JP5941407B2 - Ｈｓｐ９０阻害剤 - Google Patents

Ｈｓｐ９０阻害剤 Download PDF

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Publication number
JP5941407B2
JP5941407B2 JP2012533327A JP2012533327A JP5941407B2 JP 5941407 B2 JP5941407 B2 JP 5941407B2 JP 2012533327 A JP2012533327 A JP 2012533327A JP 2012533327 A JP2012533327 A JP 2012533327A JP 5941407 B2 JP5941407 B2 JP 5941407B2
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propyl
purin
ethyl
methyl
amine
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Japanese (ja)
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JP2013507381A (ja
Inventor
チオシス、ガブリエラ
タルドン、トニー
スン、ウェイリン
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スローン − ケッタリング インスティチュート フォー キャンサー リサーチ
スローン − ケッタリング インスティチュート フォー キャンサー リサーチ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012533327A 2009-10-07 2010-10-07 Ｈｓｐ９０阻害剤 Expired - Fee Related JP5941407B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24934909P 2009-10-07 2009-10-07
US61/249,349 2009-10-07
PCT/US2010/051872 WO2011044394A1 (en) 2009-10-07 2010-10-07 Purine derivatives useful as hsp90 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016101964A Division JP6326088B2 (ja) 2009-10-07 2016-05-20 Ｈｓｐ９０阻害剤として有用なプリン誘導体

Publications (2)

Publication Number Publication Date
JP2013507381A JP2013507381A (ja) 2013-03-04
JP5941407B2 true JP5941407B2 (ja) 2016-06-29

Family

ID=43857159

Family Applications (3)

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JP2012533327A Expired - Fee Related JP5941407B2 (ja) 2009-10-07 2010-10-07 Ｈｓｐ９０阻害剤
JP2016101964A Expired - Fee Related JP6326088B2 (ja) 2009-10-07 2016-05-20 Ｈｓｐ９０阻害剤として有用なプリン誘導体
JP2018024710A Expired - Fee Related JP6804483B2 (ja) 2009-10-07 2018-02-15 Ｈｓｐ９０阻害剤として有用なプリン誘導体

Family Applications After (2)

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JP2016101964A Expired - Fee Related JP6326088B2 (ja) 2009-10-07 2016-05-20 Ｈｓｐ９０阻害剤として有用なプリン誘導体
JP2018024710A Expired - Fee Related JP6804483B2 (ja) 2009-10-07 2018-02-15 Ｈｓｐ９０阻害剤として有用なプリン誘導体

Country Status (16)

Country Link
US (2) US9328114B2 (https=)
EP (2) EP3091019B1 (https=)
JP (3) JP5941407B2 (https=)
KR (2) KR101906568B1 (https=)
CN (3) CN106083855B (https=)
AU (1) AU2010303343B2 (https=)
BR (1) BR112012008019A2 (https=)
CA (1) CA2776308C (https=)
DK (1) DK2486039T3 (https=)
EA (1) EA029272B1 (https=)
ES (2) ES2733131T3 (https=)
LT (1) LT2486039T (https=)
MX (1) MX340714B (https=)
NZ (2) NZ599138A (https=)
PT (1) PT2486039T (https=)
WO (1) WO2011044394A1 (https=)

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WO2008005937A2 (en) 2006-06-30 2008-01-10 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases through inhibiton of hsp90
JP5941407B2 (ja) 2009-10-07 2016-06-29 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｓｐ９０阻害剤
CN103596955B (zh) 2011-04-05 2016-11-16 索隆-基特林癌症研究协会 Hsp90抑制剂
JP6266506B2 (ja) 2011-04-05 2018-01-24 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｓｐ９０阻害物質
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EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90-DESIGNING AND THERAPY
SG11201601542SA (en) 2013-08-16 2016-04-28 Sloan Kettering Inst Cancer Selective grp94 inhibitors and uses thereof
BR112016005199B1 (pt) 2013-08-23 2022-02-22 Neupharma, Inc Certos compostos químicos, composições, e métodos
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CN103596955B (zh) 2011-04-05 2016-11-16 索隆-基特林癌症研究协会 Hsp90抑制剂
JP6266506B2 (ja) 2011-04-05 2018-01-24 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｓｐ９０阻害物質
SG11201601542SA (en) 2013-08-16 2016-04-28 Sloan Kettering Inst Cancer Selective grp94 inhibitors and uses thereof

Also Published As

Publication number Publication date
US10172863B2 (en) 2019-01-08
CN106083855A (zh) 2016-11-09
CN106083855B (zh) 2020-04-10
CN102639534A (zh) 2012-08-15
CA2776308C (en) 2020-01-28
LT2486039T (lt) 2016-10-10
JP6804483B2 (ja) 2020-12-23
NZ625593A (en) 2016-03-31
ES2733131T3 (es) 2019-11-27
KR20120083898A (ko) 2012-07-26
WO2011044394A1 (en) 2011-04-14
US20120208806A1 (en) 2012-08-16
US9328114B2 (en) 2016-05-03
KR20180112117A (ko) 2018-10-11
US20160310497A1 (en) 2016-10-27
MX2012004089A (es) 2012-08-23
BR112012008019A2 (pt) 2016-03-01
EP2486039B1 (en) 2016-06-01
AU2010303343A1 (en) 2012-04-19
AU2010303343B2 (en) 2015-11-19
JP2013507381A (ja) 2013-03-04
EP3091019B1 (en) 2019-04-03
DK2486039T3 (en) 2016-09-12
EP3091019A3 (en) 2017-01-18
KR102129420B1 (ko) 2020-07-03
EP3091019A2 (en) 2016-11-09
EP2486039A4 (en) 2012-08-15
PT2486039T (pt) 2016-09-06
EP2486039A1 (en) 2012-08-15
JP2016145262A (ja) 2016-08-12
EA201270535A1 (ru) 2012-09-28
CN105924443A (zh) 2016-09-07
ES2589403T3 (es) 2016-11-14
CA2776308A1 (en) 2011-04-14
EA029272B1 (ru) 2018-03-30
KR101906568B1 (ko) 2018-10-10
MX340714B (es) 2016-07-22
NZ599138A (en) 2014-06-27
JP2018104451A (ja) 2018-07-05
JP6326088B2 (ja) 2018-05-16

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