JP5974180B2 - ピラゾール誘導体を含む腎臓疾患の予防または治療用組成物 - Google Patents
ピラゾール誘導体を含む腎臓疾患の予防または治療用組成物 Download PDFInfo
- Publication number
- JP5974180B2 JP5974180B2 JP2015529664A JP2015529664A JP5974180B2 JP 5974180 B2 JP5974180 B2 JP 5974180B2 JP 2015529664 A JP2015529664 A JP 2015529664A JP 2015529664 A JP2015529664 A JP 2015529664A JP 5974180 B2 JP5974180 B2 JP 5974180B2
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- JP
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- Prior art keywords
- pyrazol
- pyridin
- propyl
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0093936 | 2012-08-27 | ||
| KR1020120093936A KR101633957B1 (ko) | 2012-08-27 | 2012-08-27 | 피라졸 유도체를 포함하는 신장질환 예방 또는 치료용 조성물 |
| PCT/KR2013/006985 WO2014035070A1 (ko) | 2012-08-27 | 2013-08-02 | 피라졸 유도체를 포함하는 신장질환 예방 또는 치료용 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531774A JP2015531774A (ja) | 2015-11-05 |
| JP2015531774A5 JP2015531774A5 (OSRAM) | 2015-12-17 |
| JP5974180B2 true JP5974180B2 (ja) | 2016-08-23 |
Family
ID=50183832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529664A Active JP5974180B2 (ja) | 2012-08-27 | 2013-08-02 | ピラゾール誘導体を含む腎臓疾患の予防または治療用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10047067B2 (OSRAM) |
| EP (1) | EP2889032B1 (OSRAM) |
| JP (1) | JP5974180B2 (OSRAM) |
| KR (1) | KR101633957B1 (OSRAM) |
| CN (1) | CN104755077B (OSRAM) |
| ES (1) | ES2734264T3 (OSRAM) |
| PL (1) | PL2889032T3 (OSRAM) |
| TR (1) | TR201909923T4 (OSRAM) |
| WO (1) | WO2014035070A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101826208B1 (ko) | 2016-02-05 | 2018-02-06 | 경북대학교 산학협력단 | 뉴로펩타이드 y를 유효성분으로 포함하는, 신장질환의 예방 또는 치료용 약학적 조성물 |
| KR101856444B1 (ko) * | 2017-04-20 | 2018-05-10 | 압타바이오 주식회사 | 3-페닐-4-프로필-1-(피리딘-2-일)-1ｈ-피라졸-5-올 염산염의 신규 결정형 고체 화합물 |
| KR101840702B1 (ko) * | 2017-11-01 | 2018-03-22 | 압타바이오 주식회사 | 간질환 치료제 |
| TW202133845A (zh) | 2019-11-21 | 2021-09-16 | 韓商三進製藥股份有限公司 | 用於預防或治療眼部疾病之眼用組合物 |
| KR102277665B1 (ko) * | 2020-02-05 | 2021-07-15 | 바이오그래핀 주식회사 | 그래핀 기반 신장 질환 치료용 조성물 |
| KR102308991B1 (ko) * | 2020-04-08 | 2021-10-06 | 압타바이오 주식회사 | 조영제 유발 급성 신부전 치료제 |
| JP7553595B2 (ja) * | 2020-04-08 | 2024-09-18 | アプタバイオ セラピューティクス インコーポレイテッド | 造影剤誘発急性腎不全治療剤 |
| JP7539485B2 (ja) * | 2020-04-13 | 2024-08-23 | アプタバイオ セラピューティクス インコーポレイテッド | ピラゾール誘導体の肺線維症治療剤 |
| KR102386097B1 (ko) * | 2020-04-13 | 2022-04-14 | 압타바이오 주식회사 | 피라졸 유도체의 폐섬유증 치료제 |
| WO2022120194A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| KR102589130B1 (ko) * | 2021-03-24 | 2023-10-13 | 삼진제약주식회사 | N-옥소 피리딘 화합물 발생을 억제하는 안질환 예방 또는 치료용 점안 조성물 |
| IL307454A (en) | 2021-04-07 | 2023-12-01 | Battelle Memorial Institute | Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
| CN119504599B (zh) * | 2024-11-18 | 2025-09-26 | 安徽医科大学 | 一种用于治疗肾脏纤维化的吡唑类化合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4023488A1 (de) | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
| AU2697092A (en) | 1991-10-08 | 1993-05-03 | Nippon Soda Co., Ltd. | Pyrazole derivative and agrohorticultural bactericide containing same |
| JP2003098120A (ja) | 2001-09-26 | 2003-04-03 | Tokyo Weld Co Ltd | 外観検査装置 |
| JP4189850B2 (ja) | 2002-05-20 | 2008-12-03 | 味の素株式会社 | 線維化病変組織修復剤 |
| KR20040094464A (ko) * | 2003-05-02 | 2004-11-10 | 학교법인 이화학당 | 피리디닐 피라졸 유도체 |
| WO2006129587A1 (ja) | 2005-05-30 | 2006-12-07 | Genecare Research Institute Co., Ltd. | ピラゾロン誘導体を含有する医薬組成物 |
| CN101511818B (zh) * | 2006-09-01 | 2013-05-08 | 大塚农业科技株式会社 | N-吡啶基哌啶化合物、其制备方法及有害生物防治剂 |
| KR100942382B1 (ko) * | 2008-03-25 | 2010-02-12 | 이화여자대학교 산학협력단 | 피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물 |
| KR101280198B1 (ko) | 2009-09-02 | 2013-06-28 | 이화여자대학교 산학협력단 | 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물 |
| WO2011028043A2 (ko) * | 2009-09-02 | 2011-03-10 | 이화여자대학교 산학협력단 | 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물 |
-
2012
- 2012-08-27 KR KR1020120093936A patent/KR101633957B1/ko active Active
-
2013
- 2013-08-02 ES ES13834243T patent/ES2734264T3/es active Active
- 2013-08-02 CN CN201380056244.5A patent/CN104755077B/zh active Active
- 2013-08-02 JP JP2015529664A patent/JP5974180B2/ja active Active
- 2013-08-02 EP EP13834243.1A patent/EP2889032B1/en active Active
- 2013-08-02 PL PL13834243T patent/PL2889032T3/pl unknown
- 2013-08-02 TR TR2019/09923T patent/TR201909923T4/tr unknown
- 2013-08-02 US US14/424,771 patent/US10047067B2/en active Active
- 2013-08-02 WO PCT/KR2013/006985 patent/WO2014035070A1/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140027833A (ko) | 2014-03-07 |
| JP2015531774A (ja) | 2015-11-05 |
| EP2889032A1 (en) | 2015-07-01 |
| EP2889032B1 (en) | 2019-05-08 |
| KR101633957B1 (ko) | 2016-06-27 |
| US20150218125A1 (en) | 2015-08-06 |
| CN104755077B (zh) | 2018-05-15 |
| US10047067B2 (en) | 2018-08-14 |
| PL2889032T3 (pl) | 2019-09-30 |
| TR201909923T4 (tr) | 2019-07-22 |
| ES2734264T3 (es) | 2019-12-05 |
| CN104755077A (zh) | 2015-07-01 |
| WO2014035070A1 (ko) | 2014-03-06 |
| EP2889032A4 (en) | 2016-03-09 |
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