JP6009457B2 - ポリマー−デスエチルスニチニブコンジュゲート - Google Patents
ポリマー−デスエチルスニチニブコンジュゲート Download PDFInfo
- Publication number
- JP6009457B2 JP6009457B2 JP2013546457A JP2013546457A JP6009457B2 JP 6009457 B2 JP6009457 B2 JP 6009457B2 JP 2013546457 A JP2013546457 A JP 2013546457A JP 2013546457 A JP2013546457 A JP 2013546457A JP 6009457 B2 JP6009457 B2 JP 6009457B2
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- compound
- polymer
- carboxamido
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426893P | 2010-12-23 | 2010-12-23 | |
| US61/426,893 | 2010-12-23 | ||
| PCT/US2011/067240 WO2012088522A1 (en) | 2010-12-23 | 2011-12-23 | Polymer-des-ethyl sunitinib conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501765A JP2014501765A (ja) | 2014-01-23 |
| JP2014501765A5 JP2014501765A5 (OSRAM) | 2014-12-25 |
| JP6009457B2 true JP6009457B2 (ja) | 2016-10-19 |
Family
ID=45496320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546457A Active JP6009457B2 (ja) | 2010-12-23 | 2011-12-23 | ポリマー−デスエチルスニチニブコンジュゲート |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10220020B2 (OSRAM) |
| EP (1) | EP2654797B1 (OSRAM) |
| JP (1) | JP6009457B2 (OSRAM) |
| WO (1) | WO2012088522A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088506A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
| JP6002149B2 (ja) | 2010-12-23 | 2016-10-05 | ネクター セラピューティクス | ポリマー−スニチニブコンジュゲート |
| JP6009457B2 (ja) * | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
| US9295731B2 (en) * | 2013-04-01 | 2016-03-29 | Mark Quang Nguyen | Cleavable drug conjugates, compositions thereof and methods of use |
| PT3039424T (pt) | 2013-08-28 | 2020-09-03 | Crown Bioscience Inc Taicang | Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo |
| KR102138415B1 (ko) * | 2014-12-04 | 2020-07-27 | 데루타-후라이 화마 가부시키가이샤 | 신규 peg 유도체 |
| EA037327B1 (ru) | 2015-09-22 | 2021-03-12 | Грейбуг Вижн, Инк. | Соединения и композиции для лечения глазных расстройств |
| EP3600324A4 (en) | 2017-03-23 | 2020-12-09 | Graybug Vision, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS |
| JP2020519585A (ja) | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | 医学療法のための延長放出マイクロ粒子及びその懸濁液 |
| CN111995513B (zh) * | 2019-05-27 | 2022-11-01 | 天津键凯科技有限公司 | 一种9-羟甲基-芴二酸的制备方法 |
| GB201916046D0 (en) * | 2019-11-04 | 2019-12-18 | Amazentis Sa | Diagnostic method |
| WO2022103983A2 (en) * | 2020-11-11 | 2022-05-19 | Sutro Biopharma, Inc. | Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| NZ519697A (en) | 1999-12-22 | 2004-08-27 | Sugen Inc | Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds |
| PT1255752E (pt) | 2000-02-15 | 2007-10-17 | Pharmacia & Upjohn Co Llc | Inibidores de proteína quinases: 2-indolinonas substituídas com pirrolo |
| EP1299355A2 (en) | 2000-05-02 | 2003-04-09 | Sugen, Inc. | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| JP4758608B2 (ja) | 2001-11-07 | 2011-08-31 | ネクター セラピューティックス | 分枝ポリマーおよびそれらの結合体 |
| US7053144B1 (en) | 2002-06-13 | 2006-05-30 | Cmi Rubber Company, Inc. | High density rubber compounds |
| WO2004084949A2 (en) | 2003-03-20 | 2004-10-07 | Xencor | Generating protein pro-drugs using reversible ppg linkages |
| PT2644206T (pt) | 2003-05-23 | 2019-07-10 | Nektar Therapeutics | Derivados de peg contendo duas cadeias de peg |
| KR20120073370A (ko) | 2003-09-17 | 2012-07-04 | 넥타르 테라퓨틱스 | 다분지형 고분자 전구약물 |
| US9085659B2 (en) | 2004-05-03 | 2015-07-21 | Nektar Therapeutics | Polymer derivatives comprising an imide branching point |
