JP6025871B2 - ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 - Google Patents

ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 Download PDF

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JP6025871B2
JP6025871B2 JP2014554880A JP2014554880A JP6025871B2 JP 6025871 B2 JP6025871 B2 JP 6025871B2 JP 2014554880 A JP2014554880 A JP 2014554880A JP 2014554880 A JP2014554880 A JP 2014554880A JP 6025871 B2 JP6025871 B2 JP 6025871B2
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JP2015513318A5 (enExample
JP2015513318A (ja
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クリストファー ジェイ． ソアレス
クリストファー ジェイ． ソアレス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/225—Calcitonin gene related peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57527—Calcitonin gene related peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014554880A 2012-01-26 2013-01-25 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用 Active JP6025871B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591236P 2012-01-26 2012-01-26
US61/591,236 2012-01-26
PCT/US2013/023260 WO2013112912A1 (en) 2012-01-26 2013-01-25 Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016199234A Division JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用

Publications (3)

Publication Number Publication Date
JP2015513318A JP2015513318A (ja) 2015-05-07
JP2015513318A5 JP2015513318A5 (enExample) 2016-03-10
JP6025871B2 true JP6025871B2 (ja) 2016-11-16

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Family Applications (3)

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JP2014554880A Active JP6025871B2 (ja) 2012-01-26 2013-01-25 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用
JP2016199234A Active JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用
JP2018177504A Pending JP2019006821A (ja) 2012-01-26 2018-09-21 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用

Family Applications After (2)

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JP2016199234A Active JP6411425B2 (ja) 2012-01-26 2016-10-07 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用
JP2018177504A Pending JP2019006821A (ja) 2012-01-26 2018-09-21 ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用

Country Status (14)

Country Link
US (3) US9193776B2 (enExample)
EP (2) EP3272769B1 (enExample)
JP (3) JP6025871B2 (enExample)
KR (2) KR101855242B1 (enExample)
CN (2) CN108997490A (enExample)
AU (2) AU2013211929B2 (enExample)
CA (1) CA2861392C (enExample)
DK (1) DK2807187T3 (enExample)
ES (2) ES2641325T3 (enExample)
IL (2) IL233655A (enExample)
MX (1) MX347229B (enExample)
NO (1) NO2864579T3 (enExample)
RU (2) RU2624016C2 (enExample)
WO (1) WO2013112912A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017036308A (ja) * 2012-01-26 2017-02-16 クリストファー ジェイ． ソアレス ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6538682B2 (ja) * 2013-07-30 2019-07-03 ソアレス クリストファー ジェイ． Ｃｇｒｐアゴニストペプチド
JO3669B1 (ar) 2015-01-06 2020-08-27 Ferring Bv بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين
CN116063580A (zh) * 2016-01-04 2023-05-05 艾得佩索拉公司 肽类似物
JP7123932B2 (ja) * 2016-09-02 2022-08-23 クリストファー ジェイ． ソアレス 神経保護及び神経疾患におけるｃｇｒｐ受容体アンタゴニストの使用
CA2967616A1 (en) * 2016-09-19 2018-03-19 The Governors Of The University Of Alberta Brain penetrant amylin receptor based peptides for alzheimer's disease
US20200353088A1 (en) * 2017-11-06 2020-11-12 Auckland Uniservices Limited Peptide conjugate cgrp receptor antagonists and methods of preparation and uses thereof
JP7214102B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214100B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214104B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
CN116456981A (zh) * 2020-11-19 2023-07-18 辉瑞爱尔兰制药公司 用于改善的grp抑制剂递送的组合物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645090A (en) 1969-06-19 1972-02-29 Citizen Watch Co Ltd Day-date quick-adjuster for calender timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
CH657779A5 (de) 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
IT1164225B (it) 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
US4530838A (en) 1983-07-08 1985-07-23 The Salk Institute For Biological Studies Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
JPS62129297A (ja) * 1985-08-09 1987-06-11 Toyo Jozo Co Ltd カルシトニン遺伝子関連ペプチド誘導体
JPS62231168A (ja) 1986-03-21 1987-10-09 ハイブリテツク・インコ−ポレイテツド アナライト−レセプタ−分析用内部標準を設けるための改良法
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
ES2181691T5 (es) 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
AU6524794A (en) 1993-03-24 1994-10-11 Amylin Pharmaceuticals, Inc. Cloned receptors and methods for screening
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5910482A (en) * 1996-03-19 1999-06-08 Board Of Regents, The University Of Texas System Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor
WO1997041223A1 (en) 1996-04-15 1997-11-06 The University Of Miami Molecular clone of cgrp receptor component protein and uses thereof
US20050054557A1 (en) 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
WO2004084859A2 (en) 2003-03-21 2004-10-07 Nastech Pharmaceutical Company Inc. Nasal calcitonin formulations containing chlorobutanol
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
ATE471340T1 (de) 2004-02-11 2010-07-15 Amylin Pharmaceuticals Inc Peptide der amylin familie, verfahren zu deren herstellung und verwendung
JP4926069B2 (ja) 2004-11-01 2012-05-09 アミリン・ファーマシューティカルズ，インコーポレイテッド 肥満ならびに肥満関連疾患および障害の治療方法
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
EA011653B1 (ru) * 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Аналоги и гибридные полипептиды gip с избираемыми свойствами
CN101208098A (zh) * 2005-03-31 2008-06-25 安米林药品公司 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂
AU2006230420B2 (en) * 2005-03-31 2011-11-24 Amylin Pharmaceuticals, Llc Compositions and methods for the control, prevention, and treatment of obesity and eating disorders
EP1954313A1 (en) * 2005-11-01 2008-08-13 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
WO2007055743A2 (en) * 2005-11-01 2007-05-18 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
EP3045182B1 (en) * 2005-11-14 2018-03-07 Teva Pharmaceuticals International GmbH Antagonist antibodies directed against calcitonin gene-related peptide for treating cluster headache
CN101939022A (zh) 2007-11-14 2011-01-05 安米林药品公司 治疗肥胖以及肥胖相关疾病和病症的方法
US8748375B2 (en) 2009-03-17 2014-06-10 Amylin Pharmaceuticals, Llc Methods for affecting body composition using amylin agonists
WO2013059336A1 (en) 2011-10-18 2013-04-25 Amylin Pharmaceuticals, Llc Amylin-calcitonin chimeric peptides conjugated to duration enchancing moieties
MX347229B (es) 2012-01-26 2017-04-19 Christopher J Soares Antagonistas de péptido de la familia cgrp de calcitonina de hormonas de péptido y su uso.
EP2820016B1 (en) 2012-02-27 2017-08-02 Bristol-Myers Squibb Company N- (5s, 6s, 9r) - 5 -amino- 6 - (2, 3 - difluorophenyl) -6, 7, 8, 9 - tetrahydro - 5h - cyclohepta [b]pyridin-9 -yl- 4 - (2 - oxo-2, 3 - dihydro - 1h- imidazo [4, 5 -b]pyridin - 1 - yl) piperidine - 1 - carboxylate, hemisulfate salt

