JP6082396B2 - 誤差補償を伴うバイオセンサ - Google Patents
誤差補償を伴うバイオセンサ Download PDFInfo
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- JP6082396B2 JP6082396B2 JP2014531954A JP2014531954A JP6082396B2 JP 6082396 B2 JP6082396 B2 JP 6082396B2 JP 2014531954 A JP2014531954 A JP 2014531954A JP 2014531954 A JP2014531954 A JP 2014531954A JP 6082396 B2 JP6082396 B2 JP 6082396B2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Electrochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537145P | 2011-09-21 | 2011-09-21 | |
| US61/537,145 | 2011-09-21 | ||
| PCT/US2012/056280 WO2013043839A1 (en) | 2011-09-21 | 2012-09-20 | Biosensor with error compensation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527186A JP2014527186A (ja) | 2014-10-09 |
| JP2014527186A5 JP2014527186A5 (cg-RX-API-DMAC7.html) | 2015-11-12 |
| JP6082396B2 true JP6082396B2 (ja) | 2017-02-15 |
Family
ID=47881000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531954A Active JP6082396B2 (ja) | 2011-09-21 | 2012-09-20 | 誤差補償を伴うバイオセンサ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9775806B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3315123B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6082396B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140063829A (cg-RX-API-DMAC7.html) |
| ES (2) | ES2663097T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX350696B (cg-RX-API-DMAC7.html) |
| TW (1) | TWI600892B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013043839A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103003692B (zh) * | 2010-03-22 | 2015-01-14 | 拜尔健康护理有限责任公司 | 用于生物传感器的剩余补偿 |
| CA2902545A1 (en) | 2013-03-14 | 2014-10-02 | Bayer Healthcare Llc | Progressive approximation of sample analyte concentration |
| CA2902541A1 (en) * | 2013-03-14 | 2014-10-02 | Bayer Healthcare Llc | System error compensation of analyte concentration determinations |
| US9958410B2 (en) * | 2013-03-14 | 2018-05-01 | Ascensia Diabetes Care Holdings Ag | Normalized calibration of analyte concentration determinations |
| WO2014160568A2 (en) * | 2013-03-26 | 2014-10-02 | Waters Technologies Corporation | Method for extending the dynamic range of absorbance deterctors |
| GB2531728A (en) * | 2014-10-27 | 2016-05-04 | Cilag Gmbh Int | Method for determining diffusion |
| US11644434B2 (en) | 2015-05-15 | 2023-05-09 | Ascensia Diabetes Care Holdings Ag | Biosensor system analyte measurement |
| CA3028348A1 (en) * | 2016-07-12 | 2018-01-18 | Ascensia Diabetes Care Holdings Ag | Method for electrochemical analysis by use of alternating output signals from two electrodes |
| JP7074753B2 (ja) * | 2016-12-05 | 2022-05-24 | アセンシア・ダイアベティス・ケア・ホールディングス・アーゲー | リスク因子モニタリング |
| US11484876B2 (en) * | 2018-12-02 | 2022-11-01 | Polymer Technology Systems, Inc. | Systems and methods for an e-gating feature in an electrochemical test strip |
| EP3920798B1 (en) | 2019-02-05 | 2024-08-14 | Ascensia Diabetes Care Holdings AG | Apparatus and methods for probing sensor operation of continuous analyte sensing and auto-calibration |
| US11445944B2 (en) | 2019-02-22 | 2022-09-20 | Ascensia Diabetes Care Holdings Ag | Methods and apparatus for analyte concentration monitoring using harmonic relationships |
| CN109884150B (zh) * | 2019-03-08 | 2021-05-14 | 武汉璟泓科技股份有限公司 | 一种红细胞积压校正方法及存储介质 |
| US11963763B2 (en) | 2019-09-10 | 2024-04-23 | Ascensia Diabetes Care Holdings Ag | Methods and apparatus information gathering, error detection and analyte concentration determination during continuous analyte sensing |
| CN112432988B (zh) * | 2020-11-25 | 2023-03-03 | 重庆迈联医疗科技有限公司 | 电化学测试系统的温度校正方法 |
| CN114777888B (zh) * | 2022-04-28 | 2024-09-20 | 四川泛华航空仪表电器有限公司 | 一种基于光纤光栅压力传感器液位测量误差补偿修正方法 |
| CN119224239B (zh) * | 2024-12-02 | 2025-04-18 | 无锡零界净化设备股份有限公司 | 一种用于离线式浓度监测仪的信号增强方法及平台 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| US4750496A (en) | 1987-01-28 | 1988-06-14 | Xienta, Inc. | Method and apparatus for measuring blood glucose concentration |
