JP5980318B2 - 新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体 - Google Patents

新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体 Download PDF

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Publication number
JP5980318B2
JP5980318B2 JP2014515155A JP2014515155A JP5980318B2 JP 5980318 B2 JP5980318 B2 JP 5980318B2 JP 2014515155 A JP2014515155 A JP 2014515155A JP 2014515155 A JP2014515155 A JP 2014515155A JP 5980318 B2 JP5980318 B2 JP 5980318B2
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JP
Japan
Prior art keywords
oxo
dimethoxyphenyl
piperidin
pyrrolo
cyclopropylmethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2014515155A
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English (en)
Japanese (ja)
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JP2014517021A (ja
JP2014517021A5 (https=
Inventor
シュテンゲル トーマス
シュテンゲル トーマス
トーマス　マイアー
マイアー トーマス
マン アレクサンダー
マン アレクサンダー
シュタードルヴィーザー ヨーゼフ
シュタードルヴィーザー ヨーゼフ
ディーター　フロッカーツィ
フロッカーツィ ディーター
パール アンドレアス
パール アンドレアス
ベネディクトゥス エーヴァルト
ベネディクトゥス エーヴァルト
ヘスマン マヌエラ
ヘスマン マヌエラ
カーナッハー トビアス
カーナッハー トビアス
フッソング ラグナ
フッソング ラグナ
ツィット クリストフ
ツィット クリストフ
クリストフ ホルスト ハンス
クリストフ ホルスト ハンス
フメル ロルフ−ペーター
フメル ロルフ−ペーター
フィアテルハウス マーティン
フィアテルハウス マーティン
テノール ヘアマン
テノール ヘアマン
ドゥンカン トアステン
ドゥンカン トアステン
ハッツェルマン アーミン
ハッツェルマン アーミン
ヘスリンガー クリスティアン
ヘスリンガー クリスティアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Takeda GmbH
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Filing date
Publication date
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Application filed by Takeda GmbH filed Critical Takeda GmbH
Publication of JP2014517021A publication Critical patent/JP2014517021A/ja
Publication of JP2014517021A5 publication Critical patent/JP2014517021A5/ja
Application granted granted Critical
Publication of JP5980318B2 publication Critical patent/JP5980318B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014515155A 2011-06-17 2012-06-12 新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体 Expired - Fee Related JP5980318B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11170440 2011-06-17
EP11170440.9 2011-06-17
PCT/EP2012/061084 WO2012171900A1 (en) 2011-06-17 2012-06-12 Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives

Publications (3)

Publication Number Publication Date
JP2014517021A JP2014517021A (ja) 2014-07-17
JP2014517021A5 JP2014517021A5 (https=) 2015-08-06
JP5980318B2 true JP5980318B2 (ja) 2016-08-31

Family

ID=44764312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014515155A Expired - Fee Related JP5980318B2 (ja) 2011-06-17 2012-06-12 新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体

Country Status (22)

Country Link
US (2) US20140112945A1 (https=)
EP (1) EP2721030B1 (https=)
JP (1) JP5980318B2 (https=)
KR (1) KR20140037195A (https=)
CN (1) CN103582644B (https=)
AR (1) AR086915A1 (https=)
AU (1) AU2012269133A1 (https=)
BR (1) BR112013031791A2 (https=)
CA (1) CA2837248A1 (https=)
CL (1) CL2013003556A1 (https=)
CO (1) CO6852074A2 (https=)
CR (1) CR20130656A (https=)
DO (1) DOP2013000298A (https=)
EA (1) EA023713B1 (https=)
EC (1) ECSP13013076A (https=)
ES (1) ES2564882T3 (https=)
MA (1) MA35269B1 (https=)
MX (1) MX2013014888A (https=)
PE (1) PE20140648A1 (https=)
PH (1) PH12013502546A1 (https=)
TN (1) TN2013000439A1 (https=)
WO (1) WO2012171900A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170132880A (ko) 2015-04-09 2017-12-04 갈데르마 소시에떼아노님 약학 조성물 및 이의 용도
HRP20190088T1 (hr) 2015-04-09 2019-03-22 Galderma Sa Ekstrakt iz prirodnog indiga i postupak njegove priprave
EP3280428A1 (en) 2015-04-09 2018-02-14 Galderma S.A. Antibacterial indigo naturalis or indigo-producing plant extract and use thereof
EP3215169A1 (en) * 2015-04-09 2017-09-13 Galderma S.A. Treatment of atopic dermatitis with indigo naturalis or indigo producing plant extract
US12383547B2 (en) 2020-07-01 2025-08-12 Vanderbilt University Methods of treatment for a kidney disease

