JP5941926B2 - 酵素感受性連結を有するインビボポリヌクレオチド送達結合体 - Google Patents

酵素感受性連結を有するインビボポリヌクレオチド送達結合体 Download PDF

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JP5941926B2
JP5941926B2 JP2013547648A JP2013547648A JP5941926B2 JP 5941926 B2 JP5941926 B2 JP 5941926B2 JP 2013547648 A JP2013547648 A JP 2013547648A JP 2013547648 A JP2013547648 A JP 2013547648A JP 5941926 B2 JP5941926 B2 JP 5941926B2
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amino acid
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JP2014505685A (ja
JP2014505685A5 (fr
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デイビッド ビー． ロゼマ
デイビッド ビー． ロゼマ
デイビッド エル． ルイス
デイビッド エル． ルイス
ダレン エイチ． ウェイクフィールド
ダレン エイチ． ウェイクフィールド
エリック エイ． キタス
エリック エイ． キタス
フィリップ ハドウィガー
フィリップ ハドウィガー
ジョン エイ． ウォルフ
ジョン エイ． ウォルフ
インゴ ローエル
インゴ ローエル
ピーター モーア
ピーター モーア
トルステン ホフマン
トルステン ホフマン
カースティン ヤン‐ホフマン
カースティン ヤン‐ホフマン
ハンス マーティン ミューラー
ハンス マーティン ミューラー
グエンテル オット
グエンテル オット
アンドレイ ブイ． ブローキン
アンドレイ ブイ． ブローキン
ジェフリー シー． カールソン
ジェフリー シー． カールソン
ジョナサン ディー． ベンソン
ジョナサン ディー． ベンソン
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アローヘッド リサーチ コーポレイション
アローヘッド リサーチ コーポレイション
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2013547648A 2010-12-29 2011-12-28 酵素感受性連結を有するインビボポリヌクレオチド送達結合体 Active JP5941926B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061427936P 2010-12-29 2010-12-29
US61/427,936 2010-12-29
US13/336,028 US8426554B2 (en) 2010-12-29 2011-12-23 In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
US13/336,028 2011-12-23
PCT/US2011/067588 WO2012092373A2 (fr) 2010-12-29 2011-12-28 Conjugués d'administration de polynucléotide in vivo ayant des liaisons sensibles à des enzymes

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JP2014505685A JP2014505685A (ja) 2014-03-06
JP2014505685A5 JP2014505685A5 (fr) 2014-09-11
JP5941926B2 true JP5941926B2 (ja) 2016-06-29

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EP (1) EP2658579A4 (fr)
JP (1) JP5941926B2 (fr)
KR (1) KR20130136494A (fr)
CN (1) CN103491982B (fr)
AU (1) AU2011352204B2 (fr)
BR (1) BR112013014115A2 (fr)
CA (1) CA2816041C (fr)
CL (2) CL2013001876A1 (fr)
MX (2) MX341118B (fr)
NZ (1) NZ611656A (fr)
PE (1) PE20140198A1 (fr)
RU (1) RU2619453C2 (fr)
SG (1) SG189942A1 (fr)
WO (1) WO2012092373A2 (fr)
ZA (1) ZA201302896B (fr)

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PL2920304T3 (pl) 2012-11-15 2019-07-31 Roche Innovation Center Copenhagen A/S Koniugaty oligonukleotydowe
WO2015021092A1 (fr) * 2013-08-07 2015-02-12 Arrowhead Research Corporation Polyconjugués pour l'administration de déclencheurs d'arni à des cellules tumorales in vivo
JOP20210043A1 (ar) 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
US20200277647A1 (en) * 2017-05-24 2020-09-03 Ramot At Tel-Aviv University Ltd. Chemiluminescent probes for imaging/detection of proteases
MA51103A (fr) 2017-12-06 2020-10-14 Avidity Biosciences Inc Compositions et procédés de traitement de l'atrophie musculaire et de la dystrophie myotonique
CA3125289A1 (fr) * 2018-12-28 2020-07-02 Sirnaomics, Inc. Administration ciblee de molecules therapeutiques
CN115666589A (zh) 2020-03-19 2023-01-31 艾维迪提生物科学公司 治疗面肩肱型肌营养不良的组合物和方法
CA3198230A1 (fr) * 2021-01-28 2022-08-04 Jian Chen Conjugue et son utilisation
AU2022297106A1 (en) * 2021-06-24 2023-12-07 Goryo Chemical, Inc. Fluorescent probes
KR20230016999A (ko) * 2021-07-27 2023-02-03 안동대학교 산학협력단 등검은말벌 추출물을 유효성분으로 함유하는 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
CN113621003B (zh) * 2021-09-10 2023-02-03 国科温州研究院(温州生物材料与工程研究所) 一种制备有机分子共价修饰的功能化核酸材料的方法及其应用
IL311452A (en) 2021-09-16 2024-05-01 Avidity Biosciences Inc Compositions and methods for the treatment of FSHD muscular dystrophy

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US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
CN1433478A (zh) * 1999-12-30 2003-07-30 诺瓦提斯公司 用于基因治疗的新的胶体合成载体
JP2003523407A (ja) * 2000-02-24 2003-08-05 ジェネンテック・インコーポレーテッド カスパーゼ活性化プロドラック療法
EP1243276A1 (fr) * 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Prodrogues activables à séparateurs allongés et multiples
US7091186B2 (en) * 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
WO2007059404A2 (fr) * 2005-11-10 2007-05-24 Medarex, Inc. Composes et conjugues cytotoxiques
WO2008022309A2 (fr) * 2006-08-18 2008-02-21 F. Hoffmann-La Roche Ag Polyconjugués pour l'administration in vivo de polynucléotides
RU2430740C2 (ru) * 2006-08-18 2011-10-10 Ф.Хоффманн-Ля Рош Аг Поликонъюгаты для введения in vivo полинуклеотидов
CA2675014C (fr) * 2007-01-17 2016-03-29 Immunomedics, Inc. Supports polymeres d'agents therapeutiques et fractions de reconnaissance pour un ciblage a base d'anticorps de sites de maladie
TW201004647A (en) * 2008-05-20 2010-02-01 Sigma Tau Ind Farmaceuti Novel dual targeting antitumoural conjugates
US8501930B2 (en) * 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system

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CL2015003580A1 (es) 2016-07-15
RU2619453C2 (ru) 2017-05-16
JP2014505685A (ja) 2014-03-06
WO2012092373A3 (fr) 2013-10-24
MX347298B (es) 2017-04-21
WO2012092373A2 (fr) 2012-07-05
CN103491982A (zh) 2014-01-01
CA2816041C (fr) 2019-01-08
AU2011352204A1 (en) 2013-05-02
MX341118B (es) 2016-08-09
SG189942A1 (en) 2013-06-28
KR20130136494A (ko) 2013-12-12
AU2011352204B2 (en) 2015-05-21
BR112013014115A2 (pt) 2019-09-24
EP2658579A4 (fr) 2015-07-22
CN103491982B (zh) 2017-09-12
MX2013007316A (es) 2013-07-29
CA2816041A1 (fr) 2012-07-05
PE20140198A1 (es) 2014-02-21
EP2658579A2 (fr) 2013-11-06
CL2013001876A1 (es) 2014-04-11
NZ611656A (en) 2014-10-31
RU2013117286A (ru) 2015-03-10
ZA201302896B (en) 2014-07-25

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