CN102947331B - 包含额外的二硫键的胰岛素类似物 - Google Patents

包含额外的二硫键的胰岛素类似物 Download PDF

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Publication number
CN102947331B
CN102947331B CN201180030864.2A CN201180030864A CN102947331B CN 102947331 B CN102947331 B CN 102947331B CN 201180030864 A CN201180030864 A CN 201180030864A CN 102947331 B CN102947331 B CN 102947331B
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China
Prior art keywords
human insulin
insulin
desb30 human
desb30
desb27
Prior art date
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Expired - Fee Related
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CN201180030864.2A
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English (en)
Chinese (zh)
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CN102947331A (zh
Inventor
S.卢德维格森
F.胡巴莱克
T.B.克杰尔德森
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201180030864.2A 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物 Expired - Fee Related CN102947331B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033.9 2010-06-23
EP10167033 2010-06-23
US35950010P 2010-06-29 2010-06-29
US61/359500 2010-06-29
PCT/EP2011/060382 WO2011161124A1 (en) 2010-06-23 2011-06-21 Insulin analogues containing additional disulfide bonds

Publications (2)

Publication Number Publication Date
CN102947331A CN102947331A (zh) 2013-02-27
CN102947331B true CN102947331B (zh) 2016-08-03

Family

ID=43242459

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180030864.2A Expired - Fee Related CN102947331B (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物

Country Status (5)

Country Link
US (1) US8815798B2 (enExample)
EP (1) EP2585484A1 (enExample)
JP (1) JP5973427B2 (enExample)
CN (1) CN102947331B (enExample)
WO (1) WO2011161124A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
JP5931857B2 (ja) 2010-06-23 2016-06-08 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン誘導体
JP2014509603A (ja) * 2011-03-15 2014-04-21 ノヴォ ノルディスク アー／エス システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
EP2794648A1 (en) * 2011-12-21 2014-10-29 Novo Nordisk A/S N-terminally modified insulin derivatives
CN105636979B (zh) 2013-10-07 2020-01-10 诺和诺德股份有限公司 胰岛素类似物的新衍生物
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
MX2018002223A (es) 2015-08-25 2018-03-23 Novo Nordisk As Derivados de insulina novedosos y usos medicos de los mismos.
AU2016377786A1 (en) * 2015-12-23 2018-06-14 Case Western Reserve University Encapsulation of ultra-stable insulin analogues with polymer melts
BR112019011761A2 (pt) 2016-12-16 2019-11-05 Novo Nordisk As composições farmacêuticas contendo insulina
RU2020108281A (ru) 2017-08-17 2021-08-26 Ново Нордиск А/С Новые ацилированные аналоги инсулина и варианты их применения
WO2021116292A1 (en) 2019-12-11 2021-06-17 Novo Nordisk A/S Novel insulin analogues and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
JP4773023B2 (ja) 1999-12-29 2011-09-14 ノボ ノルディスク アクティーゼルスカブ インスリン前駆体及びインスリン前駆体類似体の製造方法
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
JP4463814B2 (ja) 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
EP1692168B1 (en) 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー／エス 単鎖インスリンのアナログとその製薬的製剤
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
CN101970477B (zh) * 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
WO2011028813A2 (en) * 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Improved insulin stability through amino acid substitution;Brems D N等;《Protein Engineering》;19920901;第5卷(第6期);全文 *
Insulin structure and stablility;Brange J等;《pharmaceutical biotechnology》;19930101;第5卷;全文 *

Also Published As

Publication number Publication date
US8815798B2 (en) 2014-08-26
US20130172247A1 (en) 2013-07-04
WO2011161124A1 (en) 2011-12-29
JP2013530702A (ja) 2013-08-01
JP5973427B2 (ja) 2016-08-23
EP2585484A1 (en) 2013-05-01
CN102947331A (zh) 2013-02-27

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Granted publication date: 20160803

Termination date: 20190621