Family Cites Families (30)

* Cited by examiner, † Cited by third party
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GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
DE407028T1 (de) 1989-05-31 1994-03-17 Fisons Plc Medikament und Inhalationsvorrichtung dafür.
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
AU654813B2 (en) 1990-03-23 1994-11-24 Minnesota Mining And Manufacturing Company The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
JP2769925B2 (ja) 1990-10-18 1998-06-25 ミネソタ マイニング アンド マニュファクチャリング カンパニー ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of medicament formulations
TR199901653T2 (xx) * 1997-01-15 1999-10-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Fitalazinonlar.
JP2002506856A (ja) * 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング フタラジノンｐｄｅｉｉｉ／ｉｖ阻害剤
CN1150890C (zh) 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
JP4677102B2 (ja) 1999-04-23 2011-04-27 バテル・メモリアル・インスティテュート エーロゾル給送装置及びエーロゾル小滴を給送する方法
AU777169B2 (en) 1999-04-23 2004-10-07 Battelle Memorial Institute High mass transfer electrosprayer
NZ522882A (en) * 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
CA2425035A1 (en) 2000-10-09 2002-04-18 3M Innovative Properties Company Medicinal aerosol formulations
EE05386B1 (et) 2001-02-15 2011-02-15 ALTANA�Pharma�AG Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim
NZ529221A (en) 2001-04-25 2005-04-29 Altana Pharma Ag Phthalazinones with PDE-inhibiting properties for treatment of airway disorders and other inflammatory conditions
AU2003255376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
CA2494613C (en) 2002-08-10 2011-06-28 Altana Pharma Ag Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors
WO2004018451A1 (en) 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2004062671A2 (en) * 2003-01-14 2004-07-29 Altana Pharma Ag Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
WO2005075457A1 (en) 2004-02-04 2005-08-18 Altana Pharma Ag Phthalazinone-derivatives as pde4 inhibitors
EP1716133B1 (en) 2004-02-04 2008-03-26 Nycomed GmbH 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden
AR077898A1 (es) * 2009-08-26 2011-09-28 Nycomed Gmbh Metilpirrolopirimidincarboxamidas

Also Published As

Publication number Publication date
CA2837248A1 (en) 2012-12-20
JP2014517021A (ja) 2014-07-17
US20160108049A1 (en) 2016-04-21
ES2564882T3 (es) 2016-03-29
WO2012171900A1 (en) 2012-12-20
EA023713B1 (ru) 2016-07-29
AU2012269133A1 (en) 2014-01-30
BR112013031791A2 (pt) 2017-01-31
EP2721030B1 (en) 2015-12-16
ECSP13013076A (es) 2014-01-31
MA35269B1 (fr) 2014-07-03
EA201400001A1 (ru) 2014-05-30
CN103582644A (zh) 2014-02-12
KR20140037195A (ko) 2014-03-26
EP2721030A1 (en) 2014-04-23
DOP2013000298A (es) 2014-03-31
MX2013014888A (es) 2014-02-27
PH12013502546A1 (en) 2014-01-27
CL2013003556A1 (es) 2014-06-13
CN103582644B (zh) 2016-07-20
TN2013000439A1 (en) 2015-03-30
PE20140648A1 (es) 2014-05-30
US20140112945A1 (en) 2014-04-24
CR20130656A (es) 2014-02-18
AR086915A1 (es) 2014-01-29
CO6852074A2 (es) 2014-01-30

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