JP6096798B2 - ポリアミノカルボキシレートキレート剤の精製方法 - Google Patents

ポリアミノカルボキシレートキレート剤の精製方法 Download PDF

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Publication number
JP6096798B2
JP6096798B2 JP2014542999A JP2014542999A JP6096798B2 JP 6096798 B2 JP6096798 B2 JP 6096798B2 JP 2014542999 A JP2014542999 A JP 2014542999A JP 2014542999 A JP2014542999 A JP 2014542999A JP 6096798 B2 JP6096798 B2 JP 6096798B2
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polyaminocarboxylate
resin
acid
less
chelator
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Japanese (ja)
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JP2015501807A (ja
Inventor
ジャグディーッシュ バブ ランジセッティ
ジャグディーッシュ バブ ランジセッティ
マニック レディ プラグルラ
マニック レディ プラグルラ
ラジェシュ ブーデティ
ラジェシュ ブーデティ
Original Assignee
バイオフォア インディア ファーマシューティカルズ プライベート リミテッド
バイオフォア インディア ファーマシューティカルズ プライベート リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2014542999A 2011-11-25 2012-11-26 ポリアミノカルボキシレートキレート剤の精製方法 Expired - Fee Related JP6096798B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN4068CH2011 2011-11-25
IN4068/CHE/2011 2011-11-25
PCT/IN2012/000768 WO2013076743A2 (en) 2011-11-25 2012-11-26 Process for the purification of polyaminocarboxylates

Publications (2)

Publication Number Publication Date
JP2015501807A JP2015501807A (ja) 2015-01-19
JP6096798B2 true JP6096798B2 (ja) 2017-03-15

Family

ID=48470389

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014542999A Expired - Fee Related JP6096798B2 (ja) 2011-11-25 2012-11-26 ポリアミノカルボキシレートキレート剤の精製方法

Country Status (11)

Country Link
US (1) US10106489B2 (pt)
EP (1) EP2782900B1 (pt)
JP (1) JP6096798B2 (pt)
KR (1) KR101832027B1 (pt)
CN (1) CN104169252B (pt)
AU (1) AU2012342016C1 (pt)
BR (1) BR112014012429A2 (pt)
CA (1) CA2857014C (pt)
IL (1) IL232735A (pt)
RU (1) RU2621896C2 (pt)
WO (1) WO2013076743A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10195295B2 (en) 2014-02-06 2019-02-05 T2Pharma Gmbh Process for purifying 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
CN106279220B (zh) * 2015-06-05 2018-10-30 四川科伦药物研究院有限公司 一种适于产业化的钆弗塞胺的纯化方法
DE102015013939A1 (de) 2015-09-15 2017-03-16 be imaging GmbH Verfahren zur Herstellung von Gadotersäure (Gd-DOTA)- Komplexen
GB201522412D0 (en) * 2015-12-18 2016-02-03 Ge Healthcare As Dota synthesis
CN108264491B (zh) * 2016-12-30 2022-09-16 威智医药有限公司 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3043867A (en) 1959-10-16 1962-07-10 Dow Chemical Co Method for the purification of aminocarboxylic acids
US5334729A (en) * 1989-06-29 1994-08-02 Associated Universities, Inc. Stable radiometal antibody immunoconjugates
US5491259A (en) * 1994-09-13 1996-02-13 The Dow Chemical Company Process to produce aminocarboxylic acids containing low residual salt
IT1275426B (it) * 1995-05-16 1997-08-07 Bracco Spa Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
EP1762563A1 (en) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Process for the preparation of contrast agents
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
WO2014068589A2 (en) 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of (1-{9-[(4s, 2r, 3r, 5r)-3, 4-dihydroxy-5-(hydroxymethyl) oxolan-2-yl)-6-aminopurin-2-yl} pyrazole-4-yl)-n-methylcarboxamide

Also Published As

Publication number Publication date
EP2782900A4 (en) 2015-08-12
CA2857014C (en) 2018-08-14
WO2013076743A2 (en) 2013-05-30
US20140323719A1 (en) 2014-10-30
BR112014012429A2 (pt) 2017-06-06
IL232735A0 (en) 2014-08-03
EP2782900B1 (en) 2018-01-10
KR101832027B1 (ko) 2018-04-04
RU2014125548A (ru) 2015-12-27
IL232735A (en) 2017-05-29
US10106489B2 (en) 2018-10-23
AU2012342016A1 (en) 2014-06-26
EP2782900A2 (en) 2014-10-01
CA2857014A1 (en) 2013-05-30
AU2012342016C1 (en) 2016-09-01
AU2012342016B2 (en) 2016-05-19
RU2621896C2 (ru) 2017-06-08
CN104169252A (zh) 2014-11-26
WO2013076743A3 (en) 2014-05-30
KR20140097411A (ko) 2014-08-06
CN104169252B (zh) 2017-03-22
JP2015501807A (ja) 2015-01-19

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