JP6092118B2 - ニ環式ｐｋｍ２活性化剤 - Google Patents

ニ環式ｐｋｍ２活性化剤 Download PDF

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Publication number
JP6092118B2
JP6092118B2 JP2013546384A JP2013546384A JP6092118B2 JP 6092118 B2 JP6092118 B2 JP 6092118B2 JP 2013546384 A JP2013546384 A JP 2013546384A JP 2013546384 A JP2013546384 A JP 2013546384A JP 6092118 B2 JP6092118 B2 JP 6092118B2
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alkyl
formula
independently selected
heterocyclyl
compound
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Japanese (ja)
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JP2014500330A (ja
JP2014500330A5 (enExample
Inventor
フランセスコ ジー． サリトゥロ，
フランセスコ ジー． サリトゥロ，
ジェフリー オー． サウンダーズ，
ジェフリー オー． サウンダーズ，
Original Assignee
アジオス ファーマシューティカルズ， インコーポレイテッド
アジオス ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013546384A 2010-12-21 2011-12-21 ニ環式ｐｋｍ２活性化剤 Expired - Fee Related JP6092118B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201061425557P 2010-12-21 2010-12-21
US201061425513P 2010-12-21 2010-12-21
US201061425499P 2010-12-21 2010-12-21
US201061425528P 2010-12-21 2010-12-21
US61/425,499 2010-12-21
US61/425,528 2010-12-21
US61/425,557 2010-12-21
US61/425,513 2010-12-21
PCT/US2011/066595 WO2012088314A1 (en) 2010-12-21 2011-12-21 Bicyclic pkm2 activators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016066131A Division JP2016153418A (ja) 2010-12-21 2016-03-29 ニ環式ｐｋｍ２活性化剤

Publications (3)

Publication Number Publication Date
JP2014500330A JP2014500330A (ja) 2014-01-09
JP2014500330A5 JP2014500330A5 (enExample) 2015-02-12
JP6092118B2 true JP6092118B2 (ja) 2017-03-08

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JP2013546384A Expired - Fee Related JP6092118B2 (ja) 2010-12-21 2011-12-21 ニ環式ｐｋｍ２活性化剤
JP2016066131A Withdrawn JP2016153418A (ja) 2010-12-21 2016-03-29 ニ環式ｐｋｍ２活性化剤

Family Applications After (1)

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JP2016066131A Withdrawn JP2016153418A (ja) 2010-12-21 2016-03-29 ニ環式ｐｋｍ２活性化剤

Country Status (7)

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US (3) US9328077B2 (enExample)
EP (1) EP2655350B1 (enExample)
JP (2) JP6092118B2 (enExample)
CA (1) CA2822432C (enExample)
ES (1) ES2569712T3 (enExample)
MX (1) MX336022B (enExample)
WO (1) WO2012088314A1 (enExample)

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BRPI1011587B1 (pt) 2009-06-29 2020-03-24 Agios Pharmaceuticals, Inc. Compostos de quinolina sulfonamida com atividade moduladora de pmk2 e uso dos mesmos
CA2822432C (en) * 2010-12-21 2019-09-24 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
ES2644758T3 (es) 2012-10-16 2017-11-30 Tolero Pharmaceuticals, Inc. Moduladores de PKM2 y métodos para su uso
CN105272904B (zh) * 2014-07-18 2019-04-09 中国科学院广州生物医药与健康研究院 N-苯基酰胺类化合物及其应用
DE102017005091A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one
DE102017005089A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one
HUE045261T2 (hu) 2017-03-20 2019-12-30 Forma Therapeutics Inc Pirrolopirrol kompozíciók piruvát kináz (PKR) aktivátorokként
WO2019075367A1 (en) 2017-10-13 2019-04-18 Tolero Pharmaceuticals, Inc. PKM2 ACTIVATORS IN COMBINATION WITH OXYGEN REACTIVE SPECIES FOR THE TREATMENT OF CANCER
JP2020537669A (ja) 2017-10-19 2020-12-24 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 ピラゾリル基を含む三環式誘導体、その製造方法及び用途
US12122778B2 (en) 2018-09-19 2024-10-22 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113166060B (zh) 2018-09-19 2024-01-09 诺沃挪第克健康护理股份公司 用丙酮酸激酶激活化合物治疗镰状细胞病
JP7547360B2 (ja) 2019-03-22 2024-09-09 スミトモ ファーマ オンコロジー， インコーポレイテッド Ｐｋｍ２モジュレーターを含む組成物およびそれを使用する処置の方法
ES3042390T3 (en) 2019-09-19 2025-11-20 Novo Nordisk Healthcare Ag Pyruvate kinase r (pkr) activating compositions
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US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

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JP2014500330A (ja) 2014-01-09
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US9328077B2 (en) 2016-05-03
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US20140011804A1 (en) 2014-01-09
EP2655350A1 (en) 2013-10-30
WO2012088314A1 (en) 2012-06-28
US10087169B2 (en) 2018-10-02
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