JP6096675B2 - 結核の治療又は予防に適切なリポソーム製剤 - Google Patents
結核の治療又は予防に適切なリポソーム製剤 Download PDFInfo
- Publication number
- JP6096675B2 JP6096675B2 JP2013547850A JP2013547850A JP6096675B2 JP 6096675 B2 JP6096675 B2 JP 6096675B2 JP 2013547850 A JP2013547850 A JP 2013547850A JP 2013547850 A JP2013547850 A JP 2013547850A JP 6096675 B2 JP6096675 B2 JP 6096675B2
- Authority
- JP
- Japan
- Prior art keywords
- liposome preparation
- suspension
- liposome
- pharmaceutical composition
- tuberculosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/32—Mycobacterium
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11150072.4 | 2011-01-04 | ||
| EP11150072A EP2471511A1 (en) | 2011-01-04 | 2011-01-04 | Liposome formulation suitable for treating or preventing tuberculosis |
| EP11183487.5 | 2011-09-30 | ||
| EP11183487 | 2011-09-30 | ||
| PCT/EP2012/050080 WO2012093137A1 (en) | 2011-01-04 | 2012-01-04 | Liposome formulation suitable for treating or preventing tuberculosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501768A JP2014501768A (ja) | 2014-01-23 |
| JP2014501768A5 JP2014501768A5 (enExample) | 2015-02-19 |
| JP6096675B2 true JP6096675B2 (ja) | 2017-03-15 |
Family
ID=45509459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013547850A Active JP6096675B2 (ja) | 2011-01-04 | 2012-01-04 | 結核の治療又は予防に適切なリポソーム製剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9877917B2 (enExample) |
| EP (1) | EP2661253B1 (enExample) |
| JP (1) | JP6096675B2 (enExample) |
| KR (1) | KR101820026B1 (enExample) |
| CN (2) | CN107296793A (enExample) |
| BR (1) | BR112013017267B1 (enExample) |
| CA (1) | CA2823747C (enExample) |
| CO (1) | CO6801728A2 (enExample) |
| ES (1) | ES2631556T3 (enExample) |
| HU (1) | HUE032409T2 (enExample) |
| IL (1) | IL227338B (enExample) |
| LT (1) | LT2661253T (enExample) |
| MX (1) | MX341918B (enExample) |
| PL (1) | PL2661253T3 (enExample) |
| RU (1) | RU2648842C2 (enExample) |
| SI (1) | SI2661253T1 (enExample) |
| WO (1) | WO2012093137A1 (enExample) |
| ZA (1) | ZA201305697B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720657B (zh) * | 2013-11-19 | 2017-01-04 | 广东丸美生物技术股份有限公司 | 一种可变形脂质体的制备方法，及其制备的可变性脂质体 |
| JP2016163851A (ja) * | 2015-03-06 | 2016-09-08 | 国立大学法人福井大学 | コンポジット型可溶化ナノリポソーム及びその製造方法 |
| RU2631607C1 (ru) * | 2016-11-22 | 2017-09-25 | Владислав Николаевич Ласкавый | Средство для профилактики лейкоза крупного рогатого скота и способ его применения |
| GB201707700D0 (en) * | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| CN109675059A (zh) * | 2019-01-23 | 2019-04-26 | 青岛大学 | 一种类杆菌脂质体及其制备方法与应用 |
| US11202823B2 (en) * | 2019-04-05 | 2021-12-21 | Northwestern University | Multi-subunit vaccines to elicit both MHC- and CD1-restricted T cell responses |
| CN120456894A (zh) * | 2021-10-14 | 2025-08-08 | 爱琴韦尔制药公司 | 用于治疗活动性结核病的脂质体制剂 |
| CN115850520A (zh) * | 2022-12-12 | 2023-03-28 | 中国农业大学 | 新型结核病亚单位疫苗al的制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU720288B2 (en) | 1995-02-22 | 2000-05-25 | Adcock Ingram Limited | A method for the isolation and purification of lipid cell-wall components |
| GB9813100D0 (en) * | 1998-06-18 | 1998-08-19 | Secr Defence | Method of forming liposomes |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| CA2453173C (en) | 2001-07-04 | 2013-12-10 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| BR0103887C1 (pt) * | 2001-07-17 | 2005-11-08 | Univ Minas Gerais | Composições imunogênicas contendo microesferas biodegradáveis encapsulando antìgenos, vetores gênicos e adjuvantes |
| ES2231037B1 (es) * | 2003-10-31 | 2005-12-16 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
| EP1761662A4 (en) | 2004-07-01 | 2010-02-03 | Univ California | PROTEOMICS WITH HIGH THROUGHPUT |
| SI2457926T1 (sl) | 2005-04-29 | 2015-01-30 | Glaxosmithkline Biologicals S.A. | Nov postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis |
| CN101283085A (zh) * | 2005-08-11 | 2008-10-08 | 哈佛大学的校长及成员们 | 用于干燥细胞形式的方法和组合物 |
| WO2007022152A2 (en) * | 2005-08-15 | 2007-02-22 | The Research Foundation Of State University Of New York | Lipid nano particulates containing antigens as cancer vaccines |
| WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| US20090081284A1 (en) | 2006-04-20 | 2009-03-26 | Tokai University Educational System | Therapeutic agent for allergy containing liposome having oligosaccharide on its surface |
| EP2076244B1 (en) | 2006-10-10 | 2016-12-07 | Jina Pharmaceuticals Inc. | Aqueous systems for the preparation of lipid-based pharmaceutical compounds; compositions, methods, and uses thereof |
| ES2307402B1 (es) | 2006-10-30 | 2009-09-30 | Archivel Farma, S.L. | Vacuna profilactica contra la tuberculosis. |
| BRPI0705630F8 (pt) * | 2007-12-12 | 2022-01-18 | Univ Estadual Campinas Unicamp | Processo de produção de vacina gênica lipossomal, vacina gênica lipossomal e uso da mesma |
