JP6025871B2 - ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用 - Google Patents

ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用 Download PDF

Info

Publication number
JP6025871B2
JP6025871B2 JP2014554880A JP2014554880A JP6025871B2 JP 6025871 B2 JP6025871 B2 JP 6025871B2 JP 2014554880 A JP2014554880 A JP 2014554880A JP 2014554880 A JP2014554880 A JP 2014554880A JP 6025871 B2 JP6025871 B2 JP 6025871B2
Authority
JP
Japan
Prior art keywords
leu
ala
cys
seq
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014554880A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015513318A5 (enExample
JP2015513318A (ja
Inventor
クリストファー ジェイ. ソアレス
クリストファー ジェイ. ソアレス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2015513318A publication Critical patent/JP2015513318A/ja
Publication of JP2015513318A5 publication Critical patent/JP2015513318A5/ja
Application granted granted Critical
Publication of JP6025871B2 publication Critical patent/JP6025871B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/225Calcitonin gene related peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57527Calcitonin gene related peptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/585Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014554880A 2012-01-26 2013-01-25 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用 Active JP6025871B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591236P 2012-01-26 2012-01-26
US61/591,236 2012-01-26
PCT/US2013/023260 WO2013112912A1 (en) 2012-01-26 2013-01-25 Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016199234A Division JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用

Publications (3)

Publication Number Publication Date
JP2015513318A JP2015513318A (ja) 2015-05-07
JP2015513318A5 JP2015513318A5 (enExample) 2016-03-10
JP6025871B2 true JP6025871B2 (ja) 2016-11-16

Family

ID=47682066

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014554880A Active JP6025871B2 (ja) 2012-01-26 2013-01-25 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用
JP2016199234A Active JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用
JP2018177504A Pending JP2019006821A (ja) 2012-01-26 2018-09-21 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016199234A Active JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用
JP2018177504A Pending JP2019006821A (ja) 2012-01-26 2018-09-21 ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用

Country Status (14)

Country Link
US (3) US9193776B2 (enExample)
EP (2) EP2807187B1 (enExample)
JP (3) JP6025871B2 (enExample)
KR (2) KR101855242B1 (enExample)
CN (2) CN108997490A (enExample)
AU (2) AU2013211929B2 (enExample)
CA (1) CA2861392C (enExample)
DK (1) DK2807187T3 (enExample)
ES (2) ES2819825T3 (enExample)
IL (2) IL233655A (enExample)
MX (1) MX347229B (enExample)
NO (1) NO2864579T3 (enExample)
RU (2) RU2624016C2 (enExample)
WO (1) WO2013112912A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017036308A (ja) * 2012-01-26 2017-02-16 クリストファー ジェイ. ソアレス ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6538682B2 (ja) * 2013-07-30 2019-07-03 ソアレス クリストファー ジェイ. Cgrpアゴニストペプチド
JO3669B1 (ar) 2015-01-06 2020-08-27 Ferring Bv بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين
JP7360794B2 (ja) * 2016-01-04 2023-10-13 アデプセラ エルエルシー ペプチド類似体
JP7123932B2 (ja) * 2016-09-02 2022-08-23 クリストファー ジェイ. ソアレス 神経保護及び神経疾患におけるcgrp受容体アンタゴニストの使用
CA2967616A1 (en) * 2016-09-19 2018-03-19 The Governors Of The University Of Alberta Brain penetrant amylin receptor based peptides for alzheimer's disease
EP3707157A4 (en) * 2017-11-06 2021-08-18 Auckland Uniservices Limited PEPTIDIC CONJUGATES AS ANAGONISTS OF THE CGRP RECEIVER, THEIR PREPARATION METHODS AND THEIR USES
JP7214100B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214102B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214104B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
CN116456981A (zh) * 2020-11-19 2023-07-18 辉瑞爱尔兰制药公司 用于改善的grp抑制剂递送的组合物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2046920B1 (enExample) 1969-06-19 1974-05-03 Citizen Watch Co Ltd
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
CH657779A5 (de) 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
IT1164225B (it) 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
US4530838A (en) 1983-07-08 1985-07-23 The Salk Institute For Biological Studies Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
JPS62129297A (ja) * 1985-08-09 1987-06-11 Toyo Jozo Co Ltd カルシトニン遺伝子関連ペプチド誘導体
JPS62231168A (ja) 1986-03-21 1987-10-09 ハイブリテツク・インコ−ポレイテツド アナライト−レセプタ−分析用内部標準を設けるための改良法
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
JPH07507806A (ja) 1992-06-11 1995-08-31 アルカーメス コントロールド セラピューティクス,インコーポレイテッド エリスロポエチン薬物送達システム
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
WO1994021665A1 (en) 1993-03-24 1994-09-29 Amylin Pharmaceuticals, Inc. Cloned receptors and methods for screening
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5910482A (en) * 1996-03-19 1999-06-08 Board Of Regents, The University Of Texas System Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor
WO1997041223A1 (en) 1996-04-15 1997-11-06 The University Of Miami Molecular clone of cgrp receptor component protein and uses thereof
US20050054557A1 (en) 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
WO2004084859A2 (en) 2003-03-21 2004-10-07 Nastech Pharmaceutical Company Inc. Nasal calcitonin formulations containing chlorobutanol
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
EP2233497A3 (en) * 2004-02-11 2011-01-12 Amylin Pharmaceuticals, Inc. Amylin family peptides and methods for making and using them
CA2584806C (en) 2004-11-01 2014-06-17 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
WO2007055728A1 (en) * 2005-11-01 2007-05-18 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
WO2006086769A2 (en) * 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Inc. Gip analog and hybrid polypeptides with selectable properties
EP2258382A3 (en) * 2005-03-31 2014-05-14 Amylin Pharmaceuticals, LLC Amylin and amylin agonists for treating psychiatric diseases and disorders
CN101208098A (zh) * 2005-03-31 2008-06-25 安米林药品公司 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂
WO2007055743A2 (en) * 2005-11-01 2007-05-18 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
WO2007054809A2 (en) * 2005-11-14 2007-05-18 Rinat Neuroscience Corp. Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
MX2010005345A (es) 2007-11-14 2010-08-31 Amylin Pharmaceuticals Inc Metodos para el tratamiento de la obesidad y enfermedades y trastornos relacionados con la obesidad.
WO2010107874A2 (en) 2009-03-17 2010-09-23 Amylin Pharmaceuticals, Inc. Methods for affecting body composition using amylin agonists
WO2013059336A1 (en) 2011-10-18 2013-04-25 Amylin Pharmaceuticals, Llc Amylin-calcitonin chimeric peptides conjugated to duration enchancing moieties
WO2013112912A1 (en) 2012-01-26 2013-08-01 Soares Christopher J Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
KR102076118B1 (ko) 2012-02-27 2020-02-11 브리스톨-마이어스 스큅 컴퍼니 N-(5S,6S,9R)-5-아미노-6-(2,3-디플루오로페닐)-6,7,8,9-테트라히드로-5H-시클로헵타[b]피리딘-9-일-4-(2-옥소-2,3-디히드로-1H-이미다조[4,5-b]피리딘-1-일)피페리딘-1-카르복실레이트, 헤미술페이트 염

