CN102947331B - 包含额外的二硫键的胰岛素类似物 - Google Patents

包含额外的二硫键的胰岛素类似物 Download PDF

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Publication number
CN102947331B
CN102947331B CN201180030864.2A CN201180030864A CN102947331B CN 102947331 B CN102947331 B CN 102947331B CN 201180030864 A CN201180030864 A CN 201180030864A CN 102947331 B CN102947331 B CN 102947331B
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CN
China
Prior art keywords
human insulin
insulin
desb30 human
desb30
desb27
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201180030864.2A
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English (en)
Chinese (zh)
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CN102947331A (zh
Inventor
S.卢德维格森
F.胡巴莱克
T.B.克杰尔德森
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201180030864.2A 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物 Expired - Fee Related CN102947331B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033.9 2010-06-23
EP10167033 2010-06-23
US35950010P 2010-06-29 2010-06-29
US61/359500 2010-06-29
PCT/EP2011/060382 WO2011161124A1 (en) 2010-06-23 2011-06-21 Insulin analogues containing additional disulfide bonds

Publications (2)

Publication Number Publication Date
CN102947331A CN102947331A (zh) 2013-02-27
CN102947331B true CN102947331B (zh) 2016-08-03

Family

ID=43242459

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180030864.2A Expired - Fee Related CN102947331B (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素类似物

Country Status (5)

Country Link
US (1) US8815798B2 (enExample)
EP (1) EP2585484A1 (enExample)
JP (1) JP5973427B2 (enExample)
CN (1) CN102947331B (enExample)
WO (1) WO2011161124A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010009850A (es) 2008-03-18 2010-09-30 Novo Nordisk As Analogos de insulina acilados y etabilizados contra proteasas.
WO2011161125A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
WO2012123519A2 (en) * 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
JP2015502971A (ja) * 2011-12-21 2015-01-29 ノヴォ ノルディスク アー／エス Ｎ末端修飾インスリン誘導体
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CA2996455A1 (en) 2015-08-25 2017-03-02 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
SG11201803911PA (en) * 2015-12-23 2018-07-30 Univ Case Western Reserve Encapsulation of ultra-stable insulin analogues with polymer melts
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline
PE20211264A1 (es) 2017-08-17 2021-07-15 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos
FI4073097T3 (fi) 2019-12-11 2024-08-13 Novo Nordisk As Uusia insuliinianalogeja ja niiden käyttötapoja

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
HUP0203475A3 (en) 1999-12-29 2005-11-28 Novo Nordisk As Method for making insulin precursors and insulin precursor analogs
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
KR101159559B1 (ko) 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
EP2404934A1 (en) 2006-09-22 2012-01-11 Novo Nordisk A/S Protease resistant insulin analogues
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
ES2618073T3 (es) * 2008-03-14 2017-06-20 Novo Nordisk A/S Análogos de insulina estabilizados frente a proteasas
US20120184488A1 (en) * 2009-09-01 2012-07-19 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Improved insulin stability through amino acid substitution;Brems D N等;《Protein Engineering》;19920901;第5卷(第6期);全文 *
Insulin structure and stablility;Brange J等;《pharmaceutical biotechnology》;19930101;第5卷;全文 *

Also Published As

Publication number Publication date
EP2585484A1 (en) 2013-05-01
WO2011161124A1 (en) 2011-12-29
CN102947331A (zh) 2013-02-27
US20130172247A1 (en) 2013-07-04
US8815798B2 (en) 2014-08-26
JP5973427B2 (ja) 2016-08-23
JP2013530702A (ja) 2013-08-01

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Granted publication date: 20160803

Termination date: 20190621