JP5951752B2 - Ｐｔｐ１ｂ発現のアンチセンス調節 - Google Patents

Ｐｔｐ１ｂ発現のアンチセンス調節 Download PDF

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JP5951752B2
JP5951752B2 JP2014505350A JP2014505350A JP5951752B2 JP 5951752 B2 JP5951752 B2 JP 5951752B2 JP 2014505350 A JP2014505350 A JP 2014505350A JP 2014505350 A JP2014505350 A JP 2014505350A JP 5951752 B2 JP5951752 B2 JP 5951752B2
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certain embodiments
compound
isis
antisense
ptp1b
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JP2014512186A5 (enExample
JP2014512186A (ja
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バノット，サンジェイ
フレアー，スーザン・エム
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2014505350A 2011-04-13 2012-04-13 Ｐｔｐ１ｂ発現のアンチセンス調節 Expired - Fee Related JP5951752B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161474981P 2011-04-13 2011-04-13
US61/474,981 2011-04-13
PCT/US2012/033588 WO2012142458A1 (en) 2011-04-13 2012-04-13 Antisense modulation of ptp1b expression

Publications (3)

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JP2014512186A JP2014512186A (ja) 2014-05-22
JP2014512186A5 JP2014512186A5 (enExample) 2014-09-11
JP5951752B2 true JP5951752B2 (ja) 2016-07-13

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US (4) US8658783B2 (enExample)
EP (1) EP2697244B1 (enExample)
JP (1) JP5951752B2 (enExample)
KR (1) KR101839177B1 (enExample)
CN (2) CN103547588B (enExample)
AU (2) AU2012242642A1 (enExample)
CA (1) CA2832972C (enExample)
ES (1) ES2634450T3 (enExample)
IL (1) IL228773B (enExample)
WO (1) WO2012142458A1 (enExample)

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IL228773B (en) 2018-05-31
US9034842B2 (en) 2015-05-19
IL228773A0 (en) 2013-12-31
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USRE48060E1 (en) 2020-06-23
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KR20140023344A (ko) 2014-02-26
AU2016216597A1 (en) 2016-09-01
US8658783B2 (en) 2014-02-25
US20140235694A1 (en) 2014-08-21
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US9404113B2 (en) 2016-08-02
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CA2832972C (en) 2019-04-30
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US20120289580A1 (en) 2012-11-15
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