CN101855342B - 用于还原苯乙酮的酮还原酶多肽 - Google Patents

用于还原苯乙酮的酮还原酶多肽 Download PDF

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CN101855342B
CN101855342B CN2008801157703A CN200880115770A CN101855342B CN 101855342 B CN101855342 B CN 101855342B CN 2008801157703 A CN2008801157703 A CN 2008801157703A CN 200880115770 A CN200880115770 A CN 200880115770A CN 101855342 B CN101855342 B CN 101855342B
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residue
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CN101855342A (zh
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杰克·梁
史提芬尼·J·珍妮
艾米丽·穆德弗
沙琳·奇恩
约翰·M·格鲁伯
安克·克莱伯
古伽特·W·哈思曼
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Codexis Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN2008801157703A 2007-09-13 2008-09-13 用于还原苯乙酮的酮还原酶多肽 Active CN101855342B (zh)

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Application Number Priority Date Filing Date Title
US97205807P 2007-09-13 2007-09-13
US60/972,058 2007-09-13
PCT/US2008/076333 WO2009036404A2 (en) 2007-09-13 2008-09-13 Ketoreductase polypeptides for the reduction of acetophenones

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CN101855342B true CN101855342B (zh) 2013-07-10

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EP (1) EP2198018B1 (https=)
JP (4) JP5973131B2 (https=)
KR (1) KR101586503B1 (https=)
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WO2009036404A3 (en) 2009-07-16
JP2010538657A (ja) 2010-12-16
JP6137758B2 (ja) 2017-05-31
US20180112191A1 (en) 2018-04-26
US9951318B1 (en) 2018-04-24
EP2198018B1 (en) 2013-11-20
US8748143B2 (en) 2014-06-10
US10100288B2 (en) 2018-10-16
US10927351B2 (en) 2021-02-23
JP5973131B2 (ja) 2016-08-23
US9873863B2 (en) 2018-01-23
WO2009036404A2 (en) 2009-03-19
US20170067032A1 (en) 2017-03-09
US9528131B2 (en) 2016-12-27
JP2018086028A (ja) 2018-06-07
US20230257721A1 (en) 2023-08-17
KR20100061525A (ko) 2010-06-07
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