CA2867760A CA2867760A CA2867760C CA 2867760 C CA2867760 C CA 2867760C CA 2867760 A CA2867760 A CA 2867760A CA 2867760 A CA2867760 A CA 2867760A CA 2867760 C CA2867760 C CA 2867760C
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compound
substituted
amino
ylamino
fluoro
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English (en)
French (fr)
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CA2867760A1 (en
Inventor
Rajinder Singh
Matthew Duncton
Jing Zhang
Salvador Alvarez
Kin Tso
Sacha Holland
Rose Yen
Rao Kolluri
Thilo Heckrodt
Yan Chen
Esteban Masuda
Hui Li
Donald G. Payan
Ryan Kelley
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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CA2867760A 2012-04-04 2013-04-04 Indolizinyl derivatives as protein kinase c inhibitors and uses thereof Active CA2867760C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261620232P 2012-04-04 2012-04-04
US61/620,232 2012-04-04
US201361783647P 2013-03-14 2013-03-14
US61/783,647 2013-03-14
PCT/US2013/035285 WO2013152198A1 (en) 2012-04-04 2013-04-04 Protein kinase c inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CA2867760A1 CA2867760A1 (en) 2013-10-10
CA2867760C true CA2867760C (en) 2021-10-05

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CA2867760A Active CA2867760C (en) 2012-04-04 2013-04-04 Indolizinyl derivatives as protein kinase c inhibitors and uses thereof

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US (3) US9321763B2 (enExample)
EP (1) EP2833889B1 (enExample)
JP (1) JP6113828B2 (enExample)
CA (1) CA2867760C (enExample)
ES (1) ES2658395T3 (enExample)
WO (1) WO2013152198A1 (enExample)

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* Cited by examiner, † Cited by third party
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US9321763B2 (en) 2012-04-04 2016-04-26 Rigel Pharmaceuticals, Inc. Protein kinase C inhibitors and uses thereof
US9169249B2 (en) 2013-03-14 2015-10-27 Rigel Pharmaceuticals, Inc. Protein kinase C inhibitors and uses thereof
HUE046727T2 (hu) * 2013-12-06 2020-03-30 Vertex Pharma Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
BR112016017444A2 (pt) * 2014-01-29 2017-10-10 Inst Nat Sante Rech Med molécula e método
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9399637B2 (en) 2014-03-28 2016-07-26 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
US10059689B2 (en) 2014-10-14 2018-08-28 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
HUE057041T2 (hu) 2015-07-06 2022-04-28 Alkermes Inc Hiszton deacetiláz hetero-halogén gátlói
EP3347097B1 (en) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
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