JP6044385B2 - タンデム型質量分析装置 - Google Patents

タンデム型質量分析装置 Download PDF

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Publication number
JP6044385B2
JP6044385B2 JP2013035707A JP2013035707A JP6044385B2 JP 6044385 B2 JP6044385 B2 JP 6044385B2 JP 2013035707 A JP2013035707 A JP 2013035707A JP 2013035707 A JP2013035707 A JP 2013035707A JP 6044385 B2 JP6044385 B2 JP 6044385B2
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ions
ion
mass
cleavage
unit
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Japanese (ja)
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JP2014165053A (ja
JP2014165053A5 (enExample
Inventor
大輔 奥村
大輔 奥村
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Shimadzu Corp
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Shimadzu Corp
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Priority to JP2013035707A priority Critical patent/JP6044385B2/ja
Priority to US14/188,247 priority patent/US8866074B2/en
Priority to CN201410067755.3A priority patent/CN104007163B/zh
Publication of JP2014165053A publication Critical patent/JP2014165053A/ja
Publication of JP2014165053A5 publication Critical patent/JP2014165053A5/ja
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    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
JP2013035707A 2013-02-26 2013-02-26 タンデム型質量分析装置 Expired - Fee Related JP6044385B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2013035707A JP6044385B2 (ja) 2013-02-26 2013-02-26 タンデム型質量分析装置
US14/188,247 US8866074B2 (en) 2013-02-26 2014-02-24 Tandem mass spectrometer and mass spectrometric method
CN201410067755.3A CN104007163B (zh) 2013-02-26 2014-02-26 串联质谱仪和质谱法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013035707A JP6044385B2 (ja) 2013-02-26 2013-02-26 タンデム型質量分析装置

Publications (3)

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JP2014165053A JP2014165053A (ja) 2014-09-08
JP2014165053A5 JP2014165053A5 (enExample) 2015-07-09
JP6044385B2 true JP6044385B2 (ja) 2016-12-14

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JP2013035707A Expired - Fee Related JP6044385B2 (ja) 2013-02-26 2013-02-26 タンデム型質量分析装置

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US (1) US8866074B2 (enExample)
JP (1) JP6044385B2 (enExample)
CN (1) CN104007163B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105917221B (zh) * 2014-01-20 2019-01-11 株式会社岛津制作所 串联质谱分析数据处理装置
CN106463339B (zh) * 2014-06-16 2018-06-15 株式会社岛津制作所 Ms/ms型质谱分析方法以及ms/ms型质谱分析装置
GB201509209D0 (en) * 2015-05-28 2015-07-15 Micromass Ltd Echo cancellation for time of flight analogue to digital converter
CN107923872B (zh) * 2015-07-28 2020-07-07 株式会社岛津制作所 串联型质谱分析装置
WO2017025892A1 (en) * 2015-08-13 2017-02-16 Dh Technologies Development Pte. Ltd. Deconvolution of mixed spectra
WO2017060991A1 (ja) * 2015-10-07 2017-04-13 株式会社島津製作所 タンデム型質量分析装置
JP6409987B2 (ja) * 2016-01-18 2018-10-24 株式会社島津製作所 イオントラップ質量分析装置及び該装置を用いた質量分析方法
US10665442B2 (en) * 2016-02-29 2020-05-26 Shimadzu Corporation Mass spectrometer
CN106169411B (zh) * 2016-07-13 2018-03-27 中国计量科学研究院 新型串并联质谱装置系统及其参数调节方法和使用方法
WO2018138814A1 (ja) 2017-01-25 2018-08-02 株式会社島津製作所 飛行時間型質量分析装置
CN108878253B (zh) 2017-05-15 2020-06-23 株式会社岛津制作所 质谱数据采集方法
EP3738137A1 (en) 2018-01-12 2020-11-18 The Trustees of Indiana University Electrostatic linear ion trap design for charge detection mass spectrometry
CN110082422B (zh) * 2018-07-18 2021-11-12 东华理工大学 一种测定电喷雾电离和电喷雾萃取电离所获一价正离子内能差异的方法
EP3837711B1 (en) * 2018-08-13 2022-12-07 Thermo Fisher Scientific (Bremen) GmbH Isotopic mass spectrometry
US11081333B2 (en) 2018-08-31 2021-08-03 Shimadzu Corporation Power connector for mass spectrometer
US11562896B2 (en) 2018-12-03 2023-01-24 The Trustees Of Indiana University Apparatus and method for simultaneously analyzing multiple ions with an electrostatic linear ion trap
WO2020219527A1 (en) 2019-04-23 2020-10-29 The Trustees Of Indiana University Identification of sample subspecies based on particle charge behavior under structural change-inducing sample conditions
WO2020240506A1 (en) 2019-05-31 2020-12-03 Dh Technologies Development Pte. Ltd. Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
KR102872760B1 (ko) 2019-09-25 2025-10-16 더 트러스티즈 오브 인디애나 유니버시티 펄스 모드 전하 검출 질량 분석을 위한 장치 및 방법
CN114728237A (zh) 2019-10-10 2022-07-08 印地安纳大学理事会 用于识别、选择和纯化粒子的系统和方法
EP4078654A1 (en) * 2019-12-18 2022-10-26 The Trustees of Indiana University Mass spectrometer with charge measurement arrangement
CN113948365B (zh) * 2020-07-15 2025-02-07 宁波大学 一种复合式质谱仪
CN113406182B (zh) * 2021-06-30 2024-10-11 昆山禾信质谱技术有限公司 串联质谱设备和质谱检测系统
CN116344323A (zh) * 2021-12-17 2023-06-27 昆山禾信质谱技术有限公司 串级质谱系统及质谱设备