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017036308A (ja) * 2012-01-26 2017-02-16 クリストファー ジェイ． ソアレス ペプチドホルモンのカルシトニンｃｇｒｐファミリーのペプチドアンタゴニスト及びその使用

Also Published As

Publication number Publication date
ES2819825T3 (es) 2021-04-19
MX347229B (es) 2017-04-19
KR102052983B1 (ko) 2019-12-06
US20170204155A1 (en) 2017-07-20
NO2864579T3 (enExample) 2018-01-20
KR101855242B1 (ko) 2018-05-09
RU2742826C2 (ru) 2021-02-11
AU2013211929A1 (en) 2014-09-11
EP3272769A1 (en) 2018-01-24
KR20170071613A (ko) 2017-06-23
EP2807187B1 (en) 2017-07-26
CN104271596A (zh) 2015-01-07
US20160145315A1 (en) 2016-05-26
RU2014131605A (ru) 2016-03-20
CA2861392C (en) 2021-08-17
CA2861392A1 (en) 2013-08-01
BR112014018284A2 (pt) 2017-07-04
IL233655A (en) 2017-06-29
ES2641325T3 (es) 2017-11-08
JP2019006821A (ja) 2019-01-17
CN108997490A (zh) 2018-12-14
IL252555B (en) 2020-06-30
JP2017036308A (ja) 2017-02-16
WO2013112912A1 (en) 2013-08-01
EP3272769B1 (en) 2020-06-17
HK1249915A1 (en) 2018-11-16
EP2807187A1 (en) 2014-12-03
JP2015513318A (ja) 2015-05-07
US9193776B2 (en) 2015-11-24
MX2014008960A (es) 2015-01-16
AU2016205801A1 (en) 2016-08-04
JP6411425B2 (ja) 2018-10-24
KR20140132342A (ko) 2014-11-17
AU2013211929B2 (en) 2016-05-26
HK1201068A1 (en) 2015-08-21
IL233655A0 (en) 2014-08-31
RU2624016C2 (ru) 2017-06-30
US10370425B2 (en) 2019-08-06
RU2017119773A (ru) 2018-12-06
CN104271596B (zh) 2018-09-18
IL252555A0 (en) 2017-07-31
RU2017119773A3 (enExample) 2020-11-18
DK2807187T3 (en) 2017-09-11
US20140329752A1 (en) 2014-11-06

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