| US5243516A (en) | 1989-12-15 | 1993-09-07 | Boehringer Mannheim Corporation | Biosensing instrument and method |
| US5508171A (en) | 1989-12-15 | 1996-04-16 | Boehringer Mannheim Corporation | Assay method with enzyme electrode system |
| FR2701117B1 (fr) | 1993-02-04 | 1995-03-10 | Asulab Sa | Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose. |
| US5366609A (en) | 1993-06-08 | 1994-11-22 | Boehringer Mannheim Corporation | Biosensing meter with pluggable memory key |
| US5352351A (en) | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
| US5582697A (en) | 1995-03-17 | 1996-12-10 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
| US5620579A (en) | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
| US5723284A (en) | 1996-04-01 | 1998-03-03 | Bayer Corporation | Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood |
| EP0958495B1 (en) | 1997-02-06 | 2002-11-13 | Therasense, Inc. | Small volume in vitro analyte sensor |
| US6391558B1 (en) | 1997-03-18 | 2002-05-21 | Andcare, Inc. | Electrochemical detection of nucleic acid sequences |
| US6391645B1 (en) | 1997-05-12 | 2002-05-21 | Bayer Corporation | Method and apparatus for correcting ambient temperature effect in biosensors |
| US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
| CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
| HU222809B1 (hu) | 1997-10-03 | 2003-10-28 | 77 Elektronika Műszeripari Kft. | Eljárás és készülék kémiai összetevőnek anyagmintából, különösen vér glükóztartalmának vérmintából történő meghatározásához |
| US7494816B2 (en) * | 1997-12-22 | 2009-02-24 | Roche Diagnostic Operations, Inc. | System and method for determining a temperature during analyte measurement |
| EP1042667B1 (en) | 1997-12-22 | 2009-06-17 | Roche Diagnostics Operations, Inc. | Meter |
| CA2311487C (en) | 1998-05-13 | 2004-02-10 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| JP4256588B2 (ja) | 1998-05-20 | 2009-04-22 | アークレイ株式会社 | 統計的手法を用いた電気化学的測定方法および測定装置 |
| US6475372B1 (en) | 2000-02-02 | 2002-11-05 | Lifescan, Inc. | Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations |
| CA2305922C (en) | 1999-08-02 | 2005-09-20 | Bayer Corporation | Improved electrochemical sensor design |
| JP3655587B2 (ja) | 1999-09-20 | 2005-06-02 | ロシュ ダイアグノスティックス コーポレーション | 連続アナライトモニタリング用小型バイオセンサー |
| US6616819B1 (en) | 1999-11-04 | 2003-09-09 | Therasense, Inc. | Small volume in vitro analyte sensor and methods |
| JP4050434B2 (ja) | 1999-11-29 | 2008-02-20 | 松下電器産業株式会社 | サンプルの弁別方法 |
| US7351323B2 (en) | 2001-01-17 | 2008-04-01 | Arkray, Inc. | Quantitative analyzing method and quantitative analyzer using sensor |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| AU784254B2 (en) | 2001-05-21 | 2006-03-02 | Bayer Corporation | Improved electrochemical sensor |
| US6982178B2 (en) | 2002-06-10 | 2006-01-03 | E Ink Corporation | Components and methods for use in electro-optic displays |
| US6797150B2 (en) | 2001-10-10 | 2004-09-28 | Lifescan, Inc. | Determination of sample volume adequacy in biosensor devices |
| WO2003034055A1 (en) | 2001-10-12 | 2003-04-24 | Arkray, Inc. | Concentration measuring method and concentration measuring device |
| CA2419213C (en) | 2002-03-07 | 2011-06-21 | Bayer Healthcare Llc | Improved electrical sensor |
| US6946299B2 (en) | 2002-04-25 | 2005-09-20 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
| US6964871B2 (en) | 2002-04-25 | 2005-11-15 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
| AU2003234944A1 (en) | 2002-08-27 | 2004-03-18 | Bayer Healthcare, Llc | Methods of Determining Glucose Concentration in Whole Blood Samples |
| US7132041B2 (en) | 2003-02-11 | 2006-11-07 | Bayer Healthcare Llc | Methods of determining the concentration of an analyte in a fluid test sample |
