JP5973131B2 - アセトフェノンの還元のためのケトレダクターゼポリペプチド - Google Patents

アセトフェノンの還元のためのケトレダクターゼポリペプチド Download PDF

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JP5973131B2
JP5973131B2 JP2010525057A JP2010525057A JP5973131B2 JP 5973131 B2 JP5973131 B2 JP 5973131B2 JP 2010525057 A JP2010525057 A JP 2010525057A JP 2010525057 A JP2010525057 A JP 2010525057A JP 5973131 B2 JP5973131 B2 JP 5973131B2
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residue
amino acid
ketoreductase
seq
polypeptide
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JP2010538657A (ja
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ジャック リヤン，
ジャック リヤン，
ステファン ジェイ． ジェニー，
ステファン ジェイ． ジェニー，
エミリー マンドルフ，
エミリー マンドルフ，
シャーリーン チン，
シャーリーン チン，
ジョン エム． グラバー，
ジョン エム． グラバー，
アンケ クーレバー，
アンケ クーレバー，
ジャルト ダブリュー． ヒュイスマン，
ジャルト ダブリュー． ヒュイスマン，
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コデクシス， インコーポレイテッド
コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010525057A 2007-09-13 2008-09-13 アセトフェノンの還元のためのケトレダクターゼポリペプチド Active JP5973131B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97205807P 2007-09-13 2007-09-13
US60/972,058 2007-09-13
PCT/US2008/076333 WO2009036404A2 (en) 2007-09-13 2008-09-13 Ketoreductase polypeptides for the reduction of acetophenones

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JP2010538657A JP2010538657A (ja) 2010-12-16
JP2010538657A5 JP2010538657A5 (https=) 2011-11-04
JP5973131B2 true JP5973131B2 (ja) 2016-08-23

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JP2010525057A Active JP5973131B2 (ja) 2007-09-13 2008-09-13 アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2015021874A Active JP6137758B2 (ja) 2007-09-13 2015-02-06 アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2016056646A Withdrawn JP2016105739A (ja) 2007-09-13 2016-03-22 アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2018037319A Withdrawn JP2018086028A (ja) 2007-09-13 2018-03-02 アセトフェノンの還元のためのケトレダクターゼポリペプチド

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JP2016056646A Withdrawn JP2016105739A (ja) 2007-09-13 2016-03-22 アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2018037319A Withdrawn JP2018086028A (ja) 2007-09-13 2018-03-02 アセトフェノンの還元のためのケトレダクターゼポリペプチド

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US (12) US8748143B2 (https=)
EP (1) EP2198018B1 (https=)
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KR (1) KR101586503B1 (https=)
CN (1) CN101855342B (https=)
WO (1) WO2009036404A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2015091269A (ja) * 2007-09-13 2015-05-14 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2019193640A (ja) * 2013-12-10 2019-11-07 天野エンザイム株式会社 改変型リパーゼ及びその用途

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JP2015091269A (ja) * 2007-09-13 2015-05-14 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2018086028A (ja) * 2007-09-13 2018-06-07 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
US10927351B2 (en) 2007-09-13 2021-02-23 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US11479756B2 (en) 2007-09-13 2022-10-25 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US12415990B2 (en) 2007-09-13 2025-09-16 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
JP2019193640A (ja) * 2013-12-10 2019-11-07 天野エンザイム株式会社 改変型リパーゼ及びその用途

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US9951318B1 (en) 2018-04-24
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