JP6002778B2 - アルコール依存症および乱用の治療において使用するためのｏｒｌ−１受容体アンタゴニストとしてのスピロチエノピラン−ピペリジン誘導体 - Google Patents
アルコール依存症および乱用の治療において使用するためのｏｒｌ−１受容体アンタゴニストとしてのスピロチエノピラン−ピペリジン誘導体 Download PDFInfo
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- JP6002778B2 JP6002778B2 JP2014545947A JP2014545947A JP6002778B2 JP 6002778 B2 JP6002778 B2 JP 6002778B2 JP 2014545947 A JP2014545947 A JP 2014545947A JP 2014545947 A JP2014545947 A JP 2014545947A JP 6002778 B2 JP6002778 B2 JP 6002778B2
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- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567242P | 2011-12-06 | 2011-12-06 | |
| US61/567,242 | 2011-12-06 | ||
| PCT/US2012/066918 WO2013085781A1 (en) | 2011-12-06 | 2012-11-29 | Spirothienopyran- piperidine derivatives as orl-1 receptor antagonists for their use in the treatment of alcohol dependence and abuse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502956A JP2015502956A (ja) | 2015-01-29 |
| JP6002778B2 true JP6002778B2 (ja) | 2016-10-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2014545947A Expired - Fee Related JP6002778B2 (ja) | 2011-12-06 | 2012-11-29 | アルコール依存症および乱用の治療において使用するためのｏｒｌ−１受容体アンタゴニストとしてのスピロチエノピラン−ピペリジン誘導体 |
Country Status (28)
| Country | Link |
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| EP (1) | EP2787995B1 (sl) |
| JP (1) | JP6002778B2 (sl) |
| KR (1) | KR101638265B1 (sl) |
| CN (1) | CN103987387B (sl) |
| AP (1) | AP3880A (sl) |
| AU (1) | AU2012348140B2 (sl) |
| BR (1) | BR112014012849A2 (sl) |
| CA (1) | CA2853500C (sl) |
| DK (1) | DK2787995T3 (sl) |
| EA (1) | EA022874B1 (sl) |
| ES (1) | ES2600911T3 (sl) |
| HK (1) | HK1196943A1 (sl) |
| HR (1) | HRP20161351T1 (sl) |
| HU (1) | HUE029439T2 (sl) |
| IL (1) | IL232654A (sl) |
| LT (1) | LT2787995T (sl) |
| MX (1) | MX352997B (sl) |
| MY (1) | MY172809A (sl) |
| PL (1) | PL2787995T3 (sl) |
| PT (1) | PT2787995T (sl) |
| RS (1) | RS55182B1 (sl) |
| SG (1) | SG11201402745UA (sl) |
| SI (1) | SI2787995T1 (sl) |
| TW (1) | TWI582096B (sl) |
| UA (1) | UA113859C2 (sl) |
| WO (1) | WO2013085781A1 (sl) |
| ZA (1) | ZA201403927B (sl) |
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|---|---|---|---|---|
| JO3638B1 (ar) * | 2015-09-09 | 2020-08-27 | Lilly Co Eli | مركبات مفيدة في تثبيط ror - جاما- t |
| PT3589638T (pt) | 2017-03-02 | 2021-05-27 | Lilly Co Eli | Compostos úteis para inibição do ror-gama-t |
| EP3589637B1 (en) * | 2017-03-02 | 2021-04-14 | Eli Lilly and Company | Compounds useful for inhibiting ror-gamma-t |
| CN109400618B (zh) * | 2018-11-09 | 2021-08-10 | 中国药科大学 | 一种色满衍生物及其制备方法和应用 |
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| US5140032A (en) * | 1990-10-01 | 1992-08-18 | Radecki Thomas E | Drug therapy for alcohol abusers |
| EP1873150A1 (en) * | 2006-06-30 | 2008-01-02 | Nikem Research S.R.L. | Fluorinated indoleamides useful as ligands of the ORL-1 receptor |
| US8207201B2 (en) * | 2006-10-16 | 2012-06-26 | Mitsubishi Tanabe Pharma Corporation | Agent for prophylaxis or treatment of alcohol dependence or drug dependence |
| UA107943C2 (en) * | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Compounds of spiropiperidines as antagonists of the orl-1 receptors |
| PT2501704E (pt) * | 2009-11-16 | 2013-12-05 | Lilly Co Eli | Compostos de espiropiperidina como antagonistas do receptor orl-1 |
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- 2012-11-29 WO PCT/US2012/066918 patent/WO2013085781A1/en active Application Filing
- 2012-11-29 CN CN201280059917.8A patent/CN103987387B/zh not_active Expired - Fee Related
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- 2012-11-29 RS RS20160772A patent/RS55182B1/sr unknown
- 2012-11-29 EA EA201490938A patent/EA022874B1/ru not_active IP Right Cessation
- 2012-11-29 HU HUE12795315A patent/HUE029439T2/en unknown
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- 2014-05-28 ZA ZA2014/03927A patent/ZA201403927B/en unknown
- 2014-10-16 HK HK14110358.9A patent/HK1196943A1/zh not_active IP Right Cessation
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2016
- 2016-10-17 HR HRP20161351TT patent/HRP20161351T1/hr unknown
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