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2250632B (en) * 1990-10-18 1994-11-23 Unisearch Ltd Tandem mass spectrometry systems based on time-of-flight analyser
GB9200901D0 (en) * 1992-01-16 1992-03-11 Kratos Analytical Ltd Mass spectrometry systems
US5696376A (en) * 1996-05-20 1997-12-09 The Johns Hopkins University Method and apparatus for isolating ions in an ion trap with increased resolving power
JP3300602B2 (ja) * 1996-06-20 2002-07-08 株式会社日立製作所 大気圧イオン化イオントラップ質量分析方法及び装置
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6600155B1 (en) * 1998-01-23 2003-07-29 Analytica Of Branford, Inc. Mass spectrometry from surfaces
JP2002502085A (ja) * 1998-01-23 2002-01-22 アナリティカ オブ ブランフォード インコーポレーテッド 多極イオンガイドを用いた質量分光測定法
CA2255122C (en) * 1998-12-04 2007-10-09 Mds Inc. Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer
US6507019B2 (en) * 1999-05-21 2003-01-14 Mds Inc. MS/MS scan methods for a quadrupole/time of flight tandem mass spectrometer
WO2000077823A2 (en) * 1999-06-11 2000-12-21 Perseptive Biosystems, Inc. Tandem time-of-flight mass spectometer with damping in collision cell and method for use
CA2340150C (en) 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
JP2002313276A (ja) * 2001-04-17 2002-10-25 Hitachi Ltd イオントラップ型質量分析装置及び方法
US7034292B1 (en) * 2002-05-31 2006-04-25 Analytica Of Branford, Inc. Mass spectrometry with segmented RF multiple ion guides in various pressure regions
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6987261B2 (en) * 2003-01-24 2006-01-17 Thermo Finnigan Llc Controlling ion populations in a mass analyzer
GB2449760B (en) * 2003-03-19 2009-01-14 Thermo Finnigan Llc Obtaining tandem mass spectrometry data for multiple parent lons in an ion population
EP1623351B1 (en) * 2003-04-28 2012-04-18 Cerno Bioscience LLC Computational method and system for mass spectral analysis
US6992283B2 (en) * 2003-06-06 2006-01-31 Micromass Uk Limited Mass spectrometer
US7473892B2 (en) * 2003-08-13 2009-01-06 Hitachi High-Technologies Corporation Mass spectrometer system
GB0404106D0 (en) * 2004-02-24 2004-03-31 Shimadzu Res Lab Europe Ltd An ion trap and a method for dissociating ions in an ion trap
US20060043285A1 (en) * 2004-08-26 2006-03-02 Battelle Memorial Institute Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis
US7348553B2 (en) * 2004-10-28 2008-03-25 Cerno Bioscience Llc Aspects of mass spectral calibration
WO2006049064A1 (ja) * 2004-11-02 2006-05-11 Shimadzu Corporation 質量分析方法
GB0427632D0 (en) * 2004-12-17 2005-01-19 Micromass Ltd Mass spectrometer
GB0506288D0 (en) * 2005-03-29 2005-05-04 Thermo Finnigan Llc Improvements relating to mass spectrometry
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
GB0526245D0 (en) * 2005-12-22 2006-02-01 Shimadzu Res Lab Europe Ltd A mass spectrometer using a dynamic pressure ion source
WO2008005283A2 (en) * 2006-06-29 2008-01-10 Sionex Corporation Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis
US8119982B2 (en) * 2007-04-04 2012-02-21 Shimadzu Corporation Method and system for mass spectrometry data analysis
US7838824B2 (en) * 2007-05-01 2010-11-23 Virgin Instruments Corporation TOF-TOF with high resolution precursor selection and multiplexed MS-MS
US7919745B2 (en) * 2007-09-10 2011-04-05 Dh Technologies Development Pte. Ltd. Methods and systems for background correction in tandem mass spectrometry based quantitation
JP2009068981A (ja) * 2007-09-13 2009-04-02 Hitachi High-Technologies Corp 質量分析システム及び質量分析方法
JP5124293B2 (ja) * 2008-01-11 2013-01-23 株式会社日立ハイテクノロジーズ 質量分析計および質量分析方法
WO2009095952A1 (ja) * 2008-01-30 2009-08-06 Shimadzu Corporation Ms/ms型質量分析装置
US8723113B2 (en) * 2008-05-30 2014-05-13 The State of Oregon Acting by and through the State Board of Higher Education of behalf of Oregon State University Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers
WO2010089798A1 (ja) * 2009-02-05 2010-08-12 株式会社島津製作所 Ms/ms型質量分析装置
CN102169791B (zh) * 2010-02-05 2015-11-25 岛津分析技术研发(上海)有限公司 一种串级质谱分析装置及质谱分析方法
JP5408107B2 (ja) * 2010-11-10 2014-02-05 株式会社島津製作所 Ms/ms型質量分析装置及び同装置用プログラム

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Publication number Publication date
US20140239170A1 (en) 2014-08-28
US8866074B2 (en) 2014-10-21
JP2014165053A (ja) 2014-09-08
CN104007163A (zh) 2014-08-27
CN104007163B (zh) 2016-09-28

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