| US7452457B2 (en) | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
| EP1656554B1 (en) | 2003-08-21 | 2018-11-07 | AgaMatrix, Inc. | Method and apparatus for assay of electrochemical properties |
| JP4449431B2 (ja) | 2003-11-19 | 2010-04-14 | パナソニック株式会社 | 基質濃度の測定方法 |
| WO2005078437A1 (en) * | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Electrochemical biosensor |
| CN1938590B (zh) | 2004-04-19 | 2010-05-05 | 松下电器产业株式会社 | 血液成分的测定方法、该方法中使用的生物传感器和测定装置 |
| CA2566495C (en) | 2004-05-14 | 2010-08-17 | Yingping Deng | Performing hematocrit adjustment in glucose assays |
| CN102507695B (zh) | 2004-10-12 | 2015-12-02 | 拜尔健康护理有限责任公司 | 扩散阻挡层中的浓度测定 |
| GB0428547D0 (en) | 2004-12-31 | 2005-02-09 | Euroflow Uk Ltd | Methods and apparatus for observing vessel contents |
| GB0501826D0 (en) | 2005-01-28 | 2005-03-09 | Melys Diagnostics Ltd | Apparatus for measurement of analyte concentration |
| TW200641352A (en) | 2005-04-08 | 2006-12-01 | Bayer Healthcare Llc | Oxidizable species as an internal reference in control solutions for biosensors |
| US7517439B2 (en) | 2005-04-15 | 2009-04-14 | Agamatrix, Inc. | Error detection in analyte measurements based on measurement of system resistance |
| KR101503072B1 (ko) | 2005-07-20 | 2015-03-16 | 바이엘 헬스케어 엘엘씨 | 게이트형 전류 측정법 |
| US8404100B2 (en) | 2005-09-30 | 2013-03-26 | Bayer Healthcare Llc | Gated voltammetry |
| CA2643163C (en) * | 2006-02-27 | 2020-01-28 | Bayer Healthcare Llc | Temperature-adjusted analyte determination for biosensor systems |
| US7966859B2 (en) | 2006-05-03 | 2011-06-28 | Bayer Healthcare Llc | Underfill detection system for a biosensor |
| TWI431273B (zh) | 2006-05-08 | 2014-03-21 | Bayer Healthcare Llc | 生物感測器用之異常輸出偵測系統 |
| KR101040860B1 (ko) * | 2006-07-05 | 2011-06-14 | 파나소닉 주식회사 | 액체 시료 측정 방법 및 장치 |
| US20080248581A1 (en) | 2007-04-06 | 2008-10-09 | Bayer Healthcare Llc | Method for performing correction of blood glucose assay bias using blood hemoglobin concentration |
| MX2010000971A (es) | 2007-07-26 | 2010-03-01 | Home Diagnostics Inc | Sistema y metodos que determinan concentracion de analito utilizando amperometria resuelta en tiempo. |
| US8101062B2 (en) | 2007-07-26 | 2012-01-24 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
| JP5812603B2 (ja) | 2007-12-10 | 2015-11-17 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ | 勾配ベース補正 |
| CN102239406A (zh) | 2008-12-08 | 2011-11-09 | 拜尔健康护理有限责任公司 | 具有信号调节功能的生物传感器系统 |
| US8668819B2 (en) | 2009-11-10 | 2014-03-11 | Bayer Healthcare Llc | Underfill recognition system for a biosensor |
| EP3104176B1 (en) | 2010-06-07 | 2018-08-29 | Ascensia Diabetes Care Holdings AG | Slope-based compensation including secondary output signals |
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2012
- 2012-09-20 EP EP17206329.9A patent/EP3315123B1/en active Active
- 2012-09-20 EP EP19190242.8A patent/EP3586831A1/en not_active Withdrawn
- 2012-09-20 KR KR1020147010121A patent/KR20140063829A/ko not_active Withdrawn
- 2012-09-20 WO PCT/US2012/056280 patent/WO2013043839A1/en not_active Ceased
- 2012-09-20 ES ES12779189.5T patent/ES2663097T3/es active Active
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|---|---|
| US20170360712A1 (en) | 2017-12-21 |
| EP3315123A1 (en) | 2018-05-02 |
| EP3315123B1 (en) | 2019-08-21 |
| MX2014003015A (es) | 2014-05-07 |
| ES2663097T3 (es) | 2018-04-11 |
| KR20140063829A (ko) | 2014-05-27 |
| TW201314195A (zh) | 2013-04-01 |
| JP2014527186A (ja) | 2014-10-09 |
| US9775806B2 (en) | 2017-10-03 |
| US20130071869A1 (en) | 2013-03-21 |
| EP3586831A1 (en) | 2020-01-01 |
| EP2758039B1 (en) | 2018-01-24 |
| TWI600892B (zh) | 2017-10-01 |
| EP2758039A1 (en) | 2014-07-30 |
| US10646445B2 (en) | 2020-05-12 |
| ES2757909T3 (es) | 2020-04-30 |
| WO2013043839A1 (en) | 2013-03-28 |
| MX350696B (es) | 2017-09-14 |
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