ES2641325T3 - Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso - Google Patents

Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso Download PDF

Info

Publication number
ES2641325T3
ES2641325T3 ES13703494.8T ES13703494T ES2641325T3 ES 2641325 T3 ES2641325 T3 ES 2641325T3 ES 13703494 T ES13703494 T ES 13703494T ES 2641325 T3 ES2641325 T3 ES 2641325T3
Authority
ES
Spain
Prior art keywords
leu
ala
cys
arg
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13703494.8T
Other languages
English (en)
Spanish (es)
Inventor
Christopher J. Soares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2641325T3 publication Critical patent/ES2641325T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57527Calcitonin gene related peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/225Calcitonin gene related peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/585Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ES13703494.8T 2012-01-26 2013-01-25 Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso Active ES2641325T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591236P 2012-01-26 2012-01-26
US201261591236P 2012-01-26
PCT/US2013/023260 WO2013112912A1 (en) 2012-01-26 2013-01-25 Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use

Publications (1)

Publication Number Publication Date
ES2641325T3 true ES2641325T3 (es) 2017-11-08

Family

ID=47682066

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13703494.8T Active ES2641325T3 (es) 2012-01-26 2013-01-25 Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso
ES17175988T Active ES2819825T3 (es) 2012-01-26 2013-01-25 Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES17175988T Active ES2819825T3 (es) 2012-01-26 2013-01-25 Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso

Country Status (14)

Country Link
US (3) US9193776B2 (enExample)
EP (2) EP3272769B1 (enExample)
JP (3) JP6025871B2 (enExample)
KR (2) KR101855242B1 (enExample)
CN (2) CN108997490A (enExample)
AU (2) AU2013211929B2 (enExample)
CA (1) CA2861392C (enExample)
DK (1) DK2807187T3 (enExample)
ES (2) ES2641325T3 (enExample)
IL (2) IL233655A (enExample)
MX (1) MX347229B (enExample)
NO (1) NO2864579T3 (enExample)
RU (2) RU2624016C2 (enExample)
WO (1) WO2013112912A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX347229B (es) * 2012-01-26 2017-04-19 Christopher J Soares Antagonistas de péptido de la familia cgrp de calcitonina de hormonas de péptido y su uso.
JP6538682B2 (ja) * 2013-07-30 2019-07-03 ソアレス クリストファー ジェイ. Cgrpアゴニストペプチド
JO3669B1 (ar) 2015-01-06 2020-08-27 Ferring Bv بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين
CN116063580A (zh) * 2016-01-04 2023-05-05 艾得佩索拉公司 肽类似物
JP7123932B2 (ja) * 2016-09-02 2022-08-23 クリストファー ジェイ. ソアレス 神経保護及び神経疾患におけるcgrp受容体アンタゴニストの使用
CA2967616A1 (en) * 2016-09-19 2018-03-19 The Governors Of The University Of Alberta Brain penetrant amylin receptor based peptides for alzheimer's disease
US20200353088A1 (en) * 2017-11-06 2020-11-12 Auckland Uniservices Limited Peptide conjugate cgrp receptor antagonists and methods of preparation and uses thereof
JP7214102B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214100B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
JP7214104B2 (ja) * 2019-01-18 2023-01-30 株式会社大一商会 遊技機
CN116456981A (zh) * 2020-11-19 2023-07-18 辉瑞爱尔兰制药公司 用于改善的grp抑制剂递送的组合物