| US8741313B2 (en) * | 2008-01-11 | 2014-06-03 | Emory University | Polypeptide vaccine and vaccination strategy against mycobacterium |
| ES2335177B1 (es) | 2008-09-19 | 2011-02-28 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
| KR20170072366A (ko) * | 2009-04-24 | 2017-06-26 | 스태튼스 세룸 인스티튜트 | 재활성화를 예방하기 위한 결핵 백신 |
| DK2651436T3 (da) | 2010-12-14 | 2016-06-20 | Glaxosmithkline Biologicals Sa | Mycobakterie antigen sammensætning. |
-
2012
- 2012-01-04 CN CN201710129725.4A patent/CN107296793A/zh active Pending
- 2012-01-04 LT LTEP12700624.5T patent/LT2661253T/lt unknown
- 2012-01-04 SI SI201230956A patent/SI2661253T1/sl unknown
- 2012-01-04 EP EP12700624.5A patent/EP2661253B1/en active Active
- 2012-01-04 BR BR112013017267-3A patent/BR112013017267B1/pt active IP Right Grant
- 2012-01-04 RU RU2013136379A patent/RU2648842C2/ru active
- 2012-01-04 PL PL12700624T patent/PL2661253T3/pl unknown
- 2012-01-04 MX MX2013007855A patent/MX341918B/es active IP Right Grant
- 2012-01-04 ES ES12700624.5T patent/ES2631556T3/es active Active
- 2012-01-04 CA CA2823747A patent/CA2823747C/en active Active
- 2012-01-04 HU HUE12700624A patent/HUE032409T2/en unknown
- 2012-01-04 JP JP2013547850A patent/JP6096675B2/ja active Active
- 2012-01-04 WO PCT/EP2012/050080 patent/WO2012093137A1/en not_active Ceased
- 2012-01-04 KR KR1020137020385A patent/KR101820026B1/ko active Active
- 2012-01-04 CN CN201280011787.0A patent/CN103796640A/zh active Pending
- 2012-01-04 US US13/978,001 patent/US9877917B2/en active Active
-
2013
- 2013-07-04 CO CO13158421A patent/CO6801728A2/es unknown
- 2013-07-04 IL IL227338A patent/IL227338B/en active IP Right Grant
- 2013-07-26 ZA ZA2013/05697A patent/ZA201305697B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9877917B2 (en) | 2018-01-30 |
| ES2631556T3 (es) | 2017-09-01 |
| CN107296793A (zh) | 2017-10-27 |
| IL227338A0 (en) | 2013-09-30 |
| IL227338B (en) | 2019-01-31 |
| CA2823747C (en) | 2019-07-23 |
| CO6801728A2 (es) | 2013-11-29 |
| MX2013007855A (es) | 2013-10-25 |
| SI2661253T1 (sl) | 2017-07-31 |
| ZA201305697B (en) | 2014-07-30 |
| BR112013017267B1 (pt) | 2021-06-22 |
| CA2823747A1 (en) | 2012-07-12 |
| KR101820026B1 (ko) | 2018-01-18 |
| WO2012093137A1 (en) | 2012-07-12 |
| EP2661253B1 (en) | 2017-04-19 |
| RU2013136379A (ru) | 2015-02-10 |
| EP2661253A1 (en) | 2013-11-13 |
| KR20140021538A (ko) | 2014-02-20 |
| MX341918B (es) | 2016-09-07 |
| JP2014501768A (ja) | 2014-01-23 |
| HUE032409T2 (en) | 2017-09-28 |
| BR112013017267A2 (pt) | 2018-01-09 |
| RU2648842C2 (ru) | 2018-03-28 |
| BR112013017267A8 (pt) | 2018-11-06 |
| CN103796640A (zh) | 2014-05-14 |
| LT2661253T (lt) | 2017-05-25 |
| US20150050327A1 (en) | 2015-02-19 |
| WO2012093137A9 (en) | 2012-12-27 |
| PL2661253T3 (pl) | 2017-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9877917B2 (en) | Liposome formulation suitable for treating or preventing tuberculosis | |
| Keiser et al. | A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA | |
| RU2526910C2 (ru) | Профилактическая вакцина от туберкулеза | |
| JP6655549B2 (ja) | 免疫応答を誘導するための新規方法 | |
| AU2012365465B2 (en) | MTB-C vaccine against asthma | |
| CN120456894A (zh) | 用于治疗活动性结核病的脂质体制剂 | |
| EP2332571A1 (en) | Immunotherapeutic agent suitable for the primary prophylaxis of tuberculosis | |
| US20260137766A1 (en) | Liposome formulations for treatment of active tuberculosis | |
| EP2471511A1 (en) | Liposome formulation suitable for treating or preventing tuberculosis | |
| US10973900B2 (en) | Dried composition | |
| TW201929896A (zh) | 用於常在病原疾病進展之全面性疫苗設計 | |
| EA053229B1 (ru) | Применение липосомных композиций для лечения активной формы туберкулеза | |
| HK1171659A (en) | Liposome formulation suitable for treating or preventing tuberculosis | |
| WO2025191183A1 (en) | Liposome formulations for the treatment of cancer | |
| SE2200142A1 (en) | Chrisvacc |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130806 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141222 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141222 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20151028 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160128 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160229 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160803 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161205 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20161213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170123 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170130 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170216 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6096675 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |