JP5977825B2 - マイクロチップを基盤とした血小板複合機能検査装置 - Google Patents
マイクロチップを基盤とした血小板複合機能検査装置 Download PDFInfo
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
Description
図2は、本発明によるマイクロチップを基盤とした血小板複合機能検査装置の多数個のビーズが具備されるチャンバーの構成図である。
3 撹拌器
10 並列チャネル
12 マイクロフィラー
20 光源
22 イメージセンサー
30 真空チャンバー
32 真空弁
40 シリンジ
42 ピストン
50 チャンバー
52 ビーズ
54 通孔
Claims (10)
- 血液サンプルが内部に収容されるサンプル貯蔵室と;
前記サンプル貯蔵室の内部に設置され、前記血液サンプル内にせん断流動を誘発させる撹拌器と;
前記撹拌器によって撹拌された血液を多数個の経路に分離させて流動させる並列チャネルと;
前記並列チャネルの端部にそれぞれ連結され、一定の圧力を維持し、撹拌された血液を前記並列チャネルに沿って流動させる真空装置と;
前記並列チャネルの後段側に設置され、前記並列チャネルに光を照射する光源と;
前記並列チャネル内の血液を透過した光を受信し、電気的信号に変えて、血液流動の進行距離を測定するイメージセンサーと;を含むマイクロチップを基盤とした血小板複合機能検査装置であって、
前記並列チャネルの前段部には、血液の流動速度を低減し、血小板機能検査のために血小板が付着及び凝集するようにするための多数個のマイクロフィラーが設置され、それぞれの並列チャネルに位置する前記マイクロフィラーには、互いに異なる試薬がコーティングされており、
前記真空装置は、前記並列チャネルの端部に連結された真空チャンバーと;前記真空チャンバーと連結され、内部にピストンが移動可能に設置され、真空チャンバーを一定の圧力に維持させるシリンジと;を含むことを特徴とするマイクロチップを基盤とした血小板複合機能検査装置。 - 血液サンプルが内部に収容されるサンプル貯蔵室と;
前記サンプル貯蔵室の内部に設置され、前記血液サンプル内にせん断流動を誘発させる撹拌器と;
前記撹拌器によって撹拌された血液を多数個の経路に分離させて流動させる並列チャネルと;
前記並列チャネルの端部にそれぞれ連結され、一定の圧力を維持し、撹拌された血液を前記並列チャネルに沿って流動させる真空装置と;
前記並列チャネルの後段側に設置され、前記並列チャネルに光を照射する光源と;
前記並列チャネル内の血液を透過した光を受信し、電気的信号に変えて、血液流動の進行距離を測定するイメージセンサーと;を含むマイクロチップを基盤とした血小板複合機能検査装置であって、
前記並列チャネルの前段部には、内部に多数個のビーズが具備されるチャンバーが設置されており、前記チャンバーの前面及び後面には、前記ビーズより直径が小さい通孔が形成されており、
前記真空装置は、前記並列チャネルの端部に連結された真空チャンバーと;前記真空チャンバーと連結され、内部にピストンが移動可能に設置され、真空チャンバーを一定の圧力に維持させるシリンジと;を含むことを特徴とするマイクロチップを基盤とした血小板複合機能検査装置。 - 前記並列チャネルの前段部には、血液の流動速度を低減するための流路の急拡張部が設置されていることを特徴とする請求項1又は2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記並列チャネルの前段部には、血液の流動速度を低減し、血小板機能検査のために血小板が付着及び凝集するようにするための多数個のマイクロフィラーが設置されることを特徴とする請求項2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記マイクロフィラーには、コラーゲンとエピネフリン、コラーゲンとADPで構成された試薬のうちいずれか1つがコーティングされることを特徴とする請求項1又は4に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記ビーズには、コラーゲンとエピネフリン、コラーゲンとADPで構成された試薬のうちいずれか1つがコーティングされることを特徴とする請求項2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記真空チャンバーとシリンジの間には、前記並列チャネルの開閉を制御する真空弁がさらに設置されることを特徴とする請求項1又は2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記撹拌器の撹拌による最小せん断率が5000(s-1)以上であるか、又は最小せん断力が8Pa以上であることを特徴とする請求項1又は2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記光源は、LEDアレイであり、前記イメージセンサーはCCDセンサーであることを特徴とする請求項1又は2に記載のマイクロチップを基盤とした血小板複合機能検査装置。
- 前記真空弁は、血液サンプルが注入された後、前記真空チャンバーの真空圧力が並列チャネルに連結されるように開弁された後、すぐ閉弁されるようにして、各並列チャネルの初期真空圧力が血液サンプルの流入によって減少するようにすることを特徴とする請求項7に記載のマイクロチップを基盤とした血小板複合機能検査装置。
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KR1020110079497A KR101193566B1 (ko) | 2011-08-10 | 2011-08-10 | 마이크로칩 기반 혈소판 복합기능 검사 장치 |
KR10-2011-0079497 | 2011-08-10 | ||
PCT/KR2012/006338 WO2013022284A2 (ko) | 2011-08-10 | 2012-08-09 | 마이크로칩 기반 혈소판 복합기능 검사 장치 |
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US (1) | US9239325B2 (ja) |
EP (1) | EP2743692B1 (ja) |
JP (1) | JP5977825B2 (ja) |
KR (1) | KR101193566B1 (ja) |
CN (1) | CN103718041B (ja) |
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WO2013022284A2 (ko) | 2013-02-14 |
JP2014521975A (ja) | 2014-08-28 |
EP2743692A2 (en) | 2014-06-18 |
KR101193566B1 (ko) | 2012-10-22 |
WO2013022284A3 (ko) | 2013-05-30 |
EP2743692B1 (en) | 2018-05-23 |
CN103718041B (zh) | 2016-06-22 |
CN103718041A (zh) | 2014-04-09 |
US9239325B2 (en) | 2016-01-19 |
PL2743692T3 (pl) | 2018-10-31 |
US20150010995A1 (en) | 2015-01-08 |
EP2743692A4 (en) | 2015-07-22 |
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