JP6095195B2 - 新規二環式チアゾール化合物 - Google Patents

新規二環式チアゾール化合物 Download PDF

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Publication number
JP6095195B2
JP6095195B2 JP2014556280A JP2014556280A JP6095195B2 JP 6095195 B2 JP6095195 B2 JP 6095195B2 JP 2014556280 A JP2014556280 A JP 2014556280A JP 2014556280 A JP2014556280 A JP 2014556280A JP 6095195 B2 JP6095195 B2 JP 6095195B2
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JP
Japan
Prior art keywords
group
substituted
unsubstituted
mmol
thiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014556280A
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English (en)
Japanese (ja)
Other versions
JP2015517453A (ja
JP2015517453A5 (enExample
Inventor
匡明 澤
匡明 澤
森山　英樹
英樹 森山
哲司 山田
哲司 山田
美紀 下重
美紀 下重
裕介 川瀬
裕介 川瀬
佑子 宇野
佑子 宇野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carna Biosciences Inc
National Cancer Center Japan
Original Assignee
Carna Biosciences Inc
National Cancer Center Japan
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Filing date
Publication date
Application filed by Carna Biosciences Inc, National Cancer Center Japan filed Critical Carna Biosciences Inc
Publication of JP2015517453A publication Critical patent/JP2015517453A/ja
Publication of JP2015517453A5 publication Critical patent/JP2015517453A5/ja
Application granted granted Critical
Publication of JP6095195B2 publication Critical patent/JP6095195B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2014556280A 2012-05-24 2013-05-22 新規二環式チアゾール化合物 Expired - Fee Related JP6095195B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/479,396 2012-05-24
US13/479,396 US20130317218A1 (en) 2012-05-24 2012-05-24 Novel bicyclic thiazole compounds
PCT/JP2013/064960 WO2013176293A1 (en) 2012-05-24 2013-05-22 Novel bicyclic thiazole compounds

Publications (3)

Publication Number Publication Date
JP2015517453A JP2015517453A (ja) 2015-06-22
JP2015517453A5 JP2015517453A5 (enExample) 2015-08-20
JP6095195B2 true JP6095195B2 (ja) 2017-03-15

Family

ID=48628877

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014556280A Expired - Fee Related JP6095195B2 (ja) 2012-05-24 2013-05-22 新規二環式チアゾール化合物

Country Status (6)

Country Link
US (2) US20130317218A1 (enExample)
EP (1) EP2855470B1 (enExample)
JP (1) JP6095195B2 (enExample)
KR (1) KR102042296B1 (enExample)
CN (1) CN104321321B (enExample)
WO (1) WO2013176293A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130317218A1 (en) 2012-05-24 2013-11-28 Masaaki Sawa Novel bicyclic thiazole compounds
WO2016202935A1 (en) * 2015-06-19 2016-12-22 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
KR102710871B1 (ko) * 2015-10-14 2024-09-26 닛산 가가쿠 가부시키가이샤 액정 배향제, 액정 배향막 및 액정 표시 소자
WO2024111626A1 (ja) * 2022-11-25 2024-05-30 カルナバイオサイエンス株式会社 新規チアゾール誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4038661B2 (ja) * 2002-05-21 2008-01-30 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
US8323943B2 (en) * 2008-02-21 2012-12-04 National Cancer Center Screening method for anticancer drug
US20100137386A1 (en) * 2008-12-01 2010-06-03 Tesshi Yamada Tnik inhibitor and the use
US20130317218A1 (en) 2012-05-24 2013-11-28 Masaaki Sawa Novel bicyclic thiazole compounds

Also Published As

Publication number Publication date
WO2013176293A1 (en) 2013-11-28
CN104321321A (zh) 2015-01-28
US20150133656A1 (en) 2015-05-14
JP2015517453A (ja) 2015-06-22
US9102637B2 (en) 2015-08-11
EP2855470B1 (en) 2018-10-17
KR20150014931A (ko) 2015-02-09
KR102042296B1 (ko) 2019-11-07
EP2855470A1 (en) 2015-04-08
US20130317218A1 (en) 2013-11-28
CN104321321B (zh) 2017-07-07

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