JP5973427B2 - 追加のジスルフィド結合を含有するインスリン類似体 - Google Patents

追加のジスルフィド結合を含有するインスリン類似体 Download PDF

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Publication number
JP5973427B2
JP5973427B2 JP2013515873A JP2013515873A JP5973427B2 JP 5973427 B2 JP5973427 B2 JP 5973427B2 JP 2013515873 A JP2013515873 A JP 2013515873A JP 2013515873 A JP2013515873 A JP 2013515873A JP 5973427 B2 JP5973427 B2 JP 5973427B2
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Japan
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desb30
human insulin
insulin
amino acid
cysteine
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JP2013515873A
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Japanese (ja)
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JP2013530702A (ja
JP2013530702A5 (enExample
Inventor
スヴェン・ルドヴィクセン
フランティセク・フバレク
トーマス・ベーグルム・ケルセン
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2013515873A 2010-06-23 2011-06-21 追加のジスルフィド結合を含有するインスリン類似体 Expired - Fee Related JP5973427B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033.9 2010-06-23
EP10167033 2010-06-23
US35950010P 2010-06-29 2010-06-29
US61/359,500 2010-06-29
PCT/EP2011/060382 WO2011161124A1 (en) 2010-06-23 2011-06-21 Insulin analogues containing additional disulfide bonds

Publications (3)

Publication Number Publication Date
JP2013530702A JP2013530702A (ja) 2013-08-01
JP2013530702A5 JP2013530702A5 (enExample) 2014-07-31
JP5973427B2 true JP5973427B2 (ja) 2016-08-23

Family

ID=43242459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013515873A Expired - Fee Related JP5973427B2 (ja) 2010-06-23 2011-06-21 追加のジスルフィド結合を含有するインスリン類似体

Country Status (5)

Country Link
US (1) US8815798B2 (enExample)
EP (1) EP2585484A1 (enExample)
JP (1) JP5973427B2 (enExample)
CN (1) CN102947331B (enExample)
WO (1) WO2011161124A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
JP5931857B2 (ja) 2010-06-23 2016-06-08 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン誘導体
JP2014509603A (ja) * 2011-03-15 2014-04-21 ノヴォ ノルディスク アー／エス システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
EP2794648A1 (en) * 2011-12-21 2014-10-29 Novo Nordisk A/S N-terminally modified insulin derivatives
CN105636979B (zh) 2013-10-07 2020-01-10 诺和诺德股份有限公司 胰岛素类似物的新衍生物
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
MX2018002223A (es) 2015-08-25 2018-03-23 Novo Nordisk As Derivados de insulina novedosos y usos medicos de los mismos.
AU2016377786A1 (en) * 2015-12-23 2018-06-14 Case Western Reserve University Encapsulation of ultra-stable insulin analogues with polymer melts
BR112019011761A2 (pt) 2016-12-16 2019-11-05 Novo Nordisk As composições farmacêuticas contendo insulina
RU2020108281A (ru) 2017-08-17 2021-08-26 Ново Нордиск А/С Новые ацилированные аналоги инсулина и варианты их применения
WO2021116292A1 (en) 2019-12-11 2021-06-17 Novo Nordisk A/S Novel insulin analogues and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
JP4773023B2 (ja) 1999-12-29 2011-09-14 ノボ ノルディスク アクティーゼルスカブ インスリン前駆体及びインスリン前駆体類似体の製造方法
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
JP4463814B2 (ja) 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー／エス 単鎖インスリンのアナログとその製薬的製剤
WO2007135117A2 (en) 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
CN101970477B (zh) * 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues
WO2011028813A2 (en) * 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity

Also Published As

Publication number Publication date
US8815798B2 (en) 2014-08-26
US20130172247A1 (en) 2013-07-04
WO2011161124A1 (en) 2011-12-29
JP2013530702A (ja) 2013-08-01
CN102947331B (zh) 2016-08-03
EP2585484A1 (en) 2013-05-01
CN102947331A (zh) 2013-02-27

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