| WO2005108463A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Branched polyethylen glycol derivates comprising an acetal or ketal branching point |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| KR101513732B1 (ko) | 2006-02-21 | 2015-04-21 | 넥타르 테라퓨틱스 | 분할된 분해가능한 폴리머 및 이로부터 제조된 컨주게이트 |
| US20080044438A1 (en) | 2006-03-17 | 2008-02-21 | Ostroff Gary R | Yeast Cell Particles As Oral Delivery Vehicles For Antigens |
| CA2671676C (en) * | 2006-12-27 | 2014-04-22 | Baxter Healthcare Sa | Von willebrand factor-and factor viii-polymer conjugates having a releasable linkage |
| US8569380B2 (en) | 2007-11-28 | 2013-10-29 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| JP5704925B2 (ja) * | 2008-02-08 | 2015-04-22 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−カンナビノイドコンジュゲート |
| WO2009126333A1 (en) | 2008-04-11 | 2009-10-15 | Nektar Therapeutics | Oligomer-aryloxy-substituted propanamine conjugates |
| WO2009141823A2 (en) | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| CN102159250B (zh) * | 2008-08-11 | 2014-08-06 | 尼克塔治疗公司 | 多臂的聚合烷酸酯偶联物 |
| WO2010091187A2 (en) | 2009-02-04 | 2010-08-12 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| US8816077B2 (en) | 2009-04-17 | 2014-08-26 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| WO2010120387A1 (en) | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
| JP6002149B2 (ja) | 2010-12-23 | 2016-10-05 | ネクター セラピューティクス | ポリマー−スニチニブコンジュゲート |
| US20140331425A1 (en) | 2013-05-09 | 2014-11-13 | DeAndre Charles Baker | Sqeeky kleen toilet brush |
-
2011
- 2011-12-23 JP JP2013546457A patent/JP6009457B2/ja active Active
- 2011-12-23 EP EP11809055.4A patent/EP2654797B1/en active Active
- 2011-12-23 WO PCT/US2011/067240 patent/WO2012088522A1/en not_active Ceased
- 2011-12-23 US US13/995,819 patent/US10220020B2/en active Active
-
2019
- 2019-01-09 US US16/243,914 patent/US11406618B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11406618B2 (en) | 2022-08-09 |
| WO2012088522A1 (en) | 2012-06-28 |
| US20190142798A1 (en) | 2019-05-16 |
| EP2654797B1 (en) | 2017-11-08 |
| US10220020B2 (en) | 2019-03-05 |
| JP2014501765A (ja) | 2014-01-23 |
| EP2654797A1 (en) | 2013-10-30 |
| US20140039030A1 (en) | 2014-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6009457B2 (ja) | ポリマー−デスエチルスニチニブコンジュゲート | |
| JP6002149B2 (ja) | ポリマー−スニチニブコンジュゲート | |
| CA2947895C (en) | Nanoparticle drug conjugates | |
| US11007270B2 (en) | Polymer-semaxanib moiety conjugates | |
| US9095622B2 (en) | Oligomer-protein tyrosine kinase inhibitor conjugates | |
| TW201801751A (zh) | 靶向構建體及其製劑 | |
| Kozlowski et al. | Polymer-des-ethyl sunitinib conjugates | |
| JP5792175B2 (ja) | オリゴマー−カルシミメティクスコンジュゲートおよび関連化合物 | |
| JP6265998B2 (ja) | オリゴマー含有ベンズアミド系化合物 | |
| HK1236384A1 (en) | Nanoparticle drug conjugates | |
| HK1236384B (en) | Nanoparticle drug conjugates |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20130920 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141106 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141106 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150723 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150730 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151022 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151118 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20151228 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160412 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160810 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20160819 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160907 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160914 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6009457 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |