JP5948648B2 - 安定化されたエペリゾンを含有する徐放性製剤 - Google Patents
安定化されたエペリゾンを含有する徐放性製剤 Download PDFInfo
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- JP5948648B2 JP5948648B2 JP2014536967A JP2014536967A JP5948648B2 JP 5948648 B2 JP5948648 B2 JP 5948648B2 JP 2014536967 A JP2014536967 A JP 2014536967A JP 2014536967 A JP2014536967 A JP 2014536967A JP 5948648 B2 JP5948648 B2 JP 5948648B2
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- acid
- eperisone
- sustained
- release
- release preparation
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- SQUNAWUMZGQQJD-UHFFFAOYSA-N 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one Chemical compound C1=CC(CC)=CC=C1C(=O)C(C)CN1CCCCC1 SQUNAWUMZGQQJD-UHFFFAOYSA-N 0.000 title claims description 70
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020110106388A KR101156054B1 (ko) | 2011-09-05 | 2011-10-18 | 안정한 에페리손 함유 서방성 의약조성물 |
KR10-2011-0106388 | 2011-10-18 | ||
PCT/KR2012/002288 WO2013058450A1 (ko) | 2011-10-18 | 2012-03-28 | 안정화된 에페리손 의약 조성물 및 이를 함유하는 서방성 제제 |
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JP2014530250A JP2014530250A (ja) | 2014-11-17 |
JP5948648B2 true JP5948648B2 (ja) | 2016-07-06 |
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JP2014536967A Active JP5948648B2 (ja) | 2011-10-18 | 2012-03-28 | 安定化されたエペリゾンを含有する徐放性製剤 |
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JP (1) | JP5948648B2 (pt) |
KR (1) | KR101156054B1 (pt) |
CN (1) | CN103889455B (pt) |
BR (1) | BR112014009506B1 (pt) |
MX (1) | MX346661B (pt) |
WO (1) | WO2013058450A1 (pt) |
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KR101230178B1 (ko) | 2010-06-10 | 2013-02-06 | 주식회사 네비팜 | 골다공증 예방 또는 치료용 조성물 및 이의 제조방법 |
KR101832842B1 (ko) * | 2012-01-13 | 2018-02-27 | 한미약품 주식회사 | 안정성이 향상된 에페리손 또는 이의 약학적으로 허용 가능한 염 및 특정 산성화제를 포함하는 약학 조성물 |
KR20140118410A (ko) * | 2013-03-29 | 2014-10-08 | 초당약품공업 주식회사 | 저장 및 pH 안정성이 개선된 에페리손 의약 조성물 |
KR101497354B1 (ko) * | 2013-03-29 | 2015-03-02 | 초당약품공업 주식회사 | 활성 성분으로 에페리손을 함유하는 서방성 제제 조성물 |
KR101760278B1 (ko) | 2016-08-29 | 2017-07-21 | 초당약품공업 주식회사 | 에페리손을 유효 성분으로 함유하는 서방성 미립구의 제조방법 |
KR101799321B1 (ko) | 2016-08-29 | 2017-11-20 | 초당약품공업 주식회사 | 에페리손 서방성 미립구와 아세클로페낙 복합제제 |
WO2018044020A1 (ko) * | 2016-08-29 | 2018-03-08 | 초당약품공업 주식회사 | 에페리손 서방성 미립구의 제조방법 및 에페리손 서방성 미립구와 아세클로페낙 복합제제 |
KR102254307B1 (ko) | 2019-04-03 | 2021-05-21 | 위더스제약주식회사 | 보관 안정성이 향상된 에페리손 약제학적 조성물 |
KR102444073B1 (ko) * | 2020-01-06 | 2022-09-16 | (주)휴온스 | 안정성이 향상된 메틸에르고메트린말레산염 함유 약제학적 제제 및 이의 제조방법 |
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KR0163199B1 (ko) * | 1990-05-24 | 1998-12-01 | 다이도 나오가따 | 서방성 좌제 |
JP3525225B2 (ja) * | 1992-11-09 | 2004-05-10 | 積水化学工業株式会社 | エペリゾンまたはトルペリゾン経皮吸収テープ剤またはパッチ剤、およびその製造方法 |
CA2347104A1 (en) | 1998-10-26 | 2000-04-05 | Tanabe Seiyaku Co., Ltd. | Sustained-release particles |
JP2000143510A (ja) * | 1998-11-16 | 2000-05-23 | Taisho Pharmaceut Co Ltd | 外用組成物 |
AT500144A1 (de) * | 2004-03-05 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Tolperison enthaltende, pharmazeutische zubereitung mit steuerbarer wirkstofffreisetzung zur oralen verabreichung |
DE102005014080B4 (de) * | 2005-03-21 | 2007-11-22 | Birds Pharma Gmbh Berolina Innovative Research & Development Services | Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel |
AU2007230730B2 (en) * | 2006-03-24 | 2013-03-28 | Auxilium International Holdings, Inc. | Stabilized compositions containing alkaline labile drugs |
AT505225A1 (de) * | 2007-04-26 | 2008-11-15 | Sanochemia Pharmazeutika Ag | 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen |
HUP0700828A2 (en) * | 2007-12-20 | 2010-01-28 | Richter Gedeon Nyrt | Transdermal pharmaceutical compositions containing tolperisone alone and in combination |
GEP20135986B (en) * | 2009-03-09 | 2013-12-10 | Shashikant Prabhudas Kurani | Novel sustained release composition of compounds selected from class of centrally acting muscle relaxants |
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KR101156054B1 (ko) | 2012-06-20 |
WO2013058450A1 (ko) | 2013-04-25 |
MX346661B (es) | 2017-03-28 |
BR112014009506B1 (pt) | 2020-04-07 |
MX2014004652A (es) | 2015-03-05 |
BR112014009506A2 (pt) | 2017-05-09 |
JP2014530250A (ja) | 2014-11-17 |
CN103889455A (zh) | 2014-06-25 |
CN103889455B (zh) | 2017-12-05 |
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