SG11201601542SA - Selective grp94 inhibitors and uses thereof - Google Patents

Selective grp94 inhibitors and uses thereof

Info

Publication number
SG11201601542SA
SG11201601542SA SG11201601542SA SG11201601542SA SG11201601542SA SG 11201601542S A SG11201601542S A SG 11201601542SA SG 11201601542S A SG11201601542S A SG 11201601542SA SG 11201601542S A SG11201601542S A SG 11201601542SA SG 11201601542S A SG11201601542S A SG 11201601542SA
Authority
SG
Singapore
Prior art keywords
grp94 inhibitors
selective grp94
selective
inhibitors
grp94
Prior art date
Application number
SG11201601542SA
Inventor
Gabriela Chiosis
Pengrong Yan
Pallav Patel
Hardik J Patel
Tony Taldone
Chenghua Yang
Weilin Sun
Stefan O Ochiana
Original Assignee
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer
Publication of SG11201601542SA publication Critical patent/SG11201601542SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G16C20/64—Screening of libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computing Systems (AREA)
  • Library & Information Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
SG11201601542SA 2013-08-16 2014-08-15 Selective grp94 inhibitors and uses thereof SG11201601542SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361866932P 2013-08-16 2013-08-16
PCT/US2014/051332 WO2015023976A2 (en) 2013-08-16 2014-08-15 Selective grp94 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SG11201601542SA true SG11201601542SA (en) 2016-04-28

Family

ID=52468819

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201601542SA SG11201601542SA (en) 2013-08-16 2014-08-15 Selective grp94 inhibitors and uses thereof
SG10201801281QA SG10201801281QA (en) 2013-08-16 2014-08-15 Selective grp94 inhibitors and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201801281QA SG10201801281QA (en) 2013-08-16 2014-08-15 Selective grp94 inhibitors and uses thereof

Country Status (17)

Country Link
US (3) US10421758B2 (en)
EP (1) EP3033338A4 (en)
JP (2) JP6539275B2 (en)
KR (1) KR102319582B1 (en)
CN (1) CN105899503B (en)
AU (2) AU2014306417C1 (en)
BR (1) BR112016003201A2 (en)
CA (1) CA2921571C (en)
EA (1) EA201690406A1 (en)
HK (1) HK1226063A1 (en)
IL (2) IL244251B (en)
MX (1) MX370664B (en)
PH (1) PH12016500511A1 (en)
SG (2) SG11201601542SA (en)
TW (1) TWI711618B (en)
WO (1) WO2015023976A2 (en)
ZA (1) ZA201601794B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9403828B2 (en) 2005-02-01 2016-08-02 Sloan-Kettering Institute For Cancer Research Small-molecule Hsp90 inhibitors
US7834181B2 (en) 2005-02-01 2010-11-16 Slaon-Kettering Institute For Cancer Research Small-molecule Hsp90 inhibitors
CA2656202C (en) 2006-06-30 2018-01-16 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases through inhibition of hsp90
LT2486039T (en) 2009-10-07 2016-10-10 Sloan Kettering Institute For Cancer Research Purine derivatives useful as hsp90 inhibitors
KR101984480B1 (en) 2011-04-05 2019-05-31 슬로안-케테링인스티튜트퍼캔서리서치 Hsp90 inhibitors
US9346808B2 (en) 2011-04-05 2016-05-24 Sloan-Kettering Institute For Cancer Research Hsp90 inhibitors
DK3030682T3 (en) * 2013-08-05 2020-09-14 Twist Bioscience Corp DE NOVO SYNTHESIZED GENE LIBRARIES
MX370664B (en) 2013-08-16 2019-12-19 Memorial Sloan Kettering Cancer Center Selective grp94 inhibitors and uses thereof.
AU2014386214B2 (en) * 2013-12-23 2020-05-21 Memorial Sloan-Kettering Cancer Center Methods and reagents for radiolabeling
US10617772B2 (en) * 2014-09-17 2020-04-14 Memorial Sloan Kettering Cancer Center Hsp9O-targeted inflammation and infection imaging and therapy
JP7132848B2 (en) 2015-10-05 2022-09-07 メモリアル スローン ケタリング キャンサー センター Rational combination therapy for the treatment of cancer
CN108503643B (en) * 2017-02-28 2020-09-15 泉州易初生物医药科技有限公司 Process for the preparation of protease inhibitors
CA3056797A1 (en) * 2017-03-16 2018-09-20 Children's Medical Center Corporation Engineered liposomes as cancer-targeted therapeutics
WO2019136093A1 (en) * 2018-01-02 2019-07-11 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof
US11774451B2 (en) * 2019-11-21 2023-10-03 The Board Of Trustees Of The Leland Stanford Junior University Molecular vibrational spectroscopic markers for detection of cancer
EP4163298A4 (en) * 2020-06-09 2024-06-12 Kookmin University Industry Academy Cooperation Foundation Antibody specifically binding to grp94 or antigen-binding fragment thereof, and uses thereof
KR20230000050A (en) 2021-06-24 2023-01-02 최현지 Fake Mask
CN113663078B (en) * 2021-06-28 2023-05-16 四川大学 Use of Grp94 inhibitors in the preparation of a medicament for the treatment of EGFR-driven cancers
KR20240012846A (en) 2022-07-21 2024-01-30 성균관대학교산학협력단 Novel HDAC6-selective inhibitors and uses thereof
CN115717144A (en) * 2022-08-25 2023-02-28 南通市肿瘤医院 Small interfering RNA for inhibiting HSP90B1 expression and application thereof in bladder cancer senescence
WO2024059745A2 (en) * 2022-09-15 2024-03-21 Bexson Biomedical, Inc. N-methyl-d-aspartate receptor (nmdar) antagonists and uses thereof

