JP6052180B2 - フェニル誘導体 - Google Patents
フェニル誘導体 Download PDFInfo
- Publication number
- JP6052180B2 JP6052180B2 JP2013536407A JP2013536407A JP6052180B2 JP 6052180 B2 JP6052180 B2 JP 6052180B2 JP 2013536407 A JP2013536407 A JP 2013536407A JP 2013536407 A JP2013536407 A JP 2013536407A JP 6052180 B2 JP6052180 B2 JP 6052180B2
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- JP
- Japan
- Prior art keywords
- hydroxy
- fluorophenoxy
- phenoxy
- nmr
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WCDJLRCRGQHSOY-UHFFFAOYSA-N CC(C)CC(CC1)(CCN1C(Nc1cc(Oc(cc2)ccc2F)cc(Oc2ccc(C(C)(C)C(O)=O)cc2)c1)O)O Chemical compound CC(C)CC(CC1)(CCN1C(Nc1cc(Oc(cc2)ccc2F)cc(Oc2ccc(C(C)(C)C(O)=O)cc2)c1)O)O WCDJLRCRGQHSOY-UHFFFAOYSA-N 0.000 description 1
- XWGOCGLJLLJAOE-UHFFFAOYSA-N CCC(CC)CC(CC1)(CCN1C(Nc1cc(Oc(cc2)ccc2F)cc(Oc(cc2)ccc2C(N)=O)c1)=O)O Chemical compound CCC(CC)CC(CC1)(CCN1C(Nc1cc(Oc(cc2)ccc2F)cc(Oc(cc2)ccc2C(N)=O)c1)=O)O XWGOCGLJLLJAOE-UHFFFAOYSA-N 0.000 description 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011213987 | 2011-09-29 | ||
| JP2011213987 | 2011-09-29 | ||
| PCT/JP2012/074968 WO2013047701A1 (ja) | 2011-09-29 | 2012-09-27 | フェニル誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199453A Division JP6249076B2 (ja) | 2011-09-29 | 2016-10-07 | フェニル誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2013047701A1 JPWO2013047701A1 (ja) | 2015-03-26 |
| JP6052180B2 true JP6052180B2 (ja) | 2016-12-27 |
Family
ID=47995728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536407A Active JP6052180B2 (ja) | 2011-09-29 | 2012-09-27 | フェニル誘導体 |
| JP2016199453A Expired - Fee Related JP6249076B2 (ja) | 2011-09-29 | 2016-10-07 | フェニル誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199453A Expired - Fee Related JP6249076B2 (ja) | 2011-09-29 | 2016-10-07 | フェニル誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8975409B2 (enExample) |
| EP (2) | EP2762466B1 (enExample) |
| JP (2) | JP6052180B2 (enExample) |
| KR (1) | KR101972619B1 (enExample) |
| CN (1) | CN103958465B (enExample) |
| AU (1) | AU2012317457B2 (enExample) |
| BR (1) | BR112014007790A2 (enExample) |
| CA (1) | CA2849000C (enExample) |
| DK (1) | DK2762466T3 (enExample) |
| ES (2) | ES2689132T3 (enExample) |
| HU (1) | HUE036017T2 (enExample) |
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| JP2017036309A (ja) * | 2011-09-29 | 2017-02-16 | 小野薬品工業株式会社 | フェニル誘導体 |
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| JP6245255B2 (ja) * | 2013-03-26 | 2017-12-13 | 小野薬品工業株式会社 | フェニル誘導体 |
| KR102243426B1 (ko) * | 2013-03-26 | 2021-04-21 | 오노 야꾸힝 고교 가부시키가이샤 | 페닐 유도체를 함유하는 의약 |
| EP3706728A1 (en) | 2017-11-08 | 2020-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | S1pr2 antagonists for treating diseases involving abnormal immune responses |
| EP3813817A4 (en) * | 2018-06-27 | 2022-08-10 | Algernon Pharmaceuticals Inc. | USE OF ACTARIT IN THE PROPHYLAXIS OR TREATMENT OF KIDNEY FIBROSIS OR KIDNEY DISEASE |
| CN115433107B (zh) * | 2022-09-19 | 2024-06-18 | 南京欧际医药科技服务有限公司 | S1pr2拮抗剂及其在制备治疗肺部疾病药物中的用途 |
| CN117736140B (zh) * | 2023-12-11 | 2025-10-03 | 辽宁中医药大学 | 马齿苋中一种吡啶类生物碱化合物及其提取分离方法与用途 |
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| JPH06234797A (ja) | 1993-02-10 | 1994-08-23 | Tsumura & Co | レセプター活性を有する新規ペプチドおよび該ペプチドをコードするdna |
| CZ294097B6 (cs) * | 1995-02-02 | 2004-10-13 | Smithklineábeechamáplc | Indolový derivátŹ způsob jeho přípravy a farmaceutická kompozice s jeho obsahem |
| WO2001098301A1 (en) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Pyrazolopyridine compounds and use thereof as drugs |
| TW200410688A (en) * | 2002-06-26 | 2004-07-01 | Ono Pharmaceutical Co | Therapeutics for diseases from vasoconstriction or vasodilatation |
| RU2390519C2 (ru) * | 2003-08-29 | 2010-05-27 | Оно Фармасьютикал Ко., Лтд. | Соединение, способное к связыванию с рецептором s1p, и его фармацевтическое применение |
| ES2754221T3 (es) | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| CN1590378A (zh) * | 2003-08-29 | 2005-03-09 | 中国科学院上海药物研究所 | 一类喹喔啉衍生物及其制备方法和用途 |
| US7511159B2 (en) | 2003-12-25 | 2009-03-31 | Ono Pharmaceutical Co., Ltd. | Azetidine ring compounds and drugs comprising the same |
| CN100590378C (zh) * | 2005-10-07 | 2010-02-17 | 盖天座 | 旋转箭弩 |
| WO2007125049A1 (en) | 2006-04-27 | 2007-11-08 | Solvay Pharmaceuticals Gmbh | Use of cbx cannabinoid receptor modulators as potassium channel modulators |
| JP2010514693A (ja) | 2006-12-22 | 2010-05-06 | ノバルティス アーゲー | Pdk1阻害のためのキナゾリン |
| US20100121052A1 (en) | 2008-06-20 | 2010-05-13 | Rama Jain | Novel compounds for treating proliferative diseases |
| AR076880A1 (es) | 2009-05-18 | 2011-07-13 | Orion Corp | Inhibidores de proteasa, composiciones farmaceuticas que los contienen y su uso. |
| CN102812167A (zh) | 2009-12-30 | 2012-12-05 | 阿维拉制药公司 | 蛋白的配体-介导的共价修饰 |
| PH12014500561A1 (en) * | 2011-09-29 | 2022-12-02 | Ono Pharmaceutical Co | Phenyl derivative |
| JP6245255B2 (ja) * | 2013-03-26 | 2017-12-13 | 小野薬品工業株式会社 | フェニル誘導体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2017036309A (ja) * | 2011-09-29 | 2017-02-16 | 小野薬品工業株式会社 | フェニル誘導体 |
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