JP5998152B2 - Ｂｃｌ−２／ｂｃｌ−ｘｌ阻害剤およびそれを使用する治療方法 - Google Patents

Ｂｃｌ−２／ｂｃｌ−ｘｌ阻害剤およびそれを使用する治療方法 Download PDF

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JP5998152B2
JP5998152B2 JP2013551282A JP2013551282A JP5998152B2 JP 5998152 B2 JP5998152 B2 JP 5998152B2 JP 2013551282 A JP2013551282 A JP 2013551282A JP 2013551282 A JP2013551282 A JP 2013551282A JP 5998152 B2 JP5998152 B2 JP 5998152B2
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compound
bcl
nmr
mhz
phenyl
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JP2014507421A (ja
JP2014507421A5 (enExample
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ワン，シャオメン
ツォウ，ハイビン
チェン，ジエンファン
アギラール，アンジェロ
マアー，ジェニファー，リン
サン，ドキシン
ヤン，チャオイ
リュー，リュー
バイ，ロンチュアン
マッカカーン，ドナ
スタッキー，ジーン
リー，シャオチン
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ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013551282A 2011-01-25 2012-01-24 Ｂｃｌ−２／ｂｃｌ−ｘｌ阻害剤およびそれを使用する治療方法 Active JP5998152B2 (ja)

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US201161436077P 2011-01-25 2011-01-25
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PCT/US2012/022315 WO2012103059A2 (en) 2011-01-25 2012-01-24 Bcl-2/bcl-xl inhibitors and therapeutic methods using the same

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JP2014507421A JP2014507421A (ja) 2014-03-27
JP2014507421A5 JP2014507421A5 (enExample) 2016-01-28
JP5998152B2 true JP5998152B2 (ja) 2016-09-28

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US (1) US8691184B2 (enExample)
EP (2) EP2668180B1 (enExample)
JP (1) JP5998152B2 (enExample)
KR (1) KR101762724B1 (enExample)
CN (1) CN103562202B (enExample)
AU (1) AU2012209295B2 (enExample)
CA (1) CA2825306C (enExample)
ES (1) ES2693107T3 (enExample)
SG (1) SG192126A1 (enExample)
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