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017036308A (ja) * 2012-01-26 2017-02-16 クリストファー ジェイ. ソアレス ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用

Also Published As

Publication number Publication date
RU2017119773A (ru) 2018-12-06
AU2013211929A1 (en) 2014-09-11
BR112014018284A2 (pt) 2017-07-04
IL233655A (en) 2017-06-29
IL233655A0 (en) 2014-08-31
JP2019006821A (ja) 2019-01-17
DK2807187T3 (en) 2017-09-11
RU2017119773A3 (enExample) 2020-11-18
CN104271596A (zh) 2015-01-07
KR20140132342A (ko) 2014-11-17
JP6411425B2 (ja) 2018-10-24
AU2013211929B2 (en) 2016-05-26
IL252555A0 (en) 2017-07-31
CN104271596B (zh) 2018-09-18
EP3272769B1 (en) 2020-06-17
MX347229B (es) 2017-04-19
EP3272769A1 (en) 2018-01-24
KR20170071613A (ko) 2017-06-23
EP2807187A1 (en) 2014-12-03
CA2861392C (en) 2021-08-17
CA2861392A1 (en) 2013-08-01
RU2014131605A (ru) 2016-03-20
KR101855242B1 (ko) 2018-05-09
RU2624016C2 (ru) 2017-06-30
US9193776B2 (en) 2015-11-24
AU2016205801A1 (en) 2016-08-04
IL252555B (en) 2020-06-30
HK1201068A1 (en) 2015-08-21
CN108997490A (zh) 2018-12-14
RU2742826C2 (ru) 2021-02-11
NO2864579T3 (enExample) 2018-01-20
US10370425B2 (en) 2019-08-06
US20160145315A1 (en) 2016-05-26
KR102052983B1 (ko) 2019-12-06
MX2014008960A (es) 2015-01-16
EP2807187B1 (en) 2017-07-26
WO2013112912A1 (en) 2013-08-01
ES2819825T3 (es) 2021-04-19
JP2015513318A (ja) 2015-05-07
HK1249915A1 (en) 2018-11-16
US20140329752A1 (en) 2014-11-06
ES2641325T3 (es) 2017-11-08
JP2017036308A (ja) 2017-02-16
US20170204155A1 (en) 2017-07-20

Similar Documents

Publication Publication Date Title
JP6411425B2 (ja) ペプチドホルモンのカルシトニンcgrpファミリーのペプチドアンタゴニスト及びその使用
AU2019202918B2 (en) Agonist of spexin-based galanin type 2 receptor and use thereof
EP0672054A1 (en) A novel molecule which inhibits neuropeptide tyrosine biological function
KR20010085847A (ko) 펩티드 유도체
JP2019504119A (ja) ペプチド類似体
HK1249915B (en) Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
BR112014018284B1 (pt) Antagonista de peptídeo relacionado ao gene da calcitonina, composições farmacêuticas e uso dos mesmos
HK1201068B (en) Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
JP4760377B2 (ja) GPR103−like受容体蛋白質に対するリガンドの新規用途
AU662032B2 (en) A novel molecule which inhibits neuropeptide tyrosine biological function
WO2014014816A2 (en) Methods of treating glucose metabolism disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160122

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160122

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20160122

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20160216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160223

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160509

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160721

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160913

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161011

R150 Certificate of patent or registration of utility model

Ref document number: 6025871

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250