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645090A (en) 1969-06-19 1972-02-29 Citizen Watch Co Ltd Day-date quick-adjuster for calender timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
CH657779A5 (de) 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
IT1164225B (it) 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
US4530838A (en) 1983-07-08 1985-07-23 The Salk Institute For Biological Studies Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
JPS62129297A (ja) * 1985-08-09 1987-06-11 Toyo Jozo Co Ltd カルシトニン遺伝子関連ペプチド誘導体
JPS62231168A (ja) 1986-03-21 1987-10-09 ハイブリテツク・インコ−ポレイテツド アナライト−レセプタ−分析用内部標準を設けるための改良法
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
ES2181691T5 (es) 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
AU6524794A (en) 1993-03-24 1994-10-11 Amylin Pharmaceuticals, Inc. Cloned receptors and methods for screening
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US5910482A (en) * 1996-03-19 1999-06-08 Board Of Regents, The University Of Texas System Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor
WO1997041223A1 (en) 1996-04-15 1997-11-06 The University Of Miami Molecular clone of cgrp receptor component protein and uses thereof
US20050054557A1 (en) 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
WO2004084859A2 (en) 2003-03-21 2004-10-07 Nastech Pharmaceutical Company Inc. Nasal calcitonin formulations containing chlorobutanol
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
ATE471340T1 (de) 2004-02-11 2010-07-15 Amylin Pharmaceuticals Inc Peptide der amylin familie, verfahren zu deren herstellung und verwendung
JP4926069B2 (ja) 2004-11-01 2012-05-09 アミリン・ファーマシューティカルズ,インコーポレイテッド 肥満ならびに肥満関連疾患および障害の治療方法
US8263545B2 (en) * 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
EA011653B1 (ru) * 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Аналоги и гибридные полипептиды gip с избираемыми свойствами
CN101208098A (zh) * 2005-03-31 2008-06-25 安米林药品公司 用于治疗精神病和精神障碍的胰淀素和胰淀素激动剂
AU2006230420B2 (en) * 2005-03-31 2011-11-24 Amylin Pharmaceuticals, Llc Compositions and methods for the control, prevention, and treatment of obesity and eating disorders
EP1954313A1 (en) * 2005-11-01 2008-08-13 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
WO2007055743A2 (en) * 2005-11-01 2007-05-18 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
EP3045182B1 (en) * 2005-11-14 2018-03-07 Teva Pharmaceuticals International GmbH Antagonist antibodies directed against calcitonin gene-related peptide for treating cluster headache
CN101939022A (zh) 2007-11-14 2011-01-05 安米林药品公司 治疗肥胖以及肥胖相关疾病和病症的方法
US8748375B2 (en) 2009-03-17 2014-06-10 Amylin Pharmaceuticals, Llc Methods for affecting body composition using amylin agonists
WO2013059336A1 (en) 2011-10-18 2013-04-25 Amylin Pharmaceuticals, Llc Amylin-calcitonin chimeric peptides conjugated to duration enchancing moieties
MX347229B (es) 2012-01-26 2017-04-19 Christopher J Soares Antagonistas de péptido de la familia cgrp de calcitonina de hormonas de péptido y su uso.
EP2820016B1 (en) 2012-02-27 2017-08-02 Bristol-Myers Squibb Company N- (5s, 6s, 9r) - 5 -amino- 6 - (2, 3 - difluorophenyl) -6, 7, 8, 9 - tetrahydro - 5h - cyclohepta [b]pyridin-9 -yl- 4 - (2 - oxo-2, 3 - dihydro - 1h- imidazo [4, 5 -b]pyridin - 1 - yl) piperidine - 1 - carboxylate, hemisulfate salt

Also Published As

Publication number Publication date
ES2819825T3 (es) 2021-04-19
MX347229B (es) 2017-04-19
KR102052983B1 (ko) 2019-12-06
JP6025871B2 (ja) 2016-11-16
US20170204155A1 (en) 2017-07-20
NO2864579T3 (enExample) 2018-01-20
KR101855242B1 (ko) 2018-05-09
RU2742826C2 (ru) 2021-02-11
AU2013211929A1 (en) 2014-09-11
EP3272769A1 (en) 2018-01-24
KR20170071613A (ko) 2017-06-23
EP2807187B1 (en) 2017-07-26
CN104271596A (zh) 2015-01-07
US20160145315A1 (en) 2016-05-26
RU2014131605A (ru) 2016-03-20
CA2861392C (en) 2021-08-17
CA2861392A1 (en) 2013-08-01
BR112014018284A2 (pt) 2017-07-04
IL233655A (en) 2017-06-29
JP2019006821A (ja) 2019-01-17
CN108997490A (zh) 2018-12-14
IL252555B (en) 2020-06-30
JP2017036308A (ja) 2017-02-16
WO2013112912A1 (en) 2013-08-01
EP3272769B1 (en) 2020-06-17
HK1249915A1 (en) 2018-11-16
EP2807187A1 (en) 2014-12-03
JP2015513318A (ja) 2015-05-07
US9193776B2 (en) 2015-11-24
MX2014008960A (es) 2015-01-16
AU2016205801A1 (en) 2016-08-04
JP6411425B2 (ja) 2018-10-24
KR20140132342A (ko) 2014-11-17
AU2013211929B2 (en) 2016-05-26
HK1201068A1 (en) 2015-08-21
IL233655A0 (en) 2014-08-31
RU2624016C2 (ru) 2017-06-30
US10370425B2 (en) 2019-08-06
RU2017119773A (ru) 2018-12-06
CN104271596B (zh) 2018-09-18
IL252555A0 (en) 2017-07-31
RU2017119773A3 (enExample) 2020-11-18
DK2807187T3 (en) 2017-09-11
US20140329752A1 (en) 2014-11-06

Similar Documents

Publication Publication Date Title
ES2641325T3 (es) Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso
JP6084207B2 (ja) 虚血性脳損傷及び疼痛治療用の効率的な神経保護剤としてのpsd−95の高親和性二量体阻害剤
TWI406671B (zh) 改善以神經系統為標的之藥劑之性質之方法及組合物
KR20240082377A (ko) 펩티드
HK1249915B (en) Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
HK1201068B (en) Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
BR112014018284B1 (pt) Antagonista de peptídeo relacionado ao gene da calcitonina, composições farmacêuticas e uso dos mesmos
US20140155331A1 (en) Novel high affinity bivalent helically constrained peptide against cancer
Kuhn Molecular Tools for the NPY Y₄ Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y₁R Antagonists
WO2025197823A1 (ja) ペプチド、ペプチド複合体、医薬組成物、細胞培養用組成物、及び医療用、診断用又は研究用に用いられる組成物
Kuhn Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of HPP and from Argininamide-type Y1R Antagonists
JPWO2015083816A1 (ja) 新規nk3受容体アゴニスト