JP6023358B2 - S−フルルビプロフェンを含有する外用剤組成物 - Google Patents
S−フルルビプロフェンを含有する外用剤組成物 Download PDFInfo
- Publication number
- JP6023358B2 JP6023358B2 JP2015555469A JP2015555469A JP6023358B2 JP 6023358 B2 JP6023358 B2 JP 6023358B2 JP 2015555469 A JP2015555469 A JP 2015555469A JP 2015555469 A JP2015555469 A JP 2015555469A JP 6023358 B2 JP6023358 B2 JP 6023358B2
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- Prior art keywords
- flurbiprofen
- ester
- external preparation
- chain fatty
- preparation composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
(1)S−フルルビプロフェン又はその薬学的に許容される塩と、ハッカ油と、プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上とを含む外用剤組成物、
(2)プロピレングリコールに二つの中鎖脂肪酸が結合したエステルがジカプリル酸プロピレングリコールである、(1)に記載の外用剤組成物、
(3)グリセリンに三つの中鎖脂肪酸が結合したエステルがトリカプリン酸グリセリンである、(1)に記載の外用剤組成物、
(4)プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上の配合量が、S−フルルビプロフェン又はその薬学的に許容される塩の配合量に対して重量で、0.1倍量〜10倍量である、(1)〜(3)のいずれかに記載の外用剤組成物、
(5)プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上の配合量が、S−フルルビプロフェン又はその薬学的に許容される塩の配合量に対して重量で、0.45倍量〜10倍量である、(1)〜(3)のいずれかに記載の外用剤組成物、
(6)非水系組成物である、(1)〜(5)のいずれかに記載の外用剤組成物、
(7)テープ剤である、(6)に記載の外用剤組成物
を提供するものである。
下記表1の組成に従い、S-フルルビプロフェン、ハッカ油及び多価アルコール中鎖脂肪酸エステルをガラス瓶に量り取り、ガラス瓶を65℃に加熱した水浴を用いて加熱しながら溶解して各試料を調製した。
前記試料をガラス製の試験管に分注し、苛酷な条件として50℃もしくは65℃に設定した恒温機中で保存した。保存開始前及び保存開始後1、2、3箇月経過時に試料を採取し、試料中のS−フルルビプロフェン残存率(%)を測定して安定性を評価した。
Claims (9)
- S−フルルビプロフェン又はその薬学的に許容される塩と、ハッカ油と、プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上とを含む外用剤組成物。
- プロピレングリコールに二つの中鎖脂肪酸が結合したエステルがジカプリル酸プロピレングリコールである、請求項1に記載の外用剤組成物。
- グリセリンに三つの中鎖脂肪酸が結合したエステルがトリカプリン酸グリセリンである、請求項1に記載の外用剤組成物。
- プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上の配合量が、S−フルルビプロフェン又はその薬学的に許容される塩の配合量に対して重量で、0.1倍量〜10倍量である、請求項1〜3のいずれか1項に記載の外用剤組成物。
- プロピレングリコールに二つの中鎖脂肪酸が結合したエステル及びグリセリンに三つの中鎖脂肪酸が結合したエステルからなる群から選ばれる1種以上の配合量が、S−フルルビプロフェン又はその薬学的に許容される塩の配合量に対して重量で、0.45倍量〜10倍量である、請求項1〜3のいずれか1項に記載の外用剤組成物。
- S−フルルビプロフェン又はその薬学的に許容される塩と、ハッカ油と、ジカプリル酸プロピレングリコールとを含む外用剤組成物。
- S−フルルビプロフェン又はその薬学的に許容される塩と、ハッカ油と、トリカプリン酸グリセリンとを含む外用剤組成物。
- 非水系組成物である、請求項1〜7のいずれか1項に記載の外用剤組成物。
- テープ剤である、請求項8に記載の外用剤組成物。
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JP2015555469A Active JP6023358B2 (ja) | 2014-10-07 | 2015-09-15 | S−フルルビプロフェンを含有する外用剤組成物 |
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JP (2) | JP6683443B2 (ja) |
KR (1) | KR20170063700A (ja) |
CN (1) | CN107148269B (ja) |
AU (1) | AU2015329319B2 (ja) |
BR (1) | BR112017005759A2 (ja) |
CA (1) | CA2962034A1 (ja) |
MX (1) | MX371533B (ja) |
MY (1) | MY187120A (ja) |
PH (1) | PH12017500528A1 (ja) |
RU (1) | RU2715907C2 (ja) |
SG (1) | SG11201702334SA (ja) |
