JP6076361B2 - 胃潰瘍の治療用医薬の調製におけるAlbizziachinensis抽出物の応用 - Google Patents
胃潰瘍の治療用医薬の調製におけるAlbizziachinensis抽出物の応用 Download PDFInfo
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- JP6076361B2 JP6076361B2 JP2014537478A JP2014537478A JP6076361B2 JP 6076361 B2 JP6076361 B2 JP 6076361B2 JP 2014537478 A JP2014537478 A JP 2014537478A JP 2014537478 A JP2014537478 A JP 2014537478A JP 6076361 B2 JP6076361 B2 JP 6076361B2
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- albizzia chinensis
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- chinensis
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Description
本発明は、胃潰瘍および酸関連疾患の治療用のプロトンポンプ阻害剤としての薬物の調製に使用されるAlbizzia chinensis抽出物に関し、Albizzia chinensis抽出物の調製方法は、下記の通りである:
(1)Albizzia chinensisの原料を砕いて溶媒で抽出し、溶媒抽出物を濃縮して、Albizzia chinensisの粗抽出物を得た。
本発明は、胃潰瘍および慢性胃炎の治療用の新たな薬物を提供する。Albizzia chinensis抽出物の調製プロセスは簡単であり、それゆえ生産の工業化に適している。
実施例1 Albizzia chinensis抽出物の調製
風乾してすりつぶしたAlbizzia chinensisの樹皮(1kg)を、還流の条件下で3回(毎回、3時間加熱)3.5リットルの95%EtOHで抽出し、液体抽出液を集め、次いで溶媒を減圧下で除去して、エキス(130g)を得た。エキスをH2O中20%EtOHに溶解し、次いで30〜60メッシュポリアミド(粉末、3200ml)を用いるカラムクロマトグラフィーに供し、12リットルのH2O中20%EtOHおよび12リットルのH2O中60%EtOHで連続的に溶出した。60%EtOHで溶出した溶液を濃縮して、Albizzia chinensis抽出物(8.0g)を得た。
実施例1
Albizzia chinensis抽出物は、胃H+/K+-ATPase活性を阻害する
Albizzia chinensis抽出物は、ラットにおける幽門結紮胃潰瘍に対する胃保護作用を有する
Albizzia chinensis抽出物は、ラットにおける酢酸誘導慢性胃潰瘍に対する胃保護作用を有する
Claims (5)
- 以下のステップを含む、Albizzia chinensis(Osbeck)Merr抽出物の調製方法:
A.1キログラムのすりつぶしたAlbizzia chinensisの樹皮を、還流の条件下で2〜4回(毎回、2〜3時間加熱)、3〜5リットルのH 2 O中80〜95%EtOHで抽出する、該抽出により得た液体抽出物を集め、次いで溶媒を減圧下で除去して、エキスを得る;ならびに、
B.ステップAで得られたエキスをH 2 O中10〜30%EtOHに溶解し、次いで、ポリアミド吸着剤粉末対Albizzia chinensisエキスの体積/重量(L/kg)比が25:1〜30:1であり、H 2 O中10〜30%および40〜80%EtOHで連続的に溶出する、30〜90メッシュポリアミドを用いたカラムクロマトグラフィーに供する、そして、溶出溶液の体積がポリアミドの量の3〜5倍である;40〜80%EtOHで溶出した溶液を濃縮して、Albizzia chinensis抽出物を得る。 - 請求項1に記載の調製方法により得られる、Albizzia chinensis抽出物。
- 有効量の請求項2に記載のAlbizzia chinensis抽出物と、薬学的に許容される担体とを含む、医薬組成物。
- プロトンポンプ阻害剤の調製における、請求項2に記載のAlbizzia chinensis抽出物の使用。
- 慢性胃炎または胃潰瘍の治療用薬物の調製における、請求項2に記載のAlbizzia chinensis抽出物の使用。
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CN201110326361.1A CN103054932B (zh) | 2011-10-24 | 2011-10-24 | 楹树提取物在制备治疗胃溃疡药物中的应用 |
PCT/CN2012/083458 WO2013060275A1 (zh) | 2011-10-24 | 2012-10-24 | 楹树提取物在制备治疗胃溃疡药物中的应用 |
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