JP5973427B2 - 追加のジスルフィド結合を含有するインスリン類似体 - Google Patents

追加のジスルフィド結合を含有するインスリン類似体 Download PDF

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Publication number
JP5973427B2
JP5973427B2 JP2013515873A JP2013515873A JP5973427B2 JP 5973427 B2 JP5973427 B2 JP 5973427B2 JP 2013515873 A JP2013515873 A JP 2013515873A JP 2013515873 A JP2013515873 A JP 2013515873A JP 5973427 B2 JP5973427 B2 JP 5973427B2
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Japan
Prior art keywords
desb30
human insulin
insulin
amino acid
cysteine
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JP2013515873A
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English (en)
Japanese (ja)
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JP2013530702A (ja
JP2013530702A5 (enExample
Inventor
スヴェン・ルドヴィクセン
フランティセク・フバレク
トーマス・ベーグルム・ケルセン
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2013515873A 2010-06-23 2011-06-21 追加のジスルフィド結合を含有するインスリン類似体 Expired - Fee Related JP5973427B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033 2010-06-23
EP10167033.9 2010-06-23
US35950010P 2010-06-29 2010-06-29
US61/359,500 2010-06-29
PCT/EP2011/060382 WO2011161124A1 (en) 2010-06-23 2011-06-21 Insulin analogues containing additional disulfide bonds

Publications (3)

Publication Number Publication Date
JP2013530702A JP2013530702A (ja) 2013-08-01
JP2013530702A5 JP2013530702A5 (enExample) 2014-07-31
JP5973427B2 true JP5973427B2 (ja) 2016-08-23

Family

ID=43242459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013515873A Expired - Fee Related JP5973427B2 (ja) 2010-06-23 2011-06-21 追加のジスルフィド結合を含有するインスリン類似体

Country Status (5)

Country Link
US (1) US8815798B2 (enExample)
EP (1) EP2585484A1 (enExample)
JP (1) JP5973427B2 (enExample)
CN (1) CN102947331B (enExample)
WO (1) WO2011161124A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2254906T3 (en) 2008-03-18 2017-01-23 Novo Nordisk As Protease-stabilized acylated insulin analogues
AU2011269000C1 (en) 2010-06-23 2015-10-08 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
EP2686003A2 (en) * 2011-03-15 2014-01-22 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
WO2013093009A1 (en) * 2011-12-21 2013-06-27 Novo Nordisk A/S N -terminally modified insulin derivatives
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3341403B1 (en) 2015-08-25 2022-01-05 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
HUE060149T2 (hu) 2016-12-16 2023-02-28 Novo Nordisk As Inzulint tartalmazó gyógyászati készítmények
BR112020002364A2 (pt) 2017-08-17 2020-09-01 Novo Nordisk A/S derivado de insulina, produto intermediário, uso de um derivado de insulina, e, métodos para o tratamento ou prevenção de diabetes, diabetes do tipo 1, diabetes do tipo 2, tolerância à glicose comprometida, hiperglicemia, dislipidemia, obesidade, síndrome metabólica, hipertensão, distúrbios cognitivos, aterosclerose, infarto do miocárdio, acidente vascular cerebral, distúrbios cardiovasculares, doença cardíaca coronariana, síndrome intestinal inflamatória, dispepsia, hipotensão ou úlceras gástricas, e para determinar a seletividade de um composto de insulina
MY208364A (en) 2019-12-11 2025-05-01 Novo Nordisk As Novel insulin analogues and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
KR20030004317A (ko) 1999-12-29 2003-01-14 노보 노르디스크 에이/에스 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
BRPI0413276B8 (pt) 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
ES2369895T3 (es) 2003-12-03 2011-12-07 Novo Nordisk A/S Insulina monocatenaria.
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
ES2601839T3 (es) 2006-09-22 2017-02-16 Novo Nordisk A/S Análogos de insulina resistentes a proteasas
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
EP2254905B1 (en) * 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
US20110294729A1 (en) * 2008-12-09 2011-12-01 Novo Nordisk A/S Novel Insulin Analogues
WO2011028813A2 (en) * 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity

Also Published As

Publication number Publication date
CN102947331B (zh) 2016-08-03
EP2585484A1 (en) 2013-05-01
JP2013530702A (ja) 2013-08-01
US8815798B2 (en) 2014-08-26
US20130172247A1 (en) 2013-07-04
WO2011161124A1 (en) 2011-12-29
CN102947331A (zh) 2013-02-27

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