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WO (1) | WO2016056356A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2018172340A (ja) * | 2017-03-31 | 2018-11-08 | 三笠製薬株式会社 | フルルビプロフェン含有含水系貼付剤 |
US11691940B2 (en) | 2018-08-10 | 2023-07-04 | Tohoku University | Production method for polyvalent alcohol ester compounds |
Families Citing this family (1)
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WO2018070406A1 (ja) * | 2016-10-12 | 2018-04-19 | 帝國製薬株式会社 | 水性貼付剤 |
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- 2015-09-15 AU AU2015329319A patent/AU2015329319B2/en not_active Ceased
- 2015-09-15 CA CA2962034A patent/CA2962034A1/en not_active Abandoned
- 2015-09-15 EP EP15848668.8A patent/EP3205341A4/en not_active Withdrawn
- 2015-09-15 TW TW104130446A patent/TWI717323B/zh active
- 2015-09-15 JP JP2015181508A patent/JP6683443B2/ja active Active
- 2015-09-15 JP JP2015555469A patent/JP6023358B2/ja active Active
- 2015-09-15 WO PCT/JP2015/076109 patent/WO2016056356A1/ja active Application Filing
- 2015-09-15 SG SG11201702334SA patent/SG11201702334SA/en unknown
- 2015-09-15 KR KR1020177009761A patent/KR20170063700A/ko not_active Application Discontinuation
- 2015-09-15 MX MX2017004505A patent/MX371533B/es active IP Right Grant
- 2015-09-15 RU RU2017115933A patent/RU2715907C2/ru active
- 2015-09-15 CN CN201580054268.6A patent/CN107148269B/zh active Active
- 2015-09-15 BR BR112017005759A patent/BR112017005759A2/pt not_active IP Right Cessation
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018172340A (ja) * | 2017-03-31 | 2018-11-08 | 三笠製薬株式会社 | フルルビプロフェン含有含水系貼付剤 |
US11691940B2 (en) | 2018-08-10 | 2023-07-04 | Tohoku University | Production method for polyvalent alcohol ester compounds |
Also Published As
Publication number | Publication date |
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JPWO2016056356A1 (ja) | 2017-04-27 |
PH12017500528B1 (en) | 2017-08-07 |
EP3205341A1 (en) | 2017-08-16 |
MX2017004505A (es) | 2017-06-26 |
RU2715907C2 (ru) | 2020-03-04 |
EP3205341A4 (en) | 2018-05-30 |
CN107148269B (zh) | 2020-03-31 |
CA2962034A1 (en) | 2016-04-14 |
MY187120A (en) | 2021-09-02 |
RU2017115933A (ru) | 2018-11-13 |
KR20170063700A (ko) | 2017-06-08 |
WO2016056356A1 (ja) | 2016-04-14 |
JP2016073623A (ja) | 2016-05-12 |
PH12017500528A1 (en) | 2017-08-07 |
BR112017005759A2 (pt) | 2017-12-12 |
JP6683443B2 (ja) | 2020-04-22 |
SG11201702334SA (en) | 2017-05-30 |
TWI717323B (zh) | 2021-02-01 |
TW201625228A (zh) | 2016-07-16 |
AU2015329319A1 (en) | 2017-04-20 |
CN107148269A (zh) | 2017-09-08 |
RU2017115933A3 (ja) | 2019-03-06 |
MX371533B (es) | 2020-01-30 |
AU2015329319B2 (en) | 2018-12-13 |
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