JP6009355B2 - Vap−1阻害剤、およびvap−1阻害剤の使用 - Google Patents

Vap−1阻害剤、およびvap−1阻害剤の使用 Download PDF

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Publication number
JP6009355B2
JP6009355B2 JP2012528399A JP2012528399A JP6009355B2 JP 6009355 B2 JP6009355 B2 JP 6009355B2 JP 2012528399 A JP2012528399 A JP 2012528399A JP 2012528399 A JP2012528399 A JP 2012528399A JP 6009355 B2 JP6009355 B2 JP 6009355B2
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vap
fibrosis
seq
inhibitor
variable region
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JP2013503915A5 (enExample
JP2013503915A (ja
Inventor
クリストファー ウェストン
クリストファー ウェストン
リー チャールズ クラリッジ
リー チャールズ クラリッジ
デイビッド アダムス
デイビッド アダムス
デイビッド スミス
デイビッド スミス
ニナ ウェスターランド
ニナ ウェスターランド
マルヨ ピーラヴィスト
マルヨ ピーラヴィスト
トゥア オステルマン
トゥア オステルマン
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University of Birmingham
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University of Birmingham
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/906Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/90605Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4)
    • G01N2333/90633Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general
    • G01N2333/90638Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general with a definite EC number (1.4.3.-)
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    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

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JP2012528399A 2009-09-08 2010-09-07 Vap−1阻害剤、およびvap−1阻害剤の使用 Expired - Fee Related JP6009355B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24040209P 2009-09-08 2009-09-08
US61/240,402 2009-09-08
US32303210P 2010-04-12 2010-04-12
US61/323,032 2010-04-12
PCT/FI2010/050689 WO2011029996A1 (en) 2009-09-08 2010-09-07 Use of vap-1 inhibitors for treating fibrotic conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016003089A Division JP6290940B2 (ja) 2009-09-08 2016-01-08 診断剤、完全ヒト抗vap−1抗体の使用、及びキット

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JP2013503915A JP2013503915A (ja) 2013-02-04
JP2013503915A5 JP2013503915A5 (enExample) 2016-03-31
JP6009355B2 true JP6009355B2 (ja) 2016-10-19

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JP2012528399A Expired - Fee Related JP6009355B2 (ja) 2009-09-08 2010-09-07 Vap−1阻害剤、およびvap−1阻害剤の使用
JP2016003089A Expired - Fee Related JP6290940B2 (ja) 2009-09-08 2016-01-08 診断剤、完全ヒト抗vap−1抗体の使用、及びキット
JP2018020789A Pending JP2018104445A (ja) 2009-09-08 2018-02-08 線維性疾患治療のためのvap−1阻害剤の使用

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JP2016003089A Expired - Fee Related JP6290940B2 (ja) 2009-09-08 2016-01-08 診断剤、完全ヒト抗vap−1抗体の使用、及びキット
JP2018020789A Pending JP2018104445A (ja) 2009-09-08 2018-02-08 線維性疾患治療のためのvap−1阻害剤の使用

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US (2) US9795671B2 (enExample)
EP (1) EP2475387B1 (enExample)
JP (3) JP6009355B2 (enExample)
KR (2) KR20180026808A (enExample)
CN (2) CN107661500A (enExample)
AU (1) AU2010294123B2 (enExample)
CA (1) CA2773218C (enExample)
CY (1) CY1119867T1 (enExample)
DK (1) DK2475387T3 (enExample)
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NO (1) NO2475387T3 (enExample)
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PT (1) PT2475387T (enExample)
RS (1) RS56809B1 (enExample)
RU (2) RU2667963C1 (enExample)
SG (1) SG179012A1 (enExample)
SI (1) SI2475387T1 (enExample)
SM (1) SMT201800043T1 (enExample)
UA (1) UA112154C2 (enExample)
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CA3086105A1 (en) 2012-05-02 2013-11-07 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of ssao and uses thereof
WO2014024820A1 (ja) * 2012-08-06 2014-02-13 塩野義製薬株式会社 新規慢性腎臓病治療用医薬組成物及び新規慢性腎臓病治療薬のスクリーニング方法
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WO2015189534A1 (en) * 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
JP2018080114A (ja) * 2015-05-29 2018-05-24 株式会社アールテック・ウエノ 抗ヒトvap−1モノクローナル抗体
WO2019003159A1 (en) * 2017-06-27 2019-01-03 Neuracle Science Co., Ltd. USE OF ANTI-FAM19A5 ANTIBODIES FOR THE TREATMENT OF FIBROSIS
EP4482869A4 (en) * 2022-02-23 2025-12-17 Univ Yale IL-6 inhibitor for the treatment of nephropathia
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