Family Cites Families (22)

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EP0708772B1 (en) 1993-07-15 2000-08-23 Minnesota Mining And Manufacturing Company IMIDAZO [4,5-c]PYRIDIN-4-AMINES
CA2426952C (en) * 2000-11-02 2012-06-26 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
EP2336133A1 (en) 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
EP1450784A4 (en) 2001-11-09 2005-02-09 Conforma Therapeutics Corp Hsp90-inhibiting zearalanol compounds and methods of producing and using same
EA010160B1 (en) 2003-09-18 2008-06-30 Конформа Терапьютикс Корпорейшн Novel heterocyclic compounds as hsp90-inhibitors
US9403828B2 (en) 2005-02-01 2016-08-02 Sloan-Kettering Institute For Cancer Research Small-molecule Hsp90 inhibitors
US7834181B2 (en) 2005-02-01 2010-11-16 Slaon-Kettering Institute For Cancer Research Small-molecule Hsp90 inhibitors
EP1962863A4 (en) 2005-12-22 2010-11-24 Conforma Therapeutics Corp Orally active purine-based inhibitors of heat shock protein 90
CA2652263A1 (en) * 2006-05-12 2007-11-22 Myriad Genetics, Inc. Therapeutic compounds and their use in cancer
CA2656202C (en) 2006-06-30 2018-01-16 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases through inhibition of hsp90
US20100015128A1 (en) 2006-10-03 2010-01-21 University Of Southern California GRP78 as a Predictor of Responsiveness to Therapeutic Agents
US8324240B2 (en) 2007-03-20 2012-12-04 Curis, Inc. Fused amino pyridine as HSP90 inhibitors
WO2009065035A1 (en) 2007-11-14 2009-05-22 Myriad Genetics, Inc. Therapeutic compounds and their use in treating diseases and disorders
WO2010042500A2 (en) * 2008-10-06 2010-04-15 Emory University Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
LT2486039T (en) 2009-10-07 2016-10-10 Sloan Kettering Institute For Cancer Research Purine derivatives useful as hsp90 inhibitors
US9346808B2 (en) 2011-04-05 2016-05-24 Sloan-Kettering Institute For Cancer Research Hsp90 inhibitors
KR101984480B1 (en) 2011-04-05 2019-05-31 슬로안-케테링인스티튜트퍼캔서리서치 Hsp90 inhibitors
US8685966B2 (en) 2011-04-08 2014-04-01 University Of Kansas GRP94 inhibitors
EP2714081A4 (en) 2011-05-27 2015-09-09 Cytocure Llc Methods, compositions, and kits for the treatment of cancer
MX2014000292A (en) 2011-07-08 2015-03-06 Sloan Kettering Inst Cancer Uses of labeled hsp90 inhibitors.
MX370664B (en) 2013-08-16 2019-12-19 Memorial Sloan Kettering Cancer Center Selective grp94 inhibitors and uses thereof.

Also Published As

Publication number Publication date
US20160194328A1 (en) 2016-07-07
AU2019202669B2 (en) 2020-12-03
JP2016533384A (en) 2016-10-27
US20230123747A1 (en) 2023-04-20
KR20160043534A (en) 2016-04-21
AU2014306417C1 (en) 2019-07-25
EP3033338A4 (en) 2017-06-14
TWI711618B (en) 2020-12-01
IL244251B (en) 2019-07-31
CA2921571C (en) 2022-04-05
HK1226063A1 (en) 2017-09-22
KR102319582B1 (en) 2021-11-04
CA2921571A1 (en) 2015-02-19
MX2016002077A (en) 2016-07-21
JP2019178147A (en) 2019-10-17
WO2015023976A3 (en) 2015-04-23
JP6848009B2 (en) 2021-03-24
ZA201601794B (en) 2019-09-25
IL267681B (en) 2022-11-01
AU2019202669A1 (en) 2019-05-09
EP3033338A2 (en) 2016-06-22
IL267681B2 (en) 2023-03-01
IL267681A (en) 2019-08-29
AU2014306417B2 (en) 2019-01-17
US20200102312A1 (en) 2020-04-02
JP6539275B2 (en) 2019-07-03
AU2014306417A1 (en) 2016-03-17
MX370664B (en) 2019-12-19
PH12016500511A1 (en) 2016-06-13
CN105899503A (en) 2016-08-24
IL244251A0 (en) 2016-04-21
US10421758B2 (en) 2019-09-24
BR112016003201A2 (en) 2017-11-21
EA201690406A1 (en) 2016-08-31
WO2015023976A2 (en) 2015-02-19
SG10201801281QA (en) 2018-04-27
CN105899503B (en) 2020-08-18
US11267816B2 (en) 2022-03-08
TW201516047A (en) 2015-05-01

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