JP2014505685A5 - - Google Patents
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- Publication number
- JP2014505685A5 JP2014505685A5 JP2013547648A JP2013547648A JP2014505685A5 JP 2014505685 A5 JP2014505685 A5 JP 2014505685A5 JP 2013547648 A JP2013547648 A JP 2013547648A JP 2013547648 A JP2013547648 A JP 2013547648A JP 2014505685 A5 JP2014505685 A5 JP 2014505685A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- delivery polymer
- compound
- amidobenzyl
- polymer according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JDFXJJLFADUZIY-UHFFFAOYSA-N CON(C(CC1)=O)C1=O Chemical compound CON(C(CC1)=O)C1=O JDFXJJLFADUZIY-UHFFFAOYSA-N 0.000 description 1
- ZRQUIRABLIQJRI-UHFFFAOYSA-N COc(c(F)c(c(F)c1F)F)c1F Chemical compound COc(c(F)c(c(F)c1F)F)c1F ZRQUIRABLIQJRI-UHFFFAOYSA-N 0.000 description 1
- RDWOLIZQAHPNKO-UHFFFAOYSA-N COc(cc1)ccc1[NH+]([O-])[O-] Chemical compound COc(cc1)ccc1[NH+]([O-])[O-] RDWOLIZQAHPNKO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061427936P | 2010-12-29 | 2010-12-29 | |
| US61/427,936 | 2010-12-29 | ||
| US13/336,028 US8426554B2 (en) | 2010-12-29 | 2011-12-23 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
| US13/336,028 | 2011-12-23 | ||
| PCT/US2011/067588 WO2012092373A2 (fr) | 2010-12-29 | 2011-12-28 | Conjugués d'administration de polynucléotide in vivo ayant des liaisons sensibles à des enzymes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505685A JP2014505685A (ja) | 2014-03-06 |
| JP2014505685A5 true JP2014505685A5 (fr) | 2014-09-11 |
| JP5941926B2 JP5941926B2 (ja) | 2016-06-29 |
Family
ID=46383848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013547648A Active JP5941926B2 (ja) | 2010-12-29 | 2011-12-28 | 酵素感受性連結を有するインビボポリヌクレオチド送達結合体 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2658579A4 (fr) |
| JP (1) | JP5941926B2 (fr) |
| KR (1) | KR20130136494A (fr) |
| CN (1) | CN103491982B (fr) |
| AU (1) | AU2011352204B2 (fr) |
| BR (1) | BR112013014115A2 (fr) |
| CA (1) | CA2816041C (fr) |
| CL (2) | CL2013001876A1 (fr) |
| MX (2) | MX347298B (fr) |
| NZ (1) | NZ611656A (fr) |
| PE (1) | PE20140198A1 (fr) |
| RU (1) | RU2619453C2 (fr) |
| SG (1) | SG189942A1 (fr) |
| WO (1) | WO2012092373A2 (fr) |
| ZA (1) | ZA201302896B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY173826A (en) | 2012-11-15 | 2020-02-24 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| EP3030244B1 (fr) * | 2013-08-07 | 2021-04-21 | Arrowhead Pharmaceuticals, Inc. | Polyconjugués pour l'administration de déclencheurs d'arni à des cellules tumorales in vivo |
| JOP20210043A1 (ar) | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| CN110944985B (zh) | 2017-05-24 | 2022-12-13 | 特拉维夫大学拉玛特有限公司 | 用于蛋白酶的成像/检测的化学发光探针 |
| WO2019113393A1 (fr) | 2017-12-06 | 2019-06-13 | Avidity Biosciences Llc | Compositions et procédés de traitement de l'atrophie musculaire et de la dystrophie myotonique |
| JP2023501020A (ja) * | 2018-12-28 | 2023-01-18 | サーナオミクス インコーポレイテッド | 治療用分子の標的化送達 |
| AU2021237465A1 (en) | 2020-03-19 | 2022-10-13 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
| KR20230137295A (ko) * | 2021-01-28 | 2023-10-04 | 난징 챔피언 바이오테크놀로지 컴퍼니 리미티드 | 접합체 및 이의 용도 |
| CN117480175A (zh) * | 2021-06-24 | 2024-01-30 | 东北泰克诺亚奇股份有限公司 | 荧光探针 |
| KR20230016999A (ko) * | 2021-07-27 | 2023-02-03 | 안동대학교 산학협력단 | 등검은말벌 추출물을 유효성분으로 함유하는 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품 |
| CN113621003B (zh) * | 2021-09-10 | 2023-02-03 | 国科温州研究院(温州生物材料与工程研究所) | 一种制备有机分子共价修饰的功能化核酸材料的方法及其应用 |
| US11912779B2 (en) | 2021-09-16 | 2024-02-27 | Avidity Biosciences, Inc. | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US8137695B2 (en) * | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| JP2003519199A (ja) * | 1999-12-30 | 2003-06-17 | ノバルティス アクチエンゲゼルシャフト | 遺伝子治療のための新規なコロイド合成ベクター |
| EP1257296A2 (fr) * | 2000-02-24 | 2002-11-20 | Genentech, Inc. | Therapie par promedicaments actives par une caspase |
| EP1243276A1 (fr) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Prodrogues activables à séparateurs allongés et multiples |
| US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| US7541330B2 (en) * | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
| CA2627190A1 (fr) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Composes et conjugues cytotoxiques |
| RU2430740C2 (ru) * | 2006-08-18 | 2011-10-10 | Ф.Хоффманн-Ля Рош Аг | Поликонъюгаты для введения in vivo полинуклеотидов |
| JP2010516675A (ja) * | 2007-01-17 | 2010-05-20 | イミューノメディクス、インコーポレイテッド | 治療薬剤のポリマー担体および疾病部位の抗体に基づく標的化のための認識部分 |
| TW201004647A (en) * | 2008-05-20 | 2010-02-01 | Sigma Tau Ind Farmaceuti | Novel dual targeting antitumoural conjugates |
| US8501930B2 (en) * | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
-
2011
- 2011-12-28 CA CA2816041A patent/CA2816041C/fr active Active
- 2011-12-28 AU AU2011352204A patent/AU2011352204B2/en active Active
- 2011-12-28 PE PE2013001496A patent/PE20140198A1/es not_active Application Discontinuation
- 2011-12-28 RU RU2013117286A patent/RU2619453C2/ru active
- 2011-12-28 NZ NZ611656A patent/NZ611656A/en not_active IP Right Cessation
- 2011-12-28 WO PCT/US2011/067588 patent/WO2012092373A2/fr active Application Filing
- 2011-12-28 CN CN201180061179.6A patent/CN103491982B/zh active Active
- 2011-12-28 MX MX2016006733A patent/MX347298B/es unknown
- 2011-12-28 EP EP11853858.6A patent/EP2658579A4/fr not_active Withdrawn
- 2011-12-28 BR BR112013014115A patent/BR112013014115A2/pt not_active IP Right Cessation
- 2011-12-28 KR KR1020137017195A patent/KR20130136494A/ko not_active Application Discontinuation
- 2011-12-28 MX MX2013007316A patent/MX341118B/es active IP Right Grant
- 2011-12-28 SG SG2013029830A patent/SG189942A1/en unknown
- 2011-12-28 JP JP2013547648A patent/JP5941926B2/ja active Active
-
2013
- 2013-04-22 ZA ZA2013/02896A patent/ZA201302896B/en unknown
- 2013-06-25 CL CL2013001876A patent/CL2013001876A1/es unknown
-
2015
- 2015-12-10 CL CL2015003580A patent/CL2015003580